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1. 发明申请

WO2008073451A3 BENZOIMDAZOLE DERIVATIVES AS SIRTUIN (SIR) MODULATING COMPOUNDS 审中-公开
标题翻译：苯并咪唑衍生物作为SIRTUIN（SIR）调节化合物
公开(公告)号：WO2008073451A3
公开(公告)日：2008-09-12
申请号：PCT/US2007025391
申请日：2007-12-11
申请人： SIRTRIS PHARMACEUTICALS INC , BEMIS JEAN , VU CHI B , NUNES JOSEPH J , ARMISTEAD DAVID
发明人： BEMIS JEAN , VU CHI B , NUNES JOSEPH J , ARMISTEAD DAVID
IPC分类号： C07D417/14 , A61K31/429 , C07D417/04
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds of formula (VI) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译：本文提供了式（VI）的新型沉默调节蛋白的调节性化合物及其使用方法。沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病，心血管疾病，凝血障碍，炎症，癌症和/或潮红以及由线粒体活性增加所致的疾病或病症。还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

2. 发明申请

WO2007019417A1 OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS 审中-公开
标题翻译：氧化吡啶衍生物作为SIRTUIN调节剂
公开(公告)号：WO2007019417A1
公开(公告)日：2007-02-15
申请号：PCT/US2006/030661
申请日：2006-08-04
申请人： SIRTRIS PHARMACEUTICALS, INC. , NUNES, Joseph, J. , MILNE, Jill , BEMIS, Jean , XIE, Roger , VU, Chi, B. , NG, Pui, Yee , DISCH, Jeremy, S. , SALZMANN, Thomas , ARMISTEAD, David
发明人： NUNES, Joseph, J. , MILNE, Jill , BEMIS, Jean , XIE, Roger , VU, Chi, B. , NG, Pui, Yee , DISCH, Jeremy, S. , SALZMANN, Thomas , ARMISTEAD, David
IPC分类号： C07D498/04 , A61K31/435 , A61P3/00 , A61P7/00 , A61P21/00 , A61P25/00 , A61P27/00 , A61P35/00 , A61P39/00 , A61P9/00
CPC分类号： C07D235/18 , C07D401/12 , C07D403/12 , C07D513/04
摘要： Provided herein are oxazolopyridine derivatives which are sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasingthe lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfêt from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译：本文提供的是恶唑烷并吡啶衍生物，其是沉默调节蛋白的调节性化合物及其使用方法。沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与衰老或压力相关的疾病或病症，糖尿病，肥胖，神经变性疾病，心血管疾病，凝血障碍，炎症，癌症和/或潮红，以及由于增加的线粒体活性而引起的疾病或病症。还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

3. 发明申请

WO2004072230A2 REAL-TIME POLYMERASE CHAIN REACTION USING LARGE TARGET AMPLICONS 审中-公开
标题翻译：使用大目标AMPLICON的实时聚合酶链反应
公开(公告)号：WO2004072230A2
公开(公告)日：2004-08-26
申请号：PCT/US2004/002012
申请日：2004-02-10
申请人： CLEARANT, INC. , McKENNEY, Keith , GILLMEISTER, Lidja , MARLOWE, Kristina , ARMISTEAD, David
发明人： McKENNEY, Keith , GILLMEISTER, Lidja , MARLOWE, Kristina , ARMISTEAD, David
IPC分类号： C12N
CPC分类号： C12Q1/686 , C12Q2561/113
摘要： The present invention relates to methods for analyzing a target nucleic acid sequence in a biological material. More particularly, the present invention relates to methods for analyzing a target nucleic acid sequence by real time polymerase chain reaction using nucleic acid primers that are separated by at least about 750 nucleic acid residues in the target sequence.
摘要翻译：本发明涉及分析生物材料中靶核酸序列的方法。更具体地说，本发明涉及使用在目标序列中由至少约750个核酸残基分开的核酸引物通过实时聚合酶链反应来分析靶核酸序列的方法。

4. 发明申请

WO0043373A3 KINASE INHIBITORS 审中-公开
标题翻译：激酶抑制剂
公开(公告)号：WO0043373A3
公开(公告)日：2000-12-28
申请号：PCT/US0001581
申请日：2000-01-21
申请人： KINETIX PHARMACEUTICALS INC , ARMISTEAD DAVID M , BEMIS JEAN E , ELBAUM DANIEL , HABGOOD GREGORY , NOVAK PERRY M , NUNES JOSEPH J , TOLEDO SHERMAN LETICIA M
发明人： ARMISTEAD DAVID M , BEMIS JEAN E , ELBAUM DANIEL , HABGOOD GREGORY , NOVAK PERRY M , NUNES JOSEPH J , TOLEDO-SHERMAN LETICIA M
IPC分类号： C07D239/36 , A61K31/513 , A61K31/517 , A61K31/5377 , A61P1/04 , A61P3/00 , A61P3/10 , A61P7/08 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/04 , A61P17/06 , A61P17/10 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D239/46 , C07D239/47 , C07D239/56 , C07D239/70 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D493/14 , C07D239/88 , C07D239/93
CPC分类号： C07D239/47 , C07D239/56 , C07D239/70
摘要： The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptoms.
摘要翻译：本发明涉及激酶抑制剂，包含该抑制剂的组合物，以及使用该抑制剂和抑制剂组合物的方法。抑制剂和包含它们的组合物可用于治疗疾病或疾病症状。本发明还提供了制备激酶抑制剂化合物的方法，抑制激酶活性的方法以及治疗疾病或疾病症状的方法。

5. 发明申请

WO2007019346A1 BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS 审中-公开
标题翻译：苯并噻唑和噻唑啉作为SIRTUIN调节剂
公开(公告)号：WO2007019346A1
公开(公告)日：2007-02-15
申请号：PCT/US2006/030512
申请日：2006-08-04
申请人： SIRTRIS PHARMACEUTICALS, INC. , NUNES, Joseph, J. , MILNE, Jill , BEMIS, Jean , XIE, Roger , VU, Chi, B. , NG, Pui, Yee , DISCH, Jeremy, S. , SALZMANN, Thomas , ARMISTEAD, David
发明人： NUNES, Joseph, J. , MILNE, Jill , BEMIS, Jean , XIE, Roger , VU, Chi, B. , NG, Pui, Yee , DISCH, Jeremy, S. , SALZMANN, Thomas , ARMISTEAD, David
IPC分类号： C07D513/04 , A61K31/435 , A61P3/00 , A61P7/00 , A61P21/00 , A61P25/00 , A61P27/00 , A61P35/00 , C07D277/66
CPC分类号： C07D235/18 , C07D401/12 , C07D403/12 , C07D513/04
摘要： Provided herein are benzothiazol and thizolopyridine derivatires which are sirtuin-modulating compounds and methods of use thereof . The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/ or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent .
摘要翻译：本文提供了作为沉默调节蛋白的调节性化合物的苯并噻唑和噻唑并吡啶衍生物及其使用方法。沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防多种疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病，心血管疾病，凝血障碍，炎症，癌症和/或潮红以及由线粒体活性增加所致的疾病或病症。还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

6. 发明申请

WO2004072230A3 REAL-TIME POLYMERASE CHAIN REACTION USING LARGE TARGET AMPLICONS 审中-公开
标题翻译：使用大目标AMPLICON的实时聚合酶链反应
公开(公告)号：WO2004072230A3
公开(公告)日：2005-06-30
申请号：PCT/US2004002012
申请日：2004-02-10
申请人： CLEARANT INC , MCKENNEY KEITH , GILLMEISTER LIDJA , MARLOWE KRISTINA , ARMISTEAD DAVID
发明人： MCKENNEY KEITH , GILLMEISTER LIDJA , MARLOWE KRISTINA , ARMISTEAD DAVID
IPC分类号： C12N20060101 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/686 , C12Q2561/113
摘要： The present invention relates to methods for analyzing a target nucleic acid sequence in a biological material. More particularly, the present invention relates to methods for analyzing a target nucleic acid sequence by real time polymerase chain reaction using nucleic acid primers that are separated by at least about 750 nucleic acid residues in the target sequence.
摘要翻译：本发明涉及分析生物材料中靶核酸序列的方法。更具体地说，本发明涉及使用在目标序列中由至少约750个核酸残基分开的核酸引物通过实时聚合酶链反应来分析靶核酸序列的方法。

7. 发明申请

WO2009102468A1 6-ARYL-IMIDAZ0[L, 2-A] PYRAZINE DERIVATIVES, METHOD OF MAKING, AND METHOD OF USE THEREOF 审中-公开
标题翻译： 6-ARYL-IMIDAZO [L，2-A]吡嗪衍生物，制备方法及其使用方法
公开(公告)号：WO2009102468A1
公开(公告)日：2009-08-20
申请号：PCT/US2009/000919
申请日：2009-02-12
申请人： CGI PHARMACEUTICALS, INC. , MITCHELL, Scott A. , CURRIE, Kevin S. , BLOMGREN, Peter A. , ARMISTEAD, David M. , RAKER, Joseph
发明人： MITCHELL, Scott A. , CURRIE, Kevin S. , BLOMGREN, Peter A. , ARMISTEAD, David M. , RAKER, Joseph
IPC分类号： C07D487/04 , A61K31/4985 , A61P37/00
CPC分类号： C07D487/04
摘要： Certain chemical entities chosen from compounds represented by Formula I and pharmaceutically acceptable salts and mixtures thereof, are provided herein. Pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include cancer (e.g., B -cell lymphoma and leukemia), autoimmune diseases, inflammatory diseases, acute inflammatory reactions, and allergic disorders. Methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for determining the presence or absence of Syk kinase in a sample. Formula I
摘要翻译：在本文中提供了选自由式I表示的化合物的某些化学实体及其药学上可接受的盐及其混合物。包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。公开了治疗患有对抑制Syk活性有反应的某些疾病和病症的患者的方法，所述方法包括向所述患者施用一定量的至少一种有效减少疾病或病症体征或症状的化学实体。这些疾病包括癌症（例如，B细胞淋巴瘤和白血病），自身免疫疾病，炎性疾病，急性炎症反应和过敏性疾病。治疗方法包括给予至少一种化学实体作为单一活性剂或与一种或多种其它治疗剂组合施用至少一种化学实体。还提供了用于确定样品中Syk激酶的存在或不存在的方法。一级方程式

8. 发明申请

WO2008073451A8 BENZOIMIDAZOLE DERIVATIVES AS SIRTUIN (SIR) MODULATING COMPOUNDS 审中-公开
标题翻译：苯并咪唑衍生物作为SIRTUIN（SIR）调节化合物
公开(公告)号：WO2008073451A8
公开(公告)日：2008-12-11
申请号：PCT/US2007025391
申请日：2007-12-11
申请人： SIRTRIS PHARMACEUTICALS INC , BEMIS JEAN , VU CHI B , NUNES JOSEPH J , ARMISTEAD DAVID
发明人： BEMIS JEAN , VU CHI B , NUNES JOSEPH J , ARMISTEAD DAVID
IPC分类号： C07D417/14 , A61K31/429 , C07D417/04
CPC分类号： C07D513/04
摘要： A. Provided herein are novel sirtuin-modulating compounds of formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent ( I ), wherein: one of R1 R2 R3 or R4 is selected from a 5- to 6-membered heteroaryl comprising 1 to 3 heteroatoms 'independently selected from N, O or S, wherein said heteroaryl is optionally benzofused or optionally fused to a second 5- to 6-membered heteroaryl comprising 1 to 3 heteroatoms independently selected from N, O or S and is bound to the rest of the compound via a carbon ring atom, wherein said heteroaryl is optionally substituted on a single carbon ring atom with a substituent selected from a solubilizing group, or a C1-C4 straight or branched alkyl.
摘要翻译： A.本文提供的是式（I）的新型沉默调节蛋白的调节性化合物及其使用方法。沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病，心血管疾病，血液凝固障碍，炎症，癌症和/或潮红以及将受益于增加的线粒体活性的疾病或病症。还提供了包含与另一种治疗剂（I）组合的沉默调节蛋白的调节性化合物的组合物，其中：R 1 R 2 R 3或R 4中的一个选自包含1至3个独立地选自N ，O或S，其中所述杂芳基任选地被苯并稠合或任选地与包含1至3个独立地选自N，O或S的杂原子的第二个5-至6-元杂芳基稠合，并且经由碳环与化合物的其余部分结合原子，其中所述杂芳基任选地在单个碳环原子上具有选自增溶基团或C 1 -C 4直链或支链烷基的取代基取代。

9. 发明申请

WO2008073451A2 SIRTUIN MODULATING COMPOUNDS 审中-公开
标题翻译： SIRTUIN调节化合物
公开(公告)号：WO2008073451A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/025391
申请日：2007-12-11
申请人： SIRTRIS PHARMACEUTICALS, INC. , BEMIS, Jean , VU, Chi, B. , NUNES, Joseph, J. , ARMISTEAD, David
发明人： BEMIS, Jean , VU, Chi, B. , NUNES, Joseph, J. , ARMISTEAD, David
CPC分类号： C07D513/04
摘要： Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
摘要翻译：本文提供了新的沉默调节蛋白的调节化合物及其使用方法。沉默调节蛋白的调节化合物可用于增加细胞的寿命，以及治疗和/或预防各种各样的疾病和病症，包括例如与老化或紧张相关的疾病或病症，糖尿病，肥胖症，神经变性疾病，心血管疾病，凝血障碍，炎症，癌症和/或潮红以及由线粒体活性增加所致的疾病或病症。还提供了包含与另一种治疗剂组合的沉默调节蛋白的调节化合物的组合物。

10. 发明申请

WO2004072231A3 PATHOGEN INACTIVATION ASSAY 审中-公开
标题翻译：病态灭活测定
公开(公告)号：WO2004072231A3
公开(公告)日：2007-10-04
申请号：PCT/US2004002013
申请日：2004-02-10
申请人： CLEARANT INC , MCKENNEY KEITH , GILLMEISTER LIDJA , MARLOWE KRISTINA , ARMISTEAD DAVID
发明人： MCKENNEY KEITH , GILLMEISTER LIDJA , MARLOWE KRISTINA , ARMISTEAD DAVID
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C12N20060101 , C12P19/34 , C12Q1/70
CPC分类号： C12Q1/6895 , C12Q1/689 , C12Q1/701 , C12Q2600/16
摘要： The present invention relates to methods for determining the level of potentially active biological pathogens, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), fungi (including yeasts) and single cell parasites, which may be found in a biological material. The present invention particularly relates to methods of determining the level of potentially active biological pathogens in a biological material using quantitative PCR.
摘要翻译：本发明涉及用于确定潜在活性生物病原体如病毒，细菌（包括细菌和细胞内细菌如支原体，脲酶原，纳细菌，衣原体，立克次体），真菌（包括酵母）和单细胞的水平的方法可以在生物材料中发现寄生虫。本发明特别涉及使用定量PCR确定生物材料中潜在活性生物病原体水平的方法。

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