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1. 发明专利

JP2004531291A Deseruraraizu method of bio-prosthesis manufacturing for foreign material 审中-公开
公开(公告)号：JP2004531291A
公开(公告)日：2004-10-14
申请号：JP2002551018
申请日：2001-12-05
申请人：オート・ティッシュ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングAuto Tissue GmbH
发明人：ヴォルフガング・コネルツ , パスカル・ドーメン
IPC分类号： A61L2/18 , A61F2/24 , A61L2/00 , A61L2/02 , A61L27/00 , A61L27/36 , C12N5/08
CPC分类号： A61L27/3687 , A61F2/2415 , A61L2/0011 , A61L2/0088 , A61L27/3691
摘要：この発明は同種異系および異種の外来材料をデセルラライズする方法に関し、外来材料は内生体細胞で被覆されたバイオプロテーゼを以後に製造するためのものであり、ここでは該外来材料を先ず胆汁酸溶液で処理し、次にアルコールで処理するが、両処理には中間にまたは後続して洗浄工程を行い、少なくとも最終洗浄工程では、流動性処理媒体から得られる力による組織および細胞への機械的作用と組合せる。
該処理後には組織は、外来細胞物質およびウイルスが完全に除去され、バイオプロテーゼを受けるレシピエントの細胞による被覆のために優れた出発材料となる。

2. 发明申请

WO2004052417A1 VERFAHREN ZUR HERSTELLUNG VON BIOPROTHESEN 审中-公开
标题翻译：用于生产生物瓣膜
公开(公告)号：WO2004052417A1
公开(公告)日：2004-06-24
申请号：PCT/DE2003/003997
申请日：2003-12-02
申请人： AUTO TISSUE GMBH , VATER, Joachim , ERDBRÜGGER, Wilhelm , PAULI, Georg , ELLERBROK, Heinz
发明人： VATER, Joachim , ERDBRÜGGER, Wilhelm , PAULI, Georg , ELLERBROK, Heinz
IPC分类号： A61L27/36
CPC分类号： A61L27/3843 , A61L27/3687 , A61L2430/40
摘要： Ein Verfahren zur Herstellung von Bioprothesen aus allogenem oder xenogenem Material, insbesondere Herzklappen, umfasst eine Detergenzbehandlung zum Lysieren und Herauslösen der Fremdzellen, eine Konditionierungsbehandlung mit einem zyklischen Lipopeptid, insbesondere Surfactin, und eine Besiedlungsphase der so präparierten Gewebematrix mit körpereigenen Zellen des Transplantatempfängers. Die zwischengeschaltete Behandlung mit einem Lipopeptid schafft auf der Oberfläche der Gewebematrix eine integrale, biokompatible, von Krankheitserregern freie Unterlage für eine gleichmäßige Zellbesiedlung und ein oberflächenglattes, elastisches Transplantat mit langer Lebensdauer.
摘要翻译：一种用于生产从同种异体或异种材料，特别心脏瓣膜，其包括用于裂解和提取外来细胞，具有环状脂肽调理处理，特别枯草，并与移植受体的自体细胞的如此制备的组织基质的结算相的洗涤剂处理的生物假体的过程。与脂肽的中间处理提供了一种整体的，生物相容的，无病原体的一个统一的细胞群和具有使用寿命长的组织基质的表面上的表面光滑，有弹性表面接枝。

3. 发明专利

DE10190290B4 未知
公开(公告)号：DE10190290B4
公开(公告)日：2008-06-26
申请号：DE10190290
申请日：2001-02-05
申请人： AUTO TISSUE GMBH
发明人： KONERTZ WOLFGANG , STEIN KONERTZ MARITA , DOHMEN PASCAL
IPC分类号： A61F2/24

4. 发明专利

CA2428880C METHOD FOR DECELLULARISING FOREIGN MATERIAL FOR THE PRODUCTION OF BIOPROSTHESES 未知
公开(公告)号：CA2428880C
公开(公告)日：2006-12-19
申请号：CA2428880
申请日：2001-12-05
申请人： AUTO TISSUE GMBH
发明人： DOHMEN PASCAL , KONERTZ WOLFGANG
IPC分类号： A61L2/02 , A61L2/18 , A61F2/06 , A61F2/24 , A61L2/00 , A61L2/16 , A61L27/00 , A61L27/36 , C12N5/08
摘要： The invention relates to a method for decellularising allogenic and xenogeni c foreign material for the subsequent production of bioprostheses, coated with endogenous body cells, whereby the foreign material is firstly treated in a solution of bile acid and then alcohol, each with an intermediate or subsequent rinsing step, in combination with a mechanical action on the tiss ue and the cells by the force generated from a flowing treatment medium, at lea st in the final rinsing step. After said treatment the tissue is completely rid of foreign cell material and viruses and represents an excellent starting material for the coating with cells of the bioprosthesis recipient.

5. 发明专利

AT306284T 未知
公开(公告)号：AT306284T
公开(公告)日：2005-10-15
申请号：AT01271089
申请日：2001-12-05
申请人： AUTO TISSUE GMBH
发明人： KONERTZ WOLFGANG , DOHMEN PASCAL
IPC分类号： A61L2/18 , A61F2/24 , A61L2/00 , A61L2/02 , A61L27/00 , A61L27/36 , C12N5/08 , A61L2/16 , A61F2/06
摘要： The invention relates to a method for decellularising allogenic and xenogenic foreign material for the subsequent production of bioprostheses, coated with endogenous body cells, whereby the foreign material is firstly treated in a solution of bile acid and then alcohol, each with an intermediate or subsequent rinsing step, in combination with a mechanical action on the tissue and the cells by the force generated from a flowing treatment medium, at least in the final rinsing step. After said treatment the tissue is completely rid of foreign cell material and viruses and represents an excellent starting material for the coating with cells of the bioprosthesis recipient.

6. 发明专利

AU2003293272A1 METHOD FOR THE PRODUCTION OF BIOPROSTHESES 未知
公开(公告)号：AU2003293272A1
公开(公告)日：2004-06-30
申请号：AU2003293272
申请日：2003-12-02
申请人： AUTO TISSUE GMBH
发明人： VATER JOACHIM , ERDBRUGGER WILHELM , PAULI GEORG , ELLERBROK HEINZ
IPC分类号： A61L27/36 , A61L27/38
摘要： Producing bioprostheses from allogenic or xenogenic material, involves treating with detergent (for lysis and killing of foreign cells) and inoculating the remaining collagen matrix with cells from the body of the transplant recipient, the transplant is conditioned in a solution of cyclic lipopeptide (I) (including mixtures or salts) between the detergent treatment and inoculation stages.

7. 发明专利

DE10195474D2 未知
公开(公告)号：DE10195474D2
公开(公告)日：2004-04-15
申请号：DE10195474
申请日：2001-12-05
申请人： AUTO TISSUE GMBH
发明人： KONERTZ WOLFGANG , DOHMEN PASCAL
IPC分类号： A61L2/18 , A61F2/24 , A61L2/00 , A61L2/02 , A61L27/00 , A61L27/36 , C12N5/08 , A61L2/16 , A61F2/06
摘要： The invention relates to a method for decellularising allogenic and xenogenic foreign material for the subsequent production of bioprostheses, coated with endogenous body cells, whereby the foreign material is firstly treated in a solution of bile acid and then alcohol, each with an intermediate or subsequent rinsing step, in combination with a mechanical action on the tissue and the cells by the force generated from a flowing treatment medium, at least in the final rinsing step. After said treatment the tissue is completely rid of foreign cell material and viruses and represents an excellent starting material for the coating with cells of the bioprosthesis recipient.

8. 发明专利

DE10194891D2 未知
公开(公告)号：DE10194891D2
公开(公告)日：2004-01-15
申请号：DE10194891
申请日：2001-09-19
申请人： AUTO TISSUE GMBH
发明人： KONERTZ WOLFGANG , DOCHMEN PASCAL
IPC分类号： A61F2/06 , A61F2/24 , A61L27/38
摘要： The invention relates to a method for coating biological implants with autologous cells of the recipient, according to which the cell-free allogenic or xenogenic material foreign to the body is colonized in a speed-variable pulsating cell suspension flow close to the natural conditions in the respective organ or part of the organ. The resulting cell conditioning allows a complete, fast and safe coating with cells, the formation of which comes close to the natural conditions and guarantees a trouble-free functioning and a long life of the implant. The device for carrying out the method comprises a bioreactor (2) integrated into a loop (1) and filled with the cell suspension in which the implant (8) is axially and centrally fixated in the direction of flow. The loop (1) is connected to a pump (3) that generates a pulsating flow of medium that flows through the implant (8). The inventive coating with autologous cells can also be applied to artificial prostheses.

9. 发明专利

DE102004047247B3 未知
公开(公告)号：DE102004047247B3
公开(公告)日：2006-03-16
申请号：DE102004047247
申请日：2004-09-22
申请人： AUTO TISSUE GMBH
发明人： STEIN-KONERTZ MARITA , ERDBRUEGGER WILHELM
IPC分类号： A61L2/18
摘要： The sterilization of biological material of animal or human origin, which is to be used as an implant or transplant, is performed according to a validated sterilization method with a margin of safety of 10 6 germs by which harmful microorganisms are physically separated and chemically sterilized in four successive steps, initially in an antibiotic, then in deoxicholic acid, then in a surface-active substance and finally in primary alcohol, respectively accompanied by rinsing steps involving an aqueous solution after steps two to four. A bioprosthesis sterilized with a margin of safety>10 6 germs can be implanted without any further treatment, does not have a tendency towards calcification, and ensures a long service life.

10. 发明专利

DK1343536T3 未知
公开(公告)号：DK1343536T3
公开(公告)日：2006-02-27
申请号：DK01271089
申请日：2001-12-05
申请人： AUTO TISSUE GMBH
发明人： KONERTZ WOLFGANG , DOHMEN PASCAL
IPC分类号： A61L2/02 , A61L2/18 , A61F2/06 , A61F2/24 , A61L2/00 , A61L2/16 , A61L27/00 , A61L27/36 , C12N5/08
摘要： The invention relates to a method for decellularising allogenic and xenogenic foreign material for the subsequent production of bioprostheses, coated with endogenous body cells, whereby the foreign material is firstly treated in a solution of bile acid and then alcohol, each with an intermediate or subsequent rinsing step, in combination with a mechanical action on the tissue and the cells by the force generated from a flowing treatment medium, at least in the final rinsing step. After said treatment the tissue is completely rid of foreign cell material and viruses and represents an excellent starting material for the coating with cells of the bioprosthesis recipient.

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