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    • 2. 发明授权
    • Spinning method for forming pipe end
    • 用于形成管端的纺丝方法
    • US08683843B2
    • 2014-04-01
    • US12081355
    • 2008-04-15
    • Akihiro AndoKazushi SakamotoShinobu KarinoKenji Hara
    • Akihiro AndoKazushi SakamotoShinobu KarinoKenji Hara
    • B21D19/04B21D22/14
    • B21D41/04B21D22/14
    • A spinning method for forming pipe bodies of varying diameter. In the spinning method, when a necked portion is formed at the end of the pipe material by the spinning method, working rollers are restricted so as to return immediately before the pipe end instead of being allowed to axially move beyond the end of the working object pipe. The amount of diameter reduction at the pipe end is set to be smaller than that of the most diameter reduced portion connecting to the pipe end. A protruding portion of a so-called bellmouth shape is formed at the working end, thereby preventing generation of fractures originating at the working end of the base portion or the welded portion and generation of wrinkles during the spinning process.
    • 一种用于形成直径不同的管体的纺丝方法。 在纺丝方法中,当通过纺丝方法在管材端部形成颈缩部分时,加工辊受到限制,以便在管端之前立即返回,而不允许轴向移动超过工作对象的端部 管。 管端的直径减小量被设定为小于连接到管端的最大直径减小部分的量。 在工作端形成所谓的喇叭口形状的突出部分,从而防止在基部或焊接部分的工作端产生裂缝并产生纺丝过程中的皱纹。
    • 8. 发明授权
    • Spinning method for forming a diameter reduced portion
    • 用于形成直径减小部分的旋转方法
    • US08635898B2
    • 2014-01-28
    • US13144468
    • 2010-01-05
    • Shinobu KarinoAkihiro AndoJun Kurobe
    • Shinobu KarinoAkihiro AndoJun Kurobe
    • B21D7/04B21D3/02
    • B21D22/16B21D41/04
    • Provided is a spinning method of reducing a diameter of a work piece pipe body with processing rollers disposed on an outer surface of the work piece pipe body, the processing rollers being configured to be relatively revolved around the work piece pipe body, wherein, when the processing rollers are axially reciprocated while being moved in a radius direction of the work piece pipe body, wherein the diameter reducing process with the processing rollers is performed under a state in which a wound body formed of an elastic sheet-like material is inserted as a core body into the inside of a portion of the work piece pipe body to be subjected to the diameter reducing processing.
    • 提供了一种通过设置在工件管体的外表面上的处理辊来减小工件管体的直径的纺丝方法,处理辊被构造成围绕工件管体相对旋转,其中,当 处理辊在沿着工件管体的半径方向移动的同时轴向往复运动,其中,在由弹性片状材料形成的卷绕体插入的状态下,进行处理辊的直径缩小处理 芯体进入要进行直径减小处理的工件管体的一部分的内部。
    • 9. 发明授权
    • Crystalline micropowder particles
    • 结晶微粉颗粒
    • US08198446B2
    • 2012-06-12
    • US12601150
    • 2008-05-20
    • Masahiro AkimotoToshikazu KomagataMotohiro ShirakiAkihiro Ando
    • Masahiro AkimotoToshikazu KomagataMotohiro ShirakiAkihiro Ando
    • C07D489/08
    • A61K9/1688A61K9/2018A61K31/485C07D489/08
    • Crystalline particles of N-(17-cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxy-morphinan-6β-yl)-phthalimide or a pharmaceutically acceptable salt thereof are disclosed. The crystalline particles have a particle diameter distribution in which a particle diameter (D50) at the point where cumulative frequency of volume distribution cumulatively calculated from particles having a smaller diameter reaches 50% is within a range of 1 to 30 μm, and a particle diameter (D90) at the point where cumulative frequency of volume distribution cumulatively calculated from particles having a smaller diameter reaches 90% is not more than 90 μm, which crystalline particles have a degree of crystallinity of not less than 80%. By the crystalline particles, bioavailability of the active substance may be increased while ensuring storage stability of the compound.
    • 公开了N-(17-环丙基甲基-4,5α-环氧-3,14-二羟基 - 吗啡喃-6'-基) - 邻苯二甲酰亚胺或其药学上可接受的盐的结晶颗粒。 结晶粒子具有粒径分布,其中由具有小直径的颗粒累积计算的体积分布的累积频率达到50%的点处的粒径(D50)在1至30μm的范围内,并且粒径 (D90)在由具有较小直径的颗粒累积计算的体积分布的累积频率达到90%的点处不超过90μm,该结晶颗粒的结晶度不小于80%。 通过结晶颗粒,可以提高活性物质的生物利用度,同时确保化合物的储存稳定性。