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1. 发明申请

WO2016094355A1 LIQUID AND PLATE SENSORS FOR MICROPLATE INJECTOR SYSTEM 审中-公开
标题翻译：液体和板式传感器用于微型注射器系统
公开(公告)号：WO2016094355A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/064399
申请日：2015-12-08
申请人： MOLECULAR DEVICES, LLC , ATZLER, Josef, J. , KATZLINGER, Michael , KRONBERGER, Georg , SCHINWALD, Bernhard
发明人： ATZLER, Josef, J. , KATZLINGER, Michael , KRONBERGER, Georg , SCHINWALD, Bernhard
IPC分类号： G01N21/64 , G01N21/01 , G01N1/14 , G01V3/08
CPC分类号： G01N21/76 , G01J3/02 , G01N21/15 , G01N21/253 , G01N21/763 , G01N27/223 , G01N35/028 , G01N2021/015 , G01N2021/155 , G01N2035/1025 , G01N2201/0225 , G01N2201/0245 , G01N2201/0446 , G01N2201/0806
摘要： In a sample analyzing apparatus, an injector assembly injects a reagent onto a sample, and luminescent light from the sample is transmitted to a detector. The assembly may be movable toward and away from the sample. The assembly may include one or more needles that communicate with one or more reservoirs supplying reagent or other liquids. The assembly may include a light guide for communicating with the detector. A cartridge may be provided in which the assembly, one or more reservoirs, and one or more pumps are disposed. The cartridge and/or the apparatus may be configured for enabling rinsing or priming to be done outside the apparatus. The cartridge and/or the apparatus may include one or more types of sensors configured for detecting, for example, the presence of liquid or bubbles in one or more locations of the apparatus and/or the cartridge.
摘要翻译：在样品分析装置中，注射器组件将试剂注射到样品上，并将来自样品的发光发射到检测器。组件可以朝向和远离样品移动。组件可以包括与供应试剂或其它液体的一个或多个储存器连通的一个或多个针。组件可以包括用于与检测器通信的光导。可以提供盒，其中设置组件，一个或多个储存器和一个或多个泵。墨盒和/或设备可以被配置为使得能够在设备外进行冲洗或启动。药筒和/或装置可以包括一种或多种类型的传感器，其被配置用于例如在装置和/或药筒的一个或多个位置中检测液体或气泡的存在。

2. 发明申请

WO2007092903A2 MULTIMODE READER 审中-公开
标题翻译：多模式阅读器
公开(公告)号：WO2007092903A2
公开(公告)日：2007-08-16
申请号：PCT/US2007061801
申请日：2007-02-07
申请人： BECKMAN COULTER INC , STOCK DANIEL M , ATZLER JOSEF J
发明人： STOCK DANIEL M , ATZLER JOSEF J
IPC分类号： G01N21/64 , G01J3/427 , G01N21/76
CPC分类号： G01N21/645 , G01J3/02 , G01J3/0202 , G01J3/021 , G01J3/0218 , G01J3/0232 , G01J3/0235 , G01J3/0256 , G01J3/0291 , G01J3/10 , G01J3/427 , G01J3/4406 , G01N21/6408 , G01N21/6428 , G01N21/6445 , G01N21/763 , G01N2021/1738 , G01N2021/6415 , G01N2021/6419 , G01N2021/6441 , G01N2021/6482 , G01N2201/024 , G01N2201/0618 , G01N2201/062 , G01N2201/0621 , G01N2201/0692 , G01N2201/0696
摘要： A cartridge (10, 60, 80, 110, 130, 140, 170, 180, 200, 222, 224, 226, 228, 230, 240, 242, 246, 280, 282, 300) and cartridge system (220) for use in an apparatus (12) for analyzing a sample (16) is provided. The cartridge has one or more light sources (18) and/or optical systems (22, 34, 84, 120, 162) and other components that are specific for a certain type of application such as fluorescence, absorbance, or luminescence. The light source, optical systems, and other components for a specific application are housed in a single cartridge. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with the apparatus in a "plug-in" format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed.
摘要翻译：盒（10,60,80,110,130,140,170,180,200,222,224,226,228,230,240,242,246,280,282,300）和盒系统（220），用于在用于分析样品（16）的装置（12）中使用。盒具有一个或多个光源（18）和/或光学系统（22,34,84,120,162）以及对某种类型的应用（例如荧光，吸光度或发光）特异的其它组件。用于特定应用的光源，光学系统和其他部件容纳在单个盒中。该系统具有用于多模仪器的不同应用的多个盒。墨盒以“插入”格式可拆卸地与设备接合，使得一个墨盒可以从设备中取出，另一墨盒可以容易地安装。

3. 发明申请

WO2022175898A1 METHODS FOR ORGANOID PASSAGING USING MICROPLATE WELL UNITS 审中-公开
公开(公告)号：WO2022175898A1
公开(公告)日：2022-08-25
申请号：PCT/IB2022/051484
申请日：2022-02-18
申请人： MOLECULAR DEVICES (AUSTRIA) GMBH , ATZLER, Josef , SPIRA, Felix
发明人： ATZLER, Josef , SPIRA, Felix
IPC分类号： C12M3/00 , C12M1/32 , C12N5/071
摘要： Disclosed are various embodiments related to automated cellular passaging of spheroids, tumoroids, organoids and/or other multi-cellular bodies. Organoids can be cultured in a hydrogel that is disposed in a well unit of a microwell plate. The well unit includes a primary well section that is fluidly connected to a secondary well section via at least one channel, and the hydrogel is disposed in the primary well section of the well unit. The hydrogel is dissipated into hydrogel fragments, thereby separating the organoids from the hydrogel. The hydrogel fragments are removed from the well unit, while the organoids remain in the well unit. The remaining organoids are broken into organoid fragments and corresponding debris. A fresh culture environment is created using the organoid fragments.

4. 发明申请

WO2010111166A3 COMPACT DUAL PASS MONOCHROMATOR 审中-公开
标题翻译：紧凑型双通道单色器
公开(公告)号：WO2010111166A3
公开(公告)日：2011-01-13
申请号：PCT/US2010028104
申请日：2010-03-22
申请人： BECKMAN COULTER INC , ATZLER JOSEF , KENDA ANDREAS
发明人： ATZLER JOSEF , KENDA ANDREAS
IPC分类号： G01J3/28
CPC分类号： G01J3/32 , G01J3/02 , G01J3/0208 , G01J3/024 , G01J3/0291 , G01J3/06 , G01J3/12 , G01J3/4406 , G01J2003/1204 , G01J2003/1208 , G01N21/6452 , G01N2021/6417
摘要： A dual pass monochromator for generating excitation radiation and isolating emission radiation at prescribed wavelengths, useful for analyzing florescence in multi-assay micro-titer plate readers is disclosed. The optically dispersive element can be used to receive radiation through an entrance aperture; isolate a prescribed wavelength band; and then direct the prescribed wavelength band through a first exit aperture onto a sample. The excited emissions from the sample can then be received back through the first exit aperture and be directed to the optically dispersive element to isolate the emission wavelength band and direct it onto a detector through a second exit aperture. Band pass elements can be optically coupled to the optically dispersive element to tune the excitation and emission wavelength bands. Band pass optical elements can be dispersive diffraction gratings, or non-dispersive optical filters. The dual pass monochromator can be modular and include a number of optically isolated compartments.
摘要翻译：公开了一种用于产生激发辐射并隔离规定波长的发射辐射的双通单色仪，用于分析多分析微滴定板读取器中的荧光。光学色散元件可用于通过入口孔接受辐射; 隔离规定的波段; 然后将规定的波长带通过第一出口孔引导到样品上。然后可以通过第一出口孔将来自样品的激发的排放物接收回来，并被引导到光学色散元件以隔离发射波长带，并通过第二出射孔将其引导到检测器上。带通元件可以光耦合到光学色散元件以调谐激发和发射波长带。带通光学元件可以是分散衍射光栅或非分散光学滤光器。双通单色仪可以是模块化的，并且包括多个光学隔离的隔室。

5. 发明申请

WO2022144754A1 MICROPLATE WELLS FOR CELL CULTIVATION 审中-公开
公开(公告)号：WO2022144754A1
公开(公告)日：2022-07-07
申请号：PCT/IB2021/062356
申请日：2021-12-27
申请人： MOLECULAR DEVICES (AUSTRIA) GMBH , ATZLER, Josef , KENDA, Andreas , SPIRA, Felix
发明人： ATZLER, Josef , KENDA, Andreas , SPIRA, Felix
IPC分类号： C12M1/32 , C12M1/00 , C12M1/04 , C12M3/00 , C12M1/12
摘要： Disclosed are various embodiments for growing, culturing, monitoring, and analyzing embryoid bodies, fused embryoid bodies, spheroids, organoids, or other multi-cellular bodies in a microwell structure formed in one or more wells of an assay and culturing microplate. Hydrogel deposited into a well of the microplate and supported by a support ledge and the bottom surface of the well is molded into a microwell structure using a mold insert tool. In some examples, channels can be formed in the bottom of the microwell structure to allow for an exchange of fluid between a primary well section and a secondary well section of the well. The bottom surface of the assay and culturing microplate is optically transparent and gas-permeable.

6. 发明申请

WO2017189669A1 METHODS AND SYSTEMS FOR OPTICAL-BASED MEASUREMENT WITH SELECTABLE EXCITATION LIGHT PATHS 审中-公开
标题翻译：用可选激发光路进行光学测量的方法和系统
公开(公告)号：WO2017189669A1
公开(公告)日：2017-11-02
申请号：PCT/US2017/029550
申请日：2017-04-26
申请人： MOLECULAR DEVICES, LLC , ATZLER, Josef, J. , KATZLINGER, Michael , WAGNER, Klaus
发明人： ATZLER, Josef, J. , KATZLINGER, Michael , WAGNER, Klaus
IPC分类号： G01N21/64 , G01N21/31 , G01J1/42
摘要： In an optical-based sample analysis, for example fluorescence-based or absorbance-based measurement, a selection is made between a first excitation light path and a second excitation light path. The first excitation light path directs excitation light from a light source, through an excitation monochromator, through an excitation filter, and to a sample. The second excitation light path directs excitation light from the light source, through the excitation filter, and to the sample while bypassing the excitation monochromator. Excitation light generated by the light source is transmitted along either the first excitation light path or the second excitation light path in accordance with the selection made, thereby irradiating the sample. In response the sample produces emission light (transmitted light in the case of absorbance measurements), which is transmitted to and measured by a light detector.
摘要翻译：在基于光学的样本分析中，例如基于荧光或基于吸光度的测量，在第一激励光路径和第二激励光路径之间进行选择。第一激发光路径将来自光源的激发光，激发单色器，激发滤波器以及样本引导。第二激发光路径将来自光源的激发光引导通过激发滤光片并引导至样本，同时绕过激发单色器。根据所做出的选择，由光源产生的激发光沿着第一激励光路径或第二激励光路径传输，由此照射样本。作为响应，样品产生发射光（在吸光度测量的情况下为透射光），其被发射并由光检测器测量。

7. 发明申请

WO2010111166A2 COMPACT DUAL PASS MONOCHROMATOR 审中-公开
标题翻译：紧凑型双通道单色器
公开(公告)号：WO2010111166A2
公开(公告)日：2010-09-30
申请号：PCT/US2010/028104
申请日：2010-03-22
申请人： BECKMAN COULTER, INC. , ATZLER, Josef , KENDA, Andreas
发明人： ATZLER, Josef , KENDA, Andreas
IPC分类号： G01J3/28
CPC分类号： G01J3/32 , G01J3/02 , G01J3/0208 , G01J3/024 , G01J3/0291 , G01J3/06 , G01J3/12 , G01J3/4406 , G01J2003/1204 , G01J2003/1208 , G01N21/6452 , G01N2021/6417
摘要： A dual pass monochromator for generating excitation radiation and isolating emission radiation at prescribed wavelengths, useful for analyzing florescence in multi-assay micro-titer plate readers is disclosed. The optically dispersive element can be used to receive radiation through an entrance aperture; isolate a prescribed wavelength band; and then direct the prescribed wavelength band through a first exit aperture onto a sample. The excited emissions from the sample can then be received back through the first exit aperture and be directed to the optically dispersive element to isolate the emission wavelength band and direct it onto a detector through a second exit aperture. Band pass elements can be optically coupled to the optically dispersive element to tune the excitation and emission wavelength bands. Band pass optical elements can be dispersive diffraction gratings, or non-dispersive optical filters. The dual pass monochromator can be modular and include a number of optically isolated compartments.
摘要翻译：公开了一种用于产生激发辐射并隔离规定波长的发射辐射的双通单色仪，用于分析多分析微滴定板读取器中的荧光。光学色散元件可用于通过入口孔接受辐射; 隔离规定的波段; 然后将规定的波长带通过第一出口孔引导到样品上。然后可以通过第一出口孔将来自样品的激发的排放物接收回来，并被引导到光学色散元件以隔离发射波长带，并通过第二出射孔将其引导到检测器上。带通元件可以光耦合到光学色散元件以调谐激发和发射波长带。带通光学元件可以是分散衍射光栅或非分散光学滤光器。双通单色仪可以是模块化的，并且包括多个光学隔离的隔室。

8. 发明申请

WO2007092903A3 MODULAR FLUORIMETRIC OR PHOTOMETRIC READER 审中-公开
公开(公告)号：WO2007092903A3
公开(公告)日：2007-08-16
申请号：PCT/US2007/061801
申请日：2007-02-07
申请人： BECKMAN COULTER, INC. , STOCK, Daniel, M. , ATZLER, Josef, J.
发明人： STOCK, Daniel, M. , ATZLER, Josef, J.
IPC分类号： G01N21/64 , G01N21/76 , G01J3/427
摘要： A cartridge (10, 60, 80, 110, 130, 140, 170, 180, 200, 222, 224, 226, 228, 230, 240, 242, 246, 280, 282, 300) and cartridge system (220) for use in an apparatus (12) for analyzing a sample (16) is provided. The cartridge has one or more light sources (18) and/or optical systems (22, 34, 84, 120, 162) and other components that are specific for a certain type of application such as fluorescence, absorbance, or luminescence. The light source, optical systems, and other components for a specific application are housed in a single cartridge. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with the apparatus in a "plug-in" format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed.

9. 发明申请

WO2002059677A1 OPTISCHES SYSTEM UND VERFAHREN ZUM ANREGEN UND MESSEN VON FLUORESZENZ AN ODER IN MIT FLUORESZENSFARBSTOFFEN BEHANDELTEN PROBEN 审中-公开
标题翻译：光学系统和用于刺激和测量荧光或与荧光染料处理的样品
公开(公告)号：WO2002059677A1
公开(公告)日：2002-08-01
申请号：PCT/CH2002/000014
申请日：2002-01-10
申请人： TECAN TRADING AG , GFRÖRER, Andreas , ATZLER, Josef
发明人： GFRÖRER, Andreas , ATZLER, Josef
IPC分类号： G02B21/00
CPC分类号： B01L3/50855 , B01L9/06 , G01N21/64 , G02B21/16
摘要： Optisches System und Verfahren zum Anregen und Messen von Fluoreszenz an oder in mit Fluoreszenzfarbstoffen behandelten Proben mit einem solchen optischen System mit zumindest einem ersten Laser (1); einem Spiegel (4); einem Umlenkelement (7); einer Optik (8) und einer Einheit (10), welche Spiegel (4) und Optik (8) gegeneinander unbeweglich angeordnet umfasst. Die Einheit (10) ist linear entlang der optischen Achse (5) hin-und-her beweglich angeordnet und mit einem oszillierenden Linearantrieb (11) wirkverbunden. Die Optik (8) wirkt zudem als Kollimator und der Spiegel (4) zudem zum Umlenken des kollimierten Lichtes (12) parallel zu der optischen Achse (5). Das optische System umfasst ausserdem einen zumindest in Richtung der X- und Z-Raumachsen bewegbaren Tisch (13) zur Aufnahme von Probenträgern (14) und zum Ausrichten der Proben (6) gegenüber einem ersten Brennpunkt (9); eine optische Anordnung (16) zum Abbilden eines zweiten Brennpunktes (17); eine im zweiten Brennpunkt (17) angeordnete Lochblende (18); ein erstes Spektralfilter (19) sowie einen ersten Detektor (20) und ist dadurch gekennzeichnet, dass es eine stetig und nicht durch die Probe verlaufende, geometrische Achse (G) umfasst, auf welcher die optische Anordnung (16), der zweite Brennpunkt (17), die Lochblende (18), das erste Spektralfilter (19) und der erste Detektor (20) - zusammen mit dem Spiegel (4) und dem Umlenkelement (7) - angeordnet sind, wobei diese geometrische Achse (G) im Bereich zwischen dem Spiegel (4) und dem ersten Detektor (20) zumindest teilweise mit der optischen Achse (5) identisch ist.
摘要翻译：光学系统和方法用于激励和上或在与具有至少一个第一激光器（1）这样的光学系统的荧光染料处理的样品测定荧光; 反射镜（4）; 偏转元件（7）; 的光学系统（8）和一单元（10），该反射镜（4）和透镜（8）相对于彼此不可移动地布置。所述单元（10）是沿（5），其布置回的往复可动的光轴线性的，并与可操作地连接的振荡线性驱动（11）。所述光学系统（8）还充当准直器和反射镜（4）进一步将准直的光（12）平行地偏转至（5）的光轴上。该光学系统还包括一个可动的X和Z空间轴表（13）的方向上以接收样品载体（14）和相对于对准样本（6）的第一焦点（9）至少; 的光学组件（16），用于成像的第二焦点（17）; 一个第二焦点（17），设置孔（18）; 第一光谱过滤器（19）和第一检测器（20），并且其特征在于它包括一个连续的，而不是通过样品，几何轴线（G）在其上的光学装置（16），所述第二焦点（17 ），孔（18）中，第一光谱过滤器（19）和第一检测器（20） - （连同镜4）和所述偏转元件（7） - 配置，在之间的区域中，所述几何轴线（G）镜（4）和第一检测器（20）是与所述光轴（5）至少部分相同。

10. 发明申请

WO1991006369A2 TEMPERATURE-EQUALIZATION CHAMBER FOR BRINGING THE CONTENTS OF A MICROTITRATION PLATE TO A UNIFORM TEMPERATURE 审中-公开
标题翻译：温度均匀化室将微孔板的内容制成均匀温度
公开(公告)号：WO1991006369A2
公开(公告)日：1991-05-16
申请号：PCT/AT1990000107
申请日：1990-11-02
申请人： SLT-LABINSTRUMENTS GESELLSCHAFT M.B.H. , PUCHEGGER, Karl , ATZLER, Josef
发明人： SLT-LABINSTRUMENTS GESELLSCHAFT M.B.H.
IPC分类号： B01L07/00
CPC分类号： B01L7/00 , G01N35/028
摘要： A temperature-equalization chamber for bringing the contents of a microtitration plate (4) to a uniform temperature has a base plate designed as a temperature-equalization plate, a cover (5) and at least two independently controllable heat-exchangers (9, 11, 12). The base plate advantageously has two heat-exchangers (11, 12), one of which (12) surrounds the other and is connected to the edge of the microtitration plate (4).
摘要翻译：用于使微量滴定板（4）的内容物达到均匀温度的温度均衡室具有设计为温度均衡板，盖（5）和至少两个可独立控制的热交换器（9,11）的基板，12）。基板有利地具有两个热交换器（11,12），其中一个（12）围绕另一个并且连接到微量滴定板（4）的边缘。

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