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1. 发明申请

WO1996014297A1 NOVEL LACTAM DERIVATIVES 审中-公开
标题翻译：新型乳糖衍生物
公开(公告)号：WO1996014297A1
公开(公告)日：1996-05-17
申请号：PCT/JP1995002256
申请日：1995-11-06
申请人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED , KOJIMA, Atsuyuki , ANTOKU, Fujio , YOSHIGI, Mayumi , TANNO, Norihiko , NISHIHARA, Toshio , TOYODA, Tomohiro , OHNO, Yukihiro
发明人： SUMITOMO PHARMACEUTICALS COMPANY, LIMITED
IPC分类号： C07D209/46
CPC分类号： C07D401/06 , C07D209/48 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D493/08
摘要： A lactam derivative represented by general formula (A) or an acid-addition salt thereof, having excellent characteristics as a psychotropic drug, and being useful as a remedy for schizophrenia, senile psychosis, manic-depressive psychosis, neurosis, and so forth, wherein R , R , R and R represent each hydrogen or lower alkyl, provided a pair of R and R , R and R , R and R , or R and R may form a hydrocarbon ring which may be bridged with lower alkylene or oxygen, and the lower alkylene and the hydrocarbon ring may be substituted by at least one alkyl group; n represents 0 or 1; A represents lower alkylene, lower alkenylene or a hydrocarbon ring which may be bridged with lower alkylene (which may be substituted by at least one alkyl or hydroxy group) or oxygen, and the lower alkylene, the lower alkenylene and the hydrocarbon ring may be each substituted by at least one alkyl or hydroxy group; p and q represent each 0, 1 or 2; and G represents N or CH and Ar represents a heteroaryl or aromatic hydrocarbon group, or alternatively G represents CH and Ar represents phenoxy, provided the heteroaryl group, the aromatic hydrocarbon group and the phenoxy group may be each substituted by at least one lower alkyl, lower alkoxy or halogeno.
摘要翻译：由通式（A）表示的内酰胺衍生物或其酸加成盐作为精神药物具有优异的特性，可用作精神分裂症，老年性精神病，躁狂抑郁性精神病，神经症等的补救剂，其中 R 1，R 2，R 3和R 4各自代表氢或低级烷基，只要一对R 1和R 2，R 3和R 4， R 1和R 3，或R 2和R 4可以形成可以与低级亚烷基或氧桥连的烃环，并且低级亚烷基和烃环可以被至少一个烷基; n表示0或1; A代表低级亚烷基，低级亚烯基或可与低级亚烷基（可被至少一个烷基或羟基取代）或氧键连接的烃环，低级亚烷基，低级亚烯基和烃环可以各自独立地被至少一个烷基或羟基取代; p和q分别代表0,1或2; 并且G表示N或CH，Ar表示杂芳基或芳族烃基，或者G表示CH，Ar表示苯氧基，条件是杂芳基，芳香族烃基和苯氧基可以各自被至少一个低级烷基，低级烷氧基或卤代。

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