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1. 发明申请

WO2010120524A2 METHODS OF MODULATING AN IMMUNE RESPONSE TO A VIRAL INFECTION 审中-公开
标题翻译：调节对病毒感染的免疫应答的方法
公开(公告)号：WO2010120524A2
公开(公告)日：2010-10-21
申请号：PCT/US2010/029408
申请日：2010-03-31
申请人： ALTAIR THERAPEUTICS, INC. , ISIS PHARMACEUTICALS, INC. , GREGORY, Susan , KARRAS, James, G. , CROSBY, Jeffrey, R. , YU, Zhengrong , GEARY, Richard, S.
发明人： GREGORY, Susan , KARRAS, James, G. , CROSBY, Jeffrey, R. , YU, Zhengrong , GEARY, Richard, S.
IPC分类号： C12N15/113 , C07K14/715 , A61K48/00
CPC分类号： C07K14/7155 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4Rα. Provided herein, for example, are compositions and methods of modulating immune responses to a viral infection in a subject. Also provided, for example, are compositions and methods for managing, treating, ameliorating, preventing and/or delaying the onset of pulmonary inflammation, airway hyperreactivity and/or loss of lung function, or a symptom thereof in a subject during the course of or resulting from a viral infection. Further provided, for example, are compositions and methods of inducing or augmenting hypo-responsiveness, non-responsiveness or tolerance to a virus in a subject. Also provided, for example, are compositions and methods of enhancing the efficacy of a viral vaccine in a subject. In certain embodiments, the compositions and methods provided herein utilize an antisense compound 12 to 35 nucleobases in length targeted to a nucleic acid molecule encoding human IL-4 receptor alpha IL-4Rα, wherein said antisense compound inhibits expression of human IL-4Rα protein and/or expression of functional IL-4 and IL- 13 receptors.
摘要翻译：本文公开了通过施用靶向IL-4Rα的反义化合物来治疗呼吸病症的方法。例如，本文提供了调节受试者对病毒感染的免疫应答的组合物和方法。例如，还提供了组合物和方法，所述组合物和方法用于在患者的过程期间管理，治疗，改善，预防和/或延迟肺部炎症发作，气道高反应性和/或肺功能丧失或其症状，由病毒感染引起。例如，进一步提供了诱导或增强对象中病毒的低反应性，无反应性或耐受性的组合物和方法。例如，还提供了增强病人疫苗在受试者中的功效的组合物和方法。在某些实施方案中，本文提供的组合物和方法利用靶向编码人IL-4受体αIL-4Rα的核酸分子长度为12至35个核碱基的反义化合物，其中所述反义化合物抑制人IL-4Rα蛋白的表达并且 /或功能性IL-4和IL-13受体的表达。

2. 发明申请

WO2010120524A3 METHODS OF MODULATING AN IMMUNE RESPONSE TO A VIRAL INFECTION 审中-公开
标题翻译：调节对病毒感染的免疫应答的方法
公开(公告)号：WO2010120524A3
公开(公告)日：2010-12-09
申请号：PCT/US2010029408
申请日：2010-03-31
申请人： ALTAIR THERAPEUTICS INC , ISIS PHARMACEUTICALS INC , GREGORY SUSAN , KARRAS JAMES G , CROSBY JEFFREY R , YU ZHENGRONG , GEARY RICHARD S
发明人： GREGORY SUSAN , KARRAS JAMES G , CROSBY JEFFREY R , YU ZHENGRONG , GEARY RICHARD S
IPC分类号： C12N15/113 , A61K48/00 , C07K14/715
CPC分类号： C07K14/7155 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4Ra. Provided herein, for example, are compositions and methods of modulating immune responses to a viral infection in a subject. Also provided, for example, are compositions and methods for managing, treating, ameliorating, preventing and/or delaying the onset of pulmonary inflammation, airway hyperreactivity and/or loss of lung function, or a symptom thereof in a subject during the course of or resulting from a viral infection. Further provided, for example, are compositions and methods of inducing or augmenting hypo-responsiveness, non-responsiveness or tolerance to a virus in a subject. Also provided, for example, are compositions and methods of enhancing the efficacy of a viral vaccine in a subject. In certain embodiments, the compositions and methods provided herein utilize an antisense compound 12 to 35 nucleobases in length targeted to a nucleic acid molecule encoding human IL-4 receptor alpha IL-4Ra, wherein said antisense compound inhibits expression of human IL-4Ra protein and/or expression of functional IL-4 and IL- 13 receptors.
摘要翻译：本文公开了通过施用靶向IL-4Ra的反义化合物来治疗呼吸系统疾病的方法。例如，本文提供调节受试者中病毒感染的免疫应答的组合物和方法。还提供了例如用于在过程中管理，治疗，改善，预防和/或延迟受试者的肺部炎症发作，气道高反应性和/或肺功能丧失或其症状的组合物和方法，由病毒感染引起。进一步提供的是例如诱导或增加受试者中对病毒的低反应性，非反应性或耐受性的组合物和方法。还提供了例如增强受试者中病毒疫苗功效的组合物和方法。在某些实施方案中，本文提供的组合物和方法利用长度为靶向编码人IL-4受体α-IL-4Ra的核酸分子的反义化合物12至35个核碱基，其中所述反义化合物抑制人IL-4Ra蛋白的表达和 /或功能性IL-4和IL-13受体的表达。

3. 发明申请

WO2010120511A3 METHOD OF TREATING RESPIRATORY DISORDERS 审中-公开
公开(公告)号：WO2010120511A3
公开(公告)日：2010-10-21
申请号：PCT/US2010/029379
申请日：2010-03-31
申请人： ALTAIR THERAPEUTICS, INC. , ISIS PHARMACEUTICALS, INC. , GREGORY, Susan , KARRAS, James, G. , CROSBY, Jeffrey, R. , YU, Zhengrong , GEARY, Richard, S.
发明人： GREGORY, Susan , KARRAS, James, G. , CROSBY, Jeffrey, R. , YU, Zhengrong , GEARY, Richard, S.
IPC分类号： C12N15/113 , C07K14/715 , A61K48/00
摘要： Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4Rα. Provided herein, for example, are compositions and methods for managing, treating, ameliorating, preventing and/or delaying the onset of pulmonary inflammation, airway hyperreactivity and/or loss of lung function, or a symptom thereof in a subject. Further provided, for example, are compositions and methods of inducing or augmenting hypo-responsiveness, non-responsiveness or tolerance to an antigen in a subject. Also provided, for example, are compositions and methods of enhancing the efficacy of a vaccine in a subject. In certain embodiments, the compositions and methods provided herein utilize an antisense compound 12 to 35 nucleobases in length targeted to a nucleic acid molecule encoding human IL-4 receptor alpha IL-4Rα, wherein said antisense compound inhibits expression of human IL-4Rα protein and/or expression of functional IL-4 and IL- 13 receptors.

4. 发明申请

WO2010120511A2 METHOD OF TREATING RESPIRATORY DISORDERS 审中-公开
标题翻译：治疗呼吸系统疾病的方法
公开(公告)号：WO2010120511A2
公开(公告)日：2010-10-21
申请号：PCT/US2010029379
申请日：2010-03-31
申请人： ALTAIR THERAPEUTICS INC , ISIS PHARMACEUTICALS INC , GREGORY SUSAN , KARRAS JAMES G , CROSBY JEFFREY R , YU ZHENGRONG , GEARY RICHARD S
发明人： GREGORY SUSAN , KARRAS JAMES G , CROSBY JEFFREY R , YU ZHENGRONG , GEARY RICHARD S
IPC分类号： C12N15/113
CPC分类号： C07K14/7155 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4Ra. Provided herein, for example, are compositions and methods for managing, treating, ameliorating, preventing and/or delaying the onset of pulmonary inflammation, airway hyperreactivity and/or loss of lung function, or a symptom thereof in a subject. Further provided, for example, are compositions and methods of inducing or augmenting hypo-responsiveness, non-responsiveness or tolerance to an antigen in a subject. Also provided, for example, are compositions and methods of enhancing the efficacy of a vaccine in a subject. In certain embodiments, the compositions and methods provided herein utilize an antisense compound 12 to 35 nucleobases in length targeted to a nucleic acid molecule encoding human IL-4 receptor alpha IL-4Ra, wherein said antisense compound inhibits expression of human IL-4Ra protein and/or expression of functional IL-4 and IL- 13 receptors.
摘要翻译：本文公开了通过施用靶向IL-4Rα的反义化合物来治疗呼吸病症的方法。本文提供了例如用于控制，治疗，改善，预防和/或延迟受试者的肺部炎症，气道高反应性和/或肺功能丧失或其症状的发作的组合物和方法。例如，进一步提供了诱导或增强对象中抗原的低反应性，无反应性或耐受性的组合物和方法。例如，还提供了增强受试者中疫苗功效的组合物和方法。在某些实施方案中，本文提供的组合物和方法利用靶向编码人IL-4受体αIL-4Rα的核酸分子的长度为12至35个核碱基的反义化合物，其中所述反义化合物抑制人IL-4Rα蛋白的表达并且 /或功能性IL-4和IL-13受体的表达。

5. 发明公开

EP2414520A2 METHODS OF MODULATING AN IMMUNE RESPONSE TO A VIRAL INFECTION 审中-公开
标题翻译：调制免疫反应的方法，以病毒感染
公开(公告)号：EP2414520A2
公开(公告)日：2012-02-08
申请号：EP10712640.1
申请日：2010-03-31
申请人： Altair Therapeutics, Inc. , Isis Pharmaceuticals, Inc.
发明人： GREGORY, Susan , KARRAS, James, G. , CROSBY, Jeffrey, R. , YU, Zhengrong , GEARY, Richard, S.
IPC分类号： C12N15/113 , C07K14/715 , A61K48/00
CPC分类号： C07K14/7155 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4Rα. Provided herein, for example, are compositions and methods of modulating immune responses to a viral infection in a subject. Also provided, for example, are compositions and methods for managing, treating, ameliorating, preventing and/or delaying the onset of pulmonary inflammation, airway hyperreactivity and/or loss of lung function, or a symptom thereof in a subject during the course of or resulting from a viral infection. Further provided, for example, are compositions and methods of inducing or augmenting hypo-responsiveness, non-responsiveness or tolerance to a virus in a subject. Also provided, for example, are compositions and methods of enhancing the efficacy of a viral vaccine in a subject. In certain embodiments, the compositions and methods provided herein utilize an antisense compound 12 to 35 nucleobases in length targeted to a nucleic acid molecule encoding human IL-4 receptor alpha IL-4Rα, wherein said antisense compound inhibits expression of human IL-4Rα protein and/or expression of functional IL-4 and IL- 13 receptors.

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