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1. 发明授权

US5334613A Antibacterial substance BE-24566B 失效
标题翻译：抗菌物质BE-24566B
公开(公告)号：US5334613A
公开(公告)日：1994-08-02
申请号：US974460
申请日：1992-11-12
申请人： Katsuhisa Kojiri , Shigeru Nakajima , Aisaku Fuse , Hiroyuki Suda
发明人： Katsuhisa Kojiri , Shigeru Nakajima , Aisaku Fuse , Hiroyuki Suda
IPC分类号： C07D493/08 , C12P17/18 , A01N43/32 , C07D319/08
CPC分类号： C07D493/08 , C12P17/181 , C12R1/465
摘要： Herein disclosed are an antibacterial substance: BE-24566B represented by the following structural formula (I): ##STR1## or a pharmaceutically acceptable salt thereof; and an antibacterial agent comprising, as an essential component, the foregoing antibacterial substance: BE-24566B or a pharmaceutically acceptable salt thereof. The antibacterial substance BE-24566B or pharmaceutically acceptable salts thereof can be prepared according to a method comprising the steps of inoculating an antibacterial substance: BE-24566B-producing microorganism or a variant thereof into a culture medium to cultivate the microorganism or variant, in particular the strain FERM BP-3994 or a variant thereof, and isolating the intracellularly and/or extracellularly produced antibacterial substance. The substance BE-24566B exhibits potent antibacterial effect on gram-positive bacteria represented by methicillin-resistant Staphylococcus aureus and, therefore, very useful as a therapeutic agent for treating a variety of infectious diseases caused by gram-positive bacteria.
摘要翻译：本文公开的是抗菌物质：由以下结构式（I）表示的BE-24566B：其中R 1，R 2，以及作为必要成分的上述抗菌物质BE-24566B或其药学上可接受的盐的抗菌剂。抗菌物质BE-24566B或其药学上可接受的盐可以根据包括以下步骤的方法制备：将抗菌物质：BE-24566B生产微生物或其变体接种到培养基中以培养微生物或变体，特别是菌株FERM BP-3994或其变体，并分离细胞内和/或细胞外产生的抗菌物质。物质BE-24566B对由耐甲氧西林金黄色葡萄球菌代表的革兰氏阳性细菌表现出强烈的抗菌作用，因此作为用于治疗由革兰氏阳性细菌引起的各种感染性疾病的治疗剂非常有用。

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