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1. 发明申请

WO2010022391A3 INTEGRATED, AUTOMATED SYSTEM FOR THE STUDY OF CELL AND TISSUE FUNCTION 审中-公开
公开(公告)号：WO2010022391A3
公开(公告)日：2010-02-25
申请号：PCT/US2009/054781
申请日：2009-08-24
申请人： AZTE ARIZONA TECHNOLOGY ENTERPRISES , THE UNIVERSITY OF WASHINGTON , HOLL, Mark , MELDRUM, Deirdre , ANIS, Yassir , ASHILI, Shashanka , HOUKAL, Jeff , JOHNSON, Roger , KELBAUSKAS, Laimonas , LI, Yongzhong , MERZA, Saeed , NANDAKUMAR, Vivek , SMITH, Dean , YOUNG, Cody , TIAN, Xanqing , ZHU, Haixin , CHAO, Joseph
发明人： HOLL, Mark , MELDRUM, Deirdre , ANIS, Yassir , ASHILI, Shashanka , HOUKAL, Jeff , JOHNSON, Roger , KELBAUSKAS, Laimonas , LI, Yongzhong , MERZA, Saeed , NANDAKUMAR, Vivek , SMITH, Dean , YOUNG, Cody , TIAN, Xanqing , ZHU, Haixin , CHAO, Joseph
IPC分类号： G01N33/48 , G01N35/00 , C12Q1/68
摘要： The present invention provides for an automated, high-throughput, multi-parameter integrated analysis system to monitor, in parallel, cellular parameters descriptive of cell function and associated physiology both singly and in interactions with other cells in tissues. Parameters may be measured with cell or tissue samples confined in arrays of chambers microfabricated in cassettes. System variants provide for cell or tissue harvesting for (optionally destructive) further analysis. The present invention relates to a system for biological laboratory automation, providing for full automation of cell manipulation using capillary micropipettes and associated robotics. This invention provides a robust and flexible technology that can be deployed in research and corporate laboratories, enabling new experimental protocols. Applications include microinjection and high-throughput, single- to multi-cell, multi-parameter monitoring of parameters such as respiration rates, moiety of interest concentrations, metabolic fluxes, chemotactic gradients, gene expression and transcription, translation to proteins (intracellular, membrane, and extracellular), membrane integrity, and cellular ion gradients.

2. 发明申请

WO2010022391A9 INTEGRATED, AUTOMATED SYSTEM FOR THE STUDY OF CELL AND TISSUE FUNCTION 审中-公开
标题翻译：综合自动化系统研究细胞和组织功能
公开(公告)号：WO2010022391A9
公开(公告)日：2010-04-15
申请号：PCT/US2009054781
申请日：2009-08-24
申请人： AZTE ARIZONA TECHNOLOGY ENTPR , UNIV WASHINGTON , HOLL MARK , MELDRUM DEIRDRE , ANIS YASSIR , ASHILI SHASHANKA , HOUKAL JEFF , JOHNSON ROGER , KELBAUSKAS LAIMONAS , LI YONGZHONG , MERZA SAEED , NANDAKUMAR VIVEK , SMITH DEAN , YOUNG CODY , TIAN XANQING , ZHU HAIXIN , CHAO JOSEPH
发明人： HOLL MARK , MELDRUM DEIRDRE , ANIS YASSIR , ASHILI SHASHANKA , HOUKAL JEFF , JOHNSON ROGER , KELBAUSKAS LAIMONAS , LI YONGZHONG , MERZA SAEED , NANDAKUMAR VIVEK , SMITH DEAN , YOUNG CODY , TIAN XANQING , ZHU HAIXIN , CHAO JOSEPH
IPC分类号： G01N33/48 , C12Q1/68 , G01N35/00
CPC分类号： G01N35/0092 , C12M41/36 , C12M41/38 , C12M41/48
摘要： The present invention provides for an automated, high-throughput, multi-parameter integrated analysis system to monitor, in parallel, cellular parameters descriptive of cell function and associated physiology both singly and in interactions with other cells in tissues. Parameters may be measured with cell or tissue samples confined in arrays of chambers microfabricated in cassettes. System variants provide for cell or tissue harvesting for (optionally destructive) further analysis. The present invention relates to a system for biological laboratory automation, providing for full automation of cell manipulation using capillary micropipettes and associated robotics. This invention provides a robust and flexible technology that can be deployed in research and corporate laboratories, enabling new experimental protocols. Applications include microinjection and high-throughput, single- to multi-cell, multi-parameter monitoring of parameters such as respiration rates, moiety of interest concentrations, metabolic fluxes, chemotactic gradients, gene expression and transcription, translation to proteins (intracellular, membrane, and extracellular), membrane integrity, and cellular ion gradients.
摘要翻译：本发明提供了一种自动化，高吞吐量的多参数综合分析系统，以并行地监测描述细胞功能和相关生理学的细胞参数，其单独地和与组织中的其他细胞相互作用。参数可以用限制在盒中的微室的阵列中的细胞或组织样品来测量。系统变体提供细胞或组织采集（可选择的破坏性）进一步分析。本发明涉及用于生物实验室自动化的系统，提供使用毛细管微量移液管和相关机器人的细胞操作的全自动化。本发明提供了可以在研究和公司实验室中部署的强大而灵活的技术，从而实现了新的实验方案。应用包括显微注射和高通量，单细胞，多参数监测参数，如呼吸速率，感兴趣浓度部分，代谢通量，趋化性梯度，基因表达和转录，翻译成蛋白质（细胞内，膜，和细胞外），膜完整性和细胞离子梯度。

3. 发明专利

CA2966662A1 TAMPER RESISTANT SYSTEM FOR CREATING ZONES AND MANIPULATING COMPUTING DEVICES 未知
公开(公告)号：CA2966662A1
公开(公告)日：2016-05-12
申请号：CA2966662
申请日：2015-11-07
申请人： ASHILI SHASHANKA
发明人： ASHILI SHASHANKA
IPC分类号： G06F15/16
摘要： A system for selectively manipulating a mobile device when the mobile device is present within one or more defined zones within an area. The system comprises a control device transmitting a signal, with the signal having a decreasing signal strength as distance from the control device increases. The system additional comprises one or more profiles stored in a memory for determining the one or more defined zones based on one or more values, each value corresponding to a particular signal strength of the signal, and at least one software application executing on the mobile device. The application is configured for accessing the profiles from a memory and receiving, from the mobile device, an indication of the signal received at the mobile device and a signal strength of the received signal, and selectively manipulating the mobile device as a function of the signal strength and the one or more profiles.

4. 发明专利

SA517381461B1 نظام مقاوم للتلاعب لإنشاء مناطق والتعامل مع أجهزة حاسوبية 未知
公开(公告)号：SA517381461B1
公开(公告)日：2019-01-31
申请号：SA517381461
申请日：2017-05-04
申请人： ASHILI SHASHANKA
发明人： ASHILI SHASHANKA
摘要： نظاممقاومللتلاعبلإنشاءمناطقوالتعاملمعأجهزةحاسوبية TAMPER RESISTANT SYSTEM FOR CREATING ZONES AND MANIPULATING COMPUTING DEVICES الملخـــصنظامللتعاملبشكلإختياريمعجهازنقال mobile device (20) عندمايتواجدالجهازالنقال (20) فيأماكنمحددةواحدةأوأكثرداخلمنطقة. ويشتملالنظامعلىجهازتحكم control device يرسلإشارة signal،معإشارةلهاقوةإشارةمتناقصة decreasing signal strength كلماتتزايدالمسافةعنجهازالتحكم. يشتملالنظامإضافياًعلىواحدأوأكثرمنالأنماطالمخزنةفيذاكرةلتحديدأماكنمحددةواحدةأوأكثرعلىأساسقيمةواحدةأوأكثر،تناظركلقيمةقوةإشارةمحددةللإشارة،وتطبيقبرمجيواحدعلىالأقلينفذعلىالجهازالنقال (20). تمإعدادالتطبيقللوصولإلىالأنماطمنذاكرةواستقبال،منالجهازالنقال (20)،دليلللإشارةالمستلمةمنالجهازالنقال (20) وقوةإشارةللإشارةالمستلمة،والتعاملبشكلإختياريمعالجهازالنقال (20) كوظيفةلقوةالإشارةوواحدأوأكثرمنالأنماط. شكل. 4

5. 发明申请

WO2010062654A3 DEVICE AND METHOD FOR THE STUDY OF CELL AND TISSUE FUNCTION 审中-公开
标题翻译：用于研究细胞和组织功能的装置和方法
公开(公告)号：WO2010062654A3
公开(公告)日：2010-09-02
申请号：PCT/US2009062380
申请日：2009-10-28
申请人： UNIV ARIZONA , HOLL MARK , MELDRUM DEIRDRE , YOUNG A CODY , ZHU HAIXIN , HOUKAL JEFF , TIAN YANQING , ASHILI SHASHANKA , KELBAUSKAS LAIMONAS , JOHNSON ROGER , CHAO JOSEPH , WIKTOR PETER , KAHN PETER , BRUNNER AL , JEN ALEX , BURGESS LLOYD , MCQUAID SARAH
发明人： HOLL MARK , MELDRUM DEIRDRE , YOUNG A CODY , ZHU HAIXIN , HOUKAL JEFF , TIAN YANQING , ASHILI SHASHANKA , KELBAUSKAS LAIMONAS , JOHNSON ROGER , CHAO JOSEPH , WIKTOR PETER , KAHN PETER , BRUNNER AL , JEN ALEX , BURGESS LLOYD , MCQUAID SARAH
IPC分类号： C12Q1/02 , G01N33/48
CPC分类号： C12M23/16 , C12M23/12 , C12M23/22 , C12M23/38 , C12M41/46
摘要： A chamber device for analyzing living cell(s). The chamber device includes a base and a lid that when reversibly pressed closed create a chamber. The base is configured with an optically transparent well to contain at least one cell. The lid has a breadth greater than the base and is configured to contain at least one sensor. The lid is further configured with a lip that when pressed between the lid and the base creates an impermeable seal. The base and the lid are configured so that, when closed and in use, the sensor remains spatially apart from the at least one cell.
摘要翻译：用于分析活细胞的腔室装置。腔室装置包括基座和盖子，当可逆地按压闭合时形成腔室。基座配置有光学透明井以容纳至少一个电池。盖子的宽度大于底座，并配置为包含至少一个传感器。盖子还配置有唇部，当在盖子和基部之间被按压时产生不可渗透的密封。底座和盖子被构造成使得当封闭和使用时，传感器在空间上与至少一个单元保持分开。

6. 发明申请

WO2010062654A2 DEVICE AND METHOD FOR THE STUDY OF CELL AND TISSUE FUNCTION 审中-公开
标题翻译：用于细胞和组织功能研究的装置和方法
公开(公告)号：WO2010062654A2
公开(公告)日：2010-06-03
申请号：PCT/US2009/062380
申请日：2009-10-28
申请人： ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , HOLL, Mark , MELDRUM, Deirdre , YOUNG, A., Cody , ZHU, Haixin , HOUKAL, Jeff , TIAN, Yanqing , ASHILI, Shashanka , KELBAUSKAS, Laimonas , JOHNSON, Roger , CHAO, Joseph , WIKTOR, Peter , KAHN, Peter , BRUNNER, Al , JEN, Alex , BURGESS, Lloyd , MCQUAID, Sarah
发明人： HOLL, Mark , MELDRUM, Deirdre , YOUNG, A., Cody , ZHU, Haixin , HOUKAL, Jeff , TIAN, Yanqing , ASHILI, Shashanka , KELBAUSKAS, Laimonas , JOHNSON, Roger , CHAO, Joseph , WIKTOR, Peter , KAHN, Peter , BRUNNER, Al , JEN, Alex , BURGESS, Lloyd , MCQUAID, Sarah
IPC分类号： C12Q1/02 , G01N33/48
CPC分类号： C12M23/16 , C12M23/12 , C12M23/22 , C12M23/38 , C12M41/46
摘要： A chamber device for analyzing living cell(s). The chamber device includes a base and a lid that when reversibly pressed closed create a chamber. The base is configured with an optically transparent well to contain at least one cell. The lid has a breadth greater than the base and is configured to contain at least one sensor. The lid is further configured with a lip that when pressed between the lid and the base creates an impermeable seal. The base and the lid are configured so that, when closed and in use, the sensor remains spatially apart from the at least one cell.
摘要翻译：用于分析活细胞的室装置。腔室装置包括底座和盖子，当可逆地按压时，盖子产生一个腔室。基底配置有光学透明的孔以容纳至少一个细胞。盖子的宽度大于基座，并被配置成包含至少一个传感器。盖子进一步配置有唇部，当在盖子和基座之间被按压时，唇部产生不可渗透的密封。底座和盖被构造成使得当关闭并且在使用中时，传感器在空间上保持与至少一个单元隔开。

7. 发明申请

WO2016073967A1 TAMPER RESISTANT SYSTEM FOR CREATING ZONES AND MANIPULATING COMPUTING DEVICES 审中-公开
标题翻译：用于创建区域和操纵计算设备的防篡体系统
公开(公告)号：WO2016073967A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/059635
申请日：2015-11-07
申请人： ASHILI, Shashanka
发明人： ASHILI, Shashanka
IPC分类号： G06F15/16
CPC分类号： H04M1/72577 , G06F21/629 , G06F21/86 , G06F2221/2111 , H04M1/6091 , H04M1/72572 , H04W4/021 , H04W4/046 , H04W4/40
摘要： A system for selectively manipulating a mobile device when the mobile device is present within one or more defined zones within an area. The system comprises a control device transmitting a signal, with the signal having a decreasing signal strength as distance from the control device increases. The system additional comprises one or more profiles stored in a memory for determining the one or more defined zones based on one or more values, each value corresponding to a particular signal strength of the signal, and at least one software application executing on the mobile device. The application is configured for accessing the profiles from a memory and receiving, from the mobile device, an indication of the signal received at the mobile device and a signal strength of the received signal, and selectively manipulating the mobile device as a function of the signal strength and the one or more profiles.
摘要翻译：一种用于当移动设备存在于区域内的一个或多个限定区域内时选择性地操纵移动设备的系统。该系统包括传输信号的控制装置，随着距离控制装置的距离增加，信号具有降低的信号强度。该系统附加包括存储在存储器中的一个或多个简档，用于基于一个或多个值来确定一个或多个定义的区域，每个值对应于信号的特定信号强度，以及在移动设备上执行的至少一个软件应用。应用被配置用于从存储器访问简档并从移动设备接收在移动设备处接收到的信号的指示和接收到的信号的信号强度，并且根据信号选择性地操纵移动设备强度和一个或多个轮廓。

8. 发明申请

WO2010022391A2 INTEGRATED, AUTOMATED SYSTEM FOR THE STUDY OF CELL AND TISSUE FUNCTION 审中-公开
公开(公告)号：WO2010022391A2
公开(公告)日：2010-02-25
申请号：PCT/US2009054781
申请日：2009-08-24
申请人： AZTE ARIZONA TECHNOLOGY ENTPR , UNIV WASHINGTON , HOLL MARK , MELDRUM DEIRDRE , ANIS YASSIR , ASHILI SHASHANKA , HOUKAL JEFF , JOHNSON ROGER , KELBAUSKAS LAIMONAS , LI YONGZHONG , MERZA SAEED , NANDAKUMAR VIVEK , SMITH DEAN , YOUNG CODY , TIAN XANQING , ZHU HAIXIN , CHAO JOSEPH
发明人： HOLL MARK , MELDRUM DEIRDRE , ANIS YASSIR , ASHILI SHASHANKA , HOUKAL JEFF , JOHNSON ROGER , KELBAUSKAS LAIMONAS , LI YONGZHONG , MERZA SAEED , NANDAKUMAR VIVEK , SMITH DEAN , YOUNG CODY , TIAN XANQING , ZHU HAIXIN , CHAO JOSEPH
IPC分类号： G01N33/48 , C12Q1/68 , G01N35/00
CPC分类号： G01N35/0092 , C12M41/36 , C12M41/38 , C12M41/48
摘要： The present invention provides for an automated, high-throughput, multi-parameter integrated analysis system to monitor, in parallel, cellular parameters descriptive of cell function and associated physiology both singly and in interactions with other cells in tissues. Parameters may be measured with cell or tissue samples confined in arrays of chambers microfabricated in cassettes. System variants provide for cell or tissue harvesting for (optionally destructive) further analysis. The present invention relates to a system for biological laboratory automation, providing for full automation of cell manipulation using capillary micropipettes and associated robotics. This invention provides a robust and flexible technology that can be deployed in research and corporate laboratories, enabling new experimental protocols. Applications include microinjection and high-throughput, single- to multi-cell, multi-parameter monitoring of parameters such as respiration rates, moiety of interest concentrations, metabolic fluxes, chemotactic gradients, gene expression and transcription, translation to proteins (intracellular, membrane, and extracellular), membrane integrity, and cellular ion gradients.

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