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1. 发明专利

AU2005214988A1 Super-humanized antibodies against respiratory syncytial virus 未知
公开(公告)号：AU2005214988A1
公开(公告)日：2005-09-01
申请号：AU2005214988
申请日：2005-02-17
申请人： ABSALUS INC
发明人： LARRICK JAMES W , WILSON DAVID S , NOCK STEFFEN
IPC分类号： C07K16/10 , A61K39/42 , C07K16/44
摘要： Disclosed herein are humanized antibodies that bind to an epitope on the F protein of respiratory syncytial virus. The humanized antibodies were designed by comparing the canonical CDR structure types of the CDRs from a non-human antibody (HNK20) to the canonical CDR structure types found in the human antibody germline sequences as the basis for selecting human variable region frameworks in a method denoted "super-humanization." Human antibody variable regions having the same or similar canonical CDR structure types as the non-human CDR provided a subset of candidate sequences from which to select the human frameworks. Chimeric variable regions were made comprising the non-human CDRs grafted in corresponding locations into the human frameworks from the candidate human variable regions. Several humanized antibodies that bind the same antigen as HNK20 and that have low immunogenicity were thereby designed, including examples where the framework sequences have less than 65% amino acid identity to the non-human frameworks.

2. 发明申请

WO2005079479A2 SUPER-HUMANIZED ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS 审中-公开
标题翻译：超抗人抗病毒抗呼吸道病毒
公开(公告)号：WO2005079479A2
公开(公告)日：2005-09-01
申请号：PCT/US2005005153
申请日：2005-02-17
申请人： ABSALUS INC , WILSON DAVID S , NOCK STEFFEN , LARRICK JAMES W
发明人： WILSON DAVID S , NOCK STEFFEN , LARRICK JAMES W
IPC分类号： A61K39/42 , C07K16/10 , C07K16/44
CPC分类号： C07K16/1027 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： Disclosed herein are humanized antibodies that bind to an epitope on the F protein of respiratory syncytial virus. The humanized antibodies were designed by comparing the canonical CDR structure types of the CDRs from a non-human antibody (HNK20) to the canonical CDR structure types found in the human antibody germline sequences as the basis for selecting human variable region frameworks in a method denoted "super-humanization." Human antibody variable regions having the same or similar canonical CDR structure types as the non-human CDR provided a subset of candidate sequences from which to select the human frameworks. Chimeric variable regions were made comprising the non-human CDRs grafted in corresponding locations into the human frameworks from the candidate human variable regions. Several humanized antibodies that bind the same antigen as HNK20 and that have low immunogenicity were thereby designed, including examples where the framework sequences have less than 65% amino acid identity to the non-human frameworks.
摘要翻译：本文公开了与呼吸道合胞病毒的F蛋白上的表位结合的人源化抗体。通过将来自非人抗体（HNK20）的CDR的规范CDR结构类型与在人抗体种系序列中发现的规范CDR结构类型进行比较来设计人源化抗体，作为在所述方法中选择人可变区框架的基础 “超级人性化。” 具有与非人CDR相同或相似的典型CDR结构类型的人抗体可变区提供了选择人骨架的候选序列的子集。制备嵌合可变区，其包含从候选人可变区移植到人框架中的相应位置的非人CDR。由此设计了结合与HNK20相同的抗原并且具有低免疫原性的几种人源化抗体，包括其中框架序列与非人框架具有小于65％氨基酸同一性的实例。

3. 发明申请

WO2005079479A3 SUPER-HUMANIZED ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS 审中-公开
公开(公告)号：WO2005079479A3
公开(公告)日：2005-09-01
申请号：PCT/US2005/005153
申请日：2005-02-17
申请人： ABSALUS, INC. , WILSON, David, S. , NOCK, Steffen , LARRICK, James, W.
发明人： WILSON, David, S. , NOCK, Steffen , LARRICK, James, W.
IPC分类号： C07K16/10
摘要： Disclosed herein are humanized antibodies that bind to an epitope on the F protein of respiratory syncytial virus. The humanized antibodies were designed by comparing the canonical CDR structure types of the CDRs from a non-human antibody (HNK20) to the canonical CDR structure types found in the human antibody germline sequences as the basis for selecting human variable region frameworks in a method denoted "super-humanization." Human antibody variable regions having the same or similar canonical CDR structure types as the non-human CDR provided a subset of candidate sequences from which to select the human frameworks. Chimeric variable regions were made comprising the non-human CDRs grafted in corresponding locations into the human frameworks from the candidate human variable regions. Several humanized antibodies that bind the same antigen as HNK20 and that have low immunogenicity were thereby designed, including examples where the framework sequences have less than 65% amino acid identity to the non-human frameworks.

4. 发明公开

EP1720908A2 SUPER-HUMANIZED ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS 审中-公开
标题翻译：对呼吸道合胞病毒抗体SUPERHUMANISIERTE
公开(公告)号：EP1720908A2
公开(公告)日：2006-11-15
申请号：EP05732050.9
申请日：2005-02-17
申请人： ABSALUS, INC.
发明人： WILSON, David, S. , NOCK, Steffen , LARRICK, James, W.
IPC分类号： C07K16/10
CPC分类号： C07K16/1027 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： Disclosed herein are humanized antibodies that bind to an epitope on the F protein of respiratory syncytial virus. The humanized antibodies were designed by comparing the canonical CDR structure types of the CDRs from a non-human antibody (HNK20) to the canonical CDR structure types found in the human antibody germline sequences as the basis for selecting human variable region frameworks in a method denoted 'super-humanization.' Human antibody variable regions having the same or similar canonical CDR structure types as the non-human CDR provided a subset of candidate sequences from which to select the human frameworks. Chimeric variable regions were made comprising the non-human CDRs grafted in corresponding locations into the human frameworks from the candidate human variable regions. Several humanized antibodies that bind the same antigen as HNK20 and that have low immunogenicity were thereby designed, including examples where the framework sequences have less than 65% amino acid identity to the non-human frameworks.

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