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1. 发明申请

WO2012161693A1 METHODS TO INCREASE THE NUMBER OF FILTERS PER OPTICAL PATH IN A DOWNHOLE SPECTROMETER 审中-公开
标题翻译：方法增加一个卧室光谱仪中每个光路的滤光片数量
公开(公告)号：WO2012161693A1
公开(公告)日：2012-11-29
申请号：PCT/US2011/037655
申请日：2011-05-24
申请人： HALLIBURTON ENERGY SERVICES, INC. , ZHANG, Wei , ATKINSON, Robert , PELLETIER, Michael, T. , JONES, Christopher, M.
发明人： ZHANG, Wei , ATKINSON, Robert , PELLETIER, Michael, T. , JONES, Christopher, M.
IPC分类号： G01J3/42
CPC分类号： G01N21/255 , G01J3/0202 , G01J3/12 , G01J3/51 , G01J2003/1221 , G01V8/00 , G02B26/008
摘要： Downhole spectrometer tools are provided with two ways to increase the number of filters on an optical path, A first approach employs multiple filter wheels that rotate alternately in a common plane to intersect, the optical path. Portions of the wheels are cut out to avoid mechanical interference between the wheels. A second approach drives the one or more filter wheels with a wobble that causes the filters to trace one or more hypocyeloidal curves that each intersect the optical path.
摘要翻译：井下光谱仪工具具有增加光路上滤光片数量的两种方法。第一种方法采用在公共平面中交替旋转的多个滤光轮与光路相交。切割车轮的部分以避免车轮之间的机械干扰。第二种方法是驱动一个或多个过滤轮，其摆动使得过滤器跟踪一个或多个与光路相交的下阴影曲线。

2. 发明申请

WO2012103196A2 OBSTRUCTIVE SLEEP APNEA TREATMENT DEVICES, SYSTEMS AND METHODS 审中-公开
标题翻译：阻塞性睡眠呼吸暂停治疗装置，系统和方法
公开(公告)号：WO2012103196A2
公开(公告)日：2012-08-02
申请号：PCT/US2012/022522
申请日：2012-01-25
申请人： APNEX MEDICAL, INC. , BOLEA, Stephen, L. , HOEGH, Thomas, B. , KUHNLEY, Brian, D. , SUILMANN, Dale, G. , PERSSON, Bruce, J. , BECK, John, P. , HAUSCHILD, Sidney, F. , TESFAYESUS, Wondimeneh , SKUBITZ, Jason, J. , BOSSHARD, Mark, R. , PARRISH, Daniel, A. , ATKINSON, Robert, E.
发明人： BOLEA, Stephen, L. , HOEGH, Thomas, B. , KUHNLEY, Brian, D. , SUILMANN, Dale, G. , PERSSON, Bruce, J. , BECK, John, P. , HAUSCHILD, Sidney, F. , TESFAYESUS, Wondimeneh , SKUBITZ, Jason, J. , BOSSHARD, Mark, R. , PARRISH, Daniel, A. , ATKINSON, Robert, E.
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61B5/0809 , A61B5/0826 , A61B5/4818 , A61N1/0556 , A61N1/3611 , A61N1/36132 , A61N1/36139 , A61N1/3615 , A61N1/37235
摘要： Devices, systems and methods of neurostimulation for treating obstructive sleep apnea. The system is adapted to send an electrical signal from an implanted neurostimulator through a stimulation lead to a patient's nerve at an appropriate phase of the respiratory cycle based on input from a respiration sensing lead. External components are adapted for wireless communication with the neurostimulator. The neurostimulator is adapted to deliver therapeutic stimulation based on inputs.
摘要翻译：
用于治疗阻塞性睡眠呼吸暂停的神经刺激装置，系统和方法。该系统适于基于来自呼吸感测导线的输入，在植入的神经刺激器的适当阶段通过刺激导线将电信号发送到患者的神经。外部组件适用于与神经刺激器进行无线通信。神经刺激器适用于根据输入提供治疗刺激。

3. 发明申请

WO2011094134A3 OPTICAL MEASUREMENT DEVICE 审中-公开
标题翻译：光学测量装置
公开(公告)号：WO2011094134A3
公开(公告)日：2011-10-06
申请号：PCT/US2011022104
申请日：2011-01-21
申请人： HALLIBURTON ENERGY SERV INC , ATKINSON ROBERT , JONES CHRISTOPHER M , PELLETIER MICHAEL T , HARDER NATHAN , MURPHY ROBERT J
发明人： ATKINSON ROBERT , JONES CHRISTOPHER M , PELLETIER MICHAEL T , HARDER NATHAN , MURPHY ROBERT J
IPC分类号： G01V8/10 , E21B47/01 , G01V13/00
CPC分类号： G01V8/02 , E21B47/011 , F16J15/184 , G01N21/0303 , G01N21/05
摘要： Optical measurement devices including one or more sealing assemblies are described. The sealing assemblies are configured for use at relatively high temperatures and pressures, such as temperatures over 200 degrees F and pressures over 10,000 psi. The sealing assemblies can include a deformable seal element surrounded on each side by a backup seal element. In some examples, the deformable seal element is formed of a material selected from a group consisting of a fluoroelastomer or polytetrafluoroethylene, and the backup seal elements are formed of a material selected from a group consisting of flexible graphite or metal foil. Optionally, at least one additional seal element functioning as an extrusion barrier can be placed on the opposite side of one or both backup seal elements from the deformable seal element. The additional seal element can be formed of polyether ether ketone or flexible graphite, for example. Additional devices and assemblies are described.
摘要翻译：描述了包括一个或多个密封组件的光学测量装置。密封组件被配置为在相对高的温度和压力下使用，例如超过200华氏度的温度和超过10,000psi的压力。密封组件可以包括可变形的密封元件，其在每侧由一个备用密封元件围绕。在一些示例中，可变形密封元件由选自含氟弹性体或聚四氟乙烯的材料形成，并且备用密封元件由从由柔性石墨或金属箔构成的组中选择的材料形成。可选地，用作挤压屏障的至少一个附加密封元件可以放置在一个或两个备选密封元件的与可变形密封元件相对的一侧上。例如，附加的密封元件可以由聚醚醚酮或柔性石墨形成。描述了其他设备和组件。

4. 发明申请

WO2007033052A3 ENDOVASCULAR DEVICES AND METHODS FOR EXPLOITING INTRAMURAL SPACE 审中-公开
标题翻译：内窥镜装置及其方法
公开(公告)号：WO2007033052A3
公开(公告)日：2009-04-16
申请号：PCT/US2006035244
申请日：2006-09-11
申请人： BRIDGEPOINT MEDICAL INC , KUGLER CHAD JOHN , ATKINSON ROBERT EMMETT , OLSON MATTHEW JONATHAN
发明人： KUGLER CHAD JOHN , ATKINSON ROBERT EMMETT , OLSON MATTHEW JONATHAN
IPC分类号： A61M31/00 , A61B17/22
CPC分类号： A61B17/3403 , A61B17/00008 , A61B17/22031 , A61B17/221 , A61B17/32053 , A61B17/32075 , A61B17/320758 , A61B17/3415 , A61B17/3417 , A61B17/3476 , A61B2017/00252 , A61B2017/003 , A61B2017/00455 , A61B2017/00685 , A61B2017/22034 , A61B2017/22038 , A61B2017/22044 , A61B2017/22077 , A61B2017/22094 , A61B2017/22095 , A61B2017/2212 , A61B2017/320004 , A61B2017/320044 , A61B2017/320064 , A61B2017/320741 , A61B2017/3405 , A61B2017/3454 , A61F2/88 , A61M25/003 , A61M25/0032 , A61M25/0045 , A61M25/0069 , A61M25/007 , A61M25/0074 , A61M25/0082 , A61M25/0152 , A61M25/04 , A61M25/10 , A61M2025/006 , A61M2025/018 , A61M2025/09175 , A61M2025/09191 , A61M2025/105
摘要： Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a system and method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The system and method includes inserting an intramural crossing device into the vascular lumen, positioning at least the distal tip of the crossing device in the vascular wall, advancing an orienting device over the crossing device such that an orienting element of the orienting device resides in the vascular wall, inserting a re-entry device, and re-entering the true vascular lumen.
摘要翻译：提供了用于治疗慢性完全闭塞的装置和方法。一个公开的实施例包括一种系统和方法，其便于通过限定其中包含闭塞的血管腔的血管壁进行治疗。所述系统和方法包括将血管内腔插入壁内交叉装置，至少将交叉装置的远端定位在血管壁中，使定向装置在交叉装置上方推进，使定向装置的定向元件位于血管壁，插入再输入装置，并重新进入真正的血管腔。

5. 发明申请

WO2008063621A2 ENDOVASCULAR DEVICES AND METHODS FOR EXPLOITING INTRAMURAL SPACE 审中-公开
标题翻译：内窥镜装置及其方法
公开(公告)号：WO2008063621A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/024209
申请日：2007-11-20
申请人： BRIDGEPOINT MEDICAL, INC. , KUGLER, Chad, John , OLSON, Matthew, Jonathan , OLSON, Ross, Arlen , ATKINSON, Robert, Emmett , ROBINSON, David, B.
发明人： KUGLER, Chad, John , OLSON, Matthew, Jonathan , OLSON, Ross, Arlen , ATKINSON, Robert, Emmett , ROBINSON, David, B.
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B17/221 , A61B17/320758 , A61B17/3478 , A61B90/39 , A61B2017/00252 , A61B2017/00318 , A61B2017/22038 , A61B2017/22069 , A61B2017/22071 , A61B2017/22095 , A61B2017/2212 , A61B2017/320004
摘要： Devices and methods for exploiting intramural (e.g., subintimal) space of a vascular wall to facilitate the treatment of vascular disease, particularly total occlusions. For example, the devices and methods disclosed herein may be used to visually define the vessel wall boundary, protect the vessel wall boundary from perforation, bypass an occlusion, and/or remove an occlusion.
摘要翻译：用于开发血管壁的壁内（例如，内膜下）空间的装置和方法，以便于治疗血管疾病，特别是全部闭塞。例如，本文公开的装置和方法可以用于视觉上限定血管壁边界，保护血管壁边界免受穿孔，绕过闭塞和/或移除闭塞。

6. 发明申请

WO2004099154A3 PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS 审中-公开
标题翻译：作为钠通道调节剂的吡唑胺和磺酰胺
公开(公告)号：WO2004099154A3
公开(公告)日：2005-04-14
申请号：PCT/US2004013530
申请日：2004-04-29
申请人： ABBOTT LAB , ATKINSON ROBERT N , DRIZEN IRENE , GREGG ROBERT J , GROSS MICHAEL F , KORT MICHAEL E , SHI LEI
发明人： ATKINSON ROBERT N , DRIZEN IRENE , GREGG ROBERT J , GROSS MICHAEL F , KORT MICHAEL E , SHI LEI
IPC分类号： A61K31/416 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/24 , C07D401/04 , C07D401/12 , A61K31/415
CPC分类号： C07D401/04 , A61K31/416 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/24 , C07D401/12
摘要： Compounds of formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, wherein R1 is alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, heterocycle, heterocyclealkyl, heteroaryl, or heteroarylalkyl; R4 is formula (Ia), formula (Ib), formula (Ic), formula (Id), formula (Ie) or formula (If); or formula (II), or a pharmaceutically acceptable salt, amide, ester or prodrug thereof, wherein R14 is formula (III), formula (IV), formula (V), formula (VI), formula (VII), formula (VIII), formula (IX), formula (X), formula (XI), or formula (XII); modulate PN3 in mammals and are useful in treating pain in mammals.
摘要翻译：式（I）化合物或其药学上可接受的盐，酰胺，酯或前药，其中R 1是烷基，芳基，芳基烷基，环烷基，环烷基烷基，卤代烷基，杂环，杂环烷基，杂芳基或杂芳基烷基; R4是式（Ia），式（Ib），式（Ic），式（Id），式（Ie）或式（If）; 或其药学上可接受的盐，酰胺，酯或前药，其中R 14为式（III），式（IV），式（V），式（VI），式（Ⅶ），式），式（IX），式（X），式（XI）或式（XII）; 调节哺乳动物中的PN3，可用于治疗哺乳动物的疼痛。

7. 发明申请

WO03037890A3 PIPERIDINES 审中-公开
标题翻译：哌啶
公开(公告)号：WO03037890A3
公开(公告)日：2003-08-21
申请号：PCT/US0235173
申请日：2002-11-01
申请人： ICAGEN INC , GROSS MICHAEL FRANCIS , ATKINSON ROBERT NELSON , JOHNSON MATTHEW SCOTT
发明人： GROSS MICHAEL FRANCIS , ATKINSON ROBERT NELSON , JOHNSON MATTHEW SCOTT
IPC分类号： A61K31/00 , A61K31/4439 , A61P25/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14
CPC分类号： C07D401/04 , A61K31/00 , A61K31/4439 , C07D401/14 , C07D405/14 , C07D413/14
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides substituted piperidines, and compositions containing these compounds. Also provided are methods using the compounds of the invention for the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
摘要翻译：提供了通过抑制钠离子通过电压依赖钠通道来治疗疾病的化合物，组合物和方法。更具体地说，本发明提供取代的哌啶和含有这些化合物的组合物。还提供了使用本发明化合物治疗中枢性或周围神经系统疾病，特别是疼痛和慢性疼痛的方法，其通过阻断与所述病症的发作或复发有关的钠通道。本发明的化合物，组合物和方法特别用于通过包含PN3亚基的通道抑制离子通量来治疗神经性或炎性疼痛。

8. 发明申请

WO2003037900A2 PYRAZOLOPYRIMIDINES 审中-公开
标题翻译：吡唑并嘧啶
公开(公告)号：WO2003037900A2
公开(公告)日：2003-05-08
申请号：PCT/US2002/035171
申请日：2002-11-01
申请人： ICAGEN, INC. , ATKINSON, Robert, Nelson , GROSS, Michael, Francis , VAN RHEE, Michiel, Albert
发明人： ATKINSON, Robert, Nelson , GROSS, Michael, Francis , VAN RHEE, Michiel, Albert
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
摘要翻译：提供了通过抑制钠离子通过电压依赖钠通道来治疗疾病的化合物，组合物和方法。更具体地，本发明提供了可用于治疗中枢或周围神经系统疾病，特别是疼痛和慢性疼痛的吡唑并嘧啶类，组合物和方法，其通过阻断与所述病症的发作或复发有关的钠通道。本发明的化合物，组合物和方法特别用于通过包含PN3亚基的通道抑制离子通量来治疗神经性或炎性疼痛。

9. 发明申请

WO2022170202A1 SYSTEMS AND METHODS FOR DETECTING THE PRESENCE OF AN ANALYTE, SUCH AS SARS-COV-2, IN A SAMPLE 审中-公开
公开(公告)号：WO2022170202A1
公开(公告)日：2022-08-11
申请号：PCT/US2022/015512
申请日：2022-02-07
申请人： ADL DIAGNOSTICS , ATKINSON, Robert G.
发明人： ATKINSON, Robert G.
IPC分类号： C12Q1/70
摘要： Methods for detecting an analyte in a sample are disclosed. The method can include depositing the sample in an instrument, such as a Loop-Mediated Isothermal Amplification (LAMP) instrument that is configured to selectively amplify an analyte, such as a characteristic portion of a genome of a pathogen. A moving average of the quantity of the analyte at an instance of time can be compared to a sum of (1) the moving average for a previous instance of time and (2) a multiple of the moving standard deviation at the previous instance of time. If the quantity of the analyte at the instance of time is greater than the sum of (1) the moving average for a previous instance of time and (2) a multiple of the moving standard deviation at the previous instance of time, it can be an indication that the sample is positive for the analyte.

10. 发明申请

WO2014025340A1 VARIABLE MODULATION OF RADIATION AND COMPONENTS 审中-公开
标题翻译：辐射和组件的可变调制
公开(公告)号：WO2014025340A1
公开(公告)日：2014-02-13
申请号：PCT/US2012/049841
申请日：2012-08-07
申请人： HALLIBURTON ENERGY SERVICES, INC. , PERKINS, David L. , JONES, Christopher M. , PELLETIER, Michael T. , GAO, Li , ATKINSON, Robert , SOLTMANN, William
发明人： PERKINS, David L. , JONES, Christopher M. , PELLETIER, Michael T. , GAO, Li , ATKINSON, Robert , SOLTMANN, William
IPC分类号： G01J1/02 , G01J1/04 , G01J1/20 , G01J1/22 , G01J1/28 , G01J1/42 , G01J1/46 , G01J3/02
CPC分类号： G02B26/04 , E21B47/00 , G01J1/0228 , G01J1/0295 , G01J1/0444 , G01J1/0492 , G01J1/20 , G01J1/22 , G01J1/28 , G01J1/42 , G01J1/46 , G01J3/0235 , G01J3/027 , G01J3/0297 , G01V8/10
摘要： Various embodiments include systems and methods to provide selectable variable gain to signals in measurements using incident radiation. The selectable variable gain may be used to normalize signals modulated in measurements using incident radiation. The selectable variable gain may be attained using a number of different techniques or various combinations of these techniques. These techniques may include modulating a modulator having modulating elements in which at least one modulating element acts on incident radiation differently from another modulating element of the modulator, modulating the use of electronic components in electronic circuitry of a detector, modulating a source of radiation or combinations thereof. Additional apparatus, systems, and methods are disclosed.
摘要翻译：各种实施例包括为使用入射辐射的测量中的信号提供可选择的可变增益的系统和方法。可选择的可变增益可用于使用入射辐射对在测量中调制的信号进行归一化。可选择的可变增益可以使用许多不同的技术或这些技术的各种组合来实现。这些技术可以包括调制具有调制元件的调制元件，其中至少一个调制元件作用于与调制器的另一个调制元件不同的入射辐射，调制在检测器的电子电路中使用电子元件，调制辐射源或组合它们。公开了附加装置，系统和方法。

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