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    • 2. 发明申请
    • SUSTAINED-RELEASE NIFEDIPINE FORMULATION
    • 持续释放NIFEDIPINE配方
    • WO1989002738A1
    • 1989-04-06
    • PCT/GB1988000779
    • 1988-09-22
    • APS RESEARCH LIMITEDBARRY, Brian, WilliamMULLEY, Bryan, ArthurYORK, Peter
    • APS RESEARCH LIMITED
    • A61K31/44
    • A61K9/5047A61K9/1652A61K9/5026A61K31/44
    • A sustained-release nifedipine (4-(2'-nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine) formulation comprising sufficient granules to provide a predetermined dose or number of doses of nifedipine, each of said granules having a diameter of between 0.5 and 2.5 mm and comprising: (a) a core comprising 100 parts of nifedipine and from 50 to 800 parts of hydroxypropylmethyl cellulose; and (b) a coating covering substantially the whole surface of the core and comprising 100 parts of a water insoluble but water swellable acrylic polymer and from 20 to 70 parts of a water soluble hydroxylated cellulose derivative, the weight of the coating being from 2 to 25 % of the weight of the core. A method for preparing the formulation is also provided.
    • 持续释放的硝苯地平(4-(2'-硝基苯基)-2,6-二甲基-3,5-二甲氧基-1,4-二氢吡啶)制剂,其包含足够的颗粒以提供硝苯地平的预定剂量或数量的剂量 所述颗粒的直径在0.5至2.5mm之间,并且包括:(a)包含100份硝苯地平的核心和50至800份的羟丙基甲基纤维素; 和(b)基本上覆盖芯的整个表面的涂层,并且包含100份水不溶性但可水溶胀的丙烯酸类聚合物和20至70份水溶性羟基化纤维素衍生物,涂层的重量为2至 核心重量的25%。 还提供了制备该制剂的方法。