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1. 发明申请

WO2007100206A1 A PHARMACEUTICAL AND FOOD COMPOSITION COMPRISING AGRIMONIA EXTRACTS 审中-公开
标题翻译：包含AGRIMONIA提取物的药物和食品组合物
公开(公告)号：WO2007100206A1
公开(公告)日：2007-09-07
申请号：PCT/KR2007/001010
申请日：2007-02-27
申请人： BIO KOREA CO., LTD. , LEA, Young Sung , AHN, Dong Ho , ZEE, Ok Pyo , KWAK, Jong Hwan , KANG, Se Chan , CHOI, Han , KIM, Man Bae , LEE, Min Kyung
发明人： LEA, Young Sung , AHN, Dong Ho , ZEE, Ok Pyo , KWAK, Jong Hwan , KANG, Se Chan , CHOI, Han , KIM, Man Bae , LEE, Min Kyung
IPC分类号： A61K36/73 , A23L1/29 , A61P1/16
CPC分类号： A61K36/73 , A23L33/105
摘要： The present invention relates to a pharmaceutical or food composition comprising an extract of genus Agrimonia, which has an effect of protecting hepatic cells, and is useful for preventing or treating non- viral hepatitis and hepatic disease. Further, the present invention relates to a process for preparing water-soluble and organic solvent- soluble extracts of genus Agrimonia, and to a pharmaceutical or food composition for preventing or treating non- viral hepatitis and hepatic disease, comprising the extract of genus Agrimonia obtained by the process.
摘要翻译：本发明涉及一种药物或食品组合物，其包含具有保护肝细胞作用的Agrimonia属的提取物，并且可用于预防或治疗非病毒性肝炎和肝脏疾病。此外，本发明涉及一种制备水溶性和有机溶剂可溶性提取物的方法，以及用于预防或治疗非病毒性肝炎和肝脏疾病的药物或食品组合物，其包含获得的Agrimonia属的提取物通过这个过程。

2. 发明申请

WO2004002945A1 (E)-1-[[(2E, 4E)-1-HEXYL-2,4-OCTADECADIENYL]OXY]-2-HYDROXYDIAZINE AND A PHARMACEUTICAL COMPOSITION FOR TREATING HEPATITIS 审中-公开
标题翻译：（E）-1 - [[（2E，4E）-1-HEXYL-2,4-OCTADECADIENYL] OXY] -2-羟基二苯胺和用于治疗抗坏血酸的药物组合物
公开(公告)号：WO2004002945A1
公开(公告)日：2004-01-08
申请号：PCT/KR2003/001278
申请日：2003-06-28
申请人： BIOKOREA CO., LTD , LEA, Young-Sung , AHN, Dong-Ho , LIM, Yoong-Ho , YOON, Seung-Kew , KIM, Man-Bae , KIM, Nam-Jin , CHANG, Eun-Joo , LEE, Min-Kyung
发明人： LEA, Young-Sung , AHN, Dong-Ho , LIM, Yoong-Ho , YOON, Seung-Kew , KIM, Man-Bae , KIM, Nam-Jin , CHANG, Eun-Joo , LEE, Min-Kyung
IPC分类号： C07C245/02
CPC分类号： C07C245/02
摘要： Disclosed are a (E)-1-[[(2E,4E)-1-hexyl-2,4-octadecadienyl]oxy]-2hydroxydiazine compound represented by Chemical Formula I, below, or its pharmaceutically acceptable base addition salt, a method of preparing the compound, and a pharmaceutical composition comprising the compound for treating or preventing hepatitis. [Chemical Formula I] The compound of the present invention has an inhibitory effect on HBV activity as well as being effective in reducing HBV levels. Therefore, the compound of the present invention is very useful as a therapeutic agent for treatment of hepatitis.
摘要翻译：公开了以下化学式I表示的（E）-1 - [[（2E，4E）-1-己基-2,4-辛二烯基]氧基] -2-羟基嘧啶化合物或其药学上可接受的碱加成盐，制备该化合物的方法和包含用于治疗或预防肝炎的化合物的药物组合物。 [化学式I]本发明化合物对HBV活性具有抑制作用，并且对降低HBV水平有效。因此，本发明的化合物作为治疗肝炎的治疗剂是非常有用的。

3. 发明申请

WO2003030921A1 Methods for producing agrimonia extract with improved activity against hepatitis B virus and pharmaceutical and food compositions containing said extract 审中-公开
标题翻译：用于生产具有改善乙型肝炎病毒活性的农药提取物的方法和含有所述提取物的药物和食品组合物
公开(公告)号：WO2003030921A1
公开(公告)日：2003-04-17
申请号：PCT/KR2002/001888
申请日：2002-10-09
申请人： BIOKOREA CO., LTD , LEE, Young-Sung , AHN, Dong-Ho , HONG, Sa-Min , YOON, Seung-Kew , CHANG, Eun-Joo , LEE, Min-Kyung , KWON, Hyok-Yun
发明人： LEE, Young-Sung , AHN, Dong-Ho , HONG, Sa-Min , YOON, Seung-Kew , CHANG, Eun-Joo , LEE, Min-Kyung , KWON, Hyok-Yun
IPC分类号： A61K35/78
CPC分类号： A61K36/73 , A23L33/105
摘要： Disclosed are pharmaceutical and food compositions for preventing or treating hepatic disease, containing a pharmaceutically effective amount of an extract from a plant Agrimonia eupatoria L. . Also, the present invention discloses a method of preparing a water-soluble extract from a plant of the genus Agrimonia , which has improved efficacy in preventing or treating hepatic diseases, characterized by heating a mixture of a pulverized product of a plant of the genus Agrimonia and water at about 20°C to 30°C for about 7 days or more, and pharmaceutical and food compositions for preventing or treating a hepatic disease, containing a water-soluble extract prepared according to the method. Further, the present invention discloses a method of preparing an organic solvent-soluble extract from a plant of the genus Agrimonia , which has improved efficacy in preventing or treating hepatic diseases, comprising the steps of extracting a plant of the genus Agrimonia with an organic solvent, and removing an aqueous fraction and then obtaining an organic solvent-soluble fraction, and pharmaceutical and food compositions for preventing or treating hepatic disease, containing an extract prepared according to the method.
摘要翻译：公开了用于预防或治疗肝脏疾病的药物和食品组合物，其含有药学有效量的来自植物Agrimonia eupatoria L的提取物。此外，本发明公开了一种从该属植物制备水溶性提取物的方法其具有改善预防或治疗肝脏疾病的功效，其特征在于在大约20℃至30℃加热Agrimonia属植物的粉碎产物和水的混合物约7天或更长时间，药物和用于预防或治疗肝病的食品组合物，其含有根据该方法制备的水溶性提取物。此外，本发明公开了一种制备有机溶剂可溶性提取物的方法，所述提取物具有改善预防或治疗肝病的功效，其特征在于包括以下步骤：用有机溶剂提取Agrimonia属植物并除去含水部分，然后得到有机溶剂可溶性部分，以及含有根据该方法制备的提取物的用于预防或治疗肝病的药物和食品组合物。

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