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1. 发明授权

US10314943B2 Apparatus and process for the preparation of a biomimetic tissue prosthesis of the tympanic membrane 有权
公开(公告)号：US10314943B2
公开(公告)日：2019-06-11
申请号：US15023335
申请日：2014-09-17
申请人： AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
发明人： Serena Danti , Stefano Berrettini , Stefano Marrazza , Cesare Stefanini
IPC分类号： C12M1/42 , C12M3/00 , C12N5/0775 , A61L27/36 , A61L27/58 , A61F2/18
摘要： The present invention refers to a process, and to the related apparatus, for the in vitro preparation of a biomimetic tissue prostheses of the tympanic membrane from mesenchymal stem cells; such prostheses are used for repairing or reconstructing the injured tympanic membrane in patients needing it, for example as a consequence of various trauma or pathologies.

2. 发明申请

US20160228606A1 APPARATUS AND PROCESS FOR THE PREPARATION OF A BIOMIMETIC TISSUE PROSTHESIS OF THE TYMPANIC MEMBRANE 审中-公开
标题翻译：用于制备典型膜的生物组织的装置和方法
公开(公告)号：US20160228606A1
公开(公告)日：2016-08-11
申请号：US15023335
申请日：2014-09-17
申请人： AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
发明人： Serena Danti , Stefano Berrettini , Stefano Marrazza , Cesare Stefanini
IPC分类号： A61L27/36 , C12M1/42 , C12M3/00 , A61L27/58 , C12N5/0775
CPC分类号： A61L27/3645 , A61F2002/183 , A61F2240/001 , A61L27/3604 , A61L27/58 , A61L2430/14 , C12M21/08 , C12M35/06 , C12N5/0663 , C12N2500/38 , C12N2501/15 , C12N2521/00 , C12N2533/18 , C12N2533/30
摘要： The present invention refers to a process, and to the related apparatus, for the in vitro preparation of a biomimetic tissue prostheses of the tympanic membrane from mesenchymal stem cells; such prostheses are used for repairing or reconstructing the injured tympanic membrane in patients needing it, for example as a consequence of various trauma or pathologies.
摘要翻译：本发明涉及从间充质干细胞体外制备鼓膜的仿生组织假体的方法和相关装置; 这样的假体用于修复或重建受伤的鼓膜患者，例如作为各种创伤或病变的结果。

3. 发明申请

WO2016005916A1 A METHOD AND KIT FOR THE DETECTION OF A BIOMARKER OF THYROID CANCER IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于检测生物样品中甲状腺癌生物标记物的方法和工具
公开(公告)号：WO2016005916A1
公开(公告)日：2016-01-14
申请号：PCT/IB2015/055163
申请日：2015-07-08
申请人： AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA , UNIVERSITÀ DI PISA
发明人： LUCACCHINI, Antonio , GIUSTI, Laura , CIREGIA, Federica , TONACCHERA, Massimo
IPC分类号： G01N33/574
CPC分类号： G01N33/57407 , G01N2800/046
摘要： The present invention relates to a method and to the related kit for detecting a biomarker in human biological samples, which allows a diagnosis of malignant thyroid tumours that can be discerned from benign tumour lesions and from the neoformations of microfollicles in order to identify the most suitable treatment, medical or surgical, thus restricting the surgical treatment only to cases where it is strictly necessary.
摘要翻译：本发明涉及一种用于检测人类生物样品中的生物标志物的方法和相关试剂盒，其允许诊断恶性甲状腺肿瘤，其可以从良性肿瘤损伤和微小孔的新形态鉴别，以鉴定最合适的治疗，医疗或手术，从而将手术治疗限于严格必要的情况。

4. 发明申请

WO2016097990A1 APPARATUS FOR THE ACOUSTIC EVALUATION OF MIDDLE EAR PROSTHESES 审中-公开
标题翻译：用于中耳前瞻性评估的设备
公开(公告)号：WO2016097990A1
公开(公告)日：2016-06-23
申请号：PCT/IB2015/059621
申请日：2015-12-15
申请人： AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
发明人： DANTI, Serena , STEFANINI, Cesare , BRUSCHINI, Luca , BERRETTINI, Stefano , MORONI, Lorenzo
IPC分类号： A61F2/18 , H04R25/00
CPC分类号： A61F2/18 , A61F2002/183 , A61F2240/008 , H04R25/606
摘要： Test instrument (1) for auditory prostheses, comprising a support structure (11) having a first and a second hole (12, 13) facing each other; a first hollow cylinder (14) simulating the external auditory meatus, housed in the first hole (12) and having a first end (14a) which is open and a second end (14b) which is closed by a membrane (15) of polymer material simulating the tympanic membrane; a second hollow cylinder (16) housed in the second hole (13), closed at both ends and filled with a liquid simulating the cochlear fluid, wherein one (16a) of the ends of the second cylinder (14) is closed by a membrane (17) of polymer material simulating the oval window and facing the membrane (15) of the second end (14b) of the first cylinder (14); a device positioning area located between the membrane (15) of the first cylinder (14) and the membrane (17) of the second cylinder (16) for receiving an auditory prosthesis to be tested (P); and a receiver seat (16b) formed within the second cylinder (16) for receiving a microphone (5) to be placed in contact with the liquid.
摘要翻译：用于听觉假体的测试仪器（1），包括具有彼此面对的第一和第二孔（12,13）的支撑结构（11）模拟外耳道的第一中空圆柱体（14），其容纳在第一孔（12）中并具有开口的第一端（14a）和由聚合物膜（15）封闭的第二端（14b）模拟鼓膜的材料; 容纳在所述第二孔（13）中的第二中空圆柱体（16）在两端封闭，并填充有模拟所述耳蜗流体的液体，其中所述第二圆柱体（14）的端部中的一个（16a）被膜（17），模拟所述椭圆窗并面向所述第一气缸（14）的第二端（14b）的膜（15）; 位于第一气缸（14）的膜（15）和第二气缸（16）的膜（17）之间的装置定位区域，用于接收待测试的听觉假体（P）; 以及形成在第二气缸（16）内的接收器座（16b），用于接收与液体接触的麦克风（5）。

5. 发明申请

WO2015040554A1 APPARATUS AND PROCESS FOR THE PREPARATION OF A BIOMIMETIC TISSUE PROSTHESIS OF THE TYMPANIC MEMBRANE 审中-公开
标题翻译：用于制备典型膜的生物组织的装置和方法
公开(公告)号：WO2015040554A1
公开(公告)日：2015-03-26
申请号：PCT/IB2014/064593
申请日：2014-09-17
申请人： AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
发明人： DANTI, Serena , BERRETTINI, Stefano , MARRAZZA, Stefano , STEFANINI, Cesare
IPC分类号： C12N5/00 , C12N5/0775 , A61F2/18
CPC分类号： A61L27/3645 , A61F2002/183 , A61F2240/001 , A61L27/3604 , A61L27/58 , A61L2430/14 , C12M21/08 , C12M35/06 , C12N5/0663 , C12N2500/38 , C12N2501/15 , C12N2521/00 , C12N2533/18 , C12N2533/30
摘要： The present invention refers to a process, and to the related apparatus, for the in vitro preparation of a biomimetic tissue prostheses of the tympanic membrane from mesenchymal stem cells; such prostheses are used for repairing or reconstructing the injured tympanic membrane in patients needing it, for example as a consequence of various trauma or pathologies.
摘要翻译：本发明涉及从间充质干细胞体外制备鼓膜的仿生组织假体的方法和相关装置; 这样的假体用于修复或重建受伤的鼓膜患者，例如作为各种创伤或病变的结果。

6. 发明公开

EP3047016A1 APPARATUS AND PROCESS FOR THE PREPARATION OF A BIOMIMETIC TISSUE PROSTHESIS OF THE TYMPANIC MEMBRANE 有权
标题翻译：装置及其制造方法BIOMETRIC组织移植耳膜
公开(公告)号：EP3047016A1
公开(公告)日：2016-07-27
申请号：EP14786340.1
申请日：2014-09-17
申请人： Azienda Ospedaliero-Universitaria Pisana
发明人： DANTI, Serena , BERRETTINI, Stefano , MARRAZZA, Stefano , STEFANINI, Cesare
IPC分类号： C12N5/00 , C12N5/0775 , A61F2/18
CPC分类号： A61L27/3645 , A61F2002/183 , A61F2240/001 , A61L27/3604 , A61L27/58 , A61L2430/14 , C12M21/08 , C12M35/06 , C12N5/0663 , C12N2500/38 , C12N2501/15 , C12N2521/00 , C12N2533/18 , C12N2533/30
摘要： The present invention refers to a process, and to the related apparatus, for the in vitro preparation of a biomimetic tissue prostheses of the tympanic membrane from mesenchymal stem cells; such prostheses are used for repairing or reconstructing the injured tympanic membrane in patients needing it, for example as a consequence of various trauma or pathologies.

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