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    • 2. 发明申请
    • FLUORESCENCE IMAGING APPARATUS AND METHOD
    • 荧光成像装置及方法
    • US20130126756A1
    • 2013-05-23
    • US13574363
    • 2011-01-24
    • Chunhui (Chris) XuScott HowardAdam StraubGuanghao Zhu
    • Chunhui (Chris) XuScott HowardAdam StraubGuanghao Zhu
    • G01N21/64G02F1/01
    • G01N21/64G01N21/6408G01N21/6456G02F1/01
    • A fluorescence emission imaging method and apparatus allows for high frame rate imaging in scattering medium as well as for fluorescence, phosphorescence, or luminescence lifetime imaging, time-resolved fluorescence, phosphorescence, or luminescence lifetime spectroscopy and imaging. A method involves providing an illumination beam, propagating the illumination beam to a light modulator array, modulating the illumination beam so as to generate an array of point sources, wherein each of the point sources is modulated at a frequency, imaging the modulated illumination beam on the object, and detecting a fluorescent, phosphorescent, or luminescent emission from the object. An optical imaging component in the form of a modulation mask has multiple bands. Each band has alternating transmissive and/or reflective and/or absorptive regions that are patterned such that light scanned over a band will be modulated at a band-related frequency.
    • 荧光发射成像方法和装置允许散射介质中的高帧率成像以及荧光,磷光或发光寿命成像,时间分辨荧光,磷光或发光寿命光谱和成像。 一种方法包括提供照明光束,将照明光束传播到光调制器阵列,调制照明光束以产生点光源阵列,其中每个点光源以一个频率被调制,对被调制的照明光束进行成像 并且检测来自物体的荧光,磷光或发光发射。 调制掩模形式的光学成像部件具有多个带。 每个带具有交替的透射和/或反射和/或吸收区域,其被图案化,使得在频带上扫描的光将以带相关频率被调制。