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1. 发明专利

CA2153551A1 ASPARTYLDIPEPTIDE DERIVATIVES AND SWEETENER 未知
公开(公告)号：CA2153551A1
公开(公告)日：1996-01-09
申请号：CA2153551
申请日：1995-07-10
申请人： TAKEMOTO TADASHI , AMINO YUSUKE , NAKAMURA RYOICHIRO
发明人： TAKEMOTO TADASHI , AMINO YUSUKE , NAKAMURA RYOICHIRO
IPC分类号： A23L27/30 , C07K5/072 , C07K5/075 , A23L1/236
摘要： The invention is concerned with novel aspartyldipeptide derivatives of the general formula (I): L-Asp-X-NH-C*HR1R2 (I) wherein R1 represents an alkyl group having from 1 to 6 carbon atoms or an alkoxymethyl group having from 2 to 7 carbon atoms; R2 represents a phenyl group, a benzyl group, a cyclohexyl group or a cyclohexylmethyl group; the structure having the C* atom being of (S) form when R1 is an alkyl group or of (R) form when R1 is an alkoxymethyl group; X represents a residue of a D-.alpha.-amino acid or DL-.alpha.-amino acid, or a residue of a cyclic or acyclic .alpha.,.alpha.-dialkylamino acid having from 3 to 6 carbon atoms; the bond between L-Asp and X being an .alpha.-bond, and their salts. The compounds according to the invention are highly stable and safe and have a high sweetness potency.

2. 发明申请

WO2006088239A1 PRODUCTION METHOD OF CAPSINOID BY DEHYDRATING CONDENSATION, STABILIZING METHOD OF CAPSINOID, AND CAPSINOID COMPOSITION 审中-公开
标题翻译：通过脱水凝结，卡泊霉素稳定化方法和卡皮苷组合物生产氯氰菊酯的方法
公开(公告)号：WO2006088239A1
公开(公告)日：2006-08-24
申请号：PCT/JP2006/303343
申请日：2006-02-17
申请人： AJINOMOTO CO., INC. , AMINO, Yusuke , KUROSAWA, Wataru , NAKANO, Takashi , HIRASAWA, Kazuko
发明人： AMINO, Yusuke , KUROSAWA, Wataru , NAKANO, Takashi , HIRASAWA, Kazuko
IPC分类号： C07C67/08 , C07C67/62 , C07C69/28
CPC分类号： C07C67/62 , C12P7/62 , C12P7/6418 , C12P7/6436 , C07C69/28
摘要： In the production methods of capsinoid by esterification using an enzyme, a method of conveniently obtaining capsinoid in a high yield in a short time without using a dehydrating agent is provided. In addition, a method of stable preservation of produced capsinoid by purifying the obtained capsinoid under stable conditions is provided. A fatty acid represented by the formula (1) and a hydroxymethylphenol represented by the formula (2) are condensed without solvent or in a low-polar solvent, using an enzyme as a catalyst to give an ester compound represented by the formula (3). In addition, a fatty acid represented by the formula (4) is added to the ester compound represented by the formula (3) for stabilization. wherein each symbol is as defined in the specification.
摘要翻译：在通过使用酶的酯化的制毒方法中，提供了在不使用脱水剂的情况下在短时间内以高产率方便地获得辣椒素的方法。此外，提供了通过在稳定条件下纯化获得的辣椒素来稳定保存所产生的辣椒素的方法。由式（1）表示的脂肪酸和由式（2）表示的羟甲基苯酚在无溶剂的情况下或在低极性溶剂中使用酶作为催化剂进行缩合，得到式（3）表示的酯化合物，。此外，将由式（4）表示的脂肪酸加入由式（3）表示的酯化合物中用于稳定化。其中每个符号如说明书中所定义。

3. 发明申请

WO2007055388A3 CALCIUM RECEPTOR ACTIVATOR 审中-公开
标题翻译：钙受体激活剂
公开(公告)号：WO2007055388A3
公开(公告)日：2007-09-27
申请号：PCT/JP2006322684
申请日：2006-11-08
申请人： AJINOMOTO KK , OHSU TAKEAKI , TAKESHITA SEN , ETO YUZURU , AMINO YUSUKE
发明人： OHSU TAKEAKI , TAKESHITA SEN , ETO YUZURU , AMINO YUSUKE
IPC分类号： A61K31/198 , A61K38/05 , A61K38/06 , C07K5/06 , C07K5/08 , G01N33/566
CPC分类号： A61K38/06 , A61K38/05
摘要： A calcium receptor activator containing one or more kinds of substances selected from Á-Glu-Cys-Gly, Á-Glu-Cys(SNO)-Gly, Á-Glu-Ala, Á-Glu-Gly, Á-Glu-Cys, Á-Glu-Met, Á-Glu-Thr, Á-Glu-Val, Á-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, D-Cys, Á-Glu-Met(O), Á-Glu-Val-Val, Á-Glu-Val-Glu, Á-Glu-Val-Lys, Á-Glu- Á-Glu-Val, Á-Glu-Val-NH2, Á-Glu-Val-ol, Á-Glu-Ser, Á-Glu-Tau, Á-Glu-Cys(S-Me)(O), Á-Glu-Leu, Á-Glu-Ile, Á-Glu-t-Leu, Á-Glu-Cys(S-allyl)-Gly, Á-Glu-Gly-Gly, Á-Glu-Val-Phe, Á-Glu-Val-Ser, Á-Glu-Val-Pro, Á-Glu-Val-Arg, Á-Glu-Val-Asp, Á-Glu-Val-Met, Á-Glu-Val-Thr, Á-Glu-Val-His, Á-Glu-Val-Asn,Á-Glu-Val-Gln, Á-Glu-Val-Cys, Á-Glu-Val-Orn, Á-Glu-Ser-Gly, Á-Glu-Cys(S-Me), Á-Glu-Abu-Gly, Á-Glu-Cys(S-Me)-Gly, and Á-Glu-Val-Gly.
摘要翻译：含有一种或多种选自Á-Glu-Cys-Gly，Á-Glu-Cys（SNO）-Gly，Á-Glu-Ala，Á-Glu-Gly，Á-Glu-Cys， Á-Glu-Met，Á-Glu-Thr，Á-Glu-Val，Á-Glu-Orn，Asp-Gly，Cys-Gly，Cys-Met，Glu-Cys，Gly-Cys，Leu-Asp， Cys，Á-Glu-Met（O），Á-Glu-Val-Val，Á-Glu-Val-Glu，Á-Glu-Val-Lys，Á-Glu-Á-Glu-Val， -NH 2，-Gal-Val-ol，-Glu-Ser，-Glu-Tau，-Glu-Cys（S-Me）（O），-Gly-Leu，-Glu-Ile， -Glu-t-Leu，Glu-Cys（S-烯丙基）-Gly，-Gly-Gly-Gly，-Glu-Val-Phe，-Gly-Val-Ser，-Gly-Val- Pro-Ala-Glu-Val-Arg，Glu-Val-Asp，-Glu-Val-Met，-Glu-Val-Thr，-Gly-Val-His， Á-Glu-Val-Gln，Á-Glu-Val-Cys，Á-Glu-Val-Orn，-Glu-Ser-Gly，-Gly-Cys（S-Me），Á-Glu-Abu-Gly ，Á-Glu-Cys（S-Me）-Gly和Á-Glu-Val-Gly。

4. 发明申请

WO2007052837A1 GASTROINTESTINAL FUNCTION PROMOTER 审中-公开
标题翻译：胃肠功能促进剂
公开(公告)号：WO2007052837A1
公开(公告)日：2007-05-10
申请号：PCT/JP2006/322411
申请日：2006-11-02
申请人： AJINOMOTO CO., INC. , TANAKA, Tatsuro , UNEYAMA, Hisayuki , FUJITA, Shinichi , OGAWA, Saori , AMINO, Yusuke
发明人： TANAKA, Tatsuro , UNEYAMA, Hisayuki , FUJITA, Shinichi , OGAWA, Saori , AMINO, Yusuke
IPC分类号： A61K45/00 , A23L1/30 , A61K31/165 , A61K31/166 , A61K31/343 , A61K31/36 , A61P1/00 , A61P1/14 , C07D307/85 , C07D317/68
CPC分类号： A61K31/36 , A23L33/10 , A61K31/165 , A61K31/166 , A61K31/343
摘要： The present invention aims at providing a more effective gastrointestinal function promoter, specifically, an agent for the prophylaxis or improvement of functional gastrointestinal disorders, appetite regulator and the like, and also a screening method for a substance capable of promoting a gastrointestinal function. The present invention provides a gastrointestinal function promoter containing a T1R agonist as an active ingredient and a method of screening for a substance capable of promoting a gastrointestinal function which method uses a cell expressing T1R receptor.
摘要翻译：本发明的目的在于提供一种更有效的胃肠功能促进剂，特别是用于预防或改善功能性胃肠道疾病，食欲调节剂等的药剂，以及能够促进胃肠功能的物质的筛选方法。本发明提供含有T1R激动剂作为活性成分的胃肠功能促进剂，以及筛选能够促进胃肠功能的方法的方法，该方法使用表达T1R受体的细胞。

5. 发明申请

WO2007055393A1 KOKUMI-IMPARTING AGENT 审中-公开
公开(公告)号：WO2007055393A1
公开(公告)日：2007-05-18
申请号：PCT/JP2006/322694
申请日：2006-11-08
申请人： AJINOMOTO CO., INC. , OHSU, Takeaki , TAKESHITA, Sen , ETO, Yuzuru , AMINO, Yusuke , MIYAMURA, Naohiro , YAMANAKA, Tomohiko , NAGASAKI, Hiroaki
发明人： OHSU, Takeaki , TAKESHITA, Sen , ETO, Yuzuru , AMINO, Yusuke , MIYAMURA, Naohiro , YAMANAKA, Tomohiko , NAGASAKI, Hiroaki
IPC分类号： G01N33/566 , C07K5/00 , A23L1/48
CPC分类号： G01N33/6872 , A23L27/10 , A23L33/175 , C07K5/0215 , G01N2333/726
摘要： A method for screening for a kokumi-imparting substance, which utilizes calcium receptor activity as an index, a kokumi-imparting agent containing a kokumi-imparting substance obtained by the screening method as an active ingredient, a method for producing food or drink such as food, seasoning, and drink imparted with kokumi, and food or drink imparted with kokumi.
摘要翻译：以使用钙受体活性为指标的kokumi赋予物质的筛选方法，含有通过筛选方法得到的赋予口味的物质作为活性成分的赋粉剂，生产食品或饮料的方法如食物，调味料和饮料，配以kokumi，以及送给kokumi的食物或饮料。

6. 发明申请

WO2007055388A2 CALCIUM RECEPTOR ACTIVATOR 审中-公开
标题翻译：钙受体激活剂
公开(公告)号：WO2007055388A2
公开(公告)日：2007-05-18
申请号：PCT/JP2006/322684
申请日：2006-11-08
申请人： AJINOMOTO CO., INC. , OHSU, Takeaki , TAKESHITA, Sen , ETO, Yuzuru , AMINO, Yusuke
发明人： OHSU, Takeaki , TAKESHITA, Sen , ETO, Yuzuru , AMINO, Yusuke
IPC分类号： A61K31/198 , A61K38/05 , A61K38/06 , C07K5/06 , C07K5/08 , G01N33/566
CPC分类号： A61K38/06 , A61K38/05
摘要： A calcium receptor activator containing one or more kinds of substances selected from Á-Glu-Cys-Gly, Á-Glu-Cys(SNO)-Gly, Á-Glu-Ala, Á-Glu-Gly, Á-Glu-Cys, Á-Glu-Met, Á-Glu-Thr, Á-Glu-Val, Á-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, D-Cys, Á-Glu-Met(O), Á-Glu-Val-Val, Á-Glu-Val-Glu, Á-Glu-Val-Lys, Á-Glu- Á-Glu-Val, Á-Glu-Val-NH2, Á-Glu-Val-ol, Á-Glu-Ser, Á-Glu-Tau, Á-Glu-Cys(S-Me)(O), Á-Glu-Leu, Á-Glu-Ile, Á-Glu-t-Leu, Á-Glu-Cys(S-allyl)-Gly, Á-Glu-Gly-Gly, Á-Glu-Val-Phe, Á-Glu-Val-Ser, Á-Glu-Val-Pro, Á-Glu-Val-Arg, Á-Glu-Val-Asp, Á-Glu-Val-Met, Á-Glu-Val-Thr, Á-Glu-Val-His, Á-Glu-Val-Asn,Á-Glu-Val-Gln, Á-Glu-Val-Cys, Á-Glu-Val-Orn, Á-Glu-Ser-Gly, Á-Glu-Cys(S-Me), Á-Glu-Abu-Gly, Á-Glu-Cys(S-Me)-Gly, and Á-Glu-Val-Gly.
摘要翻译：含有一种或多种选自＆Aacute; -Glu-Cys-Gly，＆Aacute; -Glu-Cys（SNO）-Gly，＆Aacute; -Glu-Ala，＆Aacute的物质的钙受体激活剂 ; -Glu-Gly，和Aacute; -Glu-Cys，和Aacute; -Glu-Met和Aacute; -Glu-Thr和Aacute; -Glu-Val和Aacute; -Glu-Orn，Asp-Gly，Cys-Gly，Cys Glu，Cys，Gly-Cys，Leu-Asp，D-Cys，Aacute; -Glu-Met（O），Aacute; -Glu-Val-Val，Aacute; -Glu-Val-Glu，Aacute; - Glu-Val-Lys，Aacute; -Glu-和Aacute; -Glu-Val，Aacute; -Glu-Val-NH 2，Aacute; -Glu-Val-ol，Aacute; -Glu-Ser，＆Aacute; -Glu-Tau，＆Aacute; -Glu-Cys（S-Me）（O），Aacute; -Glu-Leu，Aacute; -Glu-Ile，Aacute; -Glu-t-Leu，Aacute; -Glu-Cys（S-烯丙基） - Gly，Aacute; -Glu-Gly-Gly，Aacute; -Glu-Val-Phe，Aacute; -Glu-Val-Ser，Aacute; -Glu-Val-Pro，Aacute; -Glu-Val-Arg，Aacute; - Glu-Val-Asp，Aacute; -Glu-Val-Met，Aacute; -Glu-Val-Thr，Aacute; -Glu-Val-His，Aacute; -Glu-Val-Asn，Aacute; -Glu-Val-Gln ，Aacute; -Glu-Val-Cys，Aacute; -Glu-Val-Orn，Aacute; -Glu-Ser-Gly，Aacute; -Glu-Cys（S-Me），Aacute; -Glu-Abu-Gly，＆Aacute; -Glu-Cys（S-Me）-Gly和＆Aacute; -Glu-Val-Gly。

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