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1. 发明申请

US20020161218A1 Hepatitis C virus vaccine 失效
标题翻译：丙型肝炎病毒疫苗
公开(公告)号：US20020161218A1
公开(公告)日：2002-10-31
申请号：US09788934
申请日：2001-05-01
申请人： Apollon, Inc.
发明人： Catherine J. Pachuk , Jack Wands , Takaji Wakita , Vincent R. Zurawski JR. , Leslie R. Coney
IPC分类号： C07H021/04 , A61K048/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N2730/10122 , C12N2770/24222 , C12N2770/24234
摘要： Nucleic acid molecule that comprise an incomplete hepatitis C viral genome including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C viral genome including a nucleotide sequence encoding a complete hepatitis C core protein operably linked to regulatory elements functional in human cells are disclosed. Methods of immunizing individuals susceptible to or infected by hepatitis C virus comprising the step of administering such pharmaceutical compositions are disclosed.
摘要翻译：公开了包含特异性公开的DNA序列的包含不完全丙型肝炎病毒基因组的核酸分子。公开了含有包含不完全丙型肝炎病毒基因组的核酸分子的药物组合物，其包括编码与人细胞中有功能的调控元件可操作地连接的完整丙型肝炎核心蛋白的核苷酸序列。公开了对丙型肝炎病毒感染或感染的个体进行免疫的方法，包括施用该药物组合物的步骤。

2. 发明授权

US11986295B1 Apparatus for measuring blood glucose continuously based on Raman signal 有权
公开(公告)号：US11986295B1
公开(公告)日：2024-05-21
申请号：US18455492
申请日：2023-08-24
申请人： Apollon Inc.
发明人： Miyeon Jue , Young Kyu Kim , Aram Hong
IPC分类号： A61B5/1455 , A61B5/00 , A61B5/145 , G01N21/65 , G01N33/49
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/1455 , G01N21/65 , G01N33/49 , A61B5/6801 , G01N2201/061 , G01N2201/127
摘要： Disclosed is a blood glucose level measuring apparatus utilizing a Raman spectrum includes a housing defining an interior accommodation space, a light source part disposed in the housing, and that irradiates light to a subject, a light receiving part disposed in the housing, and that receives the reflected and scattered light from the subject and acquires a Raman spectrum, and a processor disposed in the housing, and that extracts information on glucose, proteins, and fats of the subject by utilizing an area of a peak included in the Raman spectrum. The processor performs a calibration by controlling the light source part and the light receiving part when the blood glucose level measuring apparatus starts to be driven or is mounted on a body of a user.

3. 发明申请

WO1994017086A1 GENE REGULATION BY TARGETING PUTATIVE INTRAMOLECULAR TRIPLE HELIX 审中-公开
标题翻译：通过靶向引物分子三肽HELIX进行基因调控
公开(公告)号：WO1994017086A1
公开(公告)日：1994-08-04
申请号：PCT/US1994000348
申请日：1994-01-10
申请人： APOLLON, INC. , YOON, Kyonggeun , LU, Meiqing
发明人： APOLLON, INC.
IPC分类号： C07H17/00
CPC分类号： C12N15/113 , C07H21/00 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N15/1136 , C12N15/1138 , C12N2310/152 , C12N2310/315 , C12N2310/321 , C12N2310/53 , C12Q1/6839
摘要： The present invention is related to oligonucleotides or derivatives thereof for decreasing transcription of a target gene having a purine-rich region of DNA that is significantly involved in transcription and has substantial mirror symmetry. The oligonucleotides of the present invention are substantially complementary to the purine stand. Certain preferred embodiments do not form a substantially stable intermolecular triple helix with the target gene in vitro at physiological pH. Other preferred embodiments are oligonucleotides having a circular or stemloop functioning structure that may form both Watson-Crick and Hoogsteen bonds with the target DNA. The invention also provides methods for preparing a composition for decreasing transcription of a target gene, methods for decreasing transcription of a target gene and methods for treating a vertebrate suspecting of having a disease involving the expression of a target gene.
摘要翻译：本发明涉及用于减少具有显着参与转录的具有嘌呤富含DNA区的靶基因的转录的寡核苷酸或其衍生物，并具有实质的镜像对称性。本发明的寡核苷酸与嘌呤体基本上是互补的。某些优选的实施方案在体外在生理pH下不与靶基因形成基本稳定的分子间三螺旋。其它优选的实施方案是具有圆形或茎环功能结构的寡核苷酸，其可以与靶DNA形成沃森 - 克里克和胡格斯汀（Hoogsteen）键。本发明还提供了制备用于降低靶基因转录的组合物的方法，用于降低靶基因转录的方法和用于治疗涉及具有涉及靶基因表达的疾病的脊椎动物的方法。

4. 发明申请

WO1994013793A1 COMPOUNDS AND METHODS FOR THE TREATMENT OF LEUKEMIAS 审中-公开
标题翻译：用于治疗白血病的化合物和方法
公开(公告)号：WO1994013793A1
公开(公告)日：1994-06-23
申请号：PCT/US1993011144
申请日：1993-11-16
申请人： APOLLON, INC. , PACHUK, Catherine, J. , CONEY, Leslie, R. , OAKES, Fred, T.
发明人： APOLLON, INC.
IPC分类号： C12N15/00
CPC分类号： C12N15/113 , C07K2319/00 , C12N15/1135 , C12N2310/111 , C12N2310/121 , C12N2310/315 , C12N2310/351 , C12N2310/353 , C12N2310/53
摘要： Ribozymes are provided in which the ribozymes have a catalytic sequence, two legs and at least one anchor sequence complementary to the substrate mRNA at a location that can be noncontiguous with the portions of the substrate mRNA complementary to the legs. In certain preferred embodiments, ribozymes capable of cleaving the L6 mRNA or both the L6 and K28 mRNAs are provided. Methods are provided for the treatment of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL) patients having the L6 and K28 translocations and, therefore, the L6 mRNA. Additionally, combination treatments comprising components specific for both the K28 and L6 mRNAs are provided. Combination treatments are also provided for those patients which express c-myc in combination with K28 and/or L6 mRNAs. Methods of treatment include, for example, administration of ribozymes and antisense oligonucleotides directed against these mRNAs.
摘要翻译：提供了核酶，其中核酶具有催化序列，两条腿和至少一条与底物mRNA互补的锚定序列，所述锚定序列可以与与腿互补的底物mRNA的部分不连续的位置。在某些优选实施方案中，提供能够切割L6 mRNA或L6和K28 mRNA两者的核酶。提供了用于治疗慢性骨髓性白血病（CML）和具有L6和K28易位的急性淋巴细胞性白血病（ALL）患者以及L6mRNA的方法。另外，提供包含对K28和L6 mRNA特异性成分的组合处理。还为那些表达c-myc与K28和/或L6mRNA组合的患者提供组合治疗。治疗方法包括例如施用针对这些mRNA的核酶和反义寡核苷酸。

5. 发明申请

WO1996008970A1 COMPOSITIONS AND METHODS FOR THE ABROGATION OF CELLULAR PROLIFERATION UTILIZING THE HUMAN IMMUNODEFICIENCY VIRUS Vpr PROTEIN 审中-公开
标题翻译：使用人免疫缺陷病毒Vpr蛋白的细胞增殖免疫的组合物和方法
公开(公告)号：WO1996008970A1
公开(公告)日：1996-03-28
申请号：PCT/US1995012344
申请日：1995-09-21
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , APOLLON, INC. , WEINER, David, B. , LEVY, David, N. , REFAELI, Yosef , WILLIAMS, William, V. , AYYAROO, Velpandi
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , APOLLON, INC.
IPC分类号： A01N63/00
CPC分类号： C07K14/005 , A61K38/162 , A61K48/00 , C12N2710/14143 , C12N2740/16322
摘要： Method of inhibiting proliferation of cells using vpr protein or nucleotide sequences that encode vpr are disclosed. Method of preventing lymphocyte activation using vpr protein or nucleotide sequences that encode vpr are disclosed. Methods of treating an individual diagnosed with or suspected of suffering from autoimmune disease, diseases characterized by proliferating cells and graft versus host disease by administering vpr protein or a functional fragment thereof, or a nucleic acid molecule that comprises a nucleotide sequence that encodes vpr protein or a functional fragment thereof are disclosed. Conjugated compositions for delivery of active agents to the nucleus of cells are disclosed.
摘要翻译：公开了使用vpr蛋白抑制细胞增殖的方法或编码vpr的核苷酸序列。公开了使用vpr蛋白或编码vpr的核苷酸序列预防淋巴细胞活化的方法。治疗患有或怀疑患有自身免疫疾病的个体的方法，通过施用vpr蛋白或其功能片段或包含编码vpr蛋白的核苷酸序列的核酸分子的核酸分子，或者包含编码vpr蛋白的核苷酸序列的核酸分子，公开了其功能片段。公开了将活性剂递送至细胞核的共轭组合物。

6. 发明申请

WO1998017799A1 IMMUNOTHERAPY AND IMPROVED VACCINES 审中-公开
标题翻译：免疫和改善的疫苗
公开(公告)号：WO1998017799A1
公开(公告)日：1998-04-30
申请号：PCT/US1997019502
申请日：1997-10-23
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , APOLLON, INC. , KIM, Jong, J. , BAGARAZZI, Mark, L. , WANG, Bin , BOYER, Jean, D. , WEINER, David, B.
发明人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , APOLLON, INC.
IPC分类号： C12N15/18
CPC分类号： A61K39/39 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/21 , A61K48/00 , A61K2039/53 , A61K2039/55522 , A61K2039/55527 , A61K2039/55533 , A61K2039/55538 , A61K2039/57 , C07K14/54 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
摘要： Improved vaccines which include a nucleotide sequence that encodes IL-12, GM-CSF, IL-1, TNF- alpha , TNF- beta , IL-2, IL-4, IL-5, IL-10, IL-15, IL-18, and/or BL-1 operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Pharmaceutical compositions comprising nucleic acid molecules that encode one or more immunomodulatory proteins selected from the group consisting of IL-12, GM-CSF, IL-1, TNF- alpha , TNF- beta , IL-2, IL-4, IL-5, IL-10, IL-15, IL-18, and BL-1 are disclosed. An immunomodulatory protein, BL-1, and nucleic acid molecules that encode BL-1 are disclosed. Methods of making and using BL-1 are disclosed.
摘要翻译：改进的疫苗包括编码IL-12，GM-CSF，IL-1，TNF-α，TNF-β，IL-2，IL-4，IL-5，IL-10，IL-15，IL的核苷酸序列 -18和/或可操作地连接到调节元件的BL-1。改进的疫苗包括DNA疫苗，用于递送外源抗原和活减毒疫苗的重组疫苗。公开了免疫个体的方法。包含编码一种或多种选自IL-12，GM-CSF，IL-1，TNF-α，TNF-β，IL-2，IL-4，IL-5的免疫调节蛋白的核酸分子的药物组合物，IL-10，IL-15，IL-18和BL-1。公开了免疫调节蛋白BL-1和编码BL-1的核酸分子。公开了制造和使用BL-1的方法。

7. 发明申请

WO1996010997A1 HEPATITIS VIRUS VACCINES 审中-公开
公开(公告)号：WO1996010997A1
公开(公告)日：1996-04-18
申请号：PCT/US1995013552
申请日：1995-10-05
申请人： APOLLON, INC. , THE GENERAL HOSPITAL CORPORATION doing business as THE MASSACHUSETTS GENERAL HOSPITAL , PACHUK, Catherine, J. , WANDS, Jack , WAKITA, Takaji , ZURAWSKI, Vincent, R., Jr. , CONEY, Leslie, R. , TOKUSHIGE, Katsutoshi
发明人： APOLLON, INC. , THE GENERAL HOSPITAL CORPORATION doing business as THE MASSACHUSETTS GENERAL HOSPITAL
IPC分类号： A61K31/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N2730/10122 , C12N2770/24222
摘要： Nucleic acid molecule that comprises an incomplete fused hepatitis C and hepatitis B viral genome or an incomplete hepatitis C viral genome including specifically disclosed DNA sequences are disclosed. Pharmaceutical compositions that contain nucleic acid molecules comprising an incomplete hepatitis C and hepatitis B viral genome including a nucleotide sequence encoding a complete hepatitis C core protein and hepatitis B S gene protein or an incomplet hepatitis C viral genome including a nucleotide sequence encoding a complete hepatitis C core protein, operably linked to regulatory elements functional in human cells are disclosed. Methods of immunizing individuals susceptible to or infected by hepatitis B virus and/or hepatitis C virus comprising the step of administering such pharmaceutical compositions are disclosed.
摘要翻译：公开了包含不完全融合丙型肝炎和乙型肝炎病毒基因组的核酸分子或包括特异性公开的DNA序列的不完全丙型肝炎病毒基因组。包含含有不完全丙型肝炎和乙型肝炎病毒基因组的核酸分子的药物组合物，包括编码完整丙型肝炎核心蛋白和乙型肝炎BS基因蛋白的核苷酸序列或不完全丙型肝炎病毒基因组，其包含编码完整丙型肝炎核心的核苷酸序列公开了可操作地连接到在人细胞中有功能的调节元件的蛋白质。公开了对乙型肝炎病毒和/或丙型肝炎病毒感染或感染的个体进行免疫的方法，包括施用该药物组合物的步骤。

8. 发明申请

WO1996010038A1 MULTIFUNCTIONAL MOLECULAR COMPLEXES FOR GENE TRANSFER TO CELLS 审中-公开
标题翻译：用于基因转移到细胞的多功能分子复合物
公开(公告)号：WO1996010038A1
公开(公告)日：1996-04-04
申请号：PCT/US1995012502
申请日：1995-09-28
申请人： APOLLON, INC. , BOUTIN, Raymond, H.
发明人： APOLLON, INC.
IPC分类号： C07K07/00
CPC分类号： C07K14/005 , A61K47/543 , A61K47/554 , A61K48/00 , C12N15/64 , C12N15/87 , C12N2760/16022
摘要： A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided. The complex is comprised of A) said nucleic acid composition and B) a transfer moiety comprising 1) one or more cationic polyamines bound to said nucleic acid composition, 2) one or more endosome membrane disrupting components attached to at least one nitrogen of the polyamine and 3) one or more receptor specific binding components.
摘要翻译：提供了用于将核酸组合物转移至靶细胞的多功能分子复合物。所述复合物由A）所述核酸组合物和B）转移部分组成，所述转移部分包含1）与所述核酸组合物结合的一种或多种阳离子多胺，2）一种或多种内连体膜破坏连接至所述多胺的至少一个氮的组分和3）一种或多种受体特异性结合组分。

9. 发明申请

WO1995017414A1 ANTI-HEPATITIS B VIRAL OLIGONUCLEOTIDES 审中-公开
标题翻译：抗乙型肝炎病毒阴性寡核苷酸
公开(公告)号：WO1995017414A1
公开(公告)日：1995-06-29
申请号：PCT/US1994013687
申请日：1994-12-01
申请人： APOLLON, INC.
发明人： APOLLON, INC. , CONEY, Leslie, R. , PACHUK, Catherine, J. , YOON, Kyonggeun
IPC分类号： C07H21/00
CPC分类号： C12N15/1131 , A61K38/00 , C07H21/00 , C12N2310/111 , C12N2310/322
摘要： The invention relates to methods and compositions for inhibition of viral replication. In particular, complete and irreversible termination of replication of hepatitis B virus is achieved by introducing into a target cell an oligonucleotide complementary to HBV plus strand and 5' and 3' flanking nucleotides.
摘要翻译：本发明涉及用于抑制病毒复制的方法和组合物。特别地，通过向靶细胞中引入与HBV加链和5'和3'侧翼核苷酸互补的寡核苷酸来实现乙型肝炎病毒的完全和不可逆的终止。

10. 发明申请

WO1997042330A1 CHAIN REACTION CLONING 审中-公开
标题翻译：链反应克隆
公开(公告)号：WO1997042330A1
公开(公告)日：1997-11-13
申请号：PCT/US1997007698
申请日：1997-05-06
申请人： APOLLON, INC.
发明人： APOLLON, INC. , PACHUK, Catherine, J. , SAMUEL, Manoj , ZURAWSKI, John, A. , SATISHCHANDRAN, C.
IPC分类号： C12N15/64
CPC分类号： C12N15/52 , A61K48/00 , C07K14/005 , C12N15/10 , C12N15/1027 , C12N2710/16622
摘要： Chain reaction cloning methods and reagents and kits for performing such methods are disclosed. Chain reaction cloning methods provide a convenient one step process that will allow site-specific ligation of DNA molecules by thermostable DNA ligases. A number of applications are disclosed for chain reaction cloning including site-specific ligation of DNA fragments generated by restriction enzyme digestion, DNAse digestion, chemical cleavage, enzymatic or chemical synthesis, and PCR amplification.
摘要翻译：公开了用于执行这些方法的链式反应克隆方法和试剂和试剂盒。链式反应克隆方法提供了一个方便的一步法，可以通过热稳定DNA连接酶使DNA分子的位点特异性连接。公开了许多用于链式反应克隆的应用，包括通过限制酶消化，DNA酶消化，化学切割，酶或化学合成和PCR扩增产生的DNA片段的位点特异性连接。

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