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1. 发明专利

JP2014217382A 毛嚢生成のための細胞同時培養有权
标题翻译：细胞共培养用于头发生产
公开(公告)号：JP2014217382A
公开(公告)日：2014-11-20
申请号：JP2014147078
申请日：2014-07-17
申请人：アデランスリサーチインスティテュートインコーポレイテッド , Aderans Research Institute Inc , アデランスリサーチインスティテュートインコーポレイテッド
发明人： QIAO JIZENG , JEFFREY KEELER TEUMER , ERICA JEAN PHILIPS
IPC分类号： C12Q1/02 , C12N5/071 , G01N33/15 , G01N33/50
CPC分类号： A61L27/3886 , A61L27/3813 , A61L2430/18 , C12N5/0627 , C12N5/0628 , C12N5/0656 , C12N5/0666 , C12N2501/415 , C12N2502/02 , C12N2502/091 , C12N2502/092 , C12N2502/094 , C12N2502/1323
摘要：【課題】インビトロにおいて毛嚢を生成する方法、インビトロにおいて毛嚢を生成するための組成物、インビトロで生成した毛嚢、濾胞間又は濾胞内の部位にインビトロで生成した毛幹を提供する方法、濾胞間又は濾胞内の部位にインビトロで生成した毛幹を提供することによる脱毛を治療する方法、及び毛髪生物学に対する試験薬物の効果を試験するためのアッセイを提供する。未成熟の毛嚢(本明細書において「原毛髪」として定義される)であるか又は使用する同様の方法及び生成物を提供する。【解決手段】皮膚乳頭細胞及び角化細胞、及び任意にメラニン細胞を同時培養することを含む毛嚢又は原毛髪をインビトロで生成するための方法を提供する。【選択図】なし
摘要翻译：要解决的问题：为了提供体外生产毛囊的方法，用于在体外生产毛囊的组合物，体外产生的毛囊，在滤泡或滤泡内部位提供体外产生的毛干的方法，治疗脱发的方法通过在滤泡或滤泡内部位提供体外产生的毛干，以及用于研究试验剂对毛发生物学的影响的测定法，以及提供类似的方法和产品，这些方法和产品是或未使用的未成熟卵泡头发）。解决方案：本发明提供了用于体外生产毛囊或原毛的方法，其包括与角质形成细胞共同培养真皮乳头细胞，以及任选地与黑素细胞共培养。

2. 发明申请

WO2010148094A1 METHODS AND COMPOSITIONS FOR INCREASING TRICHOGENIC POTENCY OF DERMAL CELLS 审中-公开
标题翻译：增加细胞的多发性磷酸化的方法和组合物
公开(公告)号：WO2010148094A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/038833
申请日：2010-06-16
申请人： ADERANS RESEARCH INSTITUTE, INC. , ZHENG, Ying , BOUCHER, Marylene , HOMAN, Ying , HOLLOW, Charles , MAMONTOV, Polina , STENN, Kurt
发明人： ZHENG, Ying , BOUCHER, Marylene , HOMAN, Ying , HOLLOW, Charles , MAMONTOV, Polina , STENN, Kurt
IPC分类号： A61K31/381 , A61K31/4436 , C07D409/14 , C07D409/00
CPC分类号： C07D409/12 , A61K31/381 , A61K31/4436
摘要： Methods and compositions for increasing trichogenicity of cells in culture are provided. One embodiment provides culturing dissociated mammalian dermal cells in vitro in the presence of an effective amount of one or more sonic hedgehog (Shh) pathway agonists to increase the trichogenicity of the dissociated mammalian dermal cells compared to untreated dissociated mammalian dermal cells. The cell culture optionally includes epidermal cells. Preferred Shh agonists include, but are not limited to CUR-0236715 and CUR-0201365 available from Curis, Inc. Trichogenicity is measured using the Aderans Hair Patch Assay TM .The cultured dermal cells can be maintained in culture in the presence of the one or more Shh agonists for at least 1 to 7 or more days prior to harvest. The treated, cultured dermal cells can be used to treat hair loss in a mammalian subject, preferably a human, by implanting them in an effective amount to induce hair follicle formation.
摘要翻译：提供了用于增加培养物中细胞的致毛性的方法和组合物。一个实施方案在有效量的一种或多种声波刺猬（Shh）途径激动剂的存在下提供培养解离的哺乳动物真皮细胞，以增加与未处理的解离的哺乳动物真皮细胞相比，解离的哺乳动物真皮细胞的毛发性。细胞培养物任选地包括表皮细胞。优选的Shh激动剂包括但不限于可从Curis，Inc。获得的CUR-0236715和CUR-0201365。使用Aderans Hair Patch AssayTM测量致敏性。培养的真皮细胞可以在存在一种或多种 Shh激动剂在收获前至少1至7天或更长时间。经处理的培养的真皮细胞可用于治疗哺乳动物受试者，优选人类的脱发，通过将它们植入有效量以诱导毛囊形成。

3. 发明申请

WO2007062386A2 HAIR FOLLICLE GRAFT FROM TISSUE ENGINEERED SKIN 审中-公开
标题翻译：来自组织工程皮肤的头发毛孔
公开(公告)号：WO2007062386A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/061192
申请日：2006-11-22
申请人： ADERANS RESEARCH INSTITUTE, INC. , BARROWS, Thomas, H. , MACINTYRE, Preeti , WASHENIK, Kenneth, Justin
发明人： BARROWS, Thomas, H. , MACINTYRE, Preeti , WASHENIK, Kenneth, Justin
IPC分类号： A61K35/36
CPC分类号： A61K35/36 , A61L27/362 , A61L27/3804 , A61L27/3886 , A61L27/58 , A61L27/60 , A61L2430/18 , A61K2300/00
摘要： The present invention provides a hair graft comprising (a) tissue engineered skin comprising a tissue engineered epidermal layer, a tissue engineered dermal layer, and hair follicle progenitor cells and (b) a scaffold. The invention also provides methods of making and using the hair grafts of the present invention.
摘要翻译：本发明提供了一种头发移植物，其包含（a）组织工程皮肤，其包含组织工程化表皮层，组织工程真皮层和毛囊祖细胞和（b）支架。本发明还提供了制造和使用本发明的头发移植物的方法。

4. 发明申请

WO2011011677A2 POTENCY MARKERS 审中-公开
公开(公告)号：WO2011011677A2
公开(公告)日：2011-01-27
申请号：PCT/US2010/043042
申请日：2010-07-23
申请人： ADERANS RESEARCH INSTITUTE, INC. , TEUMER, Jeffrey, Keeler , MASTYUGIN, Vladimir , QIAO, Jizeng , ZAWADZKA, Agatha
发明人： TEUMER, Jeffrey, Keeler , MASTYUGIN, Vladimir , QIAO, Jizeng , ZAWADZKA, Agatha
IPC分类号： C12N5/071
CPC分类号： G01N33/6881 , C12N5/0627 , G01N2800/20
摘要： Methods for identifying trichogenic dermal cells, including dermal papilla cells and dermal sheath cells, capable of inducing hair follicle formation when injected into skin are provided. Biomarkers have been discovered that can be used to detect, identify, and distinguish trichogenic dermal cells, i.e., that are able to induce hair follicle formation, from non- trichogenic skin cells. Populations of enriched trichogenic dermal cells can be produced by selecting for and enriching for dermal cells that the disclosed biomarkers. These enriched trichogenic dermal can be used for inducing hair follicle formation.
摘要翻译：提供了当注射到皮肤中时能够诱导毛囊形成的毛发真皮细胞（包括真皮乳头细胞和皮肤鞘细胞）的方法。已经发现生物标志物可用于从非致毛皮肤细胞检测，鉴定和区分毛发真皮细胞，即能够诱导毛囊形成的细胞。可以通过选择和富集所公开的生物标志物的真皮细胞来产生富集的毛发真皮细胞的群体。这些丰富的毛发真皮可用于诱导毛囊形成。

5. 发明申请

WO2006020958A2 ORGANOGENESIS FROM DISSOCIATED CELLS 审中-公开
标题翻译：离散细胞中的有机体
公开(公告)号：WO2006020958A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/028933
申请日：2005-08-15
申请人： ADERANS RESEARCH INSTITUTE, INC. , ZHENG, Ying , DU, Xiaobing , WANG, Wei , BOUCHER, Marylene , PARIMOO, Satish , STENN, Kurt, Stricker
发明人： ZHENG, Ying , DU, Xiaobing , WANG, Wei , BOUCHER, Marylene , PARIMOO, Satish , STENN, Kurt, Stricker
IPC分类号： A61K35/12 , A61K35/36 , C12N5/071
CPC分类号： A61K35/36 , A61K8/02 , A61K8/985 , A61K35/12 , A61Q7/00 , C12N5/0627
摘要： A method assay for rapidly and reproducibly generating hair follicles from dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for studying the mechanisms dissociated cells employ to assemble an organ. In a method of this application dissociated cells, isolated from newborn mouse skin, are injected into adult mouse truncal skin, hair follicles develop. This process involves the aggregation of epithelial cells to form clusters which are sculpted by apoptosis to generate "infundibular cysts". From the "infundibular cysts" hair germs form followed by follicular buds and then pegs which grow asymmetrically to differentiate into cycling mature pilosebaceous structures. Using various techniques, exposure of the "infundibular cysts" by puncturing, piercing, or scratching the skin and, in an approach, covering the exposed cysts with a wound dressing material produced egressing hair follicles.
摘要翻译：公开了用于从分离的上皮细胞和间充质细胞快速并可重复产生毛囊的方法测定。该方法既可用作测量细胞毛发生成（即毛发生长诱导）特性的工具，也可用于研究分离细胞用于组装器官的机制。在本申请的方法中，将从新生小鼠皮肤分离的分离的细胞注射到成年小鼠躯干皮肤中，形成毛囊。该过程涉及上皮细胞的聚集以形成通过细胞凋亡而雕刻以产生“漏斗状囊肿”的簇。从“漏斗囊肿” 头发细菌形成，然后是毛囊芽，然后是不对称生长的毛球，以分化成为循环成熟的毛皮脂肪结构。使用各种技术，暴露“漏斗囊肿” 通过穿刺，刺穿或刮擦皮肤，并且在一种方法中，使用流出毛囊的伤口敷料材料覆盖暴露的囊肿。

6. 发明授权

US10398735B2 Compositions and methods for producing reconstituted skin 有权
公开(公告)号：US10398735B2
公开(公告)日：2019-09-03
申请号：US15597416
申请日：2017-05-17
申请人： ADERANS RESEARCH INSTITUTE, INC.
发明人： Xunwei Wu , Kurt Stenn , Larry Scott, Jr. , Daniel J. Hussey
IPC分类号： A61K35/36 , C12N5/071 , C12N5/0775 , G01N33/50 , A61L27/18 , A61L27/38 , A61L27/60
摘要： Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.

7. 发明申请

US20160206663A9 Compositions and Methods for Producing Reconstituted Skin 有权
标题翻译：复制皮肤的组成和方法
公开(公告)号：US20160206663A9
公开(公告)日：2016-07-21
申请号：US14059240
申请日：2013-10-21
申请人： Aderans Research Institute, Inc.
发明人： Xunwei Wu , Kurt Stenn , Larry Scott, JR. , Daniel J. Hussey
IPC分类号： A61K35/36 , A61K49/00
CPC分类号： A61K35/36 , A61K49/0008 , A61L27/18 , A61L27/3804 , A61L27/3813 , A61L27/3834 , A61L27/60 , A61L2430/18 , C12N5/0698 , G01N33/5082 , G01N2500/10 , C08L83/04
摘要： Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.
摘要翻译：提供了用于在原地制备重构的人皮肤和/或毛囊的组合物和方法。生产皮肤的方法是独特的，因为组织培养将包括多能细胞如新生细胞在内的扩增细胞以及培养的表皮和真皮细胞立即置于诸如膜的底物上，然后将具有贴壁细胞的膜置于皮肤伤口。实例证明原位形成毛囊。

8. 发明申请

US20170246213A1 COMPOSITIONS AND METHODS FOR PRODUCING RECONSTITUTED SKIN 审中-公开
公开(公告)号：US20170246213A1
公开(公告)日：2017-08-31
申请号：US15597416
申请日：2017-05-17
申请人： ADERANS RESEARCH INSTITUTE, INC.
发明人： Xunwei WU , Kurt STENN , Larry SCOTT, JR. , Daniel J. HUSSEY
IPC分类号： A61K35/36 , C12N5/071 , C08L83/04 , A61K49/00 , A61L27/38 , A61L27/60 , A61L27/18 , G01N33/50
CPC分类号： A61K35/36 , A61L27/18 , A61L27/3804 , A61L27/3813 , A61L27/3834 , A61L27/60 , A61L2430/18 , C12N5/0625 , C12N5/0668 , C12N5/0698 , G01N33/5082 , G01N2500/10 , C08L83/04
摘要： Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.

9. 发明授权

US09655930B2 Compositions and methods for producing reconstituted skin 有权
公开(公告)号：US09655930B2
公开(公告)日：2017-05-23
申请号：US14059240
申请日：2013-10-21
申请人： Aderans Research Institute, Inc.
发明人： Xunwei Wu , Kurt Stenn , Larry Scott, Jr. , Daniel J. Hussey
IPC分类号： C12N5/071 , A61K35/36 , G01N33/50 , A61L27/18 , A61L27/38 , A61L27/60 , A61K49/00
CPC分类号： A61K35/36 , A61K49/0008 , A61L27/18 , A61L27/3804 , A61L27/3813 , A61L27/3834 , A61L27/60 , A61L2430/18 , C12N5/0698 , G01N33/5082 , G01N2500/10 , C08L83/04
摘要： Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.

10. 发明申请

US20150113672A1 Composition and Methods for Producing Reconstituted Skin 有权
标题翻译：复制皮肤的组成和方法
公开(公告)号：US20150113672A1
公开(公告)日：2015-04-23
申请号：US14059240
申请日：2013-10-21
申请人： Aderans Research Institute, Inc.
发明人： Xunwei Wu , Kurt Stenn , Larry Scott, JR. , Daniel J. Hussey
IPC分类号： A61K35/36 , A61K49/00
CPC分类号： A61K35/36 , A61K49/0008 , A61L27/18 , A61L27/3804 , A61L27/3813 , A61L27/3834 , A61L27/60 , A61L2430/18 , C12N5/0698 , G01N33/5082 , G01N2500/10 , C08L83/04
摘要： Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.
摘要翻译：提供了用于在原地制备重构的人皮肤和/或毛囊的组合物和方法。生产皮肤的方法是独特的，因为组织培养将包括多能细胞如新生细胞在内的扩增细胞以及培养的表皮和真皮细胞立即置于诸如膜的底物上，然后将具有贴壁细胞的膜置于皮肤伤口。实例证明原位形成毛囊。

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