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1. 发明专利

IL281171D0 Cellulose-synthase-like enzymes and uses thereof 未知
公开(公告)号：IL281171D0
公开(公告)日：2021-04-29
申请号：IL28117121
申请日：2021-03-01
申请人： YEDA RES & DEV , ASAPH AHARONI , SONAWANE PRASHANT , MAXIM ITKIN , JOZWIAK ADAM
发明人： ASAPH AHARONI , SONAWANE PRASHANT , MAXIM ITKIN , JOZWIAK ADAM
IPC分类号： C12N9/10 , C12N15/82
摘要： Provided herein are genetically modified cells and genetically modified plants having increased or decreased expression of a cellulose synthase like G (CSLG) enzyme. These cells and plants may have an increased or decreased content a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin, compared to a corresponding unmodified cell or plant. Also provided herein are methods of producing a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a genetically modified cell, as well as methods of reducing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part, and methods of increasing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part.

2. 发明专利

IL265841D0 Plant expressing animal milk proteins 未知
公开(公告)号：IL265841D0
公开(公告)日：2020-10-29
申请号：IL26584119
申请日：2019-04-04
申请人： ASAPH AHARONI , YEDA RES & DEV , EVEN AVIEL , EVEN DAN
发明人： ASAPH AHARONI , EVEN AVIEL , EVEN DAN
IPC分类号： A01H1/00
摘要： The present invention relates to key genes in the biosynthesis of animal milk proteins and to genetically modified or gene edited plants with altered content of animal milk proteins, particularly to plants with de novo production content of animal milk proteins and any of their derivatives. Additionally, the present invention relates to a DNA binary vector or viral vector for expressing in a plant, proteins from the milk of a mammal; to a genetically modified or gene-edited plant having at least one cell expressing at least two recombinant protein from the milk of a mammal and expressed in the genetically modified or gene-edited plant or a seed, bean, grain, fruit, nut, legume, leaf, stem, root, or portion thereof, the recombinant protein being produced by the plant cell; and to a method of producing a food, medicament, cosmetic or blocking composition from the genetically modified or gene-edited plant. The present invention also relates to plant- based food, medicament, cosmetic or blocking compositions comprising animal milk proteins and methods of making the same. The present invention also relates to the reduction or elimination of seed storage proteins in a cell or cells wherein the milk proteins are introduced, or reduction of plant enzymes that can increase the content of oleic and/or stearic fatty acids and/or reduce the content of saturated fats in said plants or plant products.

3. 发明专利

IL265841A Plant expressing animal milk proteins 未知
公开(公告)号：IL265841A
公开(公告)日：2020-10-29
申请号：IL26584119
申请日：2019-04-04
申请人： ASAPH AHARONI , YEDA RES & DEV , EVEN AVIEL , EVEN DAN
发明人： ASAPH AHARONI , EVEN AVIEL , EVEN DAN
IPC分类号： A01H1/00
摘要： The present invention relates to key genes in the biosynthesis of animal milk proteins and to genetically modified or gene edited plants with altered content of animal milk proteins, particularly to plants with de novo production content of animal milk proteins and any of their derivatives. Additionally, the present invention relates to a DNA binary vector or viral vector for expressing in a plant, proteins from the milk of a mammal; to a genetically modified or gene-edited plant having at least one cell expressing at least two recombinant protein from the milk of a mammal and expressed in the genetically modified or gene-edited plant or a seed, bean, grain, fruit, nut, legume, leaf, stem, root, or portion thereof, the recombinant protein being produced by the plant cell; and to a method of producing a food, medicament, cosmetic or blocking composition from the genetically modified or gene-edited plant. The present invention also relates to plant- based food, medicament, cosmetic or blocking compositions comprising animal milk proteins and methods of making the same. The present invention also relates to the reduction or elimination of seed storage proteins in a cell or cells wherein the milk proteins are introduced, or reduction of plant enzymes that can increase the content of oleic and/or stearic fatty acids and/or reduce the content of saturated fats in said plants or plant products.

4. 发明专利

IL257981D0 Compositions comprising cyp76ad1-beta clade polypeptides and uses thereof 未知
公开(公告)号：IL257981D0
公开(公告)日：2018-05-31
申请号：IL25798118
申请日：2018-03-08
申请人： ASAPH AHARONI , POLTURAK GUY , YEDA RES & DEV
发明人： ASAPH AHARONI , POLTURAK GUY
IPC分类号： A23L20060101
摘要： The invention provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD6 or related gene and their use for producing L-DOPA from tyrosine and treating dopamine-responsive disorders, such as Parkinson's Disease. The invention also provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD1 and/or CYP76AD6, a nucleic acid encoding a DOPA 4,5-dioxygenase (DOD) enzyme, such as Beta vulgaris DODA1, and, in some cases, a nucleic acid encoding betalain related glucosyltransferase, such as M. jalapa gene cyclo-DOPA 5-O-glucosyltransferase (cDOPA5GT), and their use for producing betalains. Finally, the invention provides chimeric polypeptides, expression vectors, cells, compositions, and organisms, including plants, and their uses in various methods of the invention.

5. 发明专利

IL258319D0 Methods for stimulating metabolite production and exudation in plants 未知
公开(公告)号：IL258319D0
公开(公告)日：2018-06-28
申请号：IL25831918
申请日：2018-03-22
申请人： ASAPH AHARONI , YEDA RES & DEV , KORENBLUM ELISA
发明人： ASAPH AHARONI , KORENBLUM ELISA
IPC分类号： A01H20060101
摘要： Provided is a plant exudate, methods for obtaining a plant exudate by inducing the plant to secrete an exudate and systems for the collection of a plant exudate which include: one or more plant container including at least two discrete compartments each configured to accommodate a split root of a plant, the compartments being a root stimulating compartment including one or more input being in fluid communication with at least a source of a plant root stimulant, and a root exudate harvesting compartment, and a root exudate collection compartment in fluid communication with the root exudate harvesting compartment.

6. 发明专利

IL247169D0 Biocontrol enhancers 未知
公开(公告)号：IL247169D0
公开(公告)日：2016-11-30
申请号：IL24716916
申请日：2016-08-08
申请人： YEDA RES & DEV , ASAPH AHARONI , ILANA KOLODKIN GAL
发明人： ASAPH AHARONI , ILANA KOLODKIN-GAL
IPC分类号： C12R20060101

7. 发明专利

IL257981B Compositions comprising cyp76ad1-beta clade polypeptides and uses thereof 未知
公开(公告)号：IL257981B
公开(公告)日：2022-06-01
申请号：IL25798118
申请日：2018-03-08
申请人： YEDA RES & DEV , ASAPH AHARONI , POLTURAK GUY
发明人： ASAPH AHARONI , POLTURAK GUY
摘要： The invention provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD6 or related gene and their use for producing L-DOPA from tyrosine and treating dopamine-responsive disorders, such as Parkinson's Disease. The invention also provides recombinant polynucleotides comprising a nucleic acid encoding a CYP76AD1 and/or CYP76AD6, a nucleic acid encoding a DOPA 4,5-dioxygenase (DOD) enzyme, such as Beta vulgaris DODA1, and, in some cases, a nucleic acid encoding betalain related glucosyltransferase, such as M. jalapa gene cyclo-DOPA 5-O-glucosyltransferase (cDOPA5GT), and their use for producing betalains. Finally, the invention provides chimeric polypeptides, expression vectors, cells, compositions, and organisms, including plants, and their uses in various methods of the invention.

8. 发明专利

IL268269D0 Production of high-value saponins by the use of cellulose-synthase-like family enzymes 未知
公开(公告)号：IL268269D0
公开(公告)日：2019-10-31
申请号：IL26826919
申请日：2019-07-25
申请人： ASAPH AHARONI , YEDA RES & DEV , SONAWANE PRASHANT , JOZWIAK ADAM
发明人： ASAPH AHARONI , SONAWANE PRASHANT , JOZWIAK ADAM
IPC分类号： C12P20060101

9. 发明专利

IL247752D0 Compositions and methods for regulating gene expression for targeted mutagenesis 未知
公开(公告)号：IL247752D0
公开(公告)日：2016-11-30
申请号：IL24775216
申请日：2016-09-11
申请人： YEDA RES & DEV , BOCOBZA SAMUEL , ASAPH AHARONI , DAHAN TAL , AVRAHAM A LEVY
发明人： BOCOBZA SAMUEL , ASAPH AHARONI , DAHAN TAL , AVRAHAM A LEVY
IPC分类号： A01H20060101
摘要： Disclosed herein are methods for gene targeting in a plant cell, as well as recombinant nucleic acid molecules used in these methods. Further disclosed are recombinant nucleic acid molecules comprising a target gene operably linked to a regulatory region of the UBQ10 gene.

10. 发明授权

US08338663B2 Isoprenoid synthases 有权
标题翻译：异戊二烯合酶
公开(公告)号：US08338663B2
公开(公告)日：2012-12-25
申请号：US12272329
申请日：2008-11-17
申请人： Asaph Aharoni , Maarten Anthonie Jongsma , Henricus Adrianus Verhoeven , Hendrik Jan Bouwmeester
发明人： Asaph Aharoni , Maarten Anthonie Jongsma , Henricus Adrianus Verhoeven , Hendrik Jan Bouwmeester
IPC分类号： A01H5/00 , C12N15/29 , C12N15/52 , C12N15/82
CPC分类号： C12N15/8282 , C12N9/1085 , C12N15/8243 , C12N15/8286 , Y02A40/162
摘要： The invention relates to the field of genetic engineering of flavor, fragrance and biocontrol agent development. More specifically it relates to a process for production of natural flavors, fragrances or bio-control agents by the control of one or more genes implicated in that process. The invention provides an isolated or recombinant nucleic acid or functional fragment thereof encoding a proteinaceous molecule essentially capable of flavor, fragrance and/or bio-control agent synthesis when provided with a suitable substrate under appropriate reaction conditions. The invention further provides a nucleic acid or functional fragment thereof encoding a proteinaceous molecule essentially capable of synthesizing at least a monoterpene alcohol linalool when contacted with geranyl diphosphate (GPP) and/or at least a sesquiterpene alcohol nerolidol when contacted with farnesyl diphosphate (FPP) under appropriate reaction conditions.
摘要翻译：本发明涉及风味，香精和生物防治剂开发的遗传工程领域。更具体地说，本发明涉及通过控制与该方法相关的一种或多种基因来生产天然香料，香料或生物控制剂的方法。本发明提供了在合适的反应条件下提供合适的底物时，编码蛋白质分子的分离或重组的核酸或功能片段，其基本上能够进行风味，香料和/或生物控制剂的合成。本发明进一步提供编码蛋白质分子的核酸或功能片段，当与法呢基二磷酸酯（FPP）接触时，本发明的蛋白质分子在与二香草素二磷酸酯（GPP）和/或至少一种倍半萜烯醇橙花瓶酯接触时基本能够合成至少一种单萜醇里哪醇在适当的反应条件下。

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