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1. 发明专利

JPS6044914B2 JPS6044914B2 - 失效
公开(公告)号：JPS6044914B2
公开(公告)日：1985-10-05
申请号：JP3351281
申请日：1981-03-09
申请人： Akira Endo
发明人： ENDO AKIRA
IPC分类号： C12N1/14 , A61K36/06 , A61P3/06 , A61P3/08

2. 发明专利

JPS59162890A Preparation of physiologically active substance, mutastein 失效
标题翻译：生理活性物质的制备，MUTASTEIN
公开(公告)号：JPS59162890A
公开(公告)日：1984-09-13
申请号：JP3789483
申请日：1983-03-08
申请人： Akira Endo
发明人： ENDOU AKIRA
IPC分类号： A61K36/06 , A61P1/02 , C12P1/02 , C12R1/645 , C12R1/785
摘要： PURPOSE: To prepare a physiologically active substance, mutastein, useful for the prevention and remedy of dental caries, by culturing microorganism belonging to Cercospora genus, Cladosporium genus, Collectotrichum genus, etc. under aerobic condition, and extracting the cultured liquid.
CONSTITUTION: Microorganism capable of producing mutastein and belonging to Cercospora genus, Cladosporium genus, Colletotrichum genus, Cylindrosporium genus, Dactylaria genus, Dematium genus, Diplogelasinospora genus, Drechslera genus, Endophragmia genus, Fennellia genus, Leptographium genus, Monascus genus, Mucor genus, Doratomyces genus, Sporormiella genus or Stachybotrys genus, is cultured aerobically at 20W30°C, and the objective physiologically active substance, mutastein, is separated from the culture liquid by salting-out with ammonium sulfate, pH-precipitation, ion exchange chromatography, etc.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过在需氧条件下培养属于尖孢藓属，枝孢属，藏um属等的微生物，制备用于预防和治疗龋齿的生理活性物质，可用于预防和治疗龋齿，并提取培养液。构成：能够产生突变体并属于尖孢属属，枝孢属属，Colletotrichum属，Cylindrosporium属，Dactylaria属，Dematium属，Diplogelasinospora属，Drechslera属，Endophragmia属，Fennellia属，Leptographium属，Monascus属，Mucor属，Doratomyces的微生物属，Sporormiella属或Stachybotrys属，在20-30℃有氧培养，通过用硫酸铵盐析，pH-沉淀，离子交换色谱法从培养液中分离出客观的生理活性物质，等等

3. 发明专利

JPS59137443A Metal salt and alkyl ester of dihydromonacolin l carboxylic acid and its preparation 失效
标题翻译：二羟色胺L羧酸的金属盐和烷基酯及其制备
公开(公告)号：JPS59137443A
公开(公告)日：1984-08-07
申请号：JP1174483
申请日：1983-01-27
申请人： Akira Endo
发明人： ENDOU AKIRA
IPC分类号： C07C67/03 , A61K31/19 , A61K31/215 , A61P3/06 , C07C51/00 , C07C51/09 , C07C59/46 , C07C67/00 , C07C69/732
摘要： NEW MATERIAL:A metal salt or alkyl ester of dihydromonacolin L carboxylic acid of formula I [R is 1/n M (M is metal atom; n is valency of the metal atom) or lower alkyl].
EXAMPLE: Methyl dihydromonacolin L carboxylate.
USE: It is used as a physiologically active substance having the action of lowering cholesterol.
PREPARATION: A metal hydroxide of M(OH)
n is made to act on dihydromonacolin L of formula II to give the titled compound of formula III. The compound of formula II is novel and obtained by collecting from the culture mixture of a strain in Monascus such as Monascus ruber No.1005 (FERM-P4882). The reaction is preferably carried out at 30W60°C for several hours.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I的二氢头孢菌素L羧酸的金属盐或烷基酯[R为1 / n M（M为金属原子; n为金属原子的价）或低级烷基]。实施例：甲基二氢开乐素L羧酸酯。用途：用作具有降胆固醇作用的生理活性物质。制备：使M（OH）n的金属氢氧化物作用于式II的二氢新霉素L，得到标题化合物III。式II化合物是新颖的，通过从红曲霉菌株如红曲霉No.1500（FERM-P4882）中的菌株的培养物混合物中收集得到。反应优选在30-60℃进行数小时。

4. 发明专利

JPS59113856A Saccharine food 失效
标题翻译： SACCHARINE食品
公开(公告)号：JPS59113856A
公开(公告)日：1984-06-30
申请号：JP18630583
申请日：1983-10-05
申请人： Akira Endo
发明人： ENDOU AKIRA
IPC分类号： A23L1/03 , A23L1/00
摘要： PURPOSE: To prepare a saccharine food free of the property to increase tetrose, by adding saccharides selected from hardly digestible polysaccharides produced by microorganisms, e.g. glucans, and their derivatives to a saccharine feed having the property to increase tetrose level.
CONSTITUTION: A saccharine food increasing tetrose level is added with a saccharide selected from hardly digestible polysaccharides produced by microorganisms and their derivatives. The hardly digestible saccharide is, e.g. dextran, curdlan, phosphomannan, etc., preferably glucan having α-1,6 bond. The derivative of the polysaccharide is, e.g. sulfuric acid ester, phosphoric acid ester, carboxymethyl ether derivative, etc.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过添加选自微生物产生的几乎不可消化的多糖的糖类，制备不含该物质的糖精食品以增加四糖。葡聚糖及其衍生物转化为具有增加tetrose水平的性质的糖精饲料。构成：添加糖酵解食物增加tetrose水平，其中选择了由微生物及其衍生物产生的几乎不易消化的多糖的糖。难消化的糖是例如，葡聚糖，凝胶多糖，磷酸甘露糖等，优选具有α-1,6键的葡聚糖。多糖的衍生物是例如。硫酸酯，磷酸酯，羧甲基醚衍生物等

5. 发明专利

JPS59166094A Preparation of physiologically active substance ml-236b 失效
标题翻译：生理活性物质ML-236B的制备
公开(公告)号：JPS59166094A
公开(公告)日：1984-09-19
申请号：JP3845883
申请日：1983-03-09
申请人： Akira Endo
发明人： ENDOU AKIRA
IPC分类号： C12P17/06 , A61K31/35 , A61K31/351 , A61K36/06 , A61P3/06 , A61P9/10 , C07D309/30 , C12R1/645 , C12R1/885
摘要： PURPOSE:To obtain a physiologically active substance having an inhibitory action on cholesterol synthesis, by cultivating a specific microorganism belonging to the genus Trichoderma or Eupenicillium, collecting ML-236B from the culture. CONSTITUTION:A microorganism belonging to the genus Trichoderma or Eupenicillium, capable of producing ML-236B, is cultivated aerobically, and physiologically active substance ML-236B shown by the formula is collected from the culture. Trichoderma viride IFO5836, Eupenicillium reticulisporum strain, its variant or mutant may be cited as the microorganism producing ML-236B to be used. A strain capable of producing ML-236B is cultivated aerobically by mold culture, and ML-236B is produced in the culture. For example, the strain capable of producing ML-236B is subjected to subculture in a medium consisting of 2wt% malt extract, 2wt% glucose, 1wt% peptone and 2wt% agar.
摘要翻译：目的：通过培养属于木霉属或Eupenicillium属的特定微生物，获得对胆固醇合成具有抑制作用的生理活性物质，从培养物中收集ML-236B。构成：能够生产ML-236B的属于木霉属或青霉属的微生物是有氧地培养的，并且从培养物中收集由式表示的生理活性物质ML-236B。绿色木霉IFO5836，网络丝孢菌（Eupenicillium reticulisporum），其变体或突变体可以被引用作为使用的产生ML-236B的微生物。通过模具培养有效培养能够生产ML-236B的菌株，培养中产生ML-236B。例如，能够生产ML-236B的菌株在由2重量％麦芽提取物，2重量％葡萄糖，1重量％胨和2重量％琼脂组成的培养基中进行传代培养。

6. 发明专利

JPS59112922A Agent for lowering blood sugar 失效
标题翻译：降低血糖的代理
公开(公告)号：JPS59112922A
公开(公告)日：1984-06-29
申请号：JP18630483
申请日：1983-10-05
申请人： Akira Endo
发明人： ENDOU AKIRA
IPC分类号： C08B11/12 , A61K31/70 , A61K31/715 , A61K35/74 , A61K36/00 , A61P3/08 , C08B37/00
摘要： PURPOSE: An agent for lowering blood sugar, containing a slightly digestible polysaccharide, oligosaccharide, etc. prepared from plants or animals and saccharide consisting of their derivatives as an active ingredient.
CONSTITUTION: An agent for lowering blood sugar, containing a saccharide selected from a group consisting of slightly digestible polysaccharides, oligosacchardides and their derivatives (e.g., cellulose, carboxymethyl cellulose, hydroxyethyl starch, mannan, pectic acid, viscous substance of aloe, agar, dammar gum, viscous substance of tamarind seed, etc.). The toxicity of the saccharides is >500mg/kg, extremely low, and can be used in combination with a stabilizer, a preventive or remedy for metabolic diseases or diseases of digestive organs. It can be administered orally, intra-abdominally, or intravenously, but oral administration is preferable. A dose is 0.1W10g/day, especially 0.2W5g/day preferably orally.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：降低血糖的药剂，含有由植物或动物制备的轻微消化的多糖，寡糖等，以及由其衍生物作为活性成分组成的糖类。构成：含有选自轻微消化的多糖，寡糖类及其衍生物（例如纤维素，羧甲基纤维素，羟乙基淀粉，甘露聚糖，果胶酸，芦荟粘稠物质，琼脂，dammar等）的糖类的降血糖药口香糖，罗望子籽的粘稠物质等）。糖类的毒性> 500mg / kg，极低，可与稳定剂组合使用，代谢疾病或消化器官疾病的预防或补救措施。可以口服，腹腔内或静脉内给药，但优选口服给药。剂量为0.1-10g /天，特别是0.2-5g /天，优选口服。

7. 发明专利

JPS6113798B2 JPS6113798B2 - 失效
公开(公告)号：JPS6113798B2
公开(公告)日：1986-04-15
申请号：JP4424979
申请日：1979-04-13
申请人： Akira Endo
发明人： ENDO AKIRA
IPC分类号： C07D309/30 , A61K31/351 , A61K31/355 , A61K31/365 , A61K36/06 , A61P3/06 , C07G99/00 , C12P1/02 , C12P17/06 , C12R1/645

8. 发明专利

JPS5945360B2 JPS5945360B2 - 失效
公开(公告)号：JPS5945360B2
公开(公告)日：1984-11-06
申请号：JP19688681
申请日：1981-12-09
申请人： Akira Endo
发明人： ENDO AKIRA
IPC分类号： C12P17/06 , C12R1/79

9. 发明专利

JPS59102396A Preparation of physiologically active substance ml-236b 失效
标题翻译：生理活性物质ML-236B的制备
公开(公告)号：JPS59102396A
公开(公告)日：1984-06-13
申请号：JP21298582
申请日：1982-12-03
申请人： Akira Endo
发明人： ENDOU AKIRA
IPC分类号： C12P17/06 , A61K31/35 , A61K36/00 , A61P3/06 , A61P9/10 , C12R1/645
摘要： PURPOSE:To obtain the titled substance, having the inhibitory action on cholesterol synthesis, and useful as a preventing agent and remedy for arteriosclerosis, hyperlipemia, etc., by cultivating a microorganism, belonging to the genus Hypomyces, and having the ability to produce the ML-236B, and collecting the aimed ML-236B. CONSTITUTION:A microorganism, belonging to the genus Hypomyces, and having the ability to produce ML-236B is aerobically cultivated to collect the aimed ML-236B from the resultant culture. For example, the microorganism having the ability to produce the ML-236B can be cultivated by subjecting microorganism to the subculture step in a culture medium consisting of 2% malt extract, 2% glucose, 1% peptone and 2% agar, and the grown microbial cells on the agar culture medium are then inoculated directly into a production culture medium for producing the ML-236B. The microbial cells grown on the production culture medium can be cultivated in a new production culture medium to produce the aimed ML-236B thereon. The microorganism having the ability to produce the ML-236B is capable of growing at 7-30 deg.C, but 20-30 deg.C temperature is usually preferred for producing the ML-236B.
摘要翻译：目的：为了获得具有抑制胆固醇合成作用的物质，通过培养属于Hypomyces属的属于Hypomyces属的微生物并且具有生产能力的能力，可用作预防剂和用于动脉硬化，高脂血症等的药物 ML-236B，并收集目标ML-236B。组成：属于Hypomyces属并具有产生ML-236B能力的微生物有氧地培养，从所得培养物中收集目标ML-236B。例如，可以通过在由2％麦芽提取物，2％葡萄糖，1％蛋白胨和2％琼脂组成的培养基中将微生物进行传代培养步骤培养具有生产ML-236B能力的微生物，然后将琼脂培养基上的微生物细胞直接接种到用于生产ML-236B的生产培养基中。生长在生产培养基上的微生物细胞可以在新的生产培养基中培养以在其上产生目的ML-236B。具有生产ML-236B能力的微生物能够在7-30℃生长，但通常优选用20-30℃的温度来生产ML-236B。

10. 发明专利

JPS5738724A Blood sugar level lowering agent 失效
标题翻译：血糖降低剂
公开(公告)号：JPS5738724A
公开(公告)日：1982-03-03
申请号：JP11323780
申请日：1980-08-18
申请人： Akira Endo
发明人： ENDOU AKIRA
IPC分类号： A61K38/43 , A61K38/53 , A61K38/55 , A61P3/08
摘要： PURPOSE: To prepare a blood sugar level lowering agent effective for the prevention and remedy of metabolic diseases and diseases of digestive organs, by using an enzyme capable of synthesizing hardly digestible sugars from easily digestible sugars, and a glucosidase-inhibiting agent as active components.
CONSTITUTION: An enzyme capable of synthesizing hardly digestible sugars from easily digestible sugars (e.g. dextransucrase, levansucrase, etc.) and a glucosidase- inhibitor (e.g. Bayg 5421, TAI-A, etc.) are used as active components. The pref. weight ratio of the enzyme to the inhibitor is 1:20W20:1. The agent is administered e.g. in the form of powder, capsule, tablet, injection, etc.
COPYRIGHT: (C)1982,JPO&Japio
摘要翻译：目的：通过使用能够从容易消化的糖合成难消化的糖的酶和作为活性成分的糖苷酶抑制剂，制备有效预防和补救消化器官的代谢疾病和疾病的血糖降低剂。构成：使用能够从容易消化的糖（例如葡聚糖蔗糖酶，左旋蔗糖酶等）和葡糖苷酶抑制剂（例如Bayg 5421，TAI-A等）合成难消化的糖的酶用作活性成分。前置酶与抑制剂的重量比为1:20-20:1。例如，以粉末，胶囊，片剂，注射剂等形式

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