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1. 发明申请

US20140039391A1 APPARATUS FOR INTRAOCULAR INJECTION 审中-公开
标题翻译：眼内注射装置
公开(公告)号：US20140039391A1
公开(公告)日：2014-02-06
申请号：US14110550
申请日：2012-04-11
申请人： Alastair Robert Clarke , Ross Vaughan , David Heighton
发明人： Alastair Robert Clarke , Ross Vaughan , David Heighton
IPC分类号： A61F9/00 , A61M5/42
CPC分类号： A61F9/0017 , A61F9/0008 , A61M5/3287 , A61M5/425
摘要： An apparatus for intraocular injection comprising a body adapted to accommodate an injection device, a displacement device coupled to a distal end of the body, and a sleeve coupled to the body and axially moveable relative to the body. The displacement device includes at least one rotatable member adapted to contact a superficial layer of an eye, and the sleeve engages and causes rotation of the at least one rotatable member as the sleeve moves from a first axial position to a second axial position. Rotation of the at least one rotatable member displaces the superficial layer relative to an underlying layer of the eye.
摘要翻译：一种用于眼内注射的装置，包括适于容纳注射装置的主体，联接到主体的远端的移位装置和联接到主体并且相对于主体可轴向移动的套筒。位移装置包括适于接触眼睛的表层的至少一个可旋转构件，并且当套筒从第一轴向位置移动到第二轴向位置时，套筒接合并引起至少一个可旋转构件的旋转。所述至少一个可旋转构件的旋转相对于眼睛的下层移位表层。

2. 发明申请

US20130338612A1 APPARATUS FOR INTRAOCULAR INJECTION 审中-公开
标题翻译：眼内注射装置
公开(公告)号：US20130338612A1
公开(公告)日：2013-12-19
申请号：US14002181
申请日：2012-03-09
申请人： Christopher James Smith , David Heighton , Alastair Robert Clarke
发明人： Christopher James Smith , David Heighton , Alastair Robert Clarke
IPC分类号： A61F9/00
CPC分类号： A61F9/0017
摘要： An apparatus for intraocular injection comprising a body adapted to accommodate an injection device and a displacement device coupled to a distal portion of the body. The displacement device comprises a first portion and a second portion connected to the first portion. Axial movement of the first portion within the body in a distal direction causes the second portion to displace a superficial layer of an eye relative to an underlying layer of the eye.
摘要翻译：一种用于眼内注射的装置，包括适于容纳注射装置的主体和联接到主体的远端部分的移位装置。位移装置包括连接到第一部分的第一部分和第二部分。第一部分在主体内的远端方向的轴向运动使得第二部分相对于眼睛的下层移位眼睛的表层。

3. 发明授权

US09907694B2 Intraocular medicament delivery device 有权
公开(公告)号：US09907694B2
公开(公告)日：2018-03-06
申请号：US14129856
申请日：2012-06-26
申请人： Alastair Robert Clarke , David Heighton
发明人： Alastair Robert Clarke , David Heighton
IPC分类号： A61F2/16 , A61L27/18 , A61F9/00
CPC分类号： A61F9/0017
摘要： Described is a medicament delivery device comprising a body adapted to be placed on the eye and a reservoir formed in the body containing a medicament. The body has a first surface adapted to contact at least a portion of the eye and be centered around a cornea. At least one projection is formed on the first surface. The projection includes a channel adapted to create a fluid flow path for the medicament from the reservoir to a terminal end of the projection.

4. 发明申请

US20120015335A1 DEVICE FOR SIMULATING THE OPERATION OF A MEDICATION DELIVERY DEVICE 有权
标题翻译：用于模拟药物递送装置的操作的装置
公开(公告)号：US20120015335A1
公开(公告)日：2012-01-19
申请号：US13123479
申请日：2009-10-16
申请人： Christopher James Smith , Alastair Robert Clarke , David Sanders
发明人： Christopher James Smith , Alastair Robert Clarke , David Sanders
IPC分类号： G09B23/28
CPC分类号： G09B23/28 , A61M5/24 , G09B23/285
摘要： A simulation device for simulating the operation of a medication delivery device comprises a housing (1) and a moveable element (4) partly disposed in the housing (1). The moveable element is moveable from a first position to a second position.
摘要翻译：用于模拟药物输送装置的操作的模拟装置包括壳体（1）和部分地设置在壳体（1）中的可移动元件（4）。可移动元件可从第一位置移动到第二位置。

5. 发明授权

US6109261A Powder inhaler with breath flow regulation valve 失效
标题翻译：粉末吸入器带呼吸流量调节阀
公开(公告)号：US6109261A
公开(公告)日：2000-08-29
申请号：US6725
申请日：1998-01-14
申请人： Alastair Robert Clarke , Clive Sleath , Michael Trevor Shepherd
发明人： Alastair Robert Clarke , Clive Sleath , Michael Trevor Shepherd
IPC分类号： A61M15/00 , G05D7/01
CPC分类号： G05D7/0126 , A61M15/002 , A61M15/0028 , G05D7/0113 , G05D7/0133 , G05D7/0173 , A61M2202/064
摘要： There is provided a device for the administration of an inhalation medicament, including a body defining a through-going air pathway having a longitudinal axis, an air inlet, an air outlet forming a mouthpiece, means for dispensing medicament into the pathway and air flow regulating means, characterized in that the air flow regulating means includes a movable obstructing means adapted to reduce the cross-sectional area of the pathway at a location between the air inlet and the means for dispensing medicament, and biassing means, whereby the obstructing means is biassed into a first resting position in which the cross-sectional area of the pathway is minimum and is adapted to move against the bias of the biassing means to a second position in which the cross-section area of the pathway is maximum in response to a pressure fall at the mouthpiece caused by inhalation and is adapted to move farther to a third position in which the cross-sectional area of the pathway is less than maximum in response to a greater pressure fall at the mouthpiece caused by inhalation.
摘要翻译：提供了一种用于施用吸入药物的装置，其包括限定具有纵向轴线的直通空气通道的主体，空气入口，形成接口管的空气出口，用于将药物分配到通路中的装置和气流调节装置，其特征在于，所述空气流量调节装置包括适于减小所述通道在所述空气入口与所述用于分配药物的装置之间的位置处的横截面积的可移动阻塞装置，以及所述阻塞装置被偏压进入第一静止位置，其中通路的横截面面积最小并且适于抵抗偏压装置的偏压移动到第二位置，在该第二位置，响应于压力的通道的横截面面积最大落在由吸入引起的喉舌下，并且适于移动到第三位置，在第三位置，通路的横截面积小于最大值对吸入引起的喉舌压力下降的反应。

6. 发明申请

US20140135716A1 Intraocular Medicament Delivery Device 有权
标题翻译：眼内药物输送装置
公开(公告)号：US20140135716A1
公开(公告)日：2014-05-15
申请号：US14129856
申请日：2012-06-26
申请人： Alastair Robert Clarke , David Heighton
发明人： Alastair Robert Clarke , David Heighton
IPC分类号： A61F9/00
CPC分类号： A61F9/0017
摘要： Described is a medicament delivery device comprising a body adapted to be placed on the eye and a reservoir formed in the body containing a medicament. The body has a first surface adapted to contact at least a portion of the eye and be centered around a cornea. At least one projection is formed on the first surface. The projection includes a channel adapted to create a fluid flow path for the medicament from the reservoir to a terminal end of the projection.
摘要翻译：描述了一种药物输送装置，其包括适于放置在眼睛上的主体和形成在身体中的容纳药物的储存器。身体具有适于接触眼睛的至少一部分并围绕角膜居中的第一表面。在第一表面上形成至少一个突起。突出部包括适于产生用于药物从储存器到突起的终端的流体流路的通道。

7. 发明授权

US06557550B1 Inhalation device 有权
标题翻译：吸入装置
公开(公告)号：US06557550B1
公开(公告)日：2003-05-06
申请号：US09552103
申请日：2000-04-19
申请人： Alastair Robert Clarke
发明人： Alastair Robert Clarke
IPC分类号： A61M1500
CPC分类号： A61M15/0065 , A61M2202/066
摘要： An inhalation device which contains powdered medicament in the form of a medicament compact is provided with a seal comprising a partial ring between the outer wall and inner mandrel of the medicament compact chamber. The medicament is dispensed by abrading the medicament compact by turning the compact relative to the inner mandrel against a blade. Despite only extending around part of the circumference of the mandrel the seal prevents leakage of loose powder from the compact chamber to the rest of the device. The sealing means also provides a frictional braking force on the medicament reservoir sufficient to prevent movement of the medicament reservoir when the drive mechanism for the reservoir is returning to its starting position without making the device difficult to operate by a child or infirm adult.
摘要翻译：包含药物成形体形式的粉末状药物的吸入装置设有密封件，该密封件包括药物致密腔室的外壁和内心轴之间的部分环。通过相对于刀片相对于内部心轴转动压实体来研磨药物压块来分配药物。尽管仅在心轴的周围的一部分周围延伸，但是密封件防止松散的粉末从紧凑的腔室泄漏到装置的其余部分。密封装置还在药剂储存器上提供足够的摩擦制动力，足以防止当储存器的驱动机构返回到其起始位置时药物储存器的移动，而不会使装置难以由儿童或体弱的成年人操作。

8. 发明授权

US5727546A Powder inhaler with breath flow regulation valve 失效
标题翻译：粉末吸入器带呼吸流量调节阀
公开(公告)号：US5727546A
公开(公告)日：1998-03-17
申请号：US596311
申请日：1996-07-17
申请人： Alastair Robert Clarke , Clive Sleath , Michael Trevor Shepherd
发明人： Alastair Robert Clarke , Clive Sleath , Michael Trevor Shepherd
IPC分类号： A61M15/00 , G05D7/01 , A61M16/00 , B05D7/14 , B65D83/06
CPC分类号： G05D7/0126 , A61M15/002 , A61M15/0028 , G05D7/0113 , G05D7/0133 , G05D7/0173 , A61M2202/064
摘要： There is provided a device for the administration of an inhalation medicament, including a body defining a through-going air pathway having a longitudinal axis, an air inlet, an air outlet forming a mouthpiece, means for dispensing medicament into the pathway and air flow regulating means, characterised in that the air flow regulating means includes a movable obstructing means adapted to reduce the cross-sectional area of the pathway at a location between the air inlet and the means for dispensing medicament, and biassing means, whereby the obstructing means is biassed into a first resting position in which the cross-sectional area of the pathway is minimum and is adapted to move against the bias of the biassing means to a second position in which the cross-section area of the pathway is maximum in response to a pressure fall at the moiuthpiece caused by inhalation and is adapted to move further to a third position in which the cross-sectional area of the pathway is less than maximum in response to a greater pressure fall at the mouthpiece caused by inhalation.
摘要翻译： PCT No.PCT / GB94 / 01812 Sec。 371日期：1996年7月17日 102（e）日期1996年7月17日PCT 1994年8月18日PCT PCT。出版物WO95 / 05208 日期1995年2月23日提供了一种用于给药吸入药物的装置，其包括限定具有纵向轴线的直通空气路径的主体，空气入口，形成接口管的空气出口，用于将药物分配到通路和气流调节装置，其特征在于，所述空气流量调节装置包括适于在所述进气口和用于分配药物的装置之间的位置减小所述通道的横截面面积的可移动阻塞装置和偏压装置，由此阻塞装置被偏压到第一静止位置，在该第一静止位置，通路的横截面面积最小，并适于抵抗偏压装置的偏压移动到第二位置，在该第二位置，通道的横截面面积最大响应于由吸入引起的气囊处的压力下降，并且适于进一步移动到第三位置，其中通路的横截面积为l 因为吸入引起的喉舌压力下降较大，所以最大。

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