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1. 发明专利

AU2003251604A1 VIRUSES AND VIRUS-LIKE PARTICLES FOR MULTIPLE ANTIGEN AND TARGET DISPLAY 未知
公开(公告)号：AU2003251604A1
公开(公告)日：2004-01-19
申请号：AU2003251604
申请日：2003-06-25
申请人： ALLNUTT F C THOMAS , KYLE DAVID J
发明人： ALLNUTT F C THOMAS , KYLE DAVID J
IPC分类号： A61K39/00 , A61K39/21 , A61K39/29 , C07K14/01 , C07K14/08 , C07K14/16 , C12N7/00 , C12N7/04
摘要： The present invention relates to the display of antigenic or allergenic components along with a tissue-targeting component on viruses or virus-like particles. Capsid protein genes are recombinantly modified to contain the specified components then expressed within a host organism, such as yeasts, bacteria, or algae, and allowed to spontaneously form active virus particles or virus-like particles. The recombinant complexes (virus or virus-like particle) can then be purified or used in situ as a therapeutic tool for disease or allergy prevention. The expression of multivalent and multifunctional components to increase the immunogenicity of the recombinant complexes, especially on oral administration, is provided.

2. 发明申请

WO2004003143A3 VIRUSES AND VIRUS-LIKE PARTICLES FOR MULTIPLE ANTIGEN AND TARGET DISPLAY 审中-公开
标题翻译：用于多重抗原和靶标显示的病毒和病毒样颗粒
公开(公告)号：WO2004003143A3
公开(公告)日：2004-07-08
申请号：PCT/US0319855
申请日：2003-06-25
申请人： ALLNUTT F C THOMAS , KYLE DAVID J
发明人： ALLNUTT F C THOMAS , KYLE DAVID J
IPC分类号： A61K39/00 , A61K39/21 , A61K39/29 , C07K14/01 , C07K14/08 , C07K14/16 , C12N7/00 , C12N7/04 , A61K48/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K39/292 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/542 , C07K2319/00 , C12N7/00 , C12N2720/10023 , C12N2720/10043 , C12N2720/10061 , C12N2720/10062 , C12N2720/12023 , C12N2730/10122 , C12N2730/10134 , C12N2740/16034 , C12N2740/16061 , C12N2770/22022 , C12N2770/22023 , C12N2770/22043 , C12N2770/32043 , C12N2810/854
摘要： The present invention relates to the display of antigenic or allergenic components along with a tissue-targeting component on viruses or virus-like particles. Capsid protein genes are recombinantly modified to contain the specified components, then expressed within a host organism, such as yeasts, bacteria, or algae, and allowed to spontaneously form active virus particles or virus-like particles. The recombinant complexes (virus or virus-like particle) can then be purified or used in situ as a therapeutic tool for disease or allergy prevention. The expression of multivalent and multifunctional components to increase the immunogenicity of the recombinant complexes, especially on oral administration, is provided.
摘要翻译：本发明涉及在病毒或病毒样颗粒上显示抗原或变应原组分以及组织靶向组分。将衣壳蛋白基因重组修饰以包含特定组分，然后在宿主生物如酵母，细菌或藻类内表达，并允许自发形成活性病毒颗粒或病毒样颗粒。然后可以将重组复合物（病毒或病毒样颗粒）纯化或原位用作疾病或过敏预防的治疗工具。提供了多价和多功能组分的表达以提高重组复合物的免疫原性，尤其是口服给药。

3. 发明申请

WO0196871A2 RECOMBINANT PHYCOBILIPROTEIN AND PHYCOBILIPROTEIN LINKER FUSION PROTEINS AND USES THEREFORE 审中-公开
标题翻译：重组蛋白和蛋白质连接蛋白融合蛋白及其用途
公开(公告)号：WO0196871A2
公开(公告)日：2001-12-20
申请号：PCT/US0119439
申请日：2001-06-18
申请人： MARTEK BIOSCIENCES CORP , ALLNUTT F C THOMAS , TOOLE COLLEEN M , MORSEMAN JOHN P
发明人： ALLNUTT F C THOMAS , TOOLE COLLEEN M , MORSEMAN JOHN P
IPC分类号： C07K14/195 , C07K14/405 , G01N33/533 , G01N33/542 , G01N33/53
CPC分类号： C07K14/195 , C07K14/405 , C07K2319/00 , G01N33/533 , G01N33/542
摘要： This invention is directed to the utilization of the developing methods for molecular manipulation of cyanobacteria and red algae (and potentially cryptomonad algae) to express of phycobiliproteins and phycobiliprotein linker fusion proteins and their utilization as phycobiliprotein, phycobilisome and subassembly based reagents. In particular, the present invention relates to a method for a specific binding assay to determine a target moiety which is a member of a specific binding pair, and provides an improvement in the method comprising using a detectable label which is a fusion protein containing both a phycobiliprotein domain and another domain corresponding to a first member of a specific binding pair, where the fusion protein binds to a second member of the specific binding pair to provide a detectable labeled complex. The domain derived from the first member of the specific binding pair can be directly fused to the phycobiliprotein or phycobiliprotein linker domain or be separated by a spacer that allows correct folding of both domains.
摘要翻译：本发明涉及利用蓝藻和红藻（和潜在的cryptomonad藻类）的分子操作的表达方法来表达藻胆蛋白和藻胆蛋白连接体融合蛋白，以及它们作为藻胆蛋白，藻糖酵母和基于组件的试剂的利用。特别地，本发明涉及用于确定作为特异性结合对成员的靶部分的特异性结合测定方法，并且提供了该方法的改进，该方法包括使用可检测标记，其是含有两者的融合蛋白藻类蛋白结构域和对应于特异性结合对的第一个成员的另一个结构域，其中融合蛋白与特异性结合对的第二个成员结合以提供可检测的标记复合物。衍生自特异性结合对的第一个成员的结构域可以直接融合到藻胆蛋白或藻胆蛋白连接体结构域，或者被允许正确折叠两个结构域的间隔物分离。

4. 发明专利

AU2003251604A8 Viruses and virus-like particles for multiple antigen and target display 未知
公开(公告)号：AU2003251604A8
公开(公告)日：2004-01-19
申请号：AU2003251604
申请日：2003-06-25
申请人： KYLE DAVID J , ADVANCED BIONUTRITION CORP , ALLNUTT F C THOMAS
发明人： ALLNUTT F C THOMAS , KYLE DAVID J
IPC分类号： A61K39/00 , A61K39/21 , A61K39/29 , C07K14/01 , C07K14/08 , C07K14/16 , C12N7/00 , C12N7/04 , A61K48/00
摘要： The present invention relates to the display of antigenic or allergenic components along with a tissue-targeting component on viruses or virus-like particles. Capsid protein genes are recombinantly modified to contain the specified components then expressed within a host organism, such as yeasts, bacteria, or algae, and allowed to spontaneously form active virus particles or virus-like particles. The recombinant complexes (virus or virus-like particle) can then be purified or used in situ as a therapeutic tool for disease or allergy prevention. The expression of multivalent and multifunctional components to increase the immunogenicity of the recombinant complexes, especially on oral administration, is provided.

5. 发明申请

WO2012109375A3 METHODS FOR IMPROVED MIXED TROPHIC ALGAL CULTURE 审中-公开
标题翻译：改进的混合动物阿尔法文化的方法
公开(公告)号：WO2012109375A3
公开(公告)日：2012-11-08
申请号：PCT/US2012024358
申请日：2012-02-08
申请人： PHYCAL INC , POSTIER BRADLEY LYNN , SWANSON ANDREW KEITH , ABAD MARK SCOTT , LAUDERDALE GEORGE WILLIAM , KESSLER BEN AMI , ALLNUTT F C THOMAS , PARK JONATHAN D , SPOO-CHUPKA MARGARET , SLOMCZYNSKI DAVID JOSEPH , KWIATKOWSKI JASON RICHARD
发明人： POSTIER BRADLEY LYNN , SWANSON ANDREW KEITH , ABAD MARK SCOTT , LAUDERDALE GEORGE WILLIAM , KESSLER BEN AMI , ALLNUTT F C THOMAS , PARK JONATHAN D , SPOO-CHUPKA MARGARET , SLOMCZYNSKI DAVID JOSEPH , KWIATKOWSKI JASON RICHARD
IPC分类号： C12P7/64
CPC分类号： A01G33/00 , C12N1/12 , C12P7/6463 , C12P39/00 , C12P2203/00 , Y02A40/88
摘要： The subject application is directed to methods, designs, and tools for improving the production of bioproducts from photosynthetic organisms using multiple trophic states in combination to achieve better production of a bioproduct or series of bioproducts. The subject applcation provides cost improvements with production of these bioproducts in a heterotrophic boost step in an enclosed bioreactor fed by a fixed carbon source as an intermediate within the production process.
摘要翻译：本申请涉及用于改善来自光合生物体的生物产物生产的方法，设计和工具，其使用多种营养状态组合以实现生物产物或一系列生物产品的更好的生产。受试者应用在生物过程中作为中间体的固定碳源进料的封闭式生物反应器中，在异养增强步骤中生产这些生物产物提供成本改进。

6. 发明申请

WO2004025263A2 PROTEIN AND PEPTIDE EXPRESSION FOR PASSIVE IMMUNITY 审中-公开
标题翻译：蛋白质和肽代表被动免疫
公开(公告)号：WO2004025263A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/028868
申请日：2003-09-15
申请人： ADVANCED BIONUTRITION CORPORATION , DHAR, Arun, Kumar , ALLNUTT, F., C., Thomas
发明人： DHAR, Arun, Kumar , ALLNUTT, F., C., Thomas
IPC分类号： G01N
CPC分类号： C12N15/8257 , A23K20/147 , A23L33/17 , A23L33/18 , A61K38/162 , A61K38/164 , A61K39/12 , A61K2039/517 , A61K2039/523 , A61K2039/542 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/8258 , C12N2710/18022 , C12N2710/18034 , C12N2720/10022 , C12N2720/10034 , C12N2770/22022 , C12N2770/22034
摘要： This invention relates to feeds, feed supplements, and methods for their use that provide disease controlling properties to humans, and terrestrial and aquatic animals. These methods and compositions have both acute and chronic applications. The chronic applications relate to the health of organisms that have primitive or poorly developed immune systems.
摘要翻译：本发明涉及为人类，陆生和水生动物提供疾病控制性质的饲料，饲料补充剂及其使用方法。这些方法和组合物都具有急性和慢性应用。慢性应用涉及具有原发性或发育不良的免疫系统的生物体的健康。

7. 发明申请

WO2004003143A2 VIRUSES AND VIRUS-LIKE PARTICLES FOR MULTIPLE ANTIGEN AND TARGET DISPLAY 审中-公开
标题翻译：用于多种抗原和靶标显示的病毒和病毒颗粒
公开(公告)号：WO2004003143A2
公开(公告)日：2004-01-08
申请号：PCT/US2003/019855
申请日：2003-06-25
申请人： ALLNUTT, F., C., Thomas , KYLE, David, J.
发明人： ALLNUTT, F., C., Thomas , KYLE, David, J.
IPC分类号： C12N
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K39/292 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/542 , C07K2319/00 , C12N7/00 , C12N2720/10023 , C12N2720/10043 , C12N2720/10061 , C12N2720/10062 , C12N2720/12023 , C12N2730/10122 , C12N2730/10134 , C12N2740/16034 , C12N2740/16061 , C12N2770/22022 , C12N2770/22023 , C12N2770/22043 , C12N2770/32043 , C12N2810/854
摘要： The present invention relates to the display of antigenic or allergenic components along with a tissue-targeting component on viruses or virus-like particles. Capsid protein genes are recombinantly modified to contain the specified components, then expressed within a host organism, such as yeasts, bacteria, or algae, and allowed to spontaneously form active virus particles or virus-like particles. The recombinant complexes (virus or virus-like particle) can then be purified or used in situ as a therapeutic tool for disease or allergy prevention. The expression of multivalent and multifunctional components to increase the immunogenicity of the recombinant complexes, especially on oral administration, is provided.
摘要翻译：本发明涉及在病毒或病毒样颗粒上显示抗原或致敏组分以及组织靶向组分。衣壳蛋白基因被重组修饰以含有特定成分，然后在宿主生物体如酵母，细菌或藻类中表达，并允许自发形成活性病毒颗粒或病毒样颗粒。然后可以将重组复合物（病毒或病毒样颗粒）原位纯化或用作疾病或过敏预防的治疗工具。提供了多价和多功能组分的表达，以增加重组复合物的免疫原性，特别是口服给药。

8. 发明申请

WO2004025263A3 PROTEIN AND PEPTIDE EXPRESSION FOR PASSIVE IMMUNITY 审中-公开
标题翻译：蛋白和肽在被动免疫中的表达
公开(公告)号：WO2004025263A3
公开(公告)日：2004-09-16
申请号：PCT/US0328868
申请日：2003-09-15
申请人： ADVANCED BIONUTRITION CORP , DHAR ARUN KUMAR , ALLNUTT F C THOMAS
发明人： DHAR ARUN KUMAR , ALLNUTT F C THOMAS
IPC分类号： A23K1/16 , A23K1/17 , A61K38/16 , A61K39/00 , A61K39/02 , A61K39/12 , A61K39/40 , A61K39/42 , A61K47/00 , A61K48/00 , C07K14/01 , C07K14/08 , C07K14/085 , C12N15/82 , G01N20060101
CPC分类号： C12N15/8257 , A23K20/147 , A23L33/17 , A23L33/18 , A61K38/162 , A61K38/164 , A61K39/12 , A61K2039/517 , A61K2039/523 , A61K2039/542 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N15/8258 , C12N2710/18022 , C12N2710/18034 , C12N2720/10022 , C12N2720/10034 , C12N2770/22022 , C12N2770/22034
摘要： This invention relates to feeds, feed supplements, and methods for their use that provide disease controlling properties to humans, and terrestrial and aquatic animals. These methods and compositions have both acute and chronic applications. The chronic applications relate to the health of organisms that have primitive or poorly developed immune systems.
摘要翻译：本发明涉及饲料，饲料补充剂及其使用方法，其为人类以及陆地和水生动物提供疾病控制特性。这些方法和组合物具有急性和慢性应用。慢性应用涉及具有原始或发育不良的免疫系统的生物体的健康。

9. 发明申请

WO0196383A3 HIGH FLUORESCENT INTENSITY CROSS-LINKED ALLOPHYCOCYANIN 审中-公开
标题翻译：高荧光强度交联的异环鸟苷
公开(公告)号：WO0196383A3
公开(公告)日：2002-04-11
申请号：PCT/US0119440
申请日：2001-06-18
申请人： MARTEK BIOSCIENCES CORP , MORSEMAN JOHN P , MOSS MARK W , ALLNUTT F C THOMAS
发明人： MORSEMAN JOHN P , MOSS MARK W , ALLNUTT F C THOMAS
IPC分类号： G01N33/533 , G01N33/542 , G01N33/58
CPC分类号： G01N33/582 , G01N33/533 , G01N33/542
摘要： In a method for quantitating an analyte by measuring time resolved transfer of fluorescence energy to or from a label quantitatively associated with the analyte, the present invention provides an improvement comprising measuring the energy transferred from donor compounds having the ability to absorb light energy and then transfer this energy to cross-linked allophycocyanin in a time-resolved manner, where the cross-linked allophycocyanin used according to this invention has not been exposed to strongly chaotropic agents after cross-linking.
摘要翻译：在通过测量与分析物定量相关的标记物的荧光能量的时间分辨转移的方法来定量分析物的方法，本发明提供了一种改进，其包括测量从具有吸收光能并且然后转移的能力的给体化合物转移的能量该能量以时间分辨的方式交联别藻蓝蛋白，其中根据本发明使用的交联别藻蓝蛋白在交联后未暴露于强离液剂。

10. 发明申请

WO2012109375A2 METHODS FOR IMPROVED MIXED TROPHIC ALGAL CULTURE 审中-公开
标题翻译：改进的混合特生性藻类培养物的方法
公开(公告)号：WO2012109375A2
公开(公告)日：2012-08-16
申请号：PCT/US2012/024358
申请日：2012-02-08
申请人： PHYCAL INC. , POSTIER, Bradley, Lynn , SWANSON, Andrew, Keith , ABAD, Mark, Scott , LAUDERDALE, George, William , KESSLER, Ben, Ami , ALLNUTT, F C Thomas , PARK, Jonathan, D. , SPOO-CHUPKA, Margaret , SLOMCZYNSKI, David, Joseph , KWIATKOWSKI, Jason, Richard
发明人： POSTIER, Bradley, Lynn , SWANSON, Andrew, Keith , ABAD, Mark, Scott , LAUDERDALE, George, William , KESSLER, Ben, Ami , ALLNUTT, F C Thomas , PARK, Jonathan, D. , SPOO-CHUPKA, Margaret , SLOMCZYNSKI, David, Joseph , KWIATKOWSKI, Jason, Richard
IPC分类号： C12P7/64
CPC分类号： A01G33/00 , C12N1/12 , C12P7/6463 , C12P39/00 , C12P2203/00 , Y02A40/88
摘要： The subject application is directed to methods, designs, and tools for improving the production of bioproducts from photosynthetic organisms using multiple trophic states in combination to achieve better production of a bioproduct or series of bioproducts. The subject applcation provides cost improvements with production of these bioproducts in a heterotrophic boost step in an enclosed bioreactor fed by a fixed carbon source as an intermediate within the production process.
摘要翻译：本发明的主题应用涉及使用多种营养状态组合来改进来自光合生物的生物制品生产的方法，设计和工具，以实现生物制品或一系列生物制品的更好生产。主题应用提供了生产这些生物产品的成本提高，这些生物产品是在由生产过程中的固定碳源作为中间产品供给的封闭式生物反应器中的异养增压步骤中。

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