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1. 发明授权

US07527636B2 Intraluminal guidewire with hydraulically collapsible self-expanding protection device 失效
标题翻译：管腔内导丝与液压可折叠自扩张保护装置
公开(公告)号：US07527636B2
公开(公告)日：2009-05-05
申请号：US10713503
申请日：2003-11-14
申请人： Albert H. Dunfee , David D. Barone
发明人： Albert H. Dunfee , David D. Barone
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61M25/0068 , A61M25/0069 , A61M25/0074 , A61M25/008 , A61M25/0082 , A61M2025/0175
摘要： An intraluminal guidewire system comprises a first tubular member having a proximal end and a distal end and has a fluid containing lumen therethrough. A medical device is coupled to the first tubular member proximate the distal end. A slave actuating member is coupled to the medical device and is slidably mounted proximate the distal end for longitudinal movement with respect to the first tubular member. A master actuating member is configured for longitudinal movement within the first tubular member proximate the proximal end. The master actuating member is hydraulically coupled to the slave actuating member.
摘要翻译：管腔内导丝系统包括具有近端和远端的第一管状构件，并且具有通过其的流体容纳腔。医疗装置连接到靠近远端的第一管状构件。从动执行构件联接到医疗装置并且可靠地靠近远端可滑动地安装，用于相对于第一管状构件的纵向移动。主致动构件构造成用于在靠近近端的第一管状构件内纵向移动。主致动构件液压地联接到从动执行构件。

2. 发明授权

US06716231B1 Distal protection device 失效
标题翻译：远端保护装置
公开(公告)号：US06716231B1
公开(公告)日：2004-04-06
申请号：US09578244
申请日：2000-05-24
申请人： Nasser Rafiee , Jerry R. Brightbill , David S. Brin , Timothy P. Collins , Steven R. Dapolito , Barbara S. DeVaux , Nareak Douk , Albert H. Dunfee , Heng Mao , Michael S. Noone , Dennis L. Brooks , Robert D. Lashinski
发明人： Nasser Rafiee , Jerry R. Brightbill , David S. Brin , Timothy P. Collins , Steven R. Dapolito , Barbara S. DeVaux , Nareak Douk , Albert H. Dunfee , Heng Mao , Michael S. Noone , Dennis L. Brooks , Robert D. Lashinski
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： The present invention is a distal protection device for use during a vascular treatment, such as angioplasty or atherectomy. A filter assembly located on the distal end of a delivery member is deployed distally of the vascular region to be treated to capture emboli released during and immediately after the procedure. The filter is then retracted to retain any captured emboli and then removed from the patient.
摘要翻译：本发明是一种用于血管成形术或粥样斑块切除术的血管治疗期间的远端保护装置。位于递送构件的远端上的过滤器组件被展开在待治疗的血管区域的远端以捕获在手术期间和之后立即释放的栓塞。然后将过滤器缩回以保留任何捕获的栓塞，然后从患者中取出。

3. 发明授权

US09204842B2 Medical device fixation attachment mechanism 有权
标题翻译：医疗器械固定附件机构
公开(公告)号：US09204842B2
公开(公告)日：2015-12-08
申请号：US13050417
申请日：2011-03-17
申请人： Kamal Deep Mothilal , George Patras , Albert H. Dunfee
发明人： Kamal Deep Mothilal , George Patras , Albert H. Dunfee
IPC分类号： A61B5/00 , A61B5/0215 , A61N1/05 , A61N1/372
CPC分类号： A61N1/375 , A61B5/0215 , A61B5/6876 , A61B5/6882 , A61N1/057 , A61N1/37205
摘要： A fixation member configured to anchor an implantable medical device within a patient is attached to an implantable medical device by introducing at least a portion of the fixation member in a tube mechanically connected to the medical device, and plastically deforming the tube in order to pinch the fixation member within a hollow space of the tube.
摘要翻译：构造成将可植入医疗装置固定在患者体内的固定构件通过将固定构件的至少一部分引入机械地连接到医疗装置的管中，并将管塑性变形以将夹紧固定构件在管的中空空间内。

4. 发明申请

US20120109002A1 MEDICAL DEVICE FIXATION ATTACHMENT MECHANISM 有权
标题翻译：医疗器械固定附件机构
公开(公告)号：US20120109002A1
公开(公告)日：2012-05-03
申请号：US13050417
申请日：2011-03-17
申请人： Kamal Deep Mothilal , George Patras , Albert H. Dunfee
发明人： Kamal Deep Mothilal , George Patras , Albert H. Dunfee
IPC分类号： A61B5/01 , A61B5/03
CPC分类号： A61N1/375 , A61B5/0215 , A61B5/6876 , A61B5/6882 , A61N1/057 , A61N1/37205
摘要： A fixation member configured to anchor an implantable medical device within a patient is attached to an implantable medical device by introducing at least a portion of the fixation member in a tube mechanically connected to the medical device, and plastically deforming the tube in order to pinch the fixation member within a hollow space of the tube.
摘要翻译：构造成将可植入医疗装置固定在患者体内的固定构件通过将固定构件的至少一部分引入机械地连接到医疗装置的管中，并将管塑性变形以将夹紧固定构件在管的中空空间内。

5. 发明授权

US07371248B2 Steerable distal protection guidewire and methods of use 失效
标题翻译：可靠的远端保护导线及使用方法
公开(公告)号：US07371248B2
公开(公告)日：2008-05-13
申请号：US10685903
申请日：2003-10-14
申请人： Steven Dapolito , Albert H. Dunfee
发明人： Steven Dapolito , Albert H. Dunfee
IPC分类号： A61M29/00 , A61F2/01
CPC分类号： A61M25/09 , A61F2/013 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0071 , A61M25/0133 , A61M2025/09183
摘要： A steerable guidewire apparatus for use during percutaneous catheter interventions such as angioplasty or stent deployment. A protection element comprising a filter or an occluder is mounted near the distal end of the steerable guidewire, which guides a therapeutic catheter. The guidewire comprises a hollow shaft movably disposed about a core wire. The shaft and core wire control separation of the ends of the protection element, causing transformation of the protection element from a deployed configuration to a collapsed configuration. Farther separation of the ends of the protection element, after it has been collapsed, causes deflection in a distal region of the apparatus.
摘要翻译：用于在经皮导管介入如血管成形术或支架展开期间使用的可导向的导丝装置。包括过滤器或闭塞器的保护元件安装在可引导导丝的远端附近，该引导线引导治疗导管。导丝包括围绕芯线可移动地设置的中空轴。轴和芯线控制分离保护元件的端部，导致保护元件从展开的构型转变成折叠构型。保护元件的端部在其被折叠之后进一步分离，导致设备的远侧区域中的偏转。

6. 发明授权

US06591472B1 Multiple segment catheter and method of fabrication 有权
标题翻译：多段导管及其制造方法
公开(公告)号：US06591472B1
公开(公告)日：2003-07-15
申请号：US09207644
申请日：1998-12-08
申请人： Michael S. Noone , Albert H. Dunfee , Matthew S. Poole
发明人： Michael S. Noone , Albert H. Dunfee , Matthew S. Poole
IPC分类号： B23P1700
CPC分类号： A61M25/0045 , A61M25/0009 , A61M25/0012 , A61M25/0015 , B29L2031/7542 , Y10T29/49798 , Y10T29/49982
摘要： Methods of fabricating medical vascular catheters adapted to be inserted into a blood vessel from an incision through the skin of a patient for introducing other devices or fluids for diagnostic or therapeutic purposes and particularly methods for fabricating such catheters with catheter bodies having catheter sections of differing flexibility are disclosed. Such catheter bodies having a proximal catheter body end and a distal catheter body end and formed of a proximal section and at least one distal section that have differing flexibilities are formed in a process comprising the steps of: (1) forming a continuous tubular inner jacket preferably of an inner liner and a reinforcement layer; (2) forming initial layer segments having an initial layer thickness along the length of the inner jacket from a material of first durometer hardness, whereby each initial layer segment is separated by a separation distance: (3) forming a final layer of a material of second durometer hardness with a second layer thickness over the tubular inner jacket along the separation distances and over and/or against the proximal and distal initial layer ends of the initial layer segments to form a continuous catheter body tubing; (4) severing the continuous catheter body tubing into catheter body lengths including a proximal catheter section formed of the material of second hardness and a distal catheter section of the material of first hardness; and (5) completing the catheter fabrication at the proximal catheter body end and the distal catheter body end. Centerless grinding of the catheter body or body tubing, formation of Intermediate catheter body sections, distal soft tips, and discontinuities in the reinforcement layer formed prior to step (2) are also disclosed.
摘要翻译：制造医用血管导管的方法，其适于从切口穿过患者皮肤插入血管，用于引入其他装置或流体用于诊断或治疗目的，特别是制造具有导管体的方法，导管体具有不同柔性的导管部分被披露。具有近端导管主体端部和远侧导管主体端部并且由近端部分和至少一个具有不同柔性的远端部分形成的这种导管体形成在包括以下步骤的过程中：（1）形成连续的管状内护套优选内衬和加强层; （2）从第一硬度硬度的材料形成具有沿着内护套长度的初始层厚度的初始层段，由此每个初始层段被隔开间隔距离：（3）形成最终层的材料的最终层沿着分隔距离在管状内套上方具有第二层厚度的第二硬度计硬度，并且在初始层段的上和/或靠近初始和最初的初始层端部以形成连续的导管体管; （4）将连续导管体管切断成导管主体长度，包括由第二硬度的材料形成的近端导管部分和第一硬度材料的远侧导管部分; 和（5）在近端导管主体端和远侧导管主体端完成导管制造。还公开了导管主体或体管的无心磨削，中间导管主体部分的形成，远端软尖端和在步骤（2）之前形成的加强层中的不连续性）。

7. 发明授权

US06210396B1 Guiding catheter with tungsten loaded band 有权
标题翻译：引导导管与不透射线带
公开(公告)号：US06210396B1
公开(公告)日：2001-04-03
申请号：US09339499
申请日：1999-06-24
申请人： Stuart R. MacDonald , Zelda M. Anastos , Albert H. Dunfee , Michael S. Noone
发明人： Stuart R. MacDonald , Zelda M. Anastos , Albert H. Dunfee , Michael S. Noone
IPC分类号： A61M25098
CPC分类号： A61M25/0108 , A61L29/18 , A61L31/18 , A61M25/0009
摘要： The present invention comprises a tubular catheter shaft defining at least one catheter shaft lumen and a radiopaque band made of a polymeric material loaded with a radiopaque material of greater than 40% by weight, suitable for visualization under fluoroscopy in catheters in the range of 3 French to 5 French. The distal soft tip is formed of a relatively flexible polymeric material, loaded with radiopaque material which is less radiopaque than the radiopaque band. The radiopaque band's proximal end adjoins the distal end of the catheter shaft. The radiopaque band's distal end adjoins the proximal end of the distal tip to form an attachment junction. A tubular sleeve fits coaxially over the radiopaque band, the distal end of the catheter shaft and the proximal end of the distal soft tip. The tubular sleeve adheres the catheter shaft distal end to the proximal end of the radiopaque band and adheres the soft tip proximal end to the distal end of the radiopaque band thereby aligning the soft tip lumen, the radiopaque band lumen, and the catheter shaft lumen. The proximal end of the tubular sleeve is bonded to a distal portion of the catheter shaft. The distal end of the tubular sheath is bonded to the proximal end of the soft distal tip. The radiopaque band is bonded to the tubular sheath thereby bridging the attachment junction. The tubular sleeve is made of a polymeric material loaded with a radiopaque material which is less radiopaque than the radiopaque band. The tubular sleeve is melt compatible with the radiopaque band, the catheter shaft distal end and the distal soft tip such that the tubular sleeve, the distal end of the catheter shaft, the radiopaque band and the proximal end of the distal soft tip bond.
摘要翻译：本发明包括管状导管轴，其限定至少一个导管轴腔和由装载有大于40重量％的不透射线材料的聚合物材料制成的不透射带，适合于在3个法国的导管内的荧光透视下的可视化到5法语。远端软尖端由相对柔性的聚合物材料形成，该聚合材料装载不透射线不透射线的不透射线材料。不透射线带的近端邻接导管轴的远端。不透射线带的远端与远端尖端的近端相邻以形成附着结。管状套筒同轴地配合在不透射线的带，导管轴的远端和远端软尖端的近端。管状套管将导管轴远端粘附到不透射线带的近端，并将软尖端近端粘附到不透射线带的远端，从而对准软尖端腔，不透射线带腔和导管轴腔。管状套管的近端结合到导管轴的远端部分。管状护套的远端结合到软远侧末端的近端。不透射线的带结合到管状护套，从而桥接连接结。管状套筒由装载有不透射线不透射线的不透射线材料的聚合材料制成。管状套筒与不透射线带，导管轴远端和远端软尖端熔融相容，使得管状套管，导管轴的远端，不透射线带和远端软尖端的近端结合。

8. 发明授权

US07716801B2 Low-profile distal protection device 有权
标题翻译：薄型远端保护装置
公开(公告)号：US07716801B2
公开(公告)日：2010-05-18
申请号：US10718638
申请日：2003-11-24
申请人： Nareak Douk , Nasser Rafiee , Albert H Dunfee
发明人： Nareak Douk , Nasser Rafiee , Albert H Dunfee
IPC分类号： B23P17/00
CPC分类号： A61F2/013 , A61B17/221 , A61F2002/018 , A61F2230/0006 , A61F2230/0069 , A61F2230/0097 , A61F2250/0036 , Y10T29/49801
摘要： A distal protection device captures debris during vascular procedures. In order to reduce the profile of the device, the thickness of the distal protection element is reduced in one or both of the end regions, either by reducing the thickness of filaments which form the distal protection element, or by removing portions of those filaments altogether. Various methods of reducing the thickness of the end regions and different profiles that can be created by the reduction are disclosed.
摘要翻译：远端保护装置在血管手术过程中捕获碎屑。为了减小装置的轮廓，通过减小形成远端保护元件的长丝的厚度，或者通过一起去除这些细丝的一部分，在一个或两个端部区域中减小远侧保护元件的厚度。公开了减少可以产生的端部区域的厚度和不同的轮廓的各种方法。

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