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1. 发明申请

US20160318937A1 PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL COMPOUNDS 有权
标题翻译：吡咯并[1,5-A]吡啶类作为抗病毒化合物
公开(公告)号：US20160318937A1
公开(公告)日：2016-11-03
申请号：US15107930
申请日：2015-01-21
申请人： APODEMUS AB
发明人： Jacob WESTMAN
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof, useful in therapy, in particular in the treatment of a viral infection.

2. 发明申请

WO2003019197A2 DIABETIC MODEL 审中-公开
标题翻译：糖尿病模型
公开(公告)号：WO2003019197A2
公开(公告)日：2003-03-06
申请号：PCT/IB2002/003957
申请日：2002-08-21
申请人： APODEMUS AB , NIKLASSON, Bo , LERNMARK, Åke
发明人： NIKLASSON, Bo , LERNMARK, Åke
IPC分类号： G01N33/569
CPC分类号： A01K67/027 , G01N33/564 , G01N33/56983 , G01N2333/085 , G01N2333/46 , G01N2800/042
摘要： The invention relates to an animal model for diabetes and a method for obtaining said animal model. The invention also relates to the uses of the animal model for screening for or testing compounds for treating or preventing diabetes symptoms. The invention further relates to an assay for determining an individual's susceptibility to developing diabetes. The invention also relates to nucleic acid molecules isolated from Ljungan virus and to polypeptides encoded by any portion of said nucleic acid molecule.
摘要翻译：本发明涉及一种用于糖尿病的动物模型和用于获得所述动物模型的方法。本发明还涉及动物模型用于筛选或测试用于治疗或预防糖尿病症状的化合物的用途。本发明还涉及用于确定个体对发展中的糖尿病易感性的测定。本发明还涉及从Ljungan病毒分离的核酸分子以及由所述核酸分子的任何部分编码的多肽。

3. 发明申请

WO2016206999A1 PYRAZOLO[1,5-A]TRIAZIN-4-AMINE DERIVATIVES USEFUL IN THERAPY 审中-公开
标题翻译：吡咯并[1,5-A]三氮杂-4-胺衍生物有用于治疗
公开(公告)号：WO2016206999A1
公开(公告)日：2016-12-29
申请号：PCT/EP2016/063383
申请日：2016-06-10
申请人： APODEMUS AB
发明人： WESTMAN, Jacob
IPC分类号： C07D487/04 , A61K31/53 , A61P31/12
CPC分类号： C07D487/04 , A61K31/53
摘要： A compound of formula (I), or a pharmaceutically acceptable salt thereof, useful in therapy, in particular in the treatment of a viral infection.
摘要翻译：用于治疗，特别是治疗病毒感染的式（I）化合物或其药学上可接受的盐。

4. 发明申请

WO2010073019A1 LJUNGAN VIRUS 审中-公开
标题翻译： LJUNGAN病毒
公开(公告)号：WO2010073019A1
公开(公告)日：2010-07-01
申请号：PCT/GB2009/002962
申请日：2009-12-23
申请人： APODEMUS AB , NIKLASSSON, Bo , TOLF, Conny , LINDBERG, Michael , TOMBLING, Adrian, George
发明人： NIKLASSSON, Bo , TOLF, Conny , LINDBERG, Michael
IPC分类号： A61K39/125 , C07K14/085
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/125 , A61K2039/5258 , A61K2039/53 , C12N2770/32522 , C12N2770/32534
摘要： The present invention relates to a new group of Ljungan viruses, proteins expressed by the viruses, antibodies to the viruses and proteins, vaccines against the viruses, diagnostic kits for detecting the viruses, uses of the viruses, proteins, antibodies and vaccines in therapy, uses of the viruses, proteins, antibodies and vaccines in treating diseases caused by the viruses and methods of treatment for treating diseases caused by the viruses.
摘要翻译：本发明涉及新的一组Ljungan病毒，由病毒表达的蛋白质，病毒和蛋白质的抗体，针对病毒的疫苗，用于检测病毒的诊断试剂盒，病毒，蛋白质，抗体和疫苗在治疗中的用途，病毒，蛋白质，抗体和疫苗在治疗由病毒引起的疾病中的用途以及用于治疗由病毒引起的疾病的治疗方法。

5. 发明申请

WO2015110491A3 PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL COMPOUNDS 审中-公开
公开(公告)号：WO2015110491A3
公开(公告)日：2015-07-30
申请号：PCT/EP2015/051177
申请日：2015-01-21
申请人： APODEMUS AB
发明人： WESTMAN, Jacob
IPC分类号： A61K31/519 , A61P31/12
摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof, useful in therapy, in particular in the treatment of a viral infection.

6. 发明申请

WO2015110491A2 PYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE DERIVATIVES USEFUL IN THERAPY 审中-公开
标题翻译：吡唑并[1,5-A]吡哩啶-7-胺衍生物有用于治疗
公开(公告)号：WO2015110491A2
公开(公告)日：2015-07-30
申请号：PCT/EP2015051177
申请日：2015-01-21
申请人： APODEMUS AB
发明人： WESTMAN JACOB
IPC分类号： A61K31/519 , A61P31/12
CPC分类号： C07D487/04 , A61K31/519
摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof, useful in therapy, in particular in the treatment of a viral infection.
摘要翻译：用于治疗，特别是治疗病毒感染的式（I）化合物或其药学上可接受的盐。

7. 发明申请

WO2006097723A1 DETECTION METHOD FOR LJUNGAN VIRUS 审中-公开
标题翻译： LJUNGAN病毒检测方法
公开(公告)号：WO2006097723A1
公开(公告)日：2006-09-21
申请号：PCT/GB2006/000926
申请日：2006-03-15
申请人： APODEMUS AB , ROBERT-KOCH INSTITUT , TOMBLING, Adrian, George , NIKLASSON, Bo , NITSCHE, Andreas , DONOSO-MANTKE, Oliver , NIEDRIG, Matthias
发明人： NIKLASSON, Bo , NITSCHE, Andreas , DONOSO-MANTKE, Oliver , NIEDRIG, Matthias
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701
摘要： The present invention relates to a method for specifically detecting Ljungan virus (LV). In particular, the present invention relates to a method of detecting LV using quantitative real-time reverse transcriptase PCR. The present invention also provides kits for performing the method of the invention.
摘要翻译：本发明涉及一种特异性检测Ljungan病毒（LV）的方法。特别地，本发明涉及使用定量实时逆转录酶PCR检测LV的方法。本发明还提供了用于执行本发明的方法的试剂盒。

8. 发明申请

WO2010084324A1 LJUNGAN VIRUS WITH IMPROVED REPLICATION CHARACTERISTICS 审中-公开
标题翻译： LJUNGAN病毒具有改善的复制特性
公开(公告)号：WO2010084324A1
公开(公告)日：2010-07-29
申请号：PCT/GB2010/000103
申请日：2010-01-22
申请人： APODEMUS AB , LINDBERG, Michael , TOLF, Conny , TOMBLING, Adrian, George
发明人： LINDBERG, Michael , TOLF, Conny
IPC分类号： A61K39/125 , C07K14/085
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/125 , A61K2039/505 , A61K2039/5258 , A61K2039/53 , C12N2770/32522 , C12N2770/32534
摘要： The present invention relates to a Ljungan virus with improved replication characteristic and the use of this Ljungan virus, amongst other thing, in the production of a vaccine.
摘要翻译：本发明涉及具有改进的复制特征的Ljungan病毒以及这种Ljungan病毒在生产疫苗中的用途。

9. 发明申请

WO2004073710A1 TREATMENT OF DISEASES CAUSED BY LJUNGAN VIRUS BY USING PLECONARIL 审中-公开
标题翻译：治疗LJUNGAN病毒引起的疾病使用PLECONARIL
公开(公告)号：WO2004073710A1
公开(公告)日：2004-09-02
申请号：PCT/SE2004/000226
申请日：2004-02-19
申请人： APODEMUS AB , NIKLASSON, Bo
发明人： NIKLASSON, Bo
IPC分类号： A61K31/4245
CPC分类号： A61K38/21 , A61K31/4245 , C07K16/1009 , A61K2300/00
摘要： A method of prophylactic and/or therapeutic treatment of a mammal for a disease that is caused by a Ljungan virus infection, such as Myocarditis, Cardiomyopathia, Guillain Barré Syndrome, and Diabetes Mellitus, Multiple sclerosis, Chronic Fatigue Syndrome, Myasthenia Gravis, Amyothrophic Lateral Sclerosis, Dermatomyositis, Polymyositis, Spontaneous Abortion, Intrauterine Death, Preeclampsia, Sudden Infant Death Syndrome, Bell’s (facial) paralysis, Addision’s disease, and Pernicious anemia, is described. An antiviral compound effective against a Ljungan virus, such as a compound effective against a picornavirus, e.g. Pleconaril or a derivative thereof, is used for the preparation of a medicament for the treatment of a disease in a mammal that is caused by a Ljungan virus infection, to eliminate or inhibit proliferation of the virus in the mammal and at the same time prevent and/or treat the disease in the mammal.
摘要翻译：用于由Ljungan病毒感染引起的哺乳动物的预防和/或治疗性治疗方法，例如心肌炎，心肌病，谷氨酸综合征和糖尿病，多发性硬化症，慢性疲劳综合征，重症肌无力肌营养不良描述了硬化症，皮肌炎，多发性肌炎，自发性流产，子宫内死亡，先兆子痫，突发性婴儿死亡综合征，贝尔（面部）麻痹，阑尾炎和恶性贫血。对Ljungan病毒有效的抗病毒化合物，例如对微小核糖核酸病毒有效的化合物。普朗菌素或其衍生物用于制备用于治疗由Ljungan病毒感染引起的哺乳动物疾病的药物，以消除或抑制哺乳动物中病毒的增殖，同时预防和 /或治疗哺乳动物的疾病。

10. 发明申请

WO2003019197A3 DIABETIC MODEL 审中-公开
公开(公告)号：WO2003019197A3
公开(公告)日：2003-03-06
申请号：PCT/IB2002/003957
申请日：2002-08-21
申请人： APODEMUS AB , NIKLASSON, Bo , LERNMARK, Åke
发明人： NIKLASSON, Bo , LERNMARK, Åke
IPC分类号： G01N33/569
摘要： The invention relates to an animal e.g. rodent such as bank vole (clethrionomys glareolus) model for diabetes and a method for obtaining said animal model. The invention also relates to the uses of the animal model for screening for or testing compounds for treating or preventing diabetes symptoms. The invention further relates to an assay for determining an individual's susceptibility to developing diabetes. The invention also relates to nucleic acid molecules isolated from Ljungan virus a picornavirus and to polypeptides encoded by any portion of said nucleic acid molecule.

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