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1. 发明申请

WO1995033450A1 STARCH ACETATE COMPOSITION WITH MODIFIABLE PROPERTIES, METHOD FOR PREPARATION AND USAGE THEREOF 审中-公开
标题翻译：具有可修饰性质的淀粉组合物，其制备方法及其用途
公开(公告)号：WO1995033450A1
公开(公告)日：1995-12-14
申请号：PCT/FI1995000331
申请日：1995-06-07
申请人： ALKO GROUP LTD. , PARONEN, Timo, Petteri , PELTONEN, Soili, Hellevi , URTTI, Arto, Olavi , NAKARI, Leena, Johanna
发明人： ALKO GROUP LTD.
IPC分类号： A61K09/20
CPC分类号： A61K9/2059 , C08B31/04 , C08L3/06
摘要： The present invention is related to a novel type of composition with modifiable properties and suitable for controlled release of active ingredients in industrial use. The composition contains an active ingredient and starch acetate in the form of a compact. More specifically the invention relates to active ingredients such as solid dosage forms of drugs, especially compacts and tablets. In these compacts starch acetate with distinct substitution degrees are used. The starch acetate makes the process industrially feasible with good flowability and facilitates the formation of firm tablets. Starch acetate enables the controlled release of the active ingredient. The invention also discloses method for the preparation of the composition as well as its use.
摘要翻译：本发明涉及一种具有可改性性质并适用于工业用途中活性成分的控制释放的新型组合物。该组合物含有活性成分和紧凑形式的淀粉乙酸酯。更具体地，本发明涉及活性成分，例如药物的固体剂型，特别是压块和片剂。在这些压块中，使用具有不同取代度的淀粉乙酸酯。乙酸淀粉使得该方法在工业上是可行的，具有良好的流动性并且有利于形成牢固的片剂。醋酸淀粉使活性成分受控释放。本发明还公开了组合物的制备方法及其用途。

2. 发明申请

WO1996021038A1 METHODS OF MODIFYING CARBOHYDRATE MOIETIES 审中-公开
标题翻译：修改碳水化合物的方法
公开(公告)号：WO1996021038A1
公开(公告)日：1996-07-11
申请号：PCT/FI1996000002
申请日：1996-01-02
申请人： ALKO GROUP LTD. , MARAS, Marleen , CONTRERAS, Roland
发明人： ALKO GROUP LTD.
IPC分类号： C12P19/28
CPC分类号： C12Y302/01113 , C12N9/1048 , C12N9/2402 , C12P21/005
摘要： The invention is directed to methods of converting high mannose type glycosylation patterns to hybrid or complex type glycosylation patterns.
摘要翻译：本发明涉及将高甘露糖型糖基化模式转化为杂交或复合型糖基化模式的方法。

3. 发明申请

WO1997027306A1 PRODUCTION AND SECRETION OF PROTEINS OF BACTERIAL ORIGIN IN FILAMENTOUS FUNGI 审中-公开
标题翻译：真菌真菌中细菌原始蛋白的生产和分泌
公开(公告)号：WO1997027306A1
公开(公告)日：1997-07-31
申请号：PCT/FI1997000037
申请日：1997-01-24
申请人： ALKO GROUP LTD. , MÄNTYLÄ, Arja , PALOHEIMO, Marja , LANTTO, Raija , FAGERSTRÖM, Richard , LAHTINEN, Tarja , SUOMINEN, Pirkko , VEHMAANPERÄ, Jari
发明人： ALKO GROUP LTD.
IPC分类号： C12N15/80
CPC分类号： C12Y302/01032 , C12N9/2437 , C12N9/248 , C12N15/80 , C12Y302/01001 , C12Y302/01003 , C12Y302/01004 , C12Y302/01006 , C12Y302/01008 , C12Y302/01025 , C12Y302/01039 , C12Y302/01091 , D21C5/005
摘要： The present invention is related to an improved production of bacterial proteins in filamentous fungus, e.g. in Trichoderma and Aspergillus. The improvement is achieved by constructing expression vectors, which comprise the bacterial protein encoding DNA sequences fused in frame with a DNA sequence encoding a filamentous fungus secretable protein or one or more functional domains of said protein. Filamentous fungus hosts transformed with such expression vectors secrete the desired proteins or enzymes, especially xylanases or cellulases originating from bacteria or more preferably from actinomycetes into the culture medium of the host. The desired proteins or enzymes can be used directly from the culture medium after separation of host cells or recovered and treated using down-stream processes, which are appropriate for the respective application. Xylanases or cellulases from actinomycetes produced using the above expression vectors are most suitable for treating plant derived materials, e.g. in pulp and paper industries.
摘要翻译：本发明涉及丝状真菌中细菌蛋白质的改进生产，例如，在木霉属和曲霉属中。通过构建表达载体来实现改善，所述表达载体包含编码与编码丝状真菌可分泌蛋白质的DNA序列或所述蛋白质的一个或多个功能结构域框架融合的DNA序列的细菌蛋白质。用这种表达载体转化的丝状真菌宿主分泌所需的蛋白质或酶，特别是源自细菌的木聚糖酶或纤维素酶，更优选从放线菌分泌到宿主的培养基中。所需的蛋白质或酶可以在分离宿主细胞之后直接从培养基中使用，或者使用适合于各自应用的下游过程进行回收和处理。使用上述表达载体产生的放线菌的木聚糖酶或纤维素酶最适合于处理植物来源的材料，例如在纸浆和造纸工业。

4. 发明申请

WO1997002018A1 COMPOSITION FOR PH DEPENDENT CONTROLLED RELEASE OF ACTIVE INGREDIENTS AND METHODS FOR PRODUCING IT 审中-公开
标题翻译： PH依赖性控制释放活性成分的组合物及其生产方法
公开(公告)号：WO1997002018A1
公开(公告)日：1997-01-23
申请号：PCT/FI1996000233
申请日：1996-04-29
申请人： ALKO GROUP LTD. , URTTI, Arto, Olavi , PELTONEN, Soili, Hellevi , PARONEN, Timo, Petteri , NAKARI, Leena, Johanna , VUORENPÄÄ, Jani-Emanuel
发明人： ALKO GROUP LTD.
IPC分类号： A61K09/20
CPC分类号： A61K9/2059 , C08B31/04
摘要： The present invention is related to a composition for pH dependent or pH regulated controlled release of active ingredients especially drugs. The composition consists of a compactible mixture of the active ingredient and starch molecules substituted with acetate and dicarboxylate residues. The preferred dicarboxylate acid is succinate. The average substitution degree of the acetate residue is at least 1 and 0.2 - 1.2 for the dicarboxylate residue. The starch molecules can have the acetate and dicarboxylate residues attached to the same starch molecule backbone or attached to separate starch molecule backbones. The present invention also discloses methods for preparing said starch acetate dicarboxylates by transesterification or mixing of starch acetates and starch dicarboxylates respectively.
摘要翻译：本发明涉及用于pH依赖性或pH调节的活性成分（特别是药物）的控制释放的组合物。该组合物由活性成分和被乙酸酯和二羧酸酯残基取代的淀粉分子的可压缩混合物组成。优选的二羧酸是琥珀酸。对于二羧酸酯残基，乙酸酯残基的平均取代度为至少1和0.2-1.2。淀粉分子可以具有连接到相同淀粉分子主链上的乙酸酯和二羧酸酯残基或连接到分离的淀粉分子主链上。本发明还公开了分别通过酯交换或混合淀粉乙酸酯和淀粉二羧酸盐来制备所述乙酸淀粉二羧酸淀粉的方法。

5. 发明申请

WO1996001863A1 MELT-PROCESSIBLE POLY(ESTER URETHANE) AND A PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：熔融混合物（ESTER URETHANE）及其制备方法
公开(公告)号：WO1996001863A1
公开(公告)日：1996-01-25
申请号：PCT/FI1995000396
申请日：1995-07-07
申请人： ALKO GROUP LTD. , NESTE OY , SEPPÄLÄ, Jukka , HÄRKÖNEN, Mika , HILTUNEN, Kari , MALIN, Minna , KYLMÄ, Janne
发明人： ALKO GROUP LTD. , NESTE OY
IPC分类号： C08G18/42
CPC分类号： C08G18/4283 , C08G63/06 , C08G2101/00 , C08G2230/00
摘要： The invention concerns a novel melt-processible poly(ester urethane) and a process and a prepolymer for the preparation thereof. The poly(ester urethane) contains structural units derived from a polyester and structural units derived from a diisocyanate and, according to the invention, the bonds between the structural units are at least mainly comprised only of urethane bonds, the number average molar mass, Mn, of the polymer is at least 10,000 g/mol, its mass-average molar mass, Mw, is over 20,000 g/mol and its molar mass distribution, expressed as the ratio Mw/Mn, is over 2, and the polymer is essentially free from free isocyanate groups. The poly(ester urethane) is hydrolytically decomposable and it can be used as a biodegradable polymer, e.g., for manufacturing injection moulded pieces and thermoformed and blow moulded packages, bags, sacks and bottles, for coating of sacks, bags and films made of paper or cardboard, and for manufacturing fibres and non-woven fabrics.
摘要翻译：本发明涉及一种新型的可熔融加工的聚（酯聚氨酯）及其制备方法和预聚物。聚（酯氨基甲酸酯）含有衍生自聚酯的结构单元和衍生自二异氰酸酯的结构单元，根据本发明，结构单元之间的键至少主要仅包含氨基甲酸酯键，数均摩尔质量Mn 的聚合物为至少10,000g / mol，其质均平均摩尔质量Mw为20,000g / mol以上，其摩尔质量分布（以Mw / Mn表示）大于2，聚合物基本上不含游离异氰酸酯基团。聚（酯氨基甲酸酯）可水解分解，可用作可生物降解的聚合物，例如用于制造注塑件和热成型和吹塑成型包装，袋，袋和瓶子，用于包装纸袋，袋和纸制成的纸或纸板，以及用于制造纤维和无纺织物。

6. 发明授权

EP0531415B1 METHOD FOR TREATING ALCOHOLISM WITH NALMEFENE 有权转让
标题翻译：方法酒精成瘾与纳美芬的治疗
公开(公告)号：EP0531415B1
公开(公告)日：1996-11-20
申请号：EP91910595.7
申请日：1991-05-10
申请人： Alko Group Ltd. , ORION-YHTYMÄ OY
发明人： Sinclair, John, D. , Scheinin, Harry , Lammintausta, Risto
IPC分类号： A61K31/485
CPC分类号： A61K31/485 , Y10S514/811
摘要： A method for treating alcoholism. The alcoholdrinking response of alcoholics is extinguished by having them drink alcoholic beverages while nalmefene, an opiate antagonist, blocks the positive reinforcement effect of ethanol in the brain.

7. 发明公开

EP0670893A1 NOVEL ENZYME PREPARATIONS AND METHODS FOR THEIR PRODUCTION 失效
标题翻译：新型酶组合物及其制备方法。
公开(公告)号：EP0670893A1
公开(公告)日：1995-09-13
申请号：EP93910050.0
申请日：1993-05-24
申请人： Alko Group Ltd.
发明人： SUOMINEN, Pirkko , NEVALAINEN, Helena , SAARELAINEN, Ritva , PALOHEIMO, Marja , LAHTINEN, Tarja , FAGERSTRÖM, Richard
IPC分类号： C12N15 , C12N1 , C12N9 , C12S3 , D21C3 , D21C5 , D21C9 , C12R1
CPC分类号： C12Y302/01032 , C12N9/2437 , C12N9/2482 , C12N15/80 , C12Y302/01008 , D21C5/005
摘要： The structure of the T. reesei xln1 and xln2 genes and the primary structure of proteins are described. Enzyme preparations enriched in hemicellulase enzymes are described. Such enzyme preparations may also be partially or completely deficient in cellulose degrading activity. Such preparations may be utilized in a crude, unpurified form and are especially useful in the production of pulp and paper.

8. 发明专利

AP1998000060S Bottle 未知
公开(公告)号：AP1998000060S
公开(公告)日：1999-07-14
申请号：AP1998000060
申请日：1998-01-29
申请人： WOLFGANG ZOLLER , ALKO GROUP LTD
发明人： ZOLLER WOLFGANG

9. 发明专利

CZ378296A3 TRANSGENIC PLANTS PRODUCING TREHALOSE 未知
公开(公告)号：CZ378296A3
公开(公告)日：1998-03-18
申请号：CZ378296
申请日：1995-06-29
申请人： ALKO GROUP LTD
发明人： LONDESBOROUGH JOHN , TUNNELA OUTI , HOLMSTROM KJELL-OVE , MANTYLA EINAR , WELIN BJORN , MANDAL ABUL , PALVA TAPIO E
IPC分类号： C12N15/09 , A23L21/10 , C12N5/10 , C12N9/00 , C12N9/10 , C12N9/16 , C12N15/54 , C12N15/82 , C12N15/84 , C12P19/12 , C12R1/91 , A01H5/00 , A01N3/00

10. 发明专利

ES2097209T3 未知
公开(公告)号：ES2097209T3
公开(公告)日：1997-04-01
申请号：ES91910595
申请日：1991-05-10
申请人： ALKO GROUP LTD , ORION YHTYMAE OY
发明人： SINCLAIR JOHN D , SCHEININ HARRY , LAMMINTAUSTA RISTO
IPC分类号： A61K31/485 , A61P25/32 , C07D489/08
摘要： A method for treating alcoholism. The alcohol-drinking response of alcoholics is extinguished by having them drink alcoholic beverages while nalmefene, an opiate antagonist, blocks the positive reinforcement effect of ethanol in the brain.

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