会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 3. 发明授权
    • CD20 negatively converted B-cell malignant lymphoma cell line and utilization thereof
    • CD20阴性转化B细胞恶性淋巴瘤细胞系及其利用
    • US08496927B2
    • 2013-07-30
    • US12311281
    • 2007-09-21
    • Tomoki NaoeAkihiro TomitaJunji Hiraga
    • Tomoki NaoeAkihiro TomitaJunji Hiraga
    • A01N63/00A01K67/00C12Q1/00A61K49/00
    • G01N33/5052A01K67/0271A01K2207/12A01K2227/105A01K2267/0331C12N5/0694C12N2503/02G01N33/5011G01N2800/44
    • It is intended to provide a tool, a procedure and so on which are useful in developing a therapeutic strategy efficacious in inhibiting or overcoming the resistance against a CD20-directed molecular-targeted drug. Thus, a CD20-negatively converted B-cell malignant lymphocyte cell line is provided. Also, a model animal indicating the pathological conditions of CD20-negatively converted B-cell malignant lymphocyte is provided. Further, a method of screening a substance, which is efficacious against CD20-positive B-cell malignant lymphocyte or CD20-negatively converted B cell malignant lymphocyte, is provided. Furthermore, a drug against CD20-positive B-cell malignant lymphocyte or CD20-negatively converted B-cell malignant lymphocyte, which is characterized by being used together with a CD20-directed molecular-targeted drug, is provided. In one embodiment, a DNA methylase inhibitor or a histone deacetylase inhibitor is employed as the active ingredient.
    • 旨在提供可用于开发有效抑制或克服对CD20定向分子靶向药物的抗性的治疗策略的工具,程序等。 因此,提供CD20阴性转化的B细胞恶性淋巴细胞细胞系。 另外,提供了指示CD20-负转换的B细胞恶性淋巴细胞的病理状态的模型动物。 此外,提供了筛选对CD20阳性B细胞恶性淋巴细胞或CD20-负向转化的B细胞恶性淋巴细胞有效的物质的方法。 此外,提供了抗CD20阳性B细胞恶性淋巴细胞或CD20阴性转化的B细胞恶性淋巴细胞的药物,其特征在于与CD20定向的分子靶向药物一起使用。 在一个实施方案中,使用DNA甲基化酶抑制剂或组蛋白脱乙酰酶抑制剂作为活性成分。
    • 4. 发明申请
    • LUMINOUS BUTTON DEVICE AND ELECTRONIC APPARATUS
    • LUMINOUS按钮设备和电子设备
    • US20110194303A1
    • 2011-08-11
    • US13020575
    • 2011-02-03
    • Takahiro AkaboriTakayuki TatenoShingo FukutomiAkihiro Tomita
    • Takahiro AkaboriTakayuki TatenoShingo FukutomiAkihiro Tomita
    • G02B6/00F21V8/00
    • G02B6/4298
    • A luminous button device includes: a button base which is integrally formed of a transmissive material; and a button cap which is integrally formed of a non-transmissive material and is fitted to the button base, wherein the button cap includes a cap body; a pair of arm portions which extends from the rear surface of the cap body with a gap interposed therebetween; and a pair of locking claws which is formed at the front ends of the pair of arm portions, and wherein the button base includes a movable portion which is movable in the direction of pressing a switch disposed on the rear surface side of the button base in accordance with a pressing force from the front button surface side; and a support portion which supports the movable portion so as to be movable in the direction.
    • 发光按钮装置包括:由透射材料一体形成的按钮基座; 以及钮扣帽,其由非透射材料整体形成并且装配到所述按钮底座,其中所述按钮帽包括帽体; 一对臂部,其从盖体的后表面延伸,间隙为间隙; 以及一对锁定爪,其形成在所述一对臂部的前端,并且其中所述按钮底座包括可移动部分,所述可动部分可沿按压设置在所述按钮底座的后表面侧上的开关的方向移动 根据来自前按钮表面侧的按压力; 以及支撑部,其支撑所述可动部,以能够沿所述方向移动。
    • 5. 发明授权
    • Steering angle detection device for electric power steering apparatus
    • 电动助力转向装置转向角检测装置
    • US06957713B2
    • 2005-10-25
    • US10825322
    • 2004-04-16
    • Akihiro Tomita
    • Akihiro Tomita
    • G01L3/10B62D5/04B62D15/02G01B7/00G01B7/30G01D5/245
    • B62D15/0215B62D15/0235
    • In a steering angle detection device for an electric power steering apparatus, a steering wheel shaft rotation angle is derived by calculating a rotation angle signal which corresponds to a rotation angle of a steering wheel shaft within a single rotation, based upon detection signals of first and second resolvers which detect the rotation angle of the steering wheel shaft and which have different pole pair numbers. A third resolver detects, as a motor rotation angle, a rotation angle of an output shaft of an electric motor that imparts assistance force to an output member of a steering gear having a reduction ratio that varies in accordance with a steering angle of the steering wheel from a straight ahead position. A first derivative and a second derivative of the motor rotation angle with respect to the steering wheel shaft rotation angle are calculated, and a rotational direction and a rotation number of the steering wheel shaft from a neutral position are obtained based on the first derivative and a positive-negative sign of the second derivative. A steering angle of the steering wheel is then obtained from the rotation direction and the rotation number of the steering wheel shaft from the neutral position, and the steering wheel shaft rotation angle.
    • 在用于电动助力转向装置的转向角检测装置中,通过基于第一和第二的检测信号计算与一个转动中的方向盘轴的旋转角度对应的旋转角度信号来导出方向盘轴旋转角度 第二解析器,其检测方向盘轴的旋转角并且具有不同的极对数。 第三解算装置检测作为电动机旋转角度的电动机的输出轴的旋转角度,该电动机对具有根据方向盘的转向角变化的减速比的舵机的输出构件赋予辅助力 从直线前进的位置。 计算相对于方向盘轴旋转角度的电动机旋转角度的一阶导数和二次导数,并且基于一阶导数获得方向盘轴从中立位置的旋转方向和转数,并且 二阶导数的正负号。 然后从方向盘轴的转动方向和中转位置的转数以及方向盘轴的旋转角度获得方向盘的转向角。
    • 7. 发明授权
    • Luminous button device and electronic apparatus
    • 发光按钮装置和电子设备
    • US08425100B2
    • 2013-04-23
    • US13020575
    • 2011-02-03
    • Takahiro AkaboriTakayuki TatenoShingo FukutomiAkihiro Tomita
    • Takahiro AkaboriTakayuki TatenoShingo FukutomiAkihiro Tomita
    • F21V7/04G01D11/28
    • G02B6/4298
    • A luminous button device includes: a button base which is integrally formed of a transmissive material; and a button cap which is integrally formed of a non-transmissive material and is fitted to the button base, wherein the button cap includes a cap body; a pair of arm portions which extends from the rear surface of the cap body with a gap interposed therebetween; and a pair of locking claws which is formed at the front ends of the pair of arm portions, and wherein the button base includes a movable portion which is movable in the direction of pressing a switch disposed on the rear surface side of the button base in accordance with a pressing force from the front button surface side; and a support portion which supports the movable portion so as to be movable in the direction.
    • 发光按钮装置包括:由透射材料一体形成的按钮基座; 以及钮扣帽,其由非透射材料整体形成并且装配到所述按钮底座,其中所述按钮帽包括帽体; 一对臂部,其从盖体的后表面延伸,间隙为间隙; 以及一对锁定爪,其形成在所述一对臂部的前端,并且其中所述按钮底座包括可移动部分,所述可动部分可沿按压设置在所述按钮底座的后表面侧上的开关的方向移动 根据来自前按钮表面侧的按压力; 以及支撑部,其支撑所述可动部,以能够沿所述方向移动。
    • 8. 发明授权
    • Electric power steering apparatus
    • 电动助力转向装置
    • US07913805B2
    • 2011-03-29
    • US12688250
    • 2010-01-15
    • Akihiro TomitaAtsuo SakaiSatoru Mikamo
    • Akihiro TomitaAtsuo SakaiSatoru Mikamo
    • B62D5/04
    • B62D5/046H02P21/06H02P21/18H02P2205/05
    • A rotational angle sensor used in an electric power steering apparatus detects a rotational angle of a motor shaft at a portion on a steering system side, as a motor rotational angle (θm). A MPU sets a base correction amount (Δθ′m) based on a q-axis actual current value (Iq). The MPU sets a rotational angle correction amount (Δθm) used to correct the motor rotational angle (θm) by decreasing the base correction amount (Δθ′m) as a rotational angular speed (ω) increases and by increasing the base correction amount (Δθ′m) as a torque differential value (dT/dt) increases.
    • 在电动助力转向装置中使用的旋转角度传感器作为电动机旋转角度(& m)检测转向系统侧的部分处的电动机轴的旋转角度。 MPU根据q轴实际电流值(Iq)设置基准校正量(&Dgr;& tt; m)。 MPU通过减小基准校正量(&Dgr;& tt; m)来设定用于校正电动机旋转角度(& m;)的旋转角度校正量(&Dgr;& t; m),因为旋转角速度(ω)增加 并且随着转矩差分值(dT / dt)的增加,增加基本校正量(&Dgr;& t; m)。