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1. 发明公开

EP1991538A4 ISOFLAVAN AND ISOFLAVENE COMPOUNDS AND THEIR USE AS ANGIOGENESIS INHIBITORS 审中-公开
标题翻译： ISOFLAVAN-和ISOFLAVENVERBINDUNGEN及其作为血管生成抑制剂
公开(公告)号：EP1991538A4
公开(公告)日：2011-05-25
申请号：EP07704862
申请日：2007-02-22
申请人： ADLERCREUTZ HERMAN , MURPHY CAROL , FOTSIS THEODORE , AL-MAHARIK NAWAF , HEINONEN SATU-MAARIT
发明人： ADLERCREUTZ HERMAN , MURPHY CAROL , FOTSIS THEODORE , AL-MAHARIK NAWAF , HEINONEN SATU-MAARIT
IPC分类号： C07D311/04 , A61K31/352 , A61P7/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P35/00
CPC分类号： A61K31/353 , A61K31/352 , C07D311/58

2. 发明申请

WO2007096471A1 ISOFLAVAN AND ISOFLAVENE COMPOUNDS AND THEIR USE AS ANGIOGENESIS INHIBITORS 审中-公开
标题翻译： ISOFLAVAN和ISOFLAVENE化合物及其作为血管生成抑制剂的用途
公开(公告)号：WO2007096471A1
公开(公告)日：2007-08-30
申请号：PCT/FI2007/050092
申请日：2007-02-22
申请人： ADLERCREUTZ, Herman , MURPHY, Carol , FOTSIS, Theodore , AL-MAHARIK, Nawaf , HEINONEN, Satu-Maarit
发明人： ADLERCREUTZ, Herman , MURPHY, Carol , FOTSIS, Theodore , AL-MAHARIK, Nawaf , HEINONEN, Satu-Maarit
IPC分类号： C07D311/04 , A61K31/352 , A61P35/00 , A61P7/00 , A61P17/02 , A61P17/06 , A61P19/02
CPC分类号： A61K31/353 , A61K31/352 , C07D311/58
摘要： The present invention is directed to the use of a group of isoflavan and isoflav-3-ene compounds having the formula (I) wherein R 1 and R 2 are independently hydrogen, -OR 3 , -OCOR 4 , -OCONR 5 R 6 , - OSO 2 NR 5 R 6 or -NH-CO-R 3 , and the group Ri can be in the 7- or 8-position; R and R' are independently hydrogen or -OR 3 ; R 3 is hydrogen or C 1-3 alkyl; R 4 is C 1-3 alkyl; and R 5 and R 6 are independently hydrogen or C 1-3 alkyl. and the dotted line means an optional additional bond causing a double bond between carbons 3 and 4, with the proviso that one of the groups R and R 1 is an alkoxy group - OR 3 , wherein R 3 is a C 1-3 -alkyl group, and the other is a hydroxy group, and/or one of the groups R' and R 2 is an alkoxy group -OR 3 , wherein R3 is a C 1-3 -alkyl group, and the other is a hydroxy group, whereby such a hydroxy group R 1 and/or R 2 can be replaced by any of the other groups defined for R 1 and R 2 above, except hydrogen, for the treatment of pathological conditions associated with or dependent on enhanced or abnormal angiogenesis in a mammal.
摘要翻译：本发明涉及使用一组具有式（I）的异黄酮和异唑-3-烯化合物，其中R 1和R 2独立地是氢， -OR 3，-OCOR 4，-OCONR 5 R 6， - OSO 2， N 2 NR 6或-NH-CO-R 3，并且基团R 1可以在7-位或8-位 ; R和R'独立地是氢或-OR 3 N; R 3是氢或C 1-3烷基; R 4是C 1-3烷基; 并且R 5和R 6独立地是氢或C 1-3烷基。并且虚线是指引入碳3和4之间的双键的任选的另外的键，条件是基团R和R 1中的一个是烷氧基 - OR 3，其中R 3是C 1-3 - 烷基，另一个是羟基，和/或R'和R' 其中R 3是C 1-3烷基，另一个是羟基，由此这样的羟基R _{1和/或R 2可以被以上对R 1和R 2定义的任何其它基团代替，除了氢，用于治疗与哺乳动物相关或依赖于哺乳动物增强或异常血管生成的病理状况。}

3. 发明公开

EP1991538A1 ISOFLAVAN AND ISOFLAVENE COMPOUNDS AND THEIR USE AS ANGIOGENESIS INHIBITORS 审中-公开
标题翻译： ISOFLAVAN-和ISOFLAVENVERBINDUNGEN及其作为血管生成抑制剂
公开(公告)号：EP1991538A1
公开(公告)日：2008-11-19
申请号：EP07704862.7
申请日：2007-02-22
申请人： Adlercreutz, Herman , Murphy, Carol , Fotsis, Theodore , Al- Maharik, Nawaf , Heinonen, Satu-Maarit
发明人： Adlercreutz, Herman , Murphy, Carol , Fotsis, Theodore , Al- Maharik, Nawaf , Heinonen, Satu-Maarit
IPC分类号： C07D311/04 , A61K31/352 , A61P35/00 , A61P7/00 , A61P17/02 , A61P17/06 , A61P19/02
CPC分类号： A61K31/353 , A61K31/352 , C07D311/58
摘要： The present invention is directed to the use of a group of isoflavan and isoflav-3-ene compounds having the formula (I) wherein R1 and R2 are independently hydrogen, -OR3, -OCOR4, -OCONR5R6, - OSO2NR5R6 or -NH-CO-R3, and the group Ri can be in the 7- or 8-position; R and R' are independently hydrogen or -OR3; R3 is hydrogen or C1-3 alkyl; R4 is C1-3 alkyl; and R5 and R6 are independently hydrogen or C1-3 alkyl. and the dotted line means an optional additional bond causing a double bond between carbons 3 and 4, with the proviso that one of the groups R and R1 is an alkoxy group - OR3, wherein R3 is a C 1-3 -alkyl group, and the other is a hydroxy group, and/or one of the groups R' and R2 is an alkoxy group -OR3 , wherein R3 is a C 1-3 -alkyl group, and the other is a hydroxy group, whereby such a hydroxy group R1 and/or R2 can be replaced by any of the other groups defined for R1 and R2 above, except hydrogen, for the treatment of pathological conditions associated with or dependent on enhanced or abnormal angiogenesis in a mammal.

4. 发明专利

FI20060601A0 未知
公开(公告)号：FI20060601A0
公开(公告)日：2006-06-19
申请号：FI20060601
申请日：2006-06-19
申请人： ADLERCREUTZ HERMAN , MURPHY CAROL , FOTSIS THEODORE , AL-MAHARIK NAWAF , HEINONEN SATU-MAARIT
发明人： ADLERCREUTZ HERMAN , MURPHY CAROL , FOTSIS THEODORE , AL-MAHARIK NAWAF , HEINONEN SATU-MAARIT
IPC分类号： C07D20060101
摘要： Disclosed is the use of isoflavan and isoflav-3-ene compounds for the treatment of pathological conditions associated with or dependent on enhanced or abnormal angiogenesis in a mammal.

5. 发明专利

FI934578A0 未知
公开(公告)号：FI934578A0
公开(公告)日：1993-10-15
申请号：FI934578
申请日：1993-10-15
申请人： ADLERCREUTZ HERMAN , FOTSIS THEODORE , ATTALLA HESHAM , HASE TAPIO
发明人： ADLERCREUTZ HERMAN , FOTSIS THEODORE , ATTALLA HESHAM , HASE TAPIO

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