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1. 发明申请

US20090215170A1 Plexin family-like polypeptide, DNA encoding the same and uses thereof 失效
标题翻译：丛状家族样多肽，编码它们的DNA及其用途
公开(公告)号：US20090215170A1
公开(公告)日：2009-08-27
申请号：US12318086
申请日：2008-12-22
申请人： Hisashi Koga , Osamu Ohara , Haruhiko Koseki , Mitsuhiro Okada , Akiyoshi Uemura , Hiroki Arakawa , Mitsuhiro Tada
发明人： Hisashi Koga , Osamu Ohara , Haruhiko Koseki , Mitsuhiro Okada , Akiyoshi Uemura , Hiroki Arakawa , Mitsuhiro Tada
IPC分类号： C12N5/10 , C07H21/04 , C12N15/63
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention is directed to a novel plexin family like DNA, a gene containing the DNA, novel polypeptide encoded by the DNA, a recombinant protein containing the polypeptide or heterologous polypeptide sequences, antibodies which bind to the polypeptides, methods for producing the polypeptides of the present invention. Conditions that can be diagnosed, screened, prevented, or treated by the compositions herein include prophylactic, angiogenesis and conservation of functions in various organs, angiogenesis at the time of tumor and regeneration of various organs, proliferation, differentiation and preservation of function of the cells in various organs, aging, and dysfunction of the present invention.
摘要翻译：本发明涉及一种新型的plexin家族如DNA，含有该DNA的基因，由该DNA编码的新型多肽，含有该多肽或异源多肽序列的重组蛋白，与该多肽结合的抗体，产生多肽的多肽的方法本发明。可以通过本文组合物诊断，筛选，预防或治疗的病症包括各种器官的功能的预防，血管生成和保护，肿瘤时的血管发生和各种器官的再生，细胞的功能的增殖，分化和保存在本发明的各种器官，衰老和功能障碍中。

2. 发明授权

US07482322B2 Plexin family-like polypeptide, and uses thereof 失效
标题翻译：丛状家族样多肽及其用途
公开(公告)号：US07482322B2
公开(公告)日：2009-01-27
申请号：US10573262
申请日：2004-10-28
申请人： Hisashi Koga , Osamu Ohara , Haruhiko Koseki , Mitsuhiro Okada , Akiyoshi Uemura , Hiroki Arakawa , Mitsuhiro Tada
发明人： Hisashi Koga , Osamu Ohara , Haruhiko Koseki , Mitsuhiro Okada , Akiyoshi Uemura , Hiroki Arakawa , Mitsuhiro Tada
IPC分类号： A61K38/16 , A61K38/00 , C07K14/435 , C07K14/00
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention is directed to a novel plexin family like DNA, a gene containing the DNA, novel polypeptide encoded by the DNA, a recombinant protein containing the polypeptide or heterologous polypeptide sequences, antibodies which bind to the polypeptides, methods for producing the polypeptides of the present invention. Conditions that can be diagnosed, screened, prevented, or treated by the compositions herein include prophylactic, angiogenesis and conservation of functions in various organs, angiogenesis at the time of tumor and regeneration of various organs, proliferation, differentiation and preservation of function of the cells in various organs, aging, and dysfunction of the present invention.
摘要翻译：本发明涉及一种新型的plexin家族如DNA，含有该DNA的基因，由该DNA编码的新型多肽，含有该多肽或异源多肽序列的重组蛋白，与该多肽结合的抗体，产生多肽的多肽的方法本发明。可以通过本文组合物诊断，筛选，预防或治疗的病症包括各种器官的功能的预防，血管生成和保护，肿瘤时的血管发生和各种器官的再生，细胞的功能的增殖，分化和保存在本发明的各种器官，衰老和功能障碍中。

3. 发明申请

US20070212365A1 Novel Plexin Polypeptide, Dna Encoding the Same and Use Thereof 失效
标题翻译：新型Plexin多肽，Dna编码相同，并使用它们
公开(公告)号：US20070212365A1
公开(公告)日：2007-09-13
申请号：US10573262
申请日：2004-10-28
申请人： Hisashi Koga , Osamu Ohara , Haruhiko Koseki , Mitsuhiro Okada , Akiyoshi Uemura , Hiroki Arakawa , Mitsuhiro Tada
发明人： Hisashi Koga , Osamu Ohara , Haruhiko Koseki , Mitsuhiro Okada , Akiyoshi Uemura , Hiroki Arakawa , Mitsuhiro Tada
IPC分类号： A61K39/00 , G01N33/574 , C07H21/04 , C12P21/06 , C12N5/06 , C07K14/82
CPC分类号： C07K14/705 , A61K38/00
摘要： The object of the invention is to provide novel DNA, a gene containing the DNA, novel polypeptide encoded by the DNA, a recombinant protein containing the polypeptide, or an antibody against the polypeptide, which is useful for development and screening of prophylactic, therapeutic and diagnostic drug for angiogenesis and conservation of functions in various organs, angiogenesis at the time of tumor and regeneration of various organs, proliferation, differentiation and preservation of function of the cells in various organs, aging, and dysfunction. Means to Solve the Problem A DNA comprising a base sequence encoding one of the following polypeptide (a) or (b): (a) a polypeptide comprising the full length or a part of an amino acid sequence which is the same or substantially the same as an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:15 or SEQ ID NO:18, and (b) a polypeptide comprising an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO:1, SEQ ID NO:15 or SEQ ID NO:18 by deletion, substitution or addition of a part of the amino acids and having a biological activity substantially equivalent to the polypeptide (a).
摘要翻译：本发明的目的是提供新的DNA，含有DNA的基因，由DNA编码的新型多肽，含有多肽的重组蛋白或抗多肽的抗体，其可用于开发和筛选预防性治疗和用于血管发生的诊断药物和各种器官功能的保存，肿瘤时的血管发生和各种器官的再生，增殖，分化和保存各种器官，衰老和功能障碍中的细胞的功能。解决问题的方法包含编码以下多肽（a）或（b）之一的碱基序列的DNA：（a）包含相同或基本相同的氨基酸序列的全长或部分的多肽作为由SEQ ID NO：1，SEQ ID NO：15或SEQ ID NO：18表示的氨基酸序列，和（b）包含源自SEQ ID NO：1所示氨基酸序列的氨基酸序列的多肽， SEQ ID NO：15或SEQ ID NO：18，通过缺失，取代或添加一部分氨基酸并且具有与多肽（a）基本相同的生物活性。

4. 发明授权

US07816132B2 DNA encoding plexin polypeptides and kits thereof 失效
标题翻译：编码plexin多肽的DNA及其试剂盒
公开(公告)号：US07816132B2
公开(公告)日：2010-10-19
申请号：US12318086
申请日：2008-12-22
申请人： Hisashi Koga , Osamu Ohara , Haruhiko Koseki , Mitsuhiro Okada , Akiyoshi Uemura , Hiroki Arakawa , Mitsuhiro Tada
发明人： Hisashi Koga , Osamu Ohara , Haruhiko Koseki , Mitsuhiro Okada , Akiyoshi Uemura , Hiroki Arakawa , Mitsuhiro Tada
IPC分类号： C12N5/10 , C12N15/12 , C12N15/63
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention is directed to a novel plexin family like DNA, a gene containing the DNA, novel polypeptide encoded by the DNA, a recombinant protein containing the polypeptide or heterologous polypeptide sequences, antibodies which bind to the polypeptides, methods for producing the polypeptides of the present invention. Conditions that can be diagnosed, screened, prevented, or treated by the compositions herein include prophylactic, angiogenesis and conservation of functions in various organs, angiogenesis at the time of tumor and regeneration of various organs, proliferation, differentiation and preservation of function of the cells in various organs, aging, and dysfunction of the present invention.
摘要翻译：本发明涉及一种新型的plexin家族如DNA，含有该DNA的基因，由该DNA编码的新型多肽，含有该多肽或异源多肽序列的重组蛋白，与该多肽结合的抗体，产生多肽的多肽的方法本发明。可以通过本文组合物诊断，筛选，预防或治疗的病症包括各种器官的功能的预防，血管生成和保护，肿瘤时的血管发生和各种器官的再生，细胞的功能的增殖，分化和保存在本发明的各种器官，衰老和功能障碍中。

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