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1. 发明申请

WO2004064912A1 AN OTORHINOLOGICAL DELIVERY DEVICE 审中-公开
标题翻译：一种耳毒递送装置
公开(公告)号：WO2004064912A1
公开(公告)日：2004-08-05
申请号：PCT/FI2004/000018
申请日：2004-01-14
申请人： SCHERING OY , HAAPAKUMPU, Timo , JUKARAINEN, Harri , ALA-SORVARI, Juha , RANKONEN, Henry , RIPHAGEN, Frederik, E. , ARNOLD, Wolfgang
发明人： JUKARAINEN, Harri , ALA-SORVARI, Juha , RANKONEN, Henry , RIPHAGEN, Frederik, E. , ARNOLD, Wolfgang
IPC分类号： A61M31/00
CPC分类号： A61K9/0046 , A61K9/0043 , A61L31/06 , A61L31/16 , Y10S514/953 , C08L83/04
摘要： The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof. The invention is characterized in that the pharmaceutically active agent is selected from the group comprising anti-allergic agents, anti-inflammatory agents, anti-fungicides, glucocorticoids and mixtures thereof.
摘要翻译：本发明涉及包含至少一种药物活性剂的耳鼻神经递送装置。根据本发明，所述装置包含含有所述至少一种药物活性剂的芯，其中所述芯由弹性体组合物制成，所述弹性体组合物选自聚（二甲基硅氧烷），包含3,3,3-三氟丙基的硅氧烷基弹性体与硅氧烷单元的原子连接的基团，包含聚（烯化氧）基团的硅氧烷基弹性体及其混合物，以及包封所述核的膜，所述膜由与所述核相同或不同的弹性体组合物制成，所述弹性体组合物选自聚（二甲基硅氧烷），包含连接到Si＆shy的3,3,3-三氟丙基的基于硅氧烷的弹性体;硅氧烷单元的原子，包含聚（亚烷基氧化物）基团及其混合物。本发明的特征在于药物活性剂选自抗过敏剂，抗炎剂，抗真菌剂，糖皮质激素及其混合物。

2. 发明申请

WO2003017971A1 DRUG DELIVERY SYSTEM 审中-公开
标题翻译：药物递送系统
公开(公告)号：WO2003017971A1
公开(公告)日：2003-03-06
申请号：PCT/FI2002/000692
申请日：2002-08-27
申请人： LEIRAS OY , HAAPAKUMPU, Timo , ALA-SORVARI, Juha , AALTONEN, Marko , KEINÄNEN, Antti , AHOLA, Manja
发明人： HAAPAKUMPU, Timo , ALA-SORVARI, Juha , AALTONEN, Marko , KEINÄNEN, Antti , AHOLA, Manja
IPC分类号： A61K9/00
CPC分类号： A61K9/0024 , A61K9/0036 , A61K9/0039 , A61K9/209 , A61K9/2853 , A61K9/2886 , A61K31/56
摘要： The invention relates to a delivery system comprising at least one core and a membrane. The core and the membrane consist of an elastomer composition comprising e.g poly (dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluorpropyl groups attached to the Si-atoms of the siloxane units and/or poly(alkylene oxide) groups, present as alkoxy-terminated grafts or blocks linked to the polysiloxane units by silicon-carbon bonds, or as a mixture of these forms. The delivery system is preferably an implant or an intrauterine, intracervical or intravaginal system.
摘要翻译：本发明涉及包含至少一个核心和膜的递送系统。芯和膜由弹性体组合物组成，包括例如聚（二甲基硅氧烷），包含连接到硅氧烷单元的Si原子上的3,3,3-三氟丙基和/或聚（环氧烷）基团的硅氧烷基弹性体作为以硅 - 碳键与聚硅氧烷单元连接的烷氧基封端的接枝物或嵌段，或作为这些形式的混合物存在。递送系统优选是植入物或子宫内，子宫内或阴道内系统。

3. 发明申请

WO2004064912A8 AN OTORHINOLOGICAL DELIVERY DEVICE 审中-公开
标题翻译：一种传统的交付设备
公开(公告)号：WO2004064912A8
公开(公告)日：2004-09-30
申请号：PCT/FI2004000018
申请日：2004-01-14
申请人： SCHERING OY , JUKARAINEN HARRI , ALA-SORVARI JUHA , RANKONEN HENRY , RIPHAGEN FREDERIK E , ARNOLD WOLFGANG
发明人： HAAPAKUMPU TIMO , JUKARAINEN HARRI , ALA-SORVARI JUHA , RANKONEN HENRY , RIPHAGEN FREDERIK E , ARNOLD WOLFGANG
IPC分类号： A61K9/00 , A61L31/06 , A61L31/16 , A61P9/08 , A61P23/00 , A61P25/02 , A61P25/04 , A61P27/16 , A61P29/00 , A61P31/00 , A61P37/08 , A61M31/00 , A61K47/24 , A61K47/30
CPC分类号： A61K9/0046 , A61K9/0043 , A61L31/06 , A61L31/16 , Y10S514/953 , C08L83/04
摘要： The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof. The invention is characterized in that the pharmaceutically active agent is selected from the group comprising anti-allergic agents, anti-inflammatory agents, anti-fungicides, glucocorticoids and mixtures thereof.
摘要翻译：本发明涉及包含至少一种药物活性剂的输卵管递送装置。根据本发明，该装置包括一种包含所述至少一种药物活性剂的核心，其中所述核心由弹性体组合物制成，所述弹性体组合物选自聚（二甲基硅氧烷），包含3,3,3-三氟丙基连接到硅氧烷单元的硅原子的基团，包含聚（环氧烷）基团的硅氧烷基弹性体及其混合物，以及包围所述芯的膜，所述膜由与所述芯相同或不同的弹性体组合物制成，所述弹性体组合物选自聚（二甲基硅氧烷），包含连接到硅氧烷单元的硅原子上的3,3,3-三氟丙基的硅氧烷基弹性体，包含聚（氧化烯）基团的硅氧烷基弹性体和其混合物。本发明的特征在于药物活性剂选自抗过敏剂，抗炎剂，抗真菌剂，糖皮质激素及其混合物。

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