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1. 发明申请

WO2002065981A2 CHEMOTHERAPEUTIC COMPOSITION USING CALCIUM PHOSPHATE PASTE 审中-公开
标题翻译：使用磷酸钙膏的化学治疗组合物
公开(公告)号：WO2002065981A2
公开(公告)日：2002-08-29
申请号：PCT/US2001/051381
申请日：2001-10-19
申请人： ETEX CORPORATION , LEE, Dosuk, D. , AIOLOVA, Maria
发明人： LEE, Dosuk, D. , AIOLOVA, Maria
IPC分类号： A61K
CPC分类号： A61K9/0019 , A61K9/19 , A61K31/00 , A61K33/24 , A61K33/42 , A61K45/06 , A61K47/02 , A61K2300/00
摘要： A method and composition are provided for treating cancer in a mammal. The method includes administering to a tumor site of the mammal an anticancer composition comprising a mixture of an anticancer agent and a calcium phosphate paste, said paste comprised of one or more calcium phosphates and a physiologically acceptable fluid, each calcium phosphate having a Ca/P ratio of less than or equal to 1.7, the paste having an injectable or formable consistency at the time of administration and hardenable at the tumor site.
摘要翻译：提供了用于治疗哺乳动物癌症的方法和组合物。该方法包括向哺乳动物的肿瘤部位施用包含抗癌剂和磷酸钙糊剂的混合物的抗癌组合物，所述糊剂包含一种或多种磷酸钙和生理学上可接受的流体，每种磷酸钙具有Ca / P 比率小于或等于1.7，所述糊剂在施用时具有可注射的或可成形的稠度并且在肿瘤部位可硬化。

2. 发明申请

WO9816209A3 BIOCERAMIC COMPOSITIONS 审中-公开
标题翻译：生物组成
公开(公告)号：WO9816209A3
公开(公告)日：1998-10-01
申请号：PCT/US9718528
申请日：1997-10-16
申请人： ETEX CORP , LEE DOSUK D , REY CHRISTIAN , AIOLOVA MARIA
发明人： LEE DOSUK D , REY CHRISTIAN , AIOLOVA MARIA
IPC分类号： A61K9/00 , A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/46 , A61K9/20 , A61K47/02 , A61L27/00 , A61L27/12 , A61L27/38 , A61L27/42 , A61L27/54 , A61L27/58 , A61K9/72
CPC分类号： A61L27/3804 , A61F2/28 , A61F2/30756 , A61F2002/30062 , A61F2002/30762 , A61F2002/4648 , A61F2210/0004 , A61F2310/00293 , A61K9/2009 , A61L27/12 , A61L27/3847 , A61L27/3852 , A61L27/425 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/64
摘要： The present invention provides a synthetic, poorly crystalline apatite (PCA) calcium phosphate containing a biologically active agent and/or cells (preferably tissue-forming or tissue-degrading cells). The compositions provided by the present invention are useful for a variety of in vivo and in vitro applications, including drug delivery (for example, to bony sites, the central nervous system, intramuscular sites, subcutaneous sites, interperitoneal sites, and occular sites) tissue growth (preferably bone or cartilage) osseous augmentation, and methods of diagnosing disease states by assaying tissue forming potential of cells isolated from a host. The invention also provides methods of preparing delivery vehicles, of altering delivery vehicle characteristics, and of delivering biologically active agents to a site. The invention further provides in vitro cell culture systems and cell encapsulation materials. The invention is useful for both medical and veterinary applications. 00000
摘要翻译：本发明提供了含有生物活性剂和/或细胞（优选组织形成或组织降解细胞）的合成的，结晶不良的磷酸钙（PCA）磷酸钙。本发明提供的组合物可用于各种体内和体外应用，包括药物递送（例如，骨性部位，中枢神经系统，肌内部位，皮下部位，腹膜内部位和眼部位）组织生长（优选骨或软骨）骨增大，以及通过测定从宿主分离的细胞的组织形成潜力来诊断疾病状态的方法。本发明还提供了制备递送载体，改变递送载体特性以及将生物活性剂递送到部位的方法。本发明还提供体外细胞培养系统和细胞包封材料。本发明对于医学和兽医应用都是有用的。 00000

3. 发明申请

WO1998016268A2 METHOD OF PREPARING A POORLY CRYSTALLINE CALCIUM PHOSPHATE AND METHODS OF ITS USE 审中-公开
标题翻译：磷酸钙晶体的制备方法及其使用方法
公开(公告)号：WO1998016268A2
公开(公告)日：1998-04-23
申请号：PCT/US1997018631
申请日：1997-10-16
申请人： ETEX CORPORATION , LEE, Dosuk, D. , REY, Christian , AIOLOVA, Maria
发明人： ETEX CORPORATION
IPC分类号： A61L27/00
CPC分类号： A61L24/02 , A61F2310/00293 , A61L27/12 , A61L27/425 , A61L2430/02
摘要： The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable. A method for treating a bone defect also is provided by identifying a bone site suitable for receiving an implant, and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant site. The implant site may be a variety of sites, such as a tooth socket, non-union bone, bone prosthesis, an osteoporotic bone, an intervertebral space, an alveolar ridge or a bone fracture.
摘要翻译：本发明提供了一种用于生产与吸热反应相关的以温度依赖的方式硬化的磷酸钙水泥或填料的新方法。在反应中，将有限量的水与干燥的磷酸钙前体混合以产生水合前体浆料。糊状物的硬化在体温下快速发生，伴随着一种或多种反应物转化为结晶不良的磷灰石磷酸钙。本发明的硬化水泥，填料，生长基质，矫形和递送装置可快速吸收并刺激硬组织的生长和愈合。提供了一种复合材料，其包括强生物可再吸收，结晶不良的磷灰石复合材料和补充材料。补充材料与羟基磷灰石材料紧密接触，其量有效地赋予复合材料所选择的特征。补充材料可以是生物相容的，生物可再吸收的或不可再吸收的。通过鉴定适于接收植入物的骨部位，以及在植入部位引入强吸收不良结晶的磷灰石磷酸钙，从而在植入部位形成骨，来提供治疗骨缺损的方法。植入部位可以是各种部位，例如牙槽，非联合骨，骨假体，骨质疏松的骨，椎间隙，牙槽嵴或骨折。

4. 发明申请

WO2002041844A3 CHEMOTHERAPEUTIC COMPOSITION USING NANOCRYSTALLINE CALCIUM PHOSPHATE PASTE 审中-公开
公开(公告)号：WO2002041844A3
公开(公告)日：2002-05-30
申请号：PCT/US2001/051419
申请日：2001-10-19
申请人： ETEX CORPORATION , LEE, Dosuk, D. , AIOLOVA, Maria
发明人： LEE, Dosuk, D. , AIOLOVA, Maria
IPC分类号： A01N59/26
摘要： A method and composition are provided for treating cancer in a mammal. The method includes administering to a tumor site of the mammal an anticancer composition comprising a mixture of an anticancer agent and a nanocrystalline or poorly crystalline calcium phosphate paste, said paste comprised of one or more calcium phosphates and a physiologically acceptable fluid, the paste having an injectable or formable consistency at the time of administration and hardenable at the tumor.

5. 发明申请

WO1998016209A2 BIOCERAMIC COMPOSITIONS 审中-公开
标题翻译：生物组成
公开(公告)号：WO1998016209A2
公开(公告)日：1998-04-23
申请号：PCT/US1997018528
申请日：1997-10-16
申请人： ETEX CORPORATION , LEE, Dosuk, D. , REY, Christian , AIOLOVA, Maria
发明人： ETEX CORPORATION
IPC分类号： A61K09/72
CPC分类号： A61L27/3804 , A61F2/28 , A61F2/30756 , A61F2002/30062 , A61F2002/30762 , A61F2002/4648 , A61F2210/0004 , A61F2310/00293 , A61K9/2009 , A61L27/12 , A61L27/3847 , A61L27/3852 , A61L27/425 , A61L27/54 , A61L27/58 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/64
摘要： The present invention provides a synthetic, poorly crystalline apatite (PCA) calcium phosphate containing a biologically active agent and/or cells (preferably tissue-forming or tissue-degrading cells). The compositions provided by the present invention are useful for a variety of in vivo and in vitro applications, including drug delivery (for example, to bony sites, the central nervous system, intramuscular sites, subcutaneous sites, interperitoneal sites, and occular sites) tissue growth (preferably bone or cartilage) osseous augmentation, and methods of diagnosing disease states by assaying tissue forming potential of cells isolated from a host. The invention also provides methods of preparing delivery vehicles, of altering delivery vehicle characteristics, and of delivering biologically active agents to a site. The invention further provides in vitro cell culture systems and cell encapsulation materials. The invention is useful for both medical and veterinary applications.
摘要翻译：本发明提供了含有生物活性剂和/或细胞（优选组织形成或组织降解细胞）的合成的，结晶不良的磷酸钙（PCA）磷酸钙。本发明提供的组合物可用于各种体内和体外应用，包括药物递送（例如，骨性部位，中枢神经系统，肌内部位，皮下部位，腹膜内部位和眼部位置）组织生长（优选骨或软骨）骨增大，以及通过测定从宿主分离的细胞的组织形成潜力来诊断疾病状态的方法。本发明还提供了制备递送载体，改变递送载体特性以及将生物活性剂递送至部位的方法。本发明进一步提供体外细胞培养系统和细胞包封材料。本发明对于医学和兽医应用都是有用的。

6. 发明申请

WO0241844A9 CHEMOTHERAPEUTIC COMPOSITION USING NANOCRYSTALLINE CALCIUM PHOSPHATE PASTE 审中-公开
标题翻译：使用纳米晶磷酸钙的化学成分
公开(公告)号：WO0241844A9
公开(公告)日：2003-05-22
申请号：PCT/US0151419
申请日：2001-10-19
申请人： ETEX CORP , LEE DOSUK D , AIOLOVA MARIA
发明人： LEE DOSUK D , AIOLOVA MARIA
IPC分类号： A61K9/00 , A61K47/02 , A61P35/00 , A01N59/26 , A61K9/14 , A61K39/38
CPC分类号： A61K9/0019 , A61K9/0024 , A61K47/02
摘要： A method and composition are provided for treating cancer in a mammal. The method includes administering to a tumor site of the mammal an anticancer composition comprising a mixture of an anticancer agent and a nanocrystalline or poorly crystalline calcium phosphate paste, said paste comprised of one or more calcium phosphates and a physiologically acceptable fluid, the paste having an injectable or formable consistency at the time of administration and hardenable at the tumor.
摘要翻译：提供了一种治疗哺乳动物癌症的方法和组合物。该方法包括向哺乳动物的肿瘤部位施用包含抗癌剂和纳米晶体或结晶不佳的磷酸钙浆料的混合物的抗癌组合物，所述糊剂由一种或多种磷酸钙和生理上可接受的流体组成，所述糊剂具有在给药时可注射或可形成的一致性，并在肿瘤处可硬化。

7. 发明申请

WO02065981A3 CHEMOTHERAPEUTIC COMPOSITION USING CALCIUM PHOSPHATE PASTE 审中-公开
标题翻译：使用磷酸钙的化学成分
公开(公告)号：WO02065981A3
公开(公告)日：2002-12-19
申请号：PCT/US0151381
申请日：2001-10-19
申请人： ETEX CORP , LEE DOSUK D , AIOLOVA MARIA
发明人： LEE DOSUK D , AIOLOVA MARIA
IPC分类号： A61K9/00 , A61K9/18 , A61K9/19 , A61K31/00 , A61K33/24 , A61K33/42 , A61K45/06 , A61K47/02 , A01N59/26 , A61K9/14
CPC分类号： A61K9/0019 , A61K9/19 , A61K31/00 , A61K33/24 , A61K33/42 , A61K45/06 , A61K47/02 , A61K2300/00
摘要： A method and composition are provided for treating cancer in a mammal. The method includes administering to a tumor site of the mammal an anticancer composition comprising a mixture of an anticancer agent and a calcium phosphate paste, said paste comprised of one or more calcium phosphates and a physiologically acceptable fluid, each calcium phosphate having a Ca/P ratio of less than or equal to 1.7, the paste having an injectable or formable consistency at the time of administration and hardenable at the tumor site.
摘要翻译：提供了一种治疗哺乳动物癌症的方法和组合物。该方法包括向哺乳动物的肿瘤部位施用包含抗癌剂和磷酸钙糊剂的混合物的抗癌组合物，所述糊剂由一种或多种磷酸钙和生理上可接受的液体组成，每种磷酸钙具有Ca / P 比例小于或等于1.7，糊剂在给药时具有可注射或可形成的稠度并且在肿瘤部位可硬化。

8. 发明申请

WO9816268A3 METHOD OF PREPARING A POORLY CRYSTALLINE CALCIUM PHOSPHATE AND METHODS OF ITS USE 审中-公开
标题翻译：磷酸钙晶体的制备方法及其使用方法
公开(公告)号：WO9816268A3
公开(公告)日：1998-07-30
申请号：PCT/US9718631
申请日：1997-10-16
申请人： ETEX CORP , LEE DOSUK D , REY CHRISTIAN , AIOLOVA MARIA
发明人： LEE DOSUK D , REY CHRISTIAN , AIOLOVA MARIA
IPC分类号： A61L27/00 , A61F2/00 , A61L24/00 , A61L24/02 , A61L27/12 , A61L27/42 , C04B12/02 , A61L25/00
CPC分类号： A61L24/02 , A61F2310/00293 , A61L27/12 , A61L27/425 , A61L2430/02
摘要： The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature and is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing. A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable. A method for treating a bone defect also is provided by identifying a bone site suitable for receiving an implant, and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant site. The implant site may be a variety of sites, such as a tooth socket, non-union bone, bone prosthesis, an osteoporotic bone, an intervertebral space, an alveolar ridge or a bone fracture. 00000
摘要翻译：本发明提供了一种用于生产与吸热反应相关的以温度依赖的方式硬化的磷酸钙水泥或填料的新方法。在反应中，将有限量的水与干燥的磷酸钙前体混合以产生水合前体浆料。糊状物的硬化在体温下快速发生，伴随着一种或多种反应物转化为结晶不良的磷灰石磷酸钙。本发明的硬化水泥，填料，生长基质，矫形和递送装置可快速吸收并刺激硬组织的生长和愈合。提供了一种复合材料，其包括强生物可再吸收，结晶不良的磷灰石复合材料和补充材料。补充材料与羟基磷灰石材料紧密接触，其量有效地赋予复合材料所选择的特征。补充材料可以是生物相容的，生物可再吸收的或不可再吸收的。通过鉴定适于接收植入物的骨部位，以及在植入部位引入强吸收不良结晶的磷灰石磷酸钙，从而在植入部位形成骨，来提供治疗骨缺损的方法。植入部位可以是各种部位，例如牙槽，非联合骨，骨假体，骨质疏松的骨，椎间隙，牙槽嵴或骨折。 00000

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