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1. 发明公开

EP0907371A1 A SYNTHETIC PEPTIDE AND ITS USES 失效
标题翻译：合成肽及其用途
公开(公告)号：EP0907371A1
公开(公告)日：1999-04-14
申请号：EP97917164.0
申请日：1997-04-04
申请人： ANDERSON, Byron E. , Baumann, Michael, A. , Fryer, Jonathan, P.
发明人： ANDERSON, Byron E. , Baumann, Michael, A. , Fryer, Jonathan, P.
IPC分类号： A61K38 , C07K14 , G01N33
CPC分类号： G01N33/564 , A61K38/164 , A61K38/1709 , C07K14/31 , C07K14/472
摘要： The invention provides a fragment of C1q which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides a synthetic peptide comprising the sequence [SEQ ID NO 2]: Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala Thr or variants thereof capable of binding immunoglobulin. Like the C1q fragment, a plurality of the peptides can selectively bind immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. As a result of this property, the fragments and peptides are well-adapted for removing immune complexes and aggregated immunoglobulins from fluids containing monomeric immunoglobulin, and for detecting or quantitating immune complexes in such fluids. The invention also provides a binding material for removing immune complexes or aggregated immunoglobulins from a fluid. The binding material comprises plural binding peptides, the peptides being characterized in that a plurality of them selectively binds immune complexes and aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides methods of treating an inflammatory response and prolonging the survival of transplanted tissue.

2. 发明授权

EP0605627B1 IMMUNOASSAY FOR IDENTIFYING ALCOHOLICS AND MONITORING ALCOHOL CONSUMPTION 失效
标题翻译：抗体试验识别酗酒和监测酒精录音
公开(公告)号：EP0605627B1
公开(公告)日：1999-05-19
申请号：EP92921176.1
申请日：1992-09-25
申请人： MAKHLOUF, Samar , Pankow, Mark Lee , ANDERSON, Byron E. , BEAN, Pamela
发明人： MAKHLOUF, Samar , Pankow, Mark Lee , ANDERSON, Byron E. , BEAN, Pamela
IPC分类号： C12P21/08 , C12N5/20 , G01N33/53 , G01N33/577
CPC分类号： G01N33/68 , C07K14/79 , C07K16/18 , Y10S436/811
摘要： The invention provides an antibody which reacts selectively with a transferrin homolog found in alcoholics but in non-alcoholics. The invention also provides methods of making the antibody and hybridomas producing the antibody. Finally, the invention provides an immunoassay which utilizes the antibody to detect or quantitate the alcoholic transferrin homolog and a kit for an immunoassay which comprises a container of the antibody.

3. 发明授权

EP0411017B1 BINDING OF IMMUNE COMPLEXES BY MODIFIED FORMS OF C-REACTIVE PROTEIN 失效
标题翻译：免疫复合物由C反应蛋白修饰形式装订
公开(公告)号：EP0411017B1
公开(公告)日：1996-03-06
申请号：EP89904944.9
申请日：1989-03-31
申请人： POTEMPA, Lawrence A. , ANDERSON, Byron E.
发明人： POTEMPA, Lawrence A. , ANDERSON, Byron E.
IPC分类号： A61M1/14 , C07K1/00 , C07K16/06 , C07K16/18 , G01N33/566 , G01N33/564 , A61K39/385 , A61K39/395 , A61K35/12 , A61K38/00 , A61M1/36
CPC分类号： A61M1/3687
摘要： A method of binding aggregated immunoglobulin or immune complexes comprising contacting them with modified forms of C-reactive protein. The method may be employed for diagnostic and therapeutic purposes and to deplete fluids of aggregated immunoglobulin or immune complexes. Further, a method of reducing the levels of immune complexes in a mammal comprising administering modified-CRP to the mammal, and a method of binding immunoglobulins comprising contacting them with modified C-reactive protein. Also, a method of binding aggregated immunoglobulin or immune complexes comprising contacting them with antibody to neo-CRP, and a method of modifying C-reactive protein. Finally, a test kit for detecting or quantitating immune complexes and a device for removing aggregated immunoglobulin or immune complexes from fluids are disclosed.

4. 发明公开

EP0605627A4 IMMUNOASSAY FOR IDENTIFYING ALCOHOLICS AND MONITORING ALCOHOL CONSUMPTION. 失效
标题翻译：抗体试验识别酗酒和监测酒精录制。
公开(公告)号：EP0605627A4
公开(公告)日：1995-03-29
申请号：EP92921176
申请日：1992-09-25
申请人： MAKHLOUF SAMAR , PANKOW MARK LEE , ANDERSON BYRON E , BEAN PAMELA
发明人： MAKHLOUF SAMAR , PANKOW MARK LEE , ANDERSON BYRON E , BEAN PAMELA
IPC分类号： C07K7/08 , C07K14/79 , C07K16/00 , C07K16/18 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/68 , C07K15/00 , C07K15/28 , C12N5/18 , G01N33/545 , G01N33/577
CPC分类号： G01N33/68 , C07K14/79 , C07K16/18 , Y10S436/811

5. 发明公开

EP0605627A1 IMMUNOASSAY FOR IDENTIFYING ALCOHOLICS AND MONITORING ALCOHOL CONSUMPTION 失效
标题翻译：抗体试验识别酗酒和监测酒精录制。
公开(公告)号：EP0605627A1
公开(公告)日：1994-07-13
申请号：EP92921176.0
申请日：1992-09-25
申请人： MAKHLOUF, Samar , Pankow, Mark Lee , ANDERSON, Byron E. , BEAN, Pamela
发明人： MAKHLOUF, Samar , Pankow, Mark Lee , ANDERSON, Byron E. , BEAN, Pamela
IPC分类号： C07K7 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , G01N33 , C12R1
CPC分类号： G01N33/68 , C07K14/79 , C07K16/18 , Y10S436/811
摘要： L'invention décrit un anticorps qui réagit sélectivement avec un homologue de la transferrine que l'on trouve chez les alcooliques mais pas chez ceux qui ne le sont pas. L'invention décrit également des procédés pour fabriquer un anticorps et des hybridomes produisant ce dernier. Enfin, l'invention décrit un dosage immunologique qui utilise l'anticorps pour détecter ou quantifier l'homologue de la transferrine chez les alcooliques, ainsi qu'une trousse de dosage immunologique contenant un conditionnement de l'anticorps.

6. 发明公开

EP0411017A4 BINDING OF IMMUNE COMPLEXES BY MODIFIED FORMS OF C-REACTIVE PROTEIN 失效
标题翻译：通过修饰C反应蛋白的形式结合免疫复合物
公开(公告)号：EP0411017A4
公开(公告)日：1991-11-21
申请号：EP89904944
申请日：1989-03-31
申请人： POTEMPA, LAWRENCE A. , ANDERSON, BYRON E.
发明人： POTEMPA, LAWRENCE A. , ANDERSON, BYRON E.
IPC分类号： A61M1/36 , A61M1/14 , C07K3/00 , C07K3/12 , C07K15/06 , G01N33/564 , G01N33/566
CPC分类号： A61M1/3687
摘要： A method of binding aggregated immunoglobulin or immune complexes comprising contacting them with modified forms of C-reactive protein. The method may be employed for diagnostic and therapeutic purposes and to deplete fluids of aggregated immunoglobulin or immune complexes. Further, a method of reducing the levels of immune complexes in a mammal comprising administering modified-CRP to the mammal, and a method of binding immunoglobulins comprising contacting them with modified C-reactive protein. Also, a method of binding aggregated immunoglobulin or immune complexes comprising contacting them with antibody to neo-CRP, and a method of modifying C-reactive protein. Finally, a test kit for detecting or quantitating immune complexes and a device for removing aggregated immunoglobulin or immune complexes from fluids are disclosed.

7. 发明公开

EP0411017A1 BINDING OF IMMUNE COMPLEXES BY MODIFIED FORMS OF C-REACTIVE PROTEIN 失效
标题翻译：免疫复合物由C反应蛋白修饰形式约束力。
公开(公告)号：EP0411017A1
公开(公告)日：1991-02-06
申请号：EP89904944.0
申请日：1989-03-31
申请人： POTEMPA, Lawrence A. , ANDERSON, Byron E.
发明人： POTEMPA, Lawrence A. , ANDERSON, Byron E.
IPC分类号： A61M1
CPC分类号： A61M1/3687
摘要： On a mis au point un procédé de liaison d'immunoglobuline agrégée ou de complexes immuns consistant à les mettre en contact avec des formes modifiées de protéine C-réactive (CRP). On peut employer le procédé à des fins diagnostiques ou thérapeutiques et pour appauvrir des fluides d'immunoglobuline agrégée ou de complexes immuns. On a également mis au point un procédé de réduction des niveaux de complexes immuns chez un mammifère, consistant à lui administrer une CRP modifiée, et un procédé de liaison d'immunoglobulines consistant à les mettre en contact avec ladite protéine C-réactive modifiée. On a en outre mis au point un procédé de liaison d'immunoglobuline agrégée ou de complexes immuns, consistant à les mettre en contact avec des anticorps contre la néo-CRP. Enfin, l'invention concerne un kit de test permettant de détecter ou de quantifier des complexes immuns ainsi qu'un dispositif permettant d'extraire l'immunoglobuline agrégée ou les complexes immuns de fluides.

8. 发明专利

CA2119651A1 IMMUNOASSAY FOR IDENTIFYING ALCOHOLICS AND MONITORING ALCOHOL CONSUMPTION 未知
公开(公告)号：CA2119651A1
公开(公告)日：1993-04-01
申请号：CA2119651
申请日：1992-09-25
申请人： BEAN PAMELA , ANDERSON BYRON E , PANKOW MARK L , MAKHLOUF SAMAR
发明人： BEAN PAMELA , ANDERSON BYRON E , PANKOW MARK L , MAKHLOUF SAMAR
IPC分类号： C07K7/08 , C07K14/79 , C07K16/00 , C07K16/18 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/68 , C12N5/18 , A61K39/395 , G01N33/543 , G01N33/577 , G01N33/98
摘要： The invention provides an antibody which reacts selectively with a transferrin homolog found in alcoholics but not in non-alcoholics. The invention also provides methods of making the antibody and hybridomas producing the antibody. Finally, the invention provides an immunoassay which utilizes the antibody to detect or quantitate the alcoholic transferrin homolog and a kit for an immunoassay which comprises a container of the antibody.

9. 发明申请

WO1997037677A1 A SYNTHETIC PEPTIDE AND ITS USES 审中-公开
标题翻译：合成肽及其用途
公开(公告)号：WO1997037677A1
公开(公告)日：1997-10-16
申请号：PCT/US1997005638
申请日：1997-04-04
申请人： ANDERSON, Byron, E. , BAUMANN, Michael, A. , FRYER, Jonathan, P.
IPC分类号： A61K38/10
CPC分类号： G01N33/564 , A61K38/164 , A61K38/1709 , C07K14/31 , C07K14/472
摘要： The invention provides a fragment of C1q which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides a synthetic peptide comprising the sequence [SEQ ID NO 2]: Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala Thr or variants thereof capable of binding immunoglobulin. Like the C1q fragment, a plurality of the peptides can selectively bind immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. As a result of this property, the fragments and peptides are well-adapted for removing immune complexes and aggregated immunoglobulins from fluids containing monomeric immunoglobulin, and for detecting or quantitating immune complexes in such fluids. The invention also provides a binding material for removing immune complexes or aggregated immunoglobulins from a fluid. The binding material comprises plural binding peptides, the peptides being characterized in that a plurality of them selectively binds immune complexes and aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides methods of treating an inflammatory response and prolonging the survival of transplanted tissue.
摘要翻译：本发明提供C1q的片段，其特征在于多个这样的片段在单体免疫球蛋白存在下选择性结合免疫复合物或聚集的免疫球蛋白。本发明还提供了包含序列[SEQ ID NO 2]：Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala Thr或能够结合免疫球蛋白的变体的合成肽。与C1q片段一样，多个肽可以在单体免疫球蛋白存在下选择性地结合免疫复合物或聚集的免疫球蛋白。作为该性质的结果，片段和肽适合于从含有单体免疫球蛋白的流体中除去免疫复合物和聚集的免疫球蛋白，并用于检测或定量这些流体中的免疫复合物。本发明还提供了用于从流体中除去免疫复合物或聚集的免疫球蛋白的结合材料。所述结合材料包含多个结合肽，所述肽的特征在于其多个在单体免疫球蛋白存在下选择性结合免疫复合物和聚集的免疫球蛋白。本发明还提供了治疗炎症反应并延长移植组织存活的方法。

10. 发明申请

WO1989009628A1 BINDING OF IMMUNE COMPLEXES BY MODIFIED FORMS OF C-REACTIVE PROTEIN 审中-公开
标题翻译：通过修饰C反应蛋白的形式结合免疫复合物
公开(公告)号：WO1989009628A1
公开(公告)日：1989-10-19
申请号：PCT/US1989001247
申请日：1989-03-31
申请人： POTEMPA, Lawrence, A. , ANDERSON, Byron, E.
IPC分类号： A61M01/14
CPC分类号： A61M1/3687
摘要： A method of binding aggregated immunoglobulin or immune complexes comprising contacting them with modified forms of C-reactive protein. The method may be employed for diagnostic and therapeutic purposes and to deplete fluids of aggregated immunoglobulin or immune complexes. Further, a method of reducing the levels of immune complexes in a mammal comprising administering modified-CRP to the mammal, and a method of binding immunoglobulins comprising contacting them with modified C-reactive protein. Also, a method of binding aggregated immunoglobulin or immune complexes comprising contacting them with antibody to neo-CRP, and a method of modifying C-reactive protein. Finally, a test kit for detecting or quantitating immune complexes and a device for removing aggregated immunoglobulin or immune complexes from fluids are disclosed.
摘要翻译：结合聚集的免疫球蛋白或免疫复合物的方法，包括将它们与修饰形式的C-反应蛋白接触。该方法可用于诊断和治疗目的并且消耗聚集的免疫球蛋白或免疫复合物的流体。此外，降低哺乳动物免疫复合物水平的方法包括向哺乳动物施用修饰的CRP，以及结合免疫球蛋白的方法，包括将它们与修饰的C-反应蛋白接触。另外，结合聚集的免疫球蛋白或免疫复合物的方法包括使它们与抗-CRP的抗体接触，以及一种修饰C反应蛋白的方法。最后，公开了用于检测或定量免疫复合物的测试试剂盒和用于从流体中去除聚集的免疫球蛋白或免疫复合物的装置。

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