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1. 发明申请

US20190021951A1 ASEPTIC CONNECTOR 审中-公开
公开(公告)号：US20190021951A1
公开(公告)日：2019-01-24
申请号：US16143048
申请日：2018-09-26
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf Pavlik
IPC分类号： A61J1/20 , A61M39/16 , A61M39/10 , A61M39/18 , A61M39/12 , A61M39/24 , B65B3/00
摘要： An aseptic connector assembly includes a body portion having a receptacle configured to receive a corresponding fill connector. A pivot portion is movably coupled to the body portion, the pivot portion having a channel formed therein. A conduit portion is slidably disposed within the channel formed in the pivot portion. The pivot portion has a ready position and an operative position, the pivot portion being adjustable from the ready position to the operative position via relative movement with respect to the body portion.

2. 发明申请

US20140083170A1 TEST SYSTEM AND METHOD FOR FLEXIBLE CONTAINERS 有权
标题翻译：柔性容器的测试系统和方法
公开(公告)号：US20140083170A1
公开(公告)日：2014-03-27
申请号：US13974932
申请日：2013-08-23
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf PAVLIK
IPC分类号： G01M3/32
CPC分类号： G01M3/3218 , G01M3/3263
摘要： A portable flexible container integrity test device for conducting integrity testing of flexible containers is disclosed. The test device is particularly useful for testing aseptic flexible film bags in a manner that maintains the sterile nature of the container and removes crinkles by inflating the containers to remove crinkles and establish an inflation set point. The test device includes a programmable logic controller (PLC), a pressure transducer in electronic communication with the PLC, a power source configured to provide electrical power to the PLC, a blower in electronic communication with the PLC, a gas delivery pathway in selective fluid communication with the blower, and a human/machine interface in electronic communication with the PLC. The device is portable and configured to fluidly connect to a flexible container via the gas delivery pathway.
摘要翻译：公开了用于进行柔性容器的完整性测试的便携式柔性容器完整性测试装置。测试装置特别适用于以保持容器的无菌性质的方式测试无菌柔性膜袋，并且通过使容器膨胀以除去皱纹并建立充气设定点来消除皱纹。测试装置包括可编程逻辑控制器（PLC），与PLC电子通信的压力传感器，被配置为向PLC提供电力的电源，与PLC电子通信的鼓风机，选择性流体中的气体输送路径与鼓风机的通信，以及与PLC电子通信的人机界面。该装置是便携式的并且构造成经由气体输送路径流体地连接到柔性容器。

3. 发明申请

US20140007655A1 PRESSURE DECAY TESTING SYSTEM AND TESTING DEVICE FOR A CONNECTOR AND METHOD OF TESTING 有权
标题翻译：用于连接器的压力衰减测试系统和测试装置和测试方法
公开(公告)号：US20140007655A1
公开(公告)日：2014-01-09
申请号：US13934684
申请日：2013-07-03
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf PAVLIK
IPC分类号： G01M3/26
CPC分类号： G01M3/26
摘要： A pressure decay testing system including a testing device for determining the reliability of connectors is provided and includes a pneumatic cylinder that raises and lowers a sealing member that closes a second end of a connector inserted in the device. A base member is adjacent pneumatic cylinder and includes a receiving surface having at least one receiving member for holding the connector. A channel is disposed therethrough though the receiving surface of the base member and aligns with an inner bore of the connector inserted in the testing device. An air line is attached to base member fluidly connecting inner bore of the connector with decay tester. Decay tester introduces a pressure differential through the channel to reach a predetermined set point pressure when the connector is closed by the testing device. Decay tester is configured to measure a change in pressure over time with respect to the predetermined set point.
摘要翻译：提供了包括用于确定连接器的可靠性的测试装置的压力衰减测试系统，并且包括气动缸，其升高并降低了封闭插入到装置中的连接器的第二端的密封构件。基座构件邻近气缸，并且包括具有用于保持连接器的至少一个接收构件的接收表面。通道穿过基底构件的接收表面设置并与插入测试装置中的连接器的内孔对准。将空气管线连接到基座部件上，使连接器的内孔与衰减测试器流体连接。当连接器被测试装置关闭时，衰减测试仪通过通道引入压差以达到预定的设定点压力。衰减测试器被配置成测量相对于预定设定点的时间上的压力变化。

4. 发明申请

WO2015160522A1 ASEPTIC CONNECTOR 审中-公开
标题翻译： ASEPTIC连接器
公开(公告)号：WO2015160522A1
公开(公告)日：2015-10-22
申请号：PCT/US2015/023980
申请日：2015-04-02
申请人： ADVANCED SCIENTIFICS, INC.
发明人： PAVLIK, Rudolf
IPC分类号： A61M39/10 , A61M39/18 , A61J1/20 , A61M39/12 , B65B3/00 , A61M39/24
CPC分类号： A61J1/2051 , A61J1/201 , A61J1/2048 , A61M39/10 , A61M39/1055 , A61M39/12 , A61M39/16 , A61M39/18 , A61M2039/1072 , A61M2039/2433 , A61M2039/2473 , B65B3/003
摘要： An aseptic connector assembly (100) and a method of aseptically transferring fluid are provided. The aseptic connector assembly (100) includes a body portion (101), the body portion (1014) having a receptacle (210) configured to receive a corresponding fill connector (212); a pivot portion (103) adjustably disposed within and extending partially from the body portion (101), the pivot portion (103) having a channel (107) formed therein; and a conduit portion (105) axially slidably disposed within the channel (107) formed in the pivot portion (103). The pivot portion (103) comprises a ready position and an operative position, the pivot portion (103) being adjustable from the ready position to the operative position via relative movement with respect to the body portion (101). The method includes providing an aseptic connector (100) in a ready position, coupling a flexible tubing (205) and a fill connector (212) to the aseptic connector (100), moving a pivot portion (103) to an operative position, axially sliding the conduit portion (105) into the fill connector (212), and transferring a fluid through the connector (100).
摘要翻译：提供无菌连接器组件（100）和无菌流体的方法。无菌连接器组件（100）包括主体部分（101），主体部分（1014）具有构造成容纳相应的填充连接器（212）的插座（210）; 可调节地设置在主体部分（101）内并部分地从主体部分（101）延伸的枢转部分（103），枢转部分（103）具有形成在其中的通道（107）以及轴向可滑动地设置在形成在枢转部分（103）中的通道（107）内的导管部分（105）。所述枢转部分（103）包括就绪位置和操作位置，所述枢转部分（103）可通过相对于主体部分（101）的相对运动从就绪位置调整到操作位置。该方法包括将无菌连接器（100）提供在就绪位置，将柔性管道（205）和填充连接器（212）联接到无菌连接器（100），将枢转部分（103）移动到工作位置将导管部分（105）滑入填充连接器（212）中，并且通过连接器（100）传送流体。

5. 发明申请

WO2015142699A1 TRANSPORTABLE MIXING SYSTEM FOR BIOLOGICAL AND PHARMACEUTICAL MATERIALS 审中-公开
标题翻译：用于生物和药物材料的运输混合系统
公开(公告)号：WO2015142699A1
公开(公告)日：2015-09-24
申请号：PCT/US2015/020670
申请日：2015-03-16
申请人： ADVANCED SCIENTIFICS, INC.
发明人： PAVLIK, Rudolf
IPC分类号： B01F7/16 , B01F13/00 , B01F15/00 , B65D77/06
CPC分类号： B01F13/00 , B01F7/162 , B01F7/1695 , B01F13/0032 , B01F15/00837 , B01F15/0085 , B01F2215/0032 , B01F2215/0073 , B65D77/06
摘要： A MIXING SYSTEM AND MIXING ARRANGEMENT FOR BIOLOGICAL AND PHARMACEUTICAL MATERIALS A mixing system and mixing arrangement are provided. The mixing system includes a rigid container (140) including an integral support plate (145); a mixing assembly (130) supported on the integral support plate, the mixing assembly including a pliable enclosure (131) containing a fluid and a mixing device (136), a portion of the mixing device extending from the pliable enclosure and adapted to be detachably coupled to a drive mechanism (120); and a first plate (140) detachably secured to the rigid container. The pliable enclosure is in compression between the first plate and the integral support plate. The mixing arrangement includes a docking station (110) including a drive cradle (115) and a drive mechanism (120), a rigid container removably positioned within the drive cradle, a mixing assembly positioned within the rigid container, and a first plate configured to be detachably secured to the rigid container.
摘要翻译：混合系统和生物和药物材料的混合装置提供了一种混合系统和混合装置。所述混合系统包括包括整体支撑板（145）的刚性容器（140）。混合组件（130），其支撑在所述整体支撑板上，所述混合组件包括容纳流体的柔性外壳（131）和混合装置（136），所述混合装置的一部分从所述柔性外壳延伸并适于可拆卸耦合到驱动机构（120）; 以及可拆卸地固定到刚性容器的第一板（140）。柔性外壳在第一板和整体支撑板之间处于压缩状态。混合装置包括一个对接站（110），它包括一个驱动支架（115）和一个驱动机构（120），一个可拆卸地定位在驱动支架内的刚性容器，一个位于刚性容器内的混合组件，以及一个第一板，可拆卸地固定到刚性容器。

6. 发明申请

US20190336926A1 TRANSPORTABLE MIXING SYSTEM FOR BIOLOGICAL AND PHARMACEUTICAL MATERIALS 审中-公开
公开(公告)号：US20190336926A1
公开(公告)日：2019-11-07
申请号：US16515322
申请日：2019-07-18
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf Pavlik
IPC分类号： B01F13/00 , B01F15/00 , B65D77/06 , B01F7/16
摘要： A mixing system includes a container having a support plate and a mixing assembly supported on the support plate. The mixing assembly includes a pliable enclosure containing a fluid and a mixing device. A portion of the mixing device extends from the pliable enclosure and is adapted to be detachably coupled to a drive mechanism. A first plate is detachably secured to the rigid container. The pliable enclosure is disposed between the first plate and the support plate. A mixing arrangement includes a docking station having a drive cradle and a drive mechanism. The mixing system is removably positioned within the drive cradle so that the drive mechanism is removably coupled to the mixing device.

7. 发明授权

US09968519B2 Freezer bag, storage system, and method of freezing 有权
公开(公告)号：US09968519B2
公开(公告)日：2018-05-15
申请号：US14738442
申请日：2015-06-12
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf Pavlik
IPC分类号： A61J1/16 , B65D30/16 , F25D31/00 , A61J1/10 , A61J1/14 , A01N1/02
CPC分类号： A61J1/16 , A01N1/0263 , A01N1/0268 , A61J1/10 , A61J1/1475 , B65D31/06 , F25D31/00
摘要： A freezer bag, a storage system, and a method of freezing are provided. The freezer bag includes a pliable housing having opposing sides and bounding a cavity at least partially disposed between the opposing sides, each opposing side having an interior surface communicating with the cavity and an opposing exterior surface that is openly exposed, the pliable housing including a first panel and a seam. A first tufting couples together the opposing sides of the pliable housing at a distance spaced apart from the seam so that the cavity encircles the first tufting. A first port is connected to the pliable housing and communicates with the cavity.

8. 发明申请

US20170312714A1 MIXING ASSEMBLY AND MIXING METHOD 审中-公开
公开(公告)号：US20170312714A1
公开(公告)日：2017-11-02
申请号：US15652487
申请日：2017-07-18
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf Pavlik
IPC分类号： B01F15/00 , B01F11/00 , B01F3/12 , C12M1/00
CPC分类号： B01F15/0085 , B01F3/1221 , B01F11/0048 , B01F11/0082 , B01F15/00129 , B01F15/00155 , B01F15/00207 , B01F15/00253 , B01F15/00259 , B01F15/00402 , B01F15/00467 , B01F15/00538 , B01F2215/0073 , C12M23/14
摘要： A mixing system includes a tank assembly and a container positioned within the tank assembly, the container bounding a compartment. A mixer is disposed within the compartment of the container. A shaft has a first end secured to the mixer and an opposing second end disposed outside of the container. An actuation mechanism is coupled with the second end of the shaft outside of the container and reciprocally moves the shaft and the mixer a stroke length, the stroke length being adjusted based on a pre-programmed protocol or signals from a sensor.

9. 发明申请

US20160161361A1 TEST SYSTEM AND METHOD FOR FLEXIBLE CONTAINERS 有权
标题翻译：柔性容器的测试系统和方法
公开(公告)号：US20160161361A1
公开(公告)日：2016-06-09
申请号：US15044830
申请日：2016-02-16
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf Pavlik
IPC分类号： G01M3/32
CPC分类号： G01M3/3218 , G01M3/3263
摘要： A portable test device and related method are disclosed for conducting integrity testing of flexible containers. The test is particularly useful for testing aseptic flexible film bags in a manner that maintains the sterile nature of the container and removes crinkles by inflating the containers to remove crinkles and establish an inflation set point. The decay in pressure is measured over a predetermined period of time; if pressure loss does not exceed a predetermined threshold the integrity of the bag is confirmed and it can be filled without further manipulation of the container that may result in introducing flaws.
摘要翻译：公开了用于进行柔性容器的完整性测试的便携式测试装置和相关方法。该测试对于以保持容器的无菌性质的方式测试无菌柔性膜袋特别有用，并通过使容器膨胀以除去皱纹并建立充气设定点来消除皱纹。在预定的时间段内测量压力衰减; 如果压力损失不超过预定阈值，则确认袋的完整性，并且可以在不进一步操纵可能导致缺陷的容器的情况下填充袋。

10. 发明申请

US20150258511A1 TRANSPORTABLE MIXING SYSTEM FOR BIOLOGICAL AND PHARMACEUTICAL MATERIALS 有权
标题翻译：用于生物和药物材料的运输混合系统
公开(公告)号：US20150258511A1
公开(公告)日：2015-09-17
申请号：US14657550
申请日：2015-03-13
申请人： ADVANCED SCIENTIFICS, INC.
发明人： Rudolf PAVLIK
IPC分类号： B01F13/00
CPC分类号： B01F13/00 , B01F7/162 , B01F7/1695 , B01F13/0032 , B01F15/00837 , B01F15/0085 , B01F2215/0032 , B01F2215/0073 , B65D77/06
摘要： A mixing system and mixing arrangement are provided. The mixing system includes a rigid container including an integral support plate; a mixing assembly supported on the integral support plate, the mixing assembly including a pliable enclosure containing a fluid and a mixing device, a portion of the mixing device extending from the pliable enclosure and adapted to be detachably coupled to a drive mechanism; and a first plate detachably secured to the rigid container. The pliable enclosure is in compression between the first plate and the integral support plate. The mixing arrangement includes a docking station including a drive cradle and a drive mechanism, a rigid container removably positioned within the drive cradle, a mixing assembly positioned within the rigid container, and a first plate configured to be detachably secured to the rigid container.
摘要翻译：提供混合系统和混合装置。该混合系统包括一个包含整体支撑板的刚性容器; 支撑在整体支撑板上的混合组件，所述混合组件包括容纳流体和混合装置的柔性外壳，所述混合装置的一部分从柔性外壳延伸并适于可拆卸地联接到驱动机构; 以及可拆卸地固定到刚性容器的第一板。柔性外壳在第一板和整体支撑板之间处于压缩状态。混合装置包括对接站，该对接站包括驱动支架和驱动机构，可拆卸地定位在驱动支架内的刚性容器，位于刚性容器内的混合组件以及被配置为可拆卸地固定到刚性容器的第一板。

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