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1. 发明授权

US10238535B2 Lacrimal implants and related methods 有权
公开(公告)号：US10238535B2
公开(公告)日：2019-03-26
申请号：US12710855
申请日：2010-02-23
申请人： Alan R. Rapacki , Valery Rubinchik , Charles Richard Kjellbotn
发明人： Alan R. Rapacki , Valery Rubinchik , Charles Richard Kjellbotn
IPC分类号： A61M31/00 , A61F9/007 , A61K9/00
摘要： Lacrimal implants and related methods providing secure, wedgable retention within a lacrimal punctum and associated canaliculus of an eye are disclosed. The lacrimal implants can comprise an implant body configured for at least partial insertion through the lacrimal punctum and into the canaliculus. The implant body can include first and second portions, and can extend from a proximal end of the first portion defining a longitudinal proximal axis to a distal end of the second portion defining a longitudinal distal axis. The implant body can be configured such that, when implanted using an integral dilator, an angled intersection exists between the proximal and distal axes. In this way, at least a portion of the implant body can be biased against at least a portion of the lacrimal canaliculus located at or more distal to a canalicular curvature, thereby retaining an implanted position of the lacrimal implant using anatomical structures.

2. 发明申请

US20140058433A1 BRONCHIAL ISOLATION DEVICES FOR PLACEMENT IN SHORT LUMENS 审中-公开
标题翻译：用于短裤放置的BRONCHIAL隔离装置
公开(公告)号：US20140058433A1
公开(公告)日：2014-02-27
申请号：US13767793
申请日：2013-02-14
申请人： Michael Barrett , Antony J. Fields , Michael J. Hendricksen , Ronald R. Hundertmark , John G. McCutcheon , Alan R. Rapacki , Michael Regan , Steve Wallace
发明人： Michael Barrett , Antony J. Fields , Michael J. Hendricksen , Ronald R. Hundertmark , John G. McCutcheon , Alan R. Rapacki , Michael Regan , Steve Wallace
IPC分类号： A61B17/12 , A61F2/04
CPC分类号： A61B17/12168 , A61B17/12022 , A61B17/12036 , A61B17/12104 , A61B17/12172 , A61B2017/1205 , A61F2/04 , A61F2/24 , A61F2002/043
摘要： Methods and devices are adapted for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.
摘要翻译：方法和装置适于调节流入和流出患者肺部区域的流体流动，例如在呼吸过程中实现期望的流体流动到肺部区域，和/或诱导一个或多个肺部区域的塌陷。根据示例性程序，确定的肺部区域被靶向用于治疗。然后将目标肺区域支气管分离，以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。

3. 发明申请

US20110226238A1 IMPLANTED BRONCHIAL ISOLATION DEVICES AND METHODS 有权
标题翻译：植入式隔离装置和方法
公开(公告)号：US20110226238A1
公开(公告)日：2011-09-22
申请号：US12885199
申请日：2010-09-17
申请人： Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
发明人： Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
IPC分类号： A61M16/20
CPC分类号： A61B17/12022 , A61B17/12104 , A61B17/12172 , A61F2/2412 , A61F2002/043
摘要： Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.
摘要翻译：公开了用于调节流入和流出患者肺部区域的流体的方法和装置，例如在呼吸过程中实现期望的流体流动到肺部区域，和/或诱导一个或多个肺部区域的塌陷。根据示例性程序，确定的肺部区域被靶向用于治疗。然后将目标肺区域支气管分离，以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。

4. 发明授权

US06635214B2 Manufacturing conduits for use in placing a target vessel in fluid communication with a source of blood 失效
标题翻译：用于放置目标血管与血液源流体连通的制造管道
公开(公告)号：US06635214B2
公开(公告)日：2003-10-21
申请号：US09394119
申请日：1999-09-10
申请人： Alan R. Rapacki , Dean F. Carson , A. Adam Sharkawy
发明人： Alan R. Rapacki , Dean F. Carson , A. Adam Sharkawy
IPC分类号： B29C3902
CPC分类号： A61F2/2493 , A61B2017/00252 , A61F2/064 , B29C41/14 , B29C45/14598 , B29C45/261 , B29C66/857 , B29L2023/007 , B29L2031/7534 , B29C65/00
摘要： Methods and devices for manufacturing a conduit for placing a target vessel in fluid communication with a source of blood, such as a heart chamber containing blood. The conduit includes first and second portion adapted to be placed in fluid communication with a heart chamber and a target vessel. The conduit lies on the exterior of the myocardium between the blood source and the target vessel and delivers blood in multiple directions within the lumen of the target vessel. The conduit, which may be formed of any suitable synthetic vascular graft material, is generally T-shaped with the leg having two free ends disposed in the target vessel, preferably being secured thereto via a suture-free attachment. The conduit comprises vascular graft material and may be manufactured various ways, such as molding a conduit from any suitable biocompatible material or fabricating a conduit from one or more pieces of vascular graft material.
摘要翻译：用于制造用于放置目标血管与血液源（例如含有血液的心室）流体连通的导管的方法和装置。导管包括适于与心脏腔室和靶容器流体连通的第一和第二部分。导管位于血液源和目标血管之间的心肌外部，并在目标血管内腔内的多个方向输送血液。可以由任何合适的合成血管移植材料形成的导管通常是T形的，腿部具有设置在靶容器中的两个自由端，优选通过无缝线的附件固定到其上。导管包括血管移植材料，并且可以以各种方式制造，例如从任何合适的生物相容性材料模制导管或从一个或多个血管移植物材料制造导管。

5. 发明授权

US06613069B2 Tunneling instrument for port access multivessel coronary artery bypass surgery 失效
标题翻译：用于多通道冠状动脉旁路手术的隧道掘进器
公开(公告)号：US06613069B2
公开(公告)日：2003-09-02
申请号：US09982504
申请日：2001-10-19
申请人： Stephen W. Boyd , Alan R. Rapacki , Matthias Vaska , Brian S. Donlon , William S. Peters , John H. Stevens
发明人： Stephen W. Boyd , Alan R. Rapacki , Matthias Vaska , Brian S. Donlon , William S. Peters , John H. Stevens
IPC分类号： A61B1744
CPC分类号： A61F7/10 , A61B17/00234 , A61B17/0057 , A61B17/0218 , A61B17/0467 , A61B17/0469 , A61B17/06061 , A61B17/064 , A61B17/068 , A61B17/12013 , A61B17/122 , A61B17/1227 , A61B17/1285 , A61B17/29 , A61B17/2909 , A61B17/30 , A61B17/3403 , A61B18/1442 , A61B18/1492 , A61B90/36 , A61B90/50 , A61B2017/00243 , A61B2017/00247 , A61B2017/00637 , A61B2017/00663 , A61B2017/0225 , A61B2017/0237 , A61B2017/0243 , A61B2017/047 , A61B2017/0472 , A61B2017/0474 , A61B2017/0475 , A61B2017/2912 , A61B2017/2927 , A61B2017/2932 , A61B2017/2943 , A61B2017/306 , A61B2017/308 , A61B2017/3405 , A61B2017/3427 , A61B2017/3492 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00291 , A61B2018/00363 , A61B2018/00392 , A61B2018/00577 , A61B2090/064 , A61B2090/306 , A61F2/2427 , A61F2007/0001 , A61F2007/0054 , A61F2007/101 , A61M25/0023 , A61M25/0032 , A61M25/1011 , A61M39/0247 , A61M2025/0003 , A61M2025/0031 , A61M2025/028 , A61M2025/1052 , A61M2039/0279 , A61M2202/047 , A61M2205/3344 , A61M2205/3355 , A61M2205/366 , A61M2210/127 , A61M2230/005
摘要： Surgical methods and instruments are disclosed for performing port-access or closed-chest coronary artery bypass (CABG) surgery in multivessel coronary artery disease. In contrast to standard open-chest CABG surgery, which requires a median sternotomy or other gross thoracotomy to expose the patient's heart, port-access CABG surgery is performed through small incisions or access ports made through the intercostal spaces between the patient's ribs, resulting in greatly reduced pain and morbidity to the patient. In situ arterial bypass grafts, such as the internal mammary arteries and/or the right gastroepiploic artery, are prepared for grafting by thoracoscopic or laparoscopic takedown techniques. Free grafts, such as a saphenous vein graft or a free arterial graft, can be used to augment the in situ arterial grafts. The graft vessels are anastomosed to the coronary arteries under direct visualization through a cardioscopic microscope inserted through an intercostal access port. Retraction instruments are provided to manipulate the heart within the closed chest of the patient to expose each of the coronary arteries for visualization and anastomosis. Disclosed are a tunneler and an articulated tunneling grasper for rerouting the graft vessels, and a finger-like retractor, a suction cup retractor, a snare retractor and a loop retractor for manipulating the heart. Also disclosed is a port-access topical cooling device for improving myocardial protection during the port-access CABG procedure. An alternate surgical approach using an anterior mediastinotomy is also described.
摘要翻译：公开了手术方法和手段，用于在多支冠状动脉疾病中进行门禁或封闭式冠状动脉旁路（CABG）手术。与标准的胸腔CABG手术相比，其需要中位胸骨切开术或其他大胸廓切开术来暴露患者的心脏，通过患者肋骨之间的肋间空间形成的小切口或进入端口进行口腔进入CABG手术，导致大大减轻患者的疼痛和发病率。通过胸腔镜或腹腔镜移植技术准备原位动脉旁路移植物，例如乳内动脉和/或右胃腹动脉，用于移植。可以使用游离移植物，例如隐静脉移植物或自由动脉移植物来增加原位动脉移植物。通过插入通过肋间进入口的心脏显微镜，直接观察移植血管与冠状动脉吻合。提供收缩器械以操纵患者的封闭胸部内的心脏以暴露每个冠状动脉以进行可视化和吻合。公开了一种用于重新路由移植血管的隧道器和铰接隧道抓紧器，以及用于操纵心脏的手指状牵开器，吸盘牵开器，圈套牵开器和回卷器。还公开了一种用于在端口访问CABG过程期间改善心肌保护的端口访问局部冷却装置。还描述了使用前纵隔切开术的替代手术方法。

6. 发明授权

US06517558B2 Methods and devices for forming vascular anastomoses 失效
标题翻译：用于形成血管吻合的方法和装置
公开(公告)号：US06517558B2
公开(公告)日：2003-02-11
申请号：US09776230
申请日：2001-02-01
申请人： Darin C. Gittings , Wally S. Buch , Alan R. Rapacki
发明人： Darin C. Gittings , Wally S. Buch , Alan R. Rapacki
IPC分类号： A61B1702
CPC分类号： A61B17/11 , A61B2017/00252 , A61B2017/1107 , A61B2017/1135 , A61F2/064 , A61F2/07 , A61F2/86 , A61F2/91
摘要： Methods and devices for forming an anastomosis utilize a graft vessel secured to a vessel coupling that is fixed to a target vessel without using suture. The vessel coupling may be collapsed for introduction into the target vessel and then expanded to engage the vessel wall. The vessel coupling may be a stent attached to a graft vessel to form a stent-graft assembly. The anastomosis may be carried out to place the graft and target vessels in fluid communication while preserving native proximal flow through the target vessel, which may be a coronary artery. As a result, blood flowing through the coronary artery from the aorta is not blocked by the vessel coupling and thus is free to move past the site of the anastomosis.
摘要翻译：用于形成吻合的方法和装置利用固定到血管联接的移植血管，所述移植血管在不使用缝合线的情况下固定到靶血管。血管联接器可能被塌缩以引入目标血管，然后膨胀以接合血管壁。血管联接可以是附接到移植血管以形成支架移植物组件的支架。可以进行吻合以使移植物和靶容器保持流体连通，同时保持通过可能是冠状动脉的靶血管的天然近端流。结果，从主动脉流过冠状动脉的血液不被血管联接阻塞，因此可以自由地移动通过吻合部位。

7. 发明授权

US08210902B2 Surface treated implantable articles and related methods 有权
标题翻译：表面处理可植入物品及相关方法
公开(公告)号：US08210902B2
公开(公告)日：2012-07-03
申请号：US12283002
申请日：2008-09-05
申请人： Alan R. Rapacki , Wilhelm Leung
发明人： Alan R. Rapacki , Wilhelm Leung
IPC分类号： B24B1/00
CPC分类号： A61F2/148 , A61F9/00772 , B24B9/20 , B24B31/00 , B29C37/02 , B29C71/0009 , B29C2071/0027 , B29C2071/0045 , B29L2031/7532 , B29L2031/756
摘要： Surface treated implantable articles and related methods are disclosed. The surface treated implantable articles can be substantially flash-free, include one or more rounded edges, or include an enhanced optical clarity, one or all of which can be produced by polishing. The polishing can include causing the implantable articles to be repeatedly impacted with polishing media when the articles are swelled to an enlarged state. The polishing process can be particularly useful for smoothing lacrimal implants insertable in a lacrimal canaliculus.
摘要翻译：公开了表面处理的可植入制品和相关方法。表面处理的可植入制品可以基本上无闪光，包括一个或多个圆形边缘，或包括增强的光学透明度，其中一个或全部可通过抛光产生。抛光可以包括当物品膨胀到放大状态时使可植入物品与抛光介质反复冲击。抛光过程对于平滑可插入泪小管的泪液植入物可能特别有用。

8. 发明申请

US20120004589A1 DELIVERING A CONDUIT INTO A HEART WALL TO PLACE A CORONARY VESSEL IN COMMUNICATION WITH A HEART CHAMBER AND REMOVING TISSUE FROM THE VESSEL OR HEART WALL TO FACILITATE SUCH COMMUNICATION 审中-公开
标题翻译：将心脏输送到心房内，放置一个通过心室进行通信的冠脉血管，并从血管或心脏移除组织以便于进行这种通讯
公开(公告)号：US20120004589A1
公开(公告)日：2012-01-05
申请号：US13187070
申请日：2011-07-20
申请人： Alan R. Rapacki , Darin C. Gittings , Gilbert S. Laroya , Mark J. Foley
发明人： Alan R. Rapacki , Darin C. Gittings , Gilbert S. Laroya , Mark J. Foley
IPC分类号： A61F2/06
CPC分类号： A61F2/064 , A61B17/3468 , A61B2017/00247 , A61B2017/00252 , A61B2018/00392 , A61B2090/062 , A61F2/2493 , A61F2/90 , A61F2/94 , A61F2/966 , A61F2002/30079 , A61F2002/30617 , A61F2002/9517 , A61F2210/009 , A61F2250/0097
摘要： Devices and methods for delivering conduits into the wall of a patient's heart to communicate a coronary vessel with a heart chamber. The devices are passed through the coronary vessel and the heart wall to place the conduit and establish a blood flow path between the vessel and the heart chamber. Additional devices and methods are provided for removing tissue from a coronary vessel or the heart wall to establish a flow path between the coronary vessel in communication with the heart chamber.
摘要翻译：将导管输送到患者心脏的壁中以将冠状动脉血管与心脏腔室通信的装置和方法。装置通过冠状血管和心脏壁以放置导管，并在容器和心脏腔室之间建立血流路径。提供了附加的装置和方法，用于从冠状血管或心脏壁去除组织，以建立与心室连通的冠状血管之间的流动路径。

9. 发明授权

US07036509B2 Multiple seal port anesthesia adapter 有权
标题翻译：多重密封口麻醉适配器
公开(公告)号：US07036509B2
公开(公告)日：2006-05-02
申请号：US11004560
申请日：2004-12-03
申请人： Alan R. Rapacki , Michael Barrett , Michael J. Hendricksen , Ronald R. Hundertmark
发明人： Alan R. Rapacki , Michael Barrett , Michael J. Hendricksen , Ronald R. Hundertmark
IPC分类号： A61M16/00 , A62B9/04
CPC分类号： A61M16/0463 , A61B2017/3466 , A61M16/01
摘要： Disclosed is an anesthesia adapter that is suitable for the simultaneous insertion of multiple devices or instruments into the lungs during ventilation of the patient, while minimizing or eliminating gas leaks. The anesthesia adapter comprises in one embodiment a first port sized to receive a first elongate instrument; a second port sized to receive a second elongate instrument; an endotrachial tube fitting configured to be coupled to an endotrachial tube, the endotrachial tube fitting fluidly coupled to the first and second ports; and a hose fitting configured to be coupled to a ventilator hose, the hose fitting fluidly coupled to the first and second ports. The first port seals around the first elongated instrument and the second port seals around the second elongate instrument.
摘要翻译：公开了一种麻醉适配器，其适合于在患者通气期间同时将多个装置或器械插入肺中，同时最小化或消除气体泄漏。麻醉适配器在一个实施例中包括尺寸适于接收第一细长器械的第一端口; 尺寸适于接纳第二细长仪器的第二端口; 构造成联接到血管内管的内窥镜管接头，所述内窥镜管配合流体耦合到所述第一和第二端口; 以及软管接头，其配置成联接到通气机软管，所述软管接头流体地联接到所述第一和第二端口。第一端口围绕第一细长器械密封，第二端口围绕第二细长器械密封。

10. 发明授权

US06651670B2 Delivering a conduit into a heart wall to place a coronary vessel in communication with a heart chamber and removing tissue from the vessel or heart wall to facilitate such communication 失效
标题翻译：将导管输送到心脏壁以使冠状血管与心室连通并从血管或心壁去除组织以促进这种沟通
公开(公告)号：US06651670B2
公开(公告)日：2003-11-25
申请号：US09170994
申请日：1998-10-13
申请人： Alan R. Rapacki , Darin C. Gittings , Gilbert S. Laroya , Mark J. Foley
发明人： Alan R. Rapacki , Darin C. Gittings , Gilbert S. Laroya , Mark J. Foley
IPC分类号： A61B1700
CPC分类号： A61F2/064 , A61B17/3468 , A61B2017/00247 , A61B2017/00252 , A61B2018/00392 , A61B2090/062 , A61F2/2493 , A61F2/90 , A61F2/94 , A61F2/966 , A61F2002/30079 , A61F2002/30617 , A61F2002/9517 , A61F2210/009 , A61F2250/0097
摘要： Devices and methods for delivering conduits into the wall of a patient's heart to communicate a coronary vessel with a heart chamber. The devices are passed through the coronary vessel and the heart wall to place the conduit and establish a blood flow path between the vessel and the heart chamber. Additional devices and methods are provided for removing tissue from a coronary vessel or the heart wall to establish a flow path between the coronary vessel in communication with the heart chamber.
摘要翻译：将导管输送到患者心脏的壁中以将冠状动脉血管与心脏腔室通信的装置和方法。装置通过冠状血管和心脏壁以放置导管，并在容器和心脏腔室之间建立血流路径。提供了附加的装置和方法，用于从冠状血管或心脏壁去除组织，以在与心室连通的冠状血管之间建立流路。

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