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1. 发明申请

WO2006018851A2 MONITORING, ANALYSIS, AND REGULATION OF EATING HABITS 审中-公开
标题翻译：监测，分析和监管
公开(公告)号：WO2006018851A2
公开(公告)日：2006-02-23
申请号：PCT/IL2005/000904
申请日：2005-08-18
申请人： METACURE LTD. , KLIGER, Anat , POLICKER, Shai , AVIV, Ricardo
发明人： KLIGER, Anat , POLICKER, Shai , AVIV, Ricardo
CPC分类号： A61N1/08 , A61N1/36007
摘要： Gastric apparatus (18) is provided, including one or more sensors (70, 72, 74), adapted to generate respective sensor signals responsive to activity of a gastrointestinal tract of a subject. A control unit (90) is adapted to receive and analyze the sensor signals and to determine that an eating event has occurred, responsive to at least one of the sensor signals and a threshold. The control unit identifies an aspect of at least one of the sensor signals deriving from rhythmic activity of the gastrointestinal tract that is not indicative of current eating by the subject, and modifies the threshold responsive to the aspect of the signals that derives from activity that is not indicative of current eating. For some applications, the control unit is adapted to modify the threshold if the aspect is indicative of a migrating motor complex (MMC). Other embodiments are also described.
摘要翻译：提供了胃装置（18），包括一个或多个传感器（70,72,74），适于产生响应受试者的胃肠道活动的相应传感器信号。控制单元（90）适于接收和分析传感器信号并响应于至少一个传感器信号和阈值来确定进食事件已经发生。所述控制单元识别来自所述胃肠道的节奏活动的至少一个传感器信号的一个方面，该信号不指示受试者目前的饮食，并且响应于源于活动的信号的方面修改阈值不表示目前的饮食。对于一些应用，如果该方面指示迁移电机复合体（MMC），则控制单元适于修改阈值。还描述了其它实施例。

2. 发明申请

WO2004112563A2 GASTROINTESTINAL METHODS AND APPARATUS FOR USE IN TREATING DISORDERS 审中-公开
标题翻译：用于治疗疾病的胃肠病学方法和装置
公开(公告)号：WO2004112563A2
公开(公告)日：2004-12-29
申请号：PCT/IL2004/000550
申请日：2004-06-20
申请人： IMPULSE DYNAMICS NV , BEN HAIM, Shlomo , POLICKER, Shai , AVIV, Ricardo , GLASBERG, Ofer
发明人： BEN HAIM, Shlomo , POLICKER, Shai , AVIV, Ricardo , GLASBERG, Ofer
IPC分类号： A61B
CPC分类号： A61K49/00 , A61B5/053 , A61B5/1116 , A61B5/14539 , A61B5/4238 , A61B5/6871 , A61F5/0026 , A61F5/0036 , A61N1/36007
摘要： A method is provided for detecting a change in posture of a subject. An electrical impedance is measured between two or more sites on a stomach (20) of the subject, and an impedance signal is generated responsive thereto. The change in posture is detected by performing a posture analysis of the impedance signal. A method is also provided for treating a subject. The method includes applying an electrical signal to a site of the subject selected from the list consisting of: a colon (402) of the subject, and a distal small intestine (408) of the subject. The signal is configured to stimulate cells of the subject to increase secretion of glucagon-like-peptide-1 (GLP-1) or PYY, or to decrease secretion of ghrelin, in order to treat the subject.
摘要翻译：提供一种用于检测被检体的姿势变化的方法。在受试者的胃（20）上的两个或更多个部位之间测量电阻抗，并且响应于此产生阻抗信号。通过进行阻抗信号的姿势分析来检测姿势的变化。还提供了一种治疗受试者的方法。该方法包括将电信号施加到从包括受试者的结肠（402）和受试者的远端小肠（408）的列表中选择的对象的部位。信号被配置为刺激受试者的细胞以增加胰高血糖素样肽-1（GLP-1）或PYY的分泌，或者降低生长素释放肽的分泌，以便治疗受试者。

3. 发明申请

WO0124871A3 MODULATION OF INTRACELLULAR CALCIUM CONCENTRATION USING NON-EXCITATORY ELECTRICAL SIGNALS APPLIED TO THE TISSUE 审中-公开
标题翻译：使用非组织电信号调节细胞内钙浓度，适用于组织
公开(公告)号：WO0124871A3
公开(公告)日：2002-01-10
申请号：PCT/IB0001523
申请日：2000-10-04
申请人： IMPULSE DYNAMICS NV , SHEMER ITZIK , FELZEN BELLA , DARVISH NISSIM , MIKA YUVAL , HADDAD WALID , AVIV RICARDO , HAHAM YAAKOV
发明人： SHEMER ITZIK , FELZEN BELLA , DARVISH NISSIM , MIKA YUVAL , HADDAD WALID , AVIV RICARDO , HAHAM YAAKOV
IPC分类号： A61N1/362 , A61N1/365 , A61N1/18
CPC分类号： A61N1/36514 , A61N1/3627
摘要： According to a method and device for modulating intracellular calcium concentration in biological tissue, a stimulation probe is applied to the tissue, a non-excitatory stimulation pulse is generated, and the pulse is conveyed to the stimulation probe. In one embodiment concerning cardiac tissue, a stimulation probe is applied to a patient's heart, a signal is received from at least one sensor responsive to the patient's cardiac muscle activity, a non-excitatory stimulation pulse responsive to the signal is generated, and the pulse is conveyed to the stimulation probe.
摘要翻译：根据用于调节生物组织中细胞内钙浓度的方法和装置，将刺激探针施加到组织，产生非兴奋性刺激脉冲，并将脉冲输送到刺激探针。在关于心脏组织的一个实施例中，将刺激探针应用于患者的心脏，响应于患者的心肌活动从至少一个传感器接收信号，产生响应于该信号的非兴奋性刺激脉冲，并且脉冲被传送到刺激探针。

4. 发明申请

WO2004112563A3 GASTROINTESTINAL METHODS AND APPARATUS FOR USE IN TREATING DISORDERS 审中-公开
公开(公告)号：WO2004112563A3
公开(公告)日：2004-12-29
申请号：PCT/IL2004/000550
申请日：2004-06-20
申请人： METACURE N.V., , BEN HAIM, Shlomo , POLICKER, Shai , AVIV, Ricardo , GLASBERG, Ofer
发明人： BEN HAIM, Shlomo , POLICKER, Shai , AVIV, Ricardo , GLASBERG, Ofer
IPC分类号： A61N1/18
摘要： A method is provided for detecting a change in posture of a subject. An electrical impedance is measured between two or more sites on a stomach (20) of the subject, and an impedance signal is generated responsive thereto. The change in posture is detected by performing a posture analysis of the impedance signal. A method is also provided for treating a subject. The method includes applying an electrical signal to a site of the subject selected from the list consisting of: a colon (402) of the subject, and a distal small intestine (408) of the subject. The signal is configured to stimulate cells of the subject to increase secretion of glucagon-like-peptide-1 (GLP-1) or PYY, or to decrease secretion of ghrelin, in order to treat the subject.

5. 发明申请

WO2002082968A3 ANALYSIS OF EATING HABITS 审中-公开
公开(公告)号：WO2002082968A3
公开(公告)日：2002-10-24
申请号：PCT/IL2002/000309
申请日：2002-04-16
申请人： IMPULSE DYNAMICS NV , POLICKER, Shai , AVIV, Ricardo , BITON, Ophir
发明人： POLICKER, Shai , AVIV, Ricardo , BITON, Ophir
IPC分类号： A61B5/00
摘要： Diet evaluation gastric apparatus (18) is provided, which detects when a patient (10) swallows, and detects the type and amount of matter ingested. The apparatus includes electrodes (74, 100) adapted to be coupled to the fundus and antrum of the patient and to measure electrical and mechanical activity therein, and a control unit (90) to analyze such electrical and mechanical activity and optionally apply electrical energy to modify the activity of tissue of the patient.

6. 发明申请

WO2002082968A2 ANALYSIS OF EATING HABITS 审中-公开
标题翻译：饮食习惯分析
公开(公告)号：WO2002082968A2
公开(公告)日：2002-10-24
申请号：PCT/IL2002/000309
申请日：2002-04-16
申请人： IMPULSE DYNAMICS NV , POLICKER, Shai , AVIV, Ricardo , BITON, Ophir
发明人： POLICKER, Shai , AVIV, Ricardo , BITON, Ophir
IPC分类号： A61B
CPC分类号： A61B5/42 , A61B5/04884 , A61B5/053 , A61B5/076 , A61B5/1107 , A61B5/4023 , A61B5/4233 , A61N1/36007 , Y10S128/903 , Y10S128/92
摘要： Diet evaluation gastric apparatus (18) is provided, which detects when a patient (10) swallows, and detects the type and amount of matter ingested. The apparatus includes electrodes (74, 100) adapted to be coupled to the fundus and antrum of the patient and to measure electrical and mechanical activity therein, and a control unit (90) to analyze such electrical and mechanical activity and optionally apply electrical energy to modify the activity of tissue of the patient.
摘要翻译：提供饮食评价胃装置（18），其检测患者（10）何时吞咽，并检测摄入的物质的类型和数量。所述装置包括适于耦合到患者的眼底和窦并且测量其中的电和机械活动的电极（74,100），以及控制单元（90），用于分析这种电和机械活动并且可选地将电能施加到修改患者组织的活动。

7. 发明申请

WO2011092710A2 GASTROINTESTINAL ELECTRICAL THERAPY 审中-公开
标题翻译：胃肠道电疗
公开(公告)号：WO2011092710A2
公开(公告)日：2011-08-04
申请号：PCT/IL2011/000116
申请日：2011-02-01
申请人： METACURE LIMITED , YANIV, Irit , HADDAD, Walid , GOODE, Jr., Paul V. , LEBOVITZ, Harold , AVIV, Ricardo , ROUSSO, Benny , BEN-HAIM, Shlomo
发明人： YANIV, Irit , HADDAD, Walid , GOODE, Jr., Paul V. , LEBOVITZ, Harold , AVIV, Ricardo , ROUSSO, Benny , BEN-HAIM, Shlomo
IPC分类号： A61N1/18
CPC分类号： A61N1/36139 , A61N1/0509 , A61N1/36007 , A61N1/36053 , A61N1/36085
摘要： Apparatus (18) for treating a human patient, which includes one or more electrode contact surfaces (100), which are configured to be applied to a fundus (22) of the patient. A control unit (90) is configured to drive the one or more electrode contact surfaces (100) to apply an electrical signal to the fundus (22) that chronically improves a blood glucose level of the patient, in order to treat the patient, without calculating an impedance of tissue of the fundus (22) based on a sensed parameter that varies in response to the electrical signal, for detecting eating by the patient or a characteristic of food eaten by the patient. Other embodiments are also described.
摘要翻译：用于治疗人类患者的装置（18），其包括被配置为施加到患者的眼底（22）的一个或多个电极接触表面（100）。控制单元（90）被配置为驱动所述一个或多个电极接触表面（100）以将电信号施加到眼底（22），所述电信号长期改善患者的血糖水平，以便治疗患者，而没有基于响应于电信号变化的感测参数，用于检测患者的进食或患者吃的食物的特征，计算眼底组织的阻抗（22）。还描述了其它实施例。

8. 发明申请

WO02053093A3 REGULATION OF EATING HABITS 审中-公开
标题翻译：调节饮食习惯
公开(公告)号：WO02053093A3
公开(公告)日：2002-12-19
申请号：PCT/IL0200007
申请日：2002-01-03
申请人： IMPULSE DYNAMICS NV , POLICKER SHAI , AVIV RICARDO , BITTON OPHIR
发明人： POLICKER SHAI , AVIV RICARDO , BITTON OPHIR
IPC分类号： A61K49/00 , A61N1/36 , A61N1/08
CPC分类号： A61K49/0004 , A61N1/36007
摘要： A method for treating a subject is provided, including receiving a sensor signal responsive to the subject eating, analyzing the sensor signal, and driving a current into tissue of the subject responsive to analyzing the signal. The current is typically driven into muscle tissue of the subject's stomach (20). Preferably, receiving the sensor signal includes sensing electrical potential change generated responsive to contraction of a muscle such as a stomach muscle of the subject. In a preferred embodiment, the sensor signal is analyzed with respect to the timing of ingestion, and a level of compliance of the subject with a desired ingestion schedule is determined. As appropriate, a parameter of the current driven into the tissue may be configured such that the application of the current to the tissue induces in the subject a sensation of satiation, discomfort, nausea, or vertigo.
摘要翻译：提供了一种用于治疗对象的方法，包括接收响应于对象进食的传感器信号，分析传感器信号并且响应于分析信号而将电流驱动到对象的组织中。通常将电流驱入受试者的胃的肌肉组织（20）。优选地，接收传感器信号包括感测响应于受试者的诸如胃肌肉的肌肉的收缩而产生的电势变化。在优选实施例中，关于摄取的时间来分析传感器信号，并且确定对象与期望的摄取时间表的一致性水平。适当地，驱动进入组织的电流的参数可以被配置成使得向组织施加电流引起对象饱食，不适，恶心或眩晕的感觉。

9. 发明申请

WO2006018851A3 MONITORING, ANALYSIS, AND REGULATION OF EATING HABITS 审中-公开
标题翻译：监测，分析和监管工作
公开(公告)号：WO2006018851A3
公开(公告)日：2009-04-02
申请号：PCT/IL2005000904
申请日：2005-08-18
申请人： METACURE LTD , KLIGER ANAT , POLICKER SHAI , AVIV RICARDO
发明人： KLIGER ANAT , POLICKER SHAI , AVIV RICARDO
IPC分类号： A61B5/117 , A61B5/04 , A61B5/103 , A61N1/00
CPC分类号： A61N1/08 , A61N1/36007
摘要： Gastric apparatus (18) is provided, including one or more sensors (70, 72, 74), adapted to generate respective sensor signals responsive to activity of a gastrointestinal tract of a subject. A control unit (90) is adapted to receive and analyze the sensor signals and to determine that an eating event has occurred, responsive to at least one of the sensor signals and a threshold. The control unit identifies an aspect of at least one of the sensor signals deriving from rhythmic activity of the gastrointestinal tract that is not indicative of current eating by the subject, and modifies the threshold responsive to the aspect of the signals that derives from activity that is not indicative of current eating. For some applications, the control unit is adapted to modify the threshold if the aspect is indicative of a migrating motor complex (MMC). Other embodiments are also described.
摘要翻译：提供了胃装置（18），其包括一个或多个传感器（70,72,74），适于产生响应受试者的胃肠道活动的相应传感器信号。控制单元（90）适于接收和分析传感器信号并响应于至少一个传感器信号和阈值来确定进食事件已经发生。控制单元识别出来自胃肠道节奏活动的至少一个传感器信号的一个方面，其不指示受试者目前的饮食，并且根据来自活动的信号的方面修改阈值不表示目前的饮食。对于某些应用，如果该方面指示迁移电机复合体（MMC），则控制单元适于修改阈值。还描述了其它实施例。

10. 发明申请

WO2011092710A3 GASTROINTESTINAL ELECTRICAL THERAPY 审中-公开
标题翻译：胃肠电疗法
公开(公告)号：WO2011092710A3
公开(公告)日：2011-11-03
申请号：PCT/IL2011000116
申请日：2011-02-01
申请人： METACURE LTD , YANIV IRIT , HADDAD WALID , GOODE JR PAUL V , LEBOVITZ HAROLD , AVIV RICARDO , ROUSSO BENNY , BEN-HAIM SHLOMO
发明人： YANIV IRIT , HADDAD WALID , GOODE JR PAUL V , LEBOVITZ HAROLD , AVIV RICARDO , ROUSSO BENNY , BEN-HAIM SHLOMO
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61N1/0509 , A61N1/36007 , A61N1/36053 , A61N1/36085
摘要： Apparatus (18) for treating a human patient, which includes one or more electrode contact surfaces (100), which are configured to be applied to a fundus (22) of the patient. A control unit (90) is configured to drive the one or more electrode contact surfaces (100) to apply an electrical signal to the fundus (22) that chronically improves a blood glucose level of the patient, in order to treat the patient, without calculating an impedance of tissue of the fundus (22) based on a sensed parameter that varies in response to the electrical signal, for detecting eating by the patient or a characteristic of food eaten by the patient. Other embodiments are also described.
摘要翻译：用于治疗人类患者的设备（18），其包括一个或多个电极接触表面（100），所述电极接触表面被配置为施加到患者的眼底（22）。控制单元（90）被配置成驱动一个或多个电极接触表面（100）以将电信号施加到眼底（22），以长期改善患者的血糖水平，以便治疗患者，而无需基于响应于电信号而变化的感测参数来计算眼底组织的阻抗，用于检测由患者进食或由患者食用的食物的特性。还描述了其他实施例。

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