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1. 发明申请

WO2009063336A3 AN IMMORTALIZED HUMAN CD4-POSITIVE CELL AND ITS USE FOR DETERMINING THE PHENOTYPE OF A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 审中-公开
标题翻译：一种免疫人CD4阳性细胞及其用于测定人免疫缺陷病毒1型表型的用途
公开(公告)号：WO2009063336A3
公开(公告)日：2009-09-03
申请号：PCT/IB2008003924
申请日：2008-11-14
申请人： PAUL EHRLICH INST BUNDESAMT FU , BINNINGER-SCHINZEL DOROTHEA , SCHNIERLE BARBARA , ALBRECHT WERNER
发明人： BINNINGER-SCHINZEL DOROTHEA , SCHNIERLE BARBARA , WERNER ALBRECHT
IPC分类号： C12N5/06 , G01N33/50
CPC分类号： G01N33/56988
摘要： The invention relates to an immortalized CD4-positive cell. According to the invention, this cell comprises a gene encoding a CXCR4 chemokine receptor that is capable of serving as a corecep- tor for entry of a Human Immunodeficiency Virus Type 1 (HIV-I) into the cell, and a gene en¬ coding a CCR5 receptor that is not capable of serving as a coreceptor for entry of a Human Im¬ munodeficiency Virus Type 1 into the cell. The invention furthermore relates to a method for the phenotypical characterization of a HIV-I, comprising providing such a cell, adding an HIV-I to the cell under conditions that allow for the entrance of the HIV-I into the cell and the replication of the virus in the cell, and measuring the replication of the HIV-I in the cell.
摘要翻译：本发明涉及永生化的CD4阳性细胞。根据本发明，该细胞包含编码CXCR4趋化因子受体的基因，该基因能够作为使人类免疫缺陷病毒1型（HIV-1）进入细胞的核心蛋白，以及编码 CCR5受体不能作为1型人类免疫缺陷病毒进入细胞的辅助受体。本发明还涉及用于HIV-1的表型表征的方法，包括提供这样的细胞，在允许HIV-1进入细胞的条件下将HIV-1添加到细胞中，细胞中的病毒，并测量细胞中HIV-1的复制。

2. 发明申请

WO1988004366A1 CASE HOLDER FOR TURBO-ENGINES 审中-公开
标题翻译：用于涡轮发动机的壳体
公开(公告)号：WO1988004366A1
公开(公告)日：1988-06-16
申请号：PCT/EP1987000700
申请日：1987-11-12
申请人： KLEIN, SCHANZLIN & BECKER AKTIENGESELLSCHAFT , FINK, Gerhard , ALBRECHT, Werner , KRAUSS, Arno , RIEL, Axel , SCHERER, Rolf , SCHMITT, Werner , STARKE, Joerg
发明人： KLEIN, SCHANZLIN & BECKER AKTIENGESELLSCHAFT
IPC分类号： F04D29/60
CPC分类号： F04D29/605 , F16M5/00
摘要： A support frame (5) can be mounted on the case of turbo-engines (1). Flange and footing elements (8, 10) arranged on both sides of the longitudinal axis of the case, adjacent to the case and to the fitting location, are linked by one or several carrying elements (9). To increase rigidity, the carrying element (9) is linked to the end (7) of the case.

3. 发明申请

WO9631607A3 USE OF AN "IMMUNODEFICIENCY-VIRUS SUPPRESSING LYMPUSE OF AN "IMMUNODEFICIENCY-VIRUS SUPPRESSING LYMPHOKINE (ISL)" TO INHIBIT THE REPLICATION OF VIRUSEHOKINE (ISL)" TO INHIBIT THE REPLICATION OF VIRUSES, IN PARTICULAR OF RETROVIRUSES S, IN PARTICULAR OF RETROVIRUSES 审中-公开
标题翻译：使用“免疫球蛋白抑制免疫球蛋白抑制LYMPHOKINE（ISL）免疫球蛋白”来抑制VIRUSEHOKINE（ISL）的复制“，以阻止病毒复制，尤其是肝炎病毒特别是逆转录病毒
公开(公告)号：WO9631607A3
公开(公告)日：1996-12-27
申请号：PCT/EP9601486
申请日：1996-04-04
申请人： BUNDESREP DEUTSCHLAND , KURTH REINHARD , BAIER MICHAEL , METZNER KARIN , ALBRECHT WERNER
发明人： KURTH REINHARD , BAIER MICHAEL , METZNER KARIN , WERNER ALBRECHT
IPC分类号： G01N33/53 , A61K38/00 , A61K38/19 , A61K48/00 , A61P31/12 , A61P35/00 , A61P37/04 , C07K14/52 , C07K14/54 , C07K16/24 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12Q1/68 , G01N33/569 , G01N33/68
CPC分类号： C07K14/5446 , A61K38/00 , C07K2319/00 , Y10S930/141
摘要： An isolated polypeptide which inhibits the replication of retroviruses in peripheral blood lymphocytes and i) is coded by the DNA sequence shown in SEQ ID NO: 1 or complementary sequences; ii) is coded by DNA sequences which hybridize with SEQ ID NO: 1 or SEQ ID NO: 3 under stringent conditions; iii) is coded by DNA sequences which, if there was no degeneracy of the genetic code would hybridize under stringent conditions with the sequences defined in i) to ii); is useful as a therapeutic agent for the treatment of viral infections and benign and malignant proliferation diseases.

4. 发明申请

US20110033837A1 IMMORTALIZED HUMAN CD4-POSITIVE CELL AND ITS USE FOR DETERMINING THE PHENOTYPE OF A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 审中-公开
标题翻译：人免疫球蛋白阳性细胞及其用于确定人类免疫缺陷病毒1型
公开(公告)号：US20110033837A1
公开(公告)日：2011-02-10
申请号：US12743073
申请日：2008-11-14
申请人： Dorothea Binninger-Schinzel , Barbara Schnierle , Albrecht Werner
发明人： Dorothea Binninger-Schinzel , Barbara Schnierle , Albrecht Werner
IPC分类号： C12Q1/70 , C12N5/0783 , C12N15/09
CPC分类号： G01N33/56988
摘要： The invention relates to an immortalized CD4-positive cell. According to the invention, this cell comprises a gene encoding a CXCR4 chemokine receptor that is capable of serving as a coreceptor for entry of a Human Immunodeficiency Virus Type 1 (HIV-I) into the cell, and a gene encoding a CCR5 receptor that is not capable of serving as a coreceptor for entry of a Human Immunodeficiency Virus Type 1 into the cell. The invention furthermore relates to a method for the phenotypical characterization of a HIV-I, comprising providing such a cell, adding an HIV-I to the cell under conditions that allow for the entrance of the HIV-I into the cell and the replication of the virus in the cell, and measuring the replication of the HIV-I in the cell.
摘要翻译：本发明涉及永生化的CD4阳性细胞。根据本发明，该细胞包含编码能够作为1型人类免疫缺陷病毒（HIV-1）入侵细胞的共同受体的CXCR4趋化因子受体的基因，以及编码CCR5受体的基因不能作为1型人类免疫缺陷病毒进入细胞的共同受体。本发明还涉及用于HIV-1表型表征的方法，包括提供这样的细胞，在允许HIV-1进入细胞的条件下向细胞中加入HIV-1，并且复制细胞中的病毒，并测量细胞中HIV-1的复制。

5. 发明专利

DE10327798A1 Electronic blood glucose measuring device for use by diabetic person incorporating calculation of correct insulation dosage for self-administration 未知
公开(公告)号：DE10327798A1
公开(公告)日：2005-01-13
申请号：DE10327798
申请日：2003-06-20
申请人： ALBRECHT WERNER
发明人： ALBRECHT WERNER
IPC分类号： A61B5/00 , A61B5/145
摘要： The measuring device has electronic components for measuring the blood glucose values at specific time points, for controlling a digital read-out display, the measured blood glucose values used for calculation of the correct insulin dosage, upon entering personal data for the user via an input keyboard.

6. 发明专利

DD200719A1 未知
公开(公告)号：DD200719A1
公开(公告)日：1983-06-08
申请号：DD23362081
申请日：1981-09-28
申请人： ALBRECHT WERNER , PARADOWSKI VOLKER
发明人： ALBRECHT WERNER , PARADOWSKI VOLKER
IPC分类号： B24B5/22

7. 发明授权

US06506582B1 Processed polypeptides with IL-16 activity, process for preparing the same and their use 失效
标题翻译：具有IL-16活性的加工多肽，其制备方法及其应用
公开(公告)号：US06506582B1
公开(公告)日：2003-01-14
申请号：US09171962
申请日：1999-02-25
申请人： Reinhard Kurth , Michael Baier , Norbert Bannert , Albrecht Werner , Kurt Lang
发明人： Reinhard Kurth , Michael Baier , Norbert Bannert , Albrecht Werner , Kurt Lang
IPC分类号： C12P2102
CPC分类号： C07K14/5446 , A61K38/00
摘要： A nucleic acid which can be used to express a polypeptide with interleukin-16 activity in a prokaryotic or eukaryotic host cell wherein the nucleic acid codes for a polypeptide with the amino acid sequence SEQ ID NO:2 or a SEQ ID NO:2 elongated N-terminally by an aspartic acid residue or a form shortened at the C-terminus by up to 8 amino acids, and is suitable for the production of an active IL-16 polypeptide.
摘要翻译：可用于在原核或真核宿主细胞中表达具有白细胞介素-16活性的多肽的核酸，其中所述核酸编码具有氨基酸序列SEQ ID NO：2或SEQ ID NO：2的多肽伸长N 最终由天冬氨酸残基或在C末端缩短多达8个氨基酸的形式，并且适用于生产活性IL-16多肽。

8. 发明授权

US06444202B1 Processed polypeptides with IL-16 activity, processes for their production and their use 失效
标题翻译：具有IL-16活性的加工多肽，其生产过程及其用途
公开(公告)号：US06444202B1
公开(公告)日：2002-09-03
申请号：US09308246
申请日：1999-05-24
申请人： Reinhard Kurth , Michael Baier , Albrecht Werner , Dorothee Ambrosius , Martin Lanzendörfer
发明人： Reinhard Kurth , Michael Baier , Albrecht Werner , Dorothee Ambrosius , Martin Lanzendörfer
IPC分类号： A61K3820
CPC分类号： C07K14/5446 , A61K38/00
摘要： A nucleic acid, which can be used to express a polypeptide with interleukin-16 activity in a prokaryotic or eukaryotic host cell, wherein the said nucleic acid codes for a polypeptide with the amino acid sequence SEQ ID NO:2 and/or a SEQ ID NO:2 N-terminally elongated by Ala-Ser or a form thereof which is shortened at its C-terminus by up to 8 amino acids, is suitable for producing an active IL-16 polypeptide.
摘要翻译：一种核酸，其可用于在原核或真核宿主细胞中表达具有白细胞介素-16活性的多肽，其中所述核酸编码具有氨基酸序列SEQ ID NO：2和/或SEQ ID NO： NO：2通过Ala-Ser或其形式在其C-末端缩短多达8个氨基酸的N末端延伸，适用于产生活性IL-16多肽。

9. 发明授权

US06383739B1 Method of identifying compounds capable of activating ISL production 失效
标题翻译：识别能够激活ISL生产的化合物的方法
公开(公告)号：US06383739B1
公开(公告)日：2002-05-07
申请号：US09353362
申请日：1999-07-15
申请人： Reinhard Kurth , Michael Baier , Karin Metzner , Albrecht Werner
发明人： Reinhard Kurth , Michael Baier , Karin Metzner , Albrecht Werner
IPC分类号： C12Q170
CPC分类号： C07K14/5446 , A61K38/00 , C07K2319/00 , Y10S930/141
摘要： The present invention is directed to an Immunodeficiency-virus Suppressing Lymphokine (ISL) produced by stimulated CD8+ PBMC, cloning and isolation of nucleic acid molecules for eukaryotic ISL, and methods of treating viral infections with ISL. ISL is able to suppress the replication of viruses, especially retroviruses, in vitro and in vivo. More, specifically, a method is described for detecting a compound capable of inducing the expression of ISL by measuring the presence of ISL and the ability of ISL to inhibit HIV transcription.
摘要翻译：本发明涉及通过刺激的CD8 + PBMC产生的免疫缺陷病毒抑制淋巴因子（ISL），用于真核ISL的核酸分子的克隆和分离以及用ISL治疗病毒感染的方法。 ISL能够在体外和体内抑制病毒，特别是逆转录病毒的复制。更具体地，描述了一种通过测量ISL的存在和ISL抑制HIV转录的能力来检测能够诱导ISL表达的化合物的方法。

10. 发明授权

US06207144B1 Polypeptides with interleukin-16 activity, process for the preparation and use thereof 失效
标题翻译：具有白细胞介素-16活性的多肽，其制备方法和用途
公开(公告)号：US06207144B1
公开(公告)日：2001-03-27
申请号：US09091405
申请日：1998-08-27
申请人： Reinhard Kurth , Michael Baier , Norbert Bannert , Karin Metzner , Albrecht Werner , Kurt Lang
发明人： Reinhard Kurth , Michael Baier , Norbert Bannert , Karin Metzner , Albrecht Werner , Kurt Lang
IPC分类号： C12N1524
CPC分类号： C07K14/5446 , A61K38/00
摘要： A nucleic acid which can be used to express a polypeptide with interleukin-16 activity in a prokaryotic or eukaryotic host cell, wherein in the region coding for the said polypeptide the said nucleic acid a)corresponds to the DNA sequence of nucleotides 54-1175 from SEQ ID NO:1 or to its complementary strand, b) hybridizes with the DNA of nucleotide sequence 54-785 from SEQ ID NO:1 under stringent conditions, c) hybridizes with the DNA of nucleotide sequence 786-1175 from SEQ ID NO:1 under stringent conditions and at the 5′ end begins with nucleotides 756-785 from SEQ ID NO:1 or a part thereof which codes for part of the sequence of amino acids 235-244 from SEQ ID NO:1 or d) it is a nucleic acid sequence which would hybridize under stringent conditions with the nucleic acid sequences defined by a) or b) without the degeneracy of the genetic code, codes for proteins with improved interleukin-16 activity.
摘要翻译：可用于在原核或真核宿主细胞中表达具有白细胞介素-16活性的多肽的核酸，其中在编码所述多肽的区域中，所述核酸a）对应于核苷酸54-1175的DNA序列， SEQ ID NO：1或其互补链，b）在严格条件下与SEQ ID NO：1的核苷酸序列54-785的DNA杂交，c）与SEQ ID NO：1的核苷酸序列786-1175的DNA杂交， 1在严格条件下和5'末端以SEQ ID NO：1的核苷酸756-785或编码SEQ ID NO：1的氨基酸235-244的部分序列的部分开始，或d）它是在严格条件下与在a）或b）中定义的核酸序列杂交但不具有遗传密码简并性的核酸序列，编码具有改善的白细胞介素-16活性的蛋白质。

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