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1. 发明申请

WO1987006265A1 NOVEL COMPOUNDS DC-88A AND DC-89A1 AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：新型化合物DC-88A和DC-89A1及其制备方法
公开(公告)号：WO1987006265A1
公开(公告)日：1987-10-22
申请号：PCT/JP1987000247
申请日：1987-04-17
申请人： KYOWA HAKKO KOGYO CO., LTD. , NAKANO, Hirofumi , TAKAHASHI, Isami , ICHIMURA, Michio , KAWAMOTO, Isao , ASANO, Kozo , TOMITA, Fusao , SANO, Hiroshi , YASUZAWA, Toru , MORIMOTO, Makoto , FUJIMOTO, Kazuhisa
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C12P01/06
CPC分类号： C12P1/06 , C12R1/465
摘要： New cpds. designated DC-88A and DC-89Al are obtd. by culture of Streptomyces species, specifically S. lydicus FERM-BP 988 or S. parvullus FERM-BP 1002. DC-88A has the molecular formula C26H25N3O8, mol. wt. (by EI-MS) 507.1624, and is sol. in methanol, ethanol, acetone, chloroform, ethyl acetate, DMSO; insol. in water, hexane. The Rf on silica gel using toluene/acetone (7:3 v/v) is 0.46. DC-89Al has the molecular formula C26H26N3O8Cl, mol. wt. 543, m.pt. 157.5-58.5 deg.C; sol. in methanol, ethanol, acetone, ethyl acetate, chloroform, DMSO; insol. in water, hexane, IR, UV, 1H NMR, 13C NMR spectral data are given for both cpds.

2. 发明申请

WO1988000591A1 NOVEL SUBSTANCES DC-92B AND DC-92D, AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：新型物质DC-92B和DC-92D及其制备方法
公开(公告)号：WO1988000591A1
公开(公告)日：1988-01-28
申请号：PCT/JP1987000524
申请日：1987-07-17
申请人： KYOWA HAKKO KOGYO CO., LTD. , NAKANO, Hirofumi , TAKAHASHI, Isami , TOMITA, Fusao , ASANO, Kozo , YASUZAWA, Toru , ASHIZAWA, Tadashi , TAKAHASHI, Keiichi
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07H07/06
CPC分类号： C07H15/12 , C07H17/04 , C12P19/26 , C12P19/44
摘要： Novel compounds DC-92B and DC-92D having an anthraquinone structure represented by planar structural formula (I) and a process for their preparation. These compounds are produced by cultivating microorganisms belonging to the genus Actinomajula. They have antibacterial and oncostatic activities, thus being useful as medicines. In the formula, R represents a group represented by the formula (II) or (III).

3. 发明专利

JP2008005838A New reagent composition for detecting peroxidase, and method for judging inflammatory disease or the like and method for measuring antioxidant activity by using the same 审中-公开
标题翻译：用于检测过氧化物的新试剂组合物和用于判断炎症疾病的方法或类似方法以及使用其来测量抗氧化剂活性的方法
公开(公告)号：JP2008005838A
公开(公告)日：2008-01-17
申请号：JP2007146291
申请日：2007-05-31
申请人： Asano Kozo , Hiroyuki Izumi , Wataru Sakamoto , Serotekku:Kk , 博之和泉 , 亘坂本 , 株式会社セロテック , 浅野行蔵
发明人： SAKAMOTO WATARU , MEGURIYA YASUO , IZUMI HIROYUKI
IPC分类号： C12Q1/28 , C12M1/34 , G01N21/77 , G01N21/78
摘要： PROBLEM TO BE SOLVED: To provide a new reagent composition by which peroxidase activities can be measured in high sensitivity, and a method for detecting the peroxidase activities; to provide a new retainer by which the peroxidase can easily be collected and measured; to judge the presence of inflammatory disease in an organism by the measurement of the peroxidase activities; and to measure antioxidant activities of a food or the like. SOLUTION: The reagent composition for detecting the peroxidase having excellent sensitivities contains DAB conventionally used in the detection of the peroxidase, and Guaiacol. The kit for detecting the peroxidase is also provided. The sample retainer capable of being directly used as a measuring device for readily and rapidly measuring the peroxidase activities, enabling the collection of saliva in the oral cavity, and easily applicable to food or the like containing a solid or viscous material is produced and used for judgement of dry mouth, periodontal disease, myocardial infarction, acute coronary arteriosclerosis, chronic nephritis, diabetes or the like, and measurement of the antioxidant activities. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供可以高灵敏度地测量过氧化物酶活性的新试剂组合物和检测过氧化物酶活性的方法; 提供新的保持器，通过其可以容易地收集和测量过氧化物酶; 通过测量过氧化物酶活性来判断生物体内炎症性疾病的存在; 并测量食品等的抗氧化活性。解决方案：用于检测具有优异敏感性的过氧化物酶的试剂组合物含有常用于过氧化物酶检测的DAB和愈创木酚。还提供了用于检测过氧化物酶的试剂盒。可以直接用作测量装置的样品保持器，用于容易且快速地测量过氧化物酶活性，使得能够收集口腔中的唾液，并且容易适用于含有固体或粘性物质的食品等，并用于口干，牙周病，心肌梗塞，急性冠状动脉硬化，慢性肾炎，糖尿病等的判断，抗氧化活性的测定。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JPH07177860A METHOD FOR SOFTENING SOYBEAN 失效
公开(公告)号：JPH07177860A
公开(公告)日：1995-07-18
申请号：JP34618593
申请日：1993-12-22
申请人： ASANO KOZO
发明人： ASANO KOZO , TOMINAGA KAZUYA , YOSHIKAWA SHUJI
IPC分类号： A23L11/00 , A23L11/10 , A23L1/201 , A23L1/20
摘要： PURPOSE:To efficiently soften soybeans by immersing the soybeans in a urea solution having a prescribed urea concentration and subsequently press-steaming the treated soybeans, thus enabling to produce a food, e.g. fermented soybeans, miso (salted and fermented soybeans) or soy sauce, different in the texture. CONSTITUTION:This method for softening soybeans comprises immersing the soybeans in an aqueous solution having a urea concentration of >=0.05M or in an aqueous solution having a sodium carbonate concentration of >=0.2M, and subsequently press-steaming the treated soybeans. When the soybeans are immersed in the urea aqueous solution, etc., for the softening, sodium bicarbonate is preferably simultaneously added to prevent the rise in the pH of the solution.

5. 发明专利

JPH08116928A FERMENTED FISHERY FOOD AND ITS PRODUCTION 失效
公开(公告)号：JPH08116928A
公开(公告)日：1996-05-14
申请号：JP28424494
申请日：1994-10-25
申请人： ASANO KOZO
发明人： YOSHIKAWA SHUJI , ASANO KOZO , TOMINAGA KAZUYA
IPC分类号： A23L17/00 , A23L1/325
摘要： PURPOSE: To obtain a fermented fishery food excellent in gel strength, elasticity and flavor by using a lactic bacteria starter. CONSTITUTION: This fermented fishery food is obtained by inoculating sugar and a lactic bacteria starter into scallop adductors followed by their fermentation.

6. 发明专利

JP2013217747A Simple xerostomia diagnostic kit 审中-公开
标题翻译：简单的XEROSTOMIA诊断包
公开(公告)号：JP2013217747A
公开(公告)日：2013-10-24
申请号：JP2012087962
申请日：2012-04-06
申请人： Wataru Sakamoto , 亘坂本 , Yasuo Meguriya , 靖生廻谷 , Asano Kozo , 浅野行蔵 , Kanehira Takashi , 兼平孝
发明人： SAKAMOTO WATARU , MEGURIYA YASUO
IPC分类号： G01N33/52 , A61B5/00 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a simple inspection kit for xerostomia.SOLUTION: After keeping one end of a filter paper surface of a diagnostic kit in a subject's mouth, subject's saliva quantitatively infiltrates and spreads to filter paper of paper chromatography, and previously applied melanoidin spreads together with the saliva, so that a saliva quantity can be visually easily and apparently measured without using a specific device. Further, stimulus saliva quantity measuring filter paler into which capsaicin or citric acid or tartaric acid is infiltrated together with melanoidin is provided.
摘要翻译：要解决的问题：提供一个简单的口腔干燥检查工具。解决方案：将受试者口腔中的诊断试剂盒的滤纸表面保持一端，将受试者的唾液定量渗透并扩散到纸张色谱法的滤纸上，黑色素与唾液一起扩散，使得唾液量可以在不使用特定装置的情况下在视觉上容易且明显地测量。此外，提供了刺激性唾液量测量过滤器，其中辣椒素或柠檬酸或酒石酸与黑素素一起渗透入其中。

7. 发明专利

JP2012251915A Simple bad breath diagnostic kit 审中-公开
标题翻译：简单的BAD BREATH DIAGNOSTIC KIT
公开(公告)号：JP2012251915A
公开(公告)日：2012-12-20
申请号：JP2011125887
申请日：2011-06-05
申请人： Wataru Sakamoto , 亘坂本 , Asano Kozo , 浅野行蔵 , Meguriya Yasuo , 廻谷靖生
发明人： SAKAMOTO WATARU , OSADA KAZUSANE
IPC分类号： G01N33/50 , G01N1/12 , G01N21/78 , G01N33/48 , G01N33/52
摘要： PROBLEM TO BE SOLVED: To provide a simple inspection kit for performing bad breath diagnosis.SOLUTION: Bad breath (hydrogen sulfide) is simply determined by a visual inspection by using a methylene blue method and a principle of paper chromatography for color development at a solid phase for determination of the bad breath. Reaction impurities are removed to isolate methylene blue by using a chemical reaction product composed of a color developer N, N'-Dimethyl-p-phenylenediamine and ferric chloride 'fixing solution', auxiliary filter paper after capturing and fixing hydrogen sulfide in a specimen by using filter paper or a support obtained by containing zinc in a swab. Then, quantity of hydrogen sulfide is determined by a visual inspection or a photoelectric color difference meter. Since methylene blue is a stable coloring agent, highly sensitive and certain measurement is performed.
摘要翻译：要解决的问题：提供用于进行口臭诊断的简单检查套件。
解决方案：通过使用亚甲基蓝法和目视检查方法，通过纸张色谱法在固相中进行色彩显色的原理来确定恶心（硫化氢），以测定口臭。通过使用由显色剂N，N'-二甲基 - 对苯二胺和氯化铁固定液组成的化学反应产物，辅助滤纸在样品中捕获和固定硫化氢后，除去反应杂质以分离亚甲基蓝使用滤纸或通过在棉签中含有锌获得的支持物。然后，通过目视检查或光电色差计来确定硫化氢的量。由于亚甲基蓝是稳定的着色剂，因此进行高灵敏度和一定的测量。版权所有（C）2013，JPO＆INPIT

8. 发明专利

JP2004010569A ARGININE-CONTAINING PEPTIDE HAVING CHOLECYSTOKININ SECRETION PROMOTING ACTIVITY AND FOOD CONTAINING THE SAME 审中-公开
公开(公告)号：JP2004010569A
公开(公告)日：2004-01-15
申请号：JP2002168694
申请日：2002-06-10
申请人： ASANO KOZO
发明人： NISHI TAKASHI , HARA HIROSHI , TOMITA FUSAO , ASANO KOZO
IPC分类号： A23L1/305 , C07K7/06 , C07K7/08
摘要： PROBLEM TO BE SOLVED: To produce a food having cholecystokinin secretion promoting activity and suppressing the ingestion instinct by using a specific peptide having a specific amino acid sequence as a food or a food material. SOLUTION: The ingestion suppressing food containing a specific peptide is developed based on the finding that an arginine-containing peptide having a specific amino acid sequence has a cholecystokinin secretion promoting activity. The purpose of the invention can be achieved by the use of the specific arginine-containing peptide having an amino acid sequence corresponding to soybean β-conglycinin and obtained by the decomposition of β-conglycinin with a pepsin. COPYRIGHT: (C)2004,JPO

9. 发明专利

JPH0739363A FRUIT WINE AND ITS PRODUCTION 失效
公开(公告)号：JPH0739363A
公开(公告)日：1995-02-10
申请号：JP35523392
申请日：1992-12-16
申请人： ASANO KOZO
发明人： ASANO KOZO , TOMINAGA KAZUYA
IPC分类号： C12G3/00 , C12G3/02
摘要： PURPOSE:To obtain an alcoholic beverage having characteristics of color and scent of a fruit by using the fruit (especially, Lonicera caerulea L.) having been difficult for wine fermentation of pure fruit juice because of high acid content. CONSTITUTION:In a method producing fruit wine using fruit juice pressed from a fruit and yeast for fermentation, the fruit juice is pretreated by using ion exchange resins to produce fruit wine of good quality.

10. 发明专利

JP2014105198A Salivation promoting composition 审中-公开
标题翻译：消化促进成分
公开(公告)号：JP2014105198A
公开(公告)日：2014-06-09
申请号：JP2012260241
申请日：2012-11-28
申请人： Wataru Sakamoto , 亘坂本 , Meguriya Yasuo , 廻谷靖生 , Asano Kozo , 浅野行蔵 , Kanehira Takashi , 兼平孝
发明人： SAKAMOTO WATARU
IPC分类号： A61K31/194 , A23L1/30 , A61K9/06 , A61K47/12 , A61K47/18 , A61P1/02 , A61P1/14
摘要： PROBLEM TO BE SOLVED: To provide a composition and a method, for promotion of salivation and alleviation and therapy of xerostomia.SOLUTION: Provided are: a gel formed by mixing a citric acid solution in the range of 1.2 M to 3.6 M and preferably 1.8 M to 3.6 M and a monosodium glutamate solution in the range of 1.4 M to 3.8 M and preferably 1.6 M to 3.8 M; and a food where the gel is admixed with a substance promoting salivation. The gel having no discomfort stimulation in the mouth but high salivation promoting effect and being safe is useful for therapy and improvement of xerostomia.
摘要翻译：要解决的问题：提供一种用于促进口腔唾液分泌和缓解和治疗口腔干燥症的组合物和方法。解决方案：提供：通过将1.2M至3.6M范围内的柠檬酸溶液混合并优选1.8 M至3.6M，谷氨酸单钠溶液的范围为1.4M至3.8M，优选1.6M至3.8M; 以及将凝胶与促进唾液分泌物质混合的食物。在口中没有不舒适刺激的凝胶，但是具有高的唾液促进作用并且是安全的，可用于治疗和改善口腔干燥症。

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