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    • 2. 发明申请
    • METHODS OF MODULATING AN IMMUNE RESPONSE TO A VIRAL INFECTION
    • 调节对病毒感染的免疫应答的方法
    • WO2010120524A3
    • 2010-12-09
    • PCT/US2010029408
    • 2010-03-31
    • ALTAIR THERAPEUTICS INCISIS PHARMACEUTICALS INCGREGORY SUSANKARRAS JAMES GCROSBY JEFFREY RYU ZHENGRONGGEARY RICHARD S
    • GREGORY SUSANKARRAS JAMES GCROSBY JEFFREY RYU ZHENGRONGGEARY RICHARD S
    • C12N15/113A61K48/00C07K14/715
    • C07K14/7155C12N15/1138C12N2310/11C12N2310/315C12N2310/321C12N2310/3341C12N2310/341C12N2310/346C12N2310/3525
    • Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4Ra. Provided herein, for example, are compositions and methods of modulating immune responses to a viral infection in a subject. Also provided, for example, are compositions and methods for managing, treating, ameliorating, preventing and/or delaying the onset of pulmonary inflammation, airway hyperreactivity and/or loss of lung function, or a symptom thereof in a subject during the course of or resulting from a viral infection. Further provided, for example, are compositions and methods of inducing or augmenting hypo-responsiveness, non-responsiveness or tolerance to a virus in a subject. Also provided, for example, are compositions and methods of enhancing the efficacy of a viral vaccine in a subject. In certain embodiments, the compositions and methods provided herein utilize an antisense compound 12 to 35 nucleobases in length targeted to a nucleic acid molecule encoding human IL-4 receptor alpha IL-4Ra, wherein said antisense compound inhibits expression of human IL-4Ra protein and/or expression of functional IL-4 and IL- 13 receptors.
    • 本文公开了通过施用靶向IL-4Ra的反义化合物来治疗呼吸系统疾病的方法。 例如,本文提供调节受试者中病毒感染的免疫应答的组合物和方法。 还提供了例如用于在过程中管理,治疗,改善,预防和/或延迟受试者的肺部炎症发作,气道高反应性和/或肺功能丧失或其症状的组合物和方法, 由病毒感染引起。 进一步提供的是例如诱导或增加受试者中对病毒的低反应性,非反应性或耐受性的组合物和方法。 还提供了例如增强受试者中病毒疫苗功效的组合物和方法。 在某些实施方案中,本文提供的组合物和方法利用长度为靶向编码人IL-4受体α-IL-4Ra的核酸分子的反义化合物12至35个核碱基,其中所述反义化合物抑制人IL-4Ra蛋白的表达和 /或功能性IL-4和IL-13受体的表达。