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1. 发明申请

WO2006027579A2 THE TREATMENT OF INFLAMMATORY DISORDERS AND PAIN 审中-公开
标题翻译：治疗炎症性疾病和疼痛
公开(公告)号：WO2006027579A2
公开(公告)日：2006-03-16
申请号：PCT/GB2005/003452
申请日：2005-09-07
申请人： ARAKIS LTD. , BAXTER, Andrew, Douglas , BREW, John
发明人： BAXTER, Andrew, Douglas , BREW, John
IPC分类号： A61K31/137 , A61K31/138 , A61K31/37 , A61K31/4458 , A61K31/4704 , A61P1/00 , A61P1/02 , A61P11/06 , A61P11/08 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/02 , A61P29/02 , A61P37/06
CPC分类号： A61K31/138 , A61K31/137 , A61K31/37 , A61K31/4458 , A61K31/4704
摘要： Compounds that may be used for the treatment or prevention of a condition associated with T-cell proliferation or that is mediated by pro-inflammatory cytokines are of formula (I): wherein R 1 is CHR 4 -OR 5 or CHR 4 -SR 5 , or aryl or heteroaryl optionally substituted with one or more groups R 6 ; R 2 is alkyl or is part of a ring with R 3 ; R 3 is H, alkyl or CH 2 (when forming part of a ring with R 2 ); R 4 is H or alkyl or is part of a ring with R 5 ; R 5 is aryl or heteroaryl optionally substituted with R 7 ; each R 6 is independently alkyl, CF 3 , OH, Oalkyl, OCOalkyl, CONH 2 , CN, halogen, NH 2 , NO 2 , NHCHO, NHCONH 2 , NHSO 2 alkyl, CONH 2 , SOMe, SO 2 NH 2 , Salkyl, CH 2 SO 2 alkyl or OCONalkyl 2 ; R 7 is R 8 or (CH 2 ) n OR 8 , R 9 , CF 3 , OH, OR 9 , OCOR 9 , COR 9 , COOR 9 , CONH 2 , CH 2 CONH 2 , CN, halogen, NH 2 , NO 2 , NHCHO, NHCONH 2 , NHCONHR 7 , NHCON(R 9 ) 2 , NHCOR 9 , NHCOaryl, NHSO 2 Me, CONH 2 , SMe, SOMe or SO 2 NH 2 ; R 8 is (CH 2 ) n OR 9 , (CH) n OR 9 , (CH 2 ) n COOR 9 or (CH 2 ) n COaryI; R 9 is alkyl or cycloalkyl; and n is 1 to 4; or a salt thereof.
摘要翻译：可用于治疗或预防与T细胞增殖相关或由促炎细胞因子介导的病症的化合物具有式（I）：其中R

2. 发明申请

WO2005084658A1 DERIVATIVES OF ACTARIT AND THEIR THERAPEUTIC USE 审中-公开
标题翻译： ACTARIT及其治疗用途的衍生物
公开(公告)号：WO2005084658A1
公开(公告)日：2005-09-15
申请号：PCT/GB2005/000834
申请日：2005-03-04
申请人： ARAKIS LTD. , BAXTER, Andrew, Douglas
发明人： BAXTER, Andrew, Douglas
IPC分类号： A61K31/167
CPC分类号： C07C237/22 , C07C233/54 , C07C257/04 , C07D257/04 , C07D295/13 , C07D295/185
摘要： Compounds that may have anti-inflammatory activity are of general formula wherein X is O or NR 1 ; Y isOorNR 1 ; R 2 is OR 1 or C, 1-4 alkyl substituted with R 3 , and R 2 is optionally substituted With R 4 ; each R 1 is the same or different and is H or C 1-4 alkyl, or R 1 and R 2 are joined to form a four to seven-membered ring containing one or more additional heteroatoms selected from O, N and S, and is optionally substituted with R 7 ; R 3 is OR 4 , NR 5 R 6 or a four to seven- embered ring which can contain .one or morte heteroatoms selected from O, N and S, and is optionally substituted with R 7 ;R 4 is H or C 1-4 alkyl optionally substituted with OR 8 ; R 5 and R 6 are the same or different and are each selected from H and C 1-4 alkyl optionally substituted with OR 8 ; R 7 is C 1-4 alkyl optionally substituted with OR 8 , halogen, CF 3 , NR 5 R 6 , or S(O) n R 9 where n is 0-2; each R 8 is H or C 1-4 alkyl optionally substituted with halogen or OH; and R 9 is C 1-4 alkyl; and the salts, solvates and hydrates thereof.
摘要翻译：可具有抗炎活性的化合物具有通式，其中X为O或NR 1; Y是ORNR1; R2是OR 1或被R 3取代的C 1-4烷基，R 2任选被R 4取代; 每个R 1相同或不同，为H或C 1-4烷基，或R 1和R 2连接形成含有一个或多个选自O，N和S的其它杂原子的四元至七元环，并且任选被 R7; R3是OR4，NR5R6或可以含有一个或多个选自O，N和S的杂原子的四至七个环，并且任选被R 7取代; R 4是H或任选被OR 8取代的C 1-4烷基; R5和R6相同或不同，各自选自H和任选被OR 8取代的C 1-4烷基; R 7是任选被OR 8，卤素，CF 3，NR 5 R 6或S（O）n R 9取代的C 1-4烷基，其中n是0-2; 每个R 8为H或任选被卤素或OH取代的C 1-4烷基; 并且R 9为C 1-4烷基; 及其盐，溶剂化物和水合物。

3. 发明申请

WO2005041963A1 THE USE OF NON-OPIATES FOR THE POTENTATION OF OPIATES 审中-公开
标题翻译：使用不透明度进行评估
公开(公告)号：WO2005041963A1
公开(公告)日：2005-05-12
申请号：PCT/GB2004/004446
申请日：2004-10-21
申请人： ARAKIS LTD. , BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas , ROTHAUL, Alan , LYNE, Michael, Harvey
发明人： BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas , ROTHAUL, Alan , LYNE, Michael, Harvey
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A61K31/135 , A61K31/137 , A61K31/165 , A61K31/381 , A61K31/395 , A61K31/485 , A61K31/5513 , A61K2300/00
摘要： A non-opioid analgesic is used for the treatment of intermittent or episodic pain experienced by a patient undergoing chronic pain treatment with an opioid analgesic.
摘要翻译：非阿片类镇痛药用于治疗由阿片类镇痛药进行慢性疼痛治疗的患者经历的间歇性或间歇性疼痛。

4. 发明申请

WO2004006903A1 THE TREATMENT OF EMESIS 审中-公开
标题翻译：治疗EMESIS
公开(公告)号：WO2004006903A1
公开(公告)日：2004-01-22
申请号：PCT/GB2003/003002
申请日：2003-07-11
申请人： ARAKIS LTD. , LYNE, Michael, Harvey , BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas
发明人： LYNE, Michael, Harvey , BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas
IPC分类号： A61K31/137
CPC分类号： A61K31/137
摘要： A single enantiomer of venlafaxine is used to treat nausea, dizziness, blurred vision or emesis.
摘要翻译：文拉法辛的单一对映异构体用于治疗恶心，眩晕，视力模糊或呕吐。

5. 发明申请

WO2003105833A1 FORMULATION OF NEFOPAM AND ITS USE IN THE TREATMENT OF PAIN 审中-公开
标题翻译： NEFOPAM的配方及其在治疗疼痛中的应用
公开(公告)号：WO2003105833A1
公开(公告)日：2003-12-24
申请号：PCT/GB2003/002618
申请日：2003-06-17
申请人： ARAKIS LTD. , LYNE, Michael, Harvey
发明人： LYNE, Michael, Harvey
IPC分类号： A61K31/395
CPC分类号： A61K45/06 , A61K31/395 , A61K2300/00
摘要： (+)-Nefopam is formulated for intranasal administration, for use in the treatment of pain.
摘要翻译：（+） - 奈福泮配制用于鼻内给药，用于治疗疼痛。

6. 发明申请

WO2005107873A2 THE TREATMENT OF CHILDHODD ASTHMA 审中-公开
标题翻译：治疗儿童哮喘
公开(公告)号：WO2005107873A2
公开(公告)日：2005-11-17
申请号：PCT/GB2005001791
申请日：2005-05-10
申请人： ARAKIS LTD , SNAPE SUSAN , BANNISTER ROBIN MARK
发明人： SNAPE SUSAN , BANNISTER ROBIN MARK
IPC分类号： A61K31/00 , A61K31/352 , A61K31/40 , A61K31/439 , A61K31/465 , A61P11/06
CPC分类号： A61K31/40 , A61K31/00 , A61K31/352 , A61K31/439 , A61K31/465 , A61K2300/00
摘要： Glycopyrrolate or an analogue thereof is useful for the treatment of childhood asthma.
摘要翻译：乙酰丙酸甘油酯或其类似物可用于治疗儿童哮喘。

7. 发明申请

WO2005056539A2 A PROCESS FOR THE RESOLUTION OF NEFOPAM 审中-公开
标题翻译： NEFOPAM解决方案
公开(公告)号：WO2005056539A2
公开(公告)日：2005-06-23
申请号：PCT/GB2004005198
申请日：2004-12-13
申请人： ARAKIS LTD , HARRIS MICHAEL JOHN , BROWN STUART
发明人： HARRIS MICHAEL JOHN , BROWN STUART
IPC分类号： C07D267/22 , C07D267/00
CPC分类号： C07D267/22
摘要： A process for increasing the optical purity of a mixture of enantiomers of nefopam uses a substantially single enantiomer of a O,O-diaroyltartaric acid as a resolving agent, via a bisnefopam salt of the acid. This salt is new.
摘要翻译：增加奈福泮对映异构体混合物的光学纯度的方法使用基本上单独的作为拆分剂的O，O-二芳酰基酒石酸对映异构体，通过酸的双诺芬帕盐。这种盐是新的。

8. 发明申请

WO2005041964A1 THE USE OF IFENPRODRIL IN THE TREATMENT OF PAIN 审中-公开
标题翻译：使用芬太尼治疗疼痛
公开(公告)号：WO2005041964A1
公开(公告)日：2005-05-12
申请号：PCT/GB2004/004459
申请日：2004-10-21
申请人： ARAKIS LTD. , BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas , ROTHAUL, Alan , LYNE, Michael, Harvey
发明人： BREW, John , BANNISTER, Robin, Mark , BAXTER, Andrew, Douglas , ROTHAUL, Alan , LYNE, Michael, Harvey
IPC分类号： A61K31/445
CPC分类号： A61K31/445
摘要： Ifenprodil is useful for the treatment of pain.
摘要翻译： Ifenprodil可用于治疗疼痛。

9. 发明申请

WO2003105832A1 USE OF NEFOPAM FOR THE TREATMENT OF NAUSEA OR EMESIS 审中-公开
标题翻译：使用NEFOPAM治疗NAUSEA或EMESIS
公开(公告)号：WO2003105832A1
公开(公告)日：2003-12-24
申请号：PCT/GB2003/002586
申请日：2003-06-17
申请人： ARAKIS LTD. , BANNISTER, Robin, Mark , LYNE, Michael, Harvey
发明人： BANNISTER, Robin, Mark , LYNE, Michael, Harvey
IPC分类号： A61K31/395
CPC分类号： A61K45/06 , A61K31/395 , A61K2300/00
摘要： The invention relates to the use of nefopam for the manufacture of a medicament for the treatment of nausea, dizziness, blurred vision and emesis.
摘要翻译：本发明涉及奈福泮在制备用于治疗恶心，眩晕，视力模糊和呕吐的药物中的用途。

10. 发明申请

WO0054780A3 CORTICOSTEROID FORMULATION 审中-公开
标题翻译：抗菌配方
公开(公告)号：WO0054780A3
公开(公告)日：2000-12-28
申请号：PCT/GB0000924
申请日：2000-03-14
申请人： ARAKIS LTD , BARDSLEY HAZEL JUDITH
发明人： BARDSLEY HAZEL JUDITH
IPC分类号： A61K9/52 , A61K9/28 , A61K9/50 , A61K31/57 , A61K31/58 , A61P1/04 , A61P5/44 , A61P11/06 , A61P17/04 , A61P19/02 , A61P29/00 , C07J9/00 , C07J71/00
CPC分类号： A61K31/573 , A61K9/2866 , A61K9/5073 , A61K31/58
摘要： A unit dose formulation comprising 0.25 to 2 mg of a corticosteroid. This small dose can be used to treat rheumatoid arthritis, especially if adapted to release at least 90 % by weight of the corticosteroid, 2 to 8 hours after administration.
摘要翻译：包含0.25至2mg皮质类固醇的单位剂量制剂。这种小剂量可用于治疗类风湿性关节炎，特别是如果适应于在给药后2至8小时释放皮质类固醇的至少90重量％。

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