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1. 发明申请

WO2009151741A1 METHODS AND COMPOSITIONS FOR THE INTRACEREBROVENTRICULAR ADMINISTRATION OF FELBAMATE 审中-公开
标题翻译：纤维母细胞瘤内分泌治疗方法与组合物
公开(公告)号：WO2009151741A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/039205
申请日：2009-04-01
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO , ABRAMS, Daniel, J. , ANCHORDOQUY, Tom , STEVENS, Karen, E.
发明人： ABRAMS, Daniel, J. , ANCHORDOQUY, Tom , STEVENS, Karen, E.
IPC分类号： A61K31/54
CPC分类号： A61K31/54 , A61K9/0019 , A61K9/0085 , A61K31/27
摘要： The present invention concerns methods, compositions, and apparatus for the ICV administration of felbamate. In particular embodiments, ICV administration is advantageous for decreasing the systemic concentrations of felbamate, thereby decreasing side-effect toxicity, while allowing more effective delivery of felbamate to the site of action, simultaneously decreasing the dosage delivered to the individual. In particular embodiments, ICV delivery may be of use for individuals who have previously proven to be refractory to systemic administration of anti-epilepsy agents, in some cases due to systemic side-effects, or for those individuals whose symptoms are of sufficient severity to warrant more aggressive therapeutic intervention. ICV administration allows not only lower systemic concentration but also higher therapeutically effective concentration within the CNS.
摘要翻译：本发明涉及用于ICV施用费尔班宾的方法，组合物和装置。在具体实施方案中，ICV施用有利于降低麦芽糖苷的全身浓度，从而降低副作用毒性，同时允许更有效地递送弗来宾酸盐至作用部位，同时降低递送至个体的剂量。在具体的实施方案中，ICV递送可以用于以前被证明对全身施用抗癫痫药物是有难度的个体，在某些情况下由于全身副作用，或者对于症状足够严重的那些个体来说，更积极的治疗干预。 ICV治疗不仅能够降低CNS内的全身浓度，还可以提高治疗有效浓度。

2. 发明申请

WO2007084777A3 MULTI-PARAMETER MONITORING DEVICE FOR USE WITH CENTRAL AND INTRAVENOUS ADMINISTRATION OF MEDICATION 审中-公开
标题翻译：多参数监测装置，用于中央和静脉内施用药物
公开(公告)号：WO2007084777A3
公开(公告)日：2008-11-20
申请号：PCT/US2007001692
申请日：2007-01-22
申请人： UNIV COLORADO , ABRAMS DANIEL J , BUNCH RAYMOND , ROYALS MICHAEL
发明人： ABRAMS DANIEL J , BUNCH RAYMOND , ROYALS MICHAEL
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61M2210/0693 , A61M2210/1003
摘要： The invention generally relates to a multi-parameter monitoring device for in-line use to monitor a therapeutic agent solution passing therethrough prior to being centrally administered in connection with treatment of a CNS-related condition or disorder, e.g., a neuro-psychiatric disorder. In another aspect, the invention relates to a multi-parameter monitoring device for in-line use to monitor a therapeutic agent solution passing therethrough prior to being (a) intravenously administered to a patient in connection with a treatment, such as is the case where the therapeutic agent solution comprises an IV administerable solution, or (b) administered to a patient in connection with a treatment for diabetes, such as is the case where the therapeutic agent comprises insulin.
摘要翻译：本发明一般涉及一种多参数监测装置，用于在与CNS相关病症或紊乱（例如神经精神障碍）的治疗相关联的中央给药之前，一直用于监测通过其中的治疗剂溶液。在另一方面，本发明涉及一种多参数监测装置，用于在（a）静脉内施用于与治疗有关的患者的情况下，用于在线使用来监测通过其中的治疗剂溶液，所述治疗剂溶液通过其中，例如在治疗剂溶液包含IV可施用的溶液，或（b）与治疗糖尿病有关的给予患者，例如治疗剂包括胰岛素的情况。

3. 发明申请

WO2007067927A9 INTRA-OPERATIVE OCULAR PARAMETER SENSING 审中-公开
标题翻译：手术视野参数检测
公开(公告)号：WO2007067927A9
公开(公告)日：2007-09-07
申请号：PCT/US2006061693
申请日：2006-12-06
申请人： OPTHO SYSTEMS INC , ABRAMS DANIEL J , CROWLEY CHRISTOPHER , KEILBACH KEVIN
发明人： ABRAMS DANIEL J , CROWLEY CHRISTOPHER , KEILBACH KEVIN
IPC分类号： A61B5/00
CPC分类号： A61B3/18 , A61B3/1233 , A61B3/125 , A61B3/16 , A61B5/0261 , A61B5/14555
摘要： A patient is monitored during a medical procedure, such as spinal surgery, to identify a condition indicative of the possible onset of blindness or damage to the patient's eye or eyes. Parameters that may be monitored in this regard include ocular perfusion, retinal oxygen saturation and ocular pressure. In one implementation, a device for monitoring the desired parameters includes a contact lens with fiber optic pathways mounted thereon. Light of multiple wavelengths can be transmitted into the patient's eyes via input optical pathways. Output optical pathways are associated with a camera for obtaining images of an area of interest within the patient's eyes. The images can be processed to obtain information regarding ocular perfusion and/or oxygen saturation. Changes in this regard can be used to identify a condition of interest.
摘要翻译：在医疗过程（例如脊柱手术）期间监测患者，以识别指示可能发生失明或损害患者眼睛或眼睛的状况。在这方面可以监测的参数包括眼睛灌注，视网膜氧饱和度和眼压。在一个实施方案中，用于监测所需参数的装置包括其上安装有光纤路径的隐形眼镜。多个波长的光可以通过输入光学路径传输到患者的眼睛。输出光学路径与用于获得患者眼睛内的感兴趣区域的图像的相机相关联。可以处理图像以获得关于眼睛灌注和/或氧饱和度的信息。这方面的变化可以用来识别感兴趣的条件。

4. 发明申请

WO2009014762A1 CENTRAL ADMINISTRATION OF STABLE FORMULATIONS OF THERAPEUTIC AGENTS FOR CNS CONDITIONS 审中-公开
标题翻译：中枢神经系统疾病治疗药物稳定剂型的中央管理
公开(公告)号：WO2009014762A1
公开(公告)日：2009-01-29
申请号：PCT/US2008/009109
申请日：2008-07-25
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO , STEVENS, Karen, E. , ABRAMS, Daniel, J. , ANCHORDOQUY, Tom , BUNCH, Raymond
发明人： STEVENS, Karen, E. , ABRAMS, Daniel, J. , ANCHORDOQUY, Tom , BUNCH, Raymond
IPC分类号： A61K9/22
CPC分类号： A61K9/0085 , A61K31/00 , A61K31/145 , A61K31/19 , A61K31/27 , A61K31/53 , A61K31/55 , A61K31/7076 , A61K47/10 , A61K47/26 , A61K47/40
摘要： The present invention concerns compositions, methods and/or apparatus of central administration of various CNS-active agents. In particular embodiments, intrathecal administration is advantageous for decreasing the systemic concentrations of CNS agent, thereby decreasing side effect toxicity, while allowing more effective delivery of the agent to the site of action, simultaneously decreasing the dosage delivered to the subject. In particular embodiments, ICV delivery may be of use for patients who have previously proven to be refractory to systemic administration of CNS agents, in some cases due to systemic side effects, or for those patients whose symptoms are of sufficient severity to warrant more aggressive therapeutic intervention. ICV administration allows not only lower systemic concentration but also higher therapeutically effective concentration within the CNS.
摘要翻译：本发明涉及各种CNS活性剂的中枢给药的组合物，方法和/或装置。在具体实施方案中，鞘内给药有利于降低CNS剂的全身浓度，从而降低副作用毒性，同时允许药物更有效地递送至作用部位，同时降低递送至受试者的剂量。在具体实施方案中，ICV递送可用于以前被证明对全身施用CNS药物难治的患者，在某些情况下由于全身性副作用，或对于那些症状足够严重以致需要更积极治疗的患者介入。 ICV治疗不仅能够降低CNS内的全身浓度，还可以提高治疗有效浓度。

5. 发明申请

WO2007067927A3 INTRA-OPERATIVE OCULAR PARAMETER SENSING 审中-公开
标题翻译：手术中的眼睛参数检测
公开(公告)号：WO2007067927A3
公开(公告)日：2007-11-01
申请号：PCT/US2006061693
申请日：2006-12-06
申请人： OPTHO SYSTEMS INC , ABRAMS DANIEL J , CROWLEY CHRISTOPHER , KEILBACH KEVIN
发明人： ABRAMS DANIEL J , CROWLEY CHRISTOPHER , KEILBACH KEVIN
IPC分类号： A61B3/16
CPC分类号： A61B3/18 , A61B3/1233 , A61B3/125 , A61B3/16 , A61B5/0261 , A61B5/14555
摘要： A patient is monitored during a medical procedure, such as spinal surgery, to identify a condition indicative of the possible onset of blindness or damage to the patient's eye or eyes. Parameters that may be monitored in this regard include ocular perfusion, retinal oxygen saturation and ocular pressure. In one implementation, a device for monitoring the desired parameters includes a contact lens with fiber optic pathways mounted thereon. Light of multiple wavelengths can be transmitted into the patient's eyes via input optical pathways. Output optical pathways are associated with a camera for obtaining images of an area of interest within the patient's eyes. The images can be processed to obtain information regarding ocular perfusion and/or oxygen saturation. Changes in this regard can be used to identify a condition of interest.
摘要翻译：在诸如脊柱手术的医疗程序期间监视患者以识别指示可能发生的失明或对患者的眼睛或眼睛的损伤的状况。在这方面可以监测的参数包括眼部灌注，视网膜氧饱和度和眼压。在一个实施方式中，用于监视期望参数的装置包括其上安装有光纤通路的隐形眼镜。多个波长的光可以通过输入光路传输到患者的眼睛。输出光学路径与用于获得患者眼睛内的感兴趣区域的图像的照相机相关联。可以处理图像以获得关于眼部灌注和/或氧饱和度的信息。这方面的变化可以用来确定一个感兴趣的条件。

6. 发明申请

WO2007084777A9 MULTI-PARAMETER MONITORING DEVICE FOR USE WITH CENTRAL AND INTRAVENOUS ADMINISTRATION OF MEDICATION 审中-公开
标题翻译：多参数监测装置，用于中央和静脉内施用药物
公开(公告)号：WO2007084777A9
公开(公告)日：2007-10-04
申请号：PCT/US2007001692
申请日：2007-01-22
申请人： UNIV COLORADO , ABRAMS DANIEL J , BUNCH RAYMOND , ROYALS MICHAEL
发明人： ABRAMS DANIEL J , BUNCH RAYMOND , ROYALS MICHAEL
IPC分类号： A61K31/551 , A61M35/00
CPC分类号： A61M5/14276 , A61M2210/0693 , A61M2210/1003
摘要： The invention generally relates to a multi-parameter monitoring device for in-line use to monitor a therapeutic agent solution passing therethrough prior to being centrally administered in connection with treatment of a CNS-related condition or disorder, e.g., a neuro-psychiatric disorder. In another aspect, the invention relates to a multi-parameter monitoring device for in-line use to monitor a therapeutic agent solution passing therethrough prior to being (a) intravenously administered to a patient in connection with a treatment, such as is the case where the therapeutic agent solution comprises an IV administerable solution, or (b) administered to a patient in connection with a treatment for diabetes, such as is the case where the therapeutic agent comprises insulin.
摘要翻译：本发明一般涉及一种多参数监测装置，用于在与CNS相关病症或紊乱（例如神经精神障碍）的治疗相关联的中央给药之前，一直用于监测通过其中的治疗剂溶液。在另一方面，本发明涉及一种多参数监测装置，用于在（a）静脉内施用于与治疗有关的患者的情况下，用于在线使用来监测通过其中的治疗剂溶液，所述治疗剂溶液通过其中，例如在治疗剂溶液包含IV可施用的溶液，或（b）与治疗糖尿病有关的给予患者，例如治疗剂包括胰岛素的情况。

7. 发明申请

WO2007084777A2 MULTI-PARAMETER MONITORING DEVICE FOR USE WITH CENTRAL AND INTRAVENOUS ADMINISTRATION OF MEDICATION 审中-公开
标题翻译：用于中央和静脉注射药物的多参数监测设备
公开(公告)号：WO2007084777A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/001692
申请日：2007-01-22
申请人： REGENTS OF THE UNIVERSITY OF COLORADO , ABRAMS, Daniel J. , BUNCH, Raymond , ROYALS, Michael
发明人： ABRAMS, Daniel J. , BUNCH, Raymond , ROYALS, Michael
IPC分类号： A61K31/551 , A61M35/00
CPC分类号： A61M5/14276 , A61M2210/0693 , A61M2210/1003
摘要： The invention generally relates to a multi-parameter monitoring device for in-line use to monitor a therapeutic agent solution passing therethrough prior to being centrally administered in connection with treatment of a CNS-related condition or disorder, e.g., a neuro-psychiatric disorder. In another aspect, the invention relates to a multi-parameter monitoring device for in-line use to monitor a therapeutic agent solution passing therethrough prior to being (a) intravenously administered to a patient in connection with a treatment, such as is the case where the therapeutic agent solution comprises an IV administerable solution, or (b) administered to a patient in connection with a treatment for diabetes, such as is the case where the therapeutic agent comprises insulin.
摘要翻译：本发明一般涉及一种用于在线使用的多参数监测装置，用于监测通过其中的治疗剂溶液，然后集中施用以治疗CNS相关病症或病症，例如神经精神障碍。另一方面，本发明涉及一种用于在线使用的多参数监测装置，以监测通过其中的治疗剂溶液，之后（a）与治疗相关的静脉内给予患者，例如治疗剂溶液包含IV给药溶液，或（b）与糖尿病治疗相关地给予患者，例如治疗剂包含胰岛素的情况。

8. 发明申请

WO2007084541A2 CENTRAL ADMINISTRATION OF STABLE FORMULATIONS OF THERAPEUTIC AGENTS FOR CNS CONDITIONS 审中-公开
标题翻译：中枢神经系统疾病治疗药物稳定剂型的中央管理
公开(公告)号：WO2007084541A2
公开(公告)日：2007-07-26
申请号：PCT/US2007001201
申请日：2007-01-17
申请人： UNIV COLORADO , ABRAMS DANIEL J , BUNCH RAYMOND , ANCHORDOQUY TOM , STEVENS ELIZABETH
发明人： ABRAMS DANIEL J , BUNCH RAYMOND , ANCHORDOQUY TOM , STEVENS ELIZABETH
IPC分类号： A61K9/08 , A61K31/135 , A61K47/10 , A61K47/26 , A61K47/40 , A61K47/48
CPC分类号： A61K47/40 , A61K9/0019 , A61K9/0085 , A61K9/08 , A61K31/135 , A61K31/138 , A61K31/15 , A61K31/19 , A61K31/196 , A61K31/27 , A61K31/325 , A61K31/4166 , A61K31/4168 , A61K31/4178 , A61K31/52 , A61K31/53 , A61K31/55 , A61K31/5513 , A61K31/7076
摘要： The present invention concerns compositions, methods and/or apparatus of central administration of various CNS-active agents. In particular embodiments, intrathecal administration is advantageous for decreasing the systemic concentrations of CNS agent, thereby decreasing side effect toxicity, while allowing more effective delivery of the agent to the site of action, simultaneously decreasing the dosage delivered to the subject. In particular embodiments, ICV delivery may be of use for patients who have previously proven to be refractory to systemic administration of CNS agents, in some cases due to systemic side effects, or for those patients whose symptoms are of sufficient severity to warrant more aggressive therapeutic intervention. ICV administration allows not only lower systemic concentration but also higher therapeutically effective concentration within the CNS.
摘要翻译：本发明涉及各种CNS活性剂的中枢给药的组合物，方法和/或装置。在具体实施方案中，鞘内给药有利于降低CNS剂的全身浓度，从而降低副作用毒性，同时允许药物更有效地递送至作用部位，同时降低递送至受试者的剂量。在具体实施方案中，ICV递送可以用于以前被证明对全身施用CNS药物难治的患者，在某些情况下由于全身性副作用，或者对于那些症状足够严重以致需要更积极治疗的患者介入。 ICV管理不仅可以降低全身浓度，而且可以使CNS内的治疗有效浓度更高。

9. 发明申请

WO2007084541A3 CENTRAL ADMINISTRATION OF STABLE FORMULATIONS OF THERAPEUTIC AGENTS FOR CNS CONDITIONS 审中-公开
公开(公告)号：WO2007084541A3
公开(公告)日：2007-07-26
申请号：PCT/US2007/001201
申请日：2007-01-17
申请人： REGENTS OF THE UNIVERSITY OF COLORADO , ABRAMS, Daniel, J. , BUNCH, Raymond , ANCHORDOQUY, Tom , STEVENS, Elizabeth
发明人： ABRAMS, Daniel, J. , BUNCH, Raymond , ANCHORDOQUY, Tom , STEVENS, Elizabeth
IPC分类号： A61K9/08 , A61K47/48 , A61K47/10 , A61K47/26 , A61K47/40 , A61K31/135 , A61K31/15 , A61K31/19 , A61K31/196 , A61K31/27 , A61K31/4166 , A61K31/4168 , A61K31/52 , A61K31/53 , A61K31/55
摘要： The present invention concerns compositions, methods and/or apparatus of central administration of various CNS-active agents. In particular embodiments, intrathecal administration is advantageous for decreasing the systemic concentrations of CNS agent, thereby decreasing side effect toxicity, while allowing more effective delivery of the agent to the site of action, simultaneously decreasing the dosage delivered to the subject. In particular embodiments, ICV delivery may be of use for patients who have previously proven to be refractory to systemic administration of CNS agents, in some cases due to systemic side effects, or for those patients whose symptoms are of sufficient severity to warrant more aggressive therapeutic intervention. ICV administration allows not only lower systemic concentration but also higher therapeutically effective concentration within the CNS.

10. 发明申请

WO2007067927A2 INTRA-OPERATIVE OCULAR PARAMETER SENSING 审中-公开
标题翻译：手术中的眼睛参数检测
公开(公告)号：WO2007067927A2
公开(公告)日：2007-06-14
申请号：PCT/US2006/061693
申请日：2006-12-06
申请人： OPTHO SYSTEMS, INC. , ABRAMS, Daniel, J. , CROWLEY, Christopher , KEILBACH, Kevin
发明人： ABRAMS, Daniel, J. , CROWLEY, Christopher , KEILBACH, Kevin
IPC分类号： A61B5/00
CPC分类号： A61B3/18 , A61B3/1233 , A61B3/125 , A61B3/16 , A61B5/0261 , A61B5/14555 , G06F19/00
摘要： A patient is monitored during a medical procedure, such as spinal surgery, to identify a condition indicative of the possible onset of blindness or damage to the patient's eye or eyes. Parameters that may be monitored in this regard include ocular perfusion, retinal oxygen saturation and ocular pressure. In one implementation, a device for monitoring the desired parameters includes a contact lens with fiber optic pathways mounted thereon. Light of multiple wavelengths can be transmitted into the patient's eyes via input optical pathways. Output optical pathways are associated with a camera for obtaining images of an area of interest within the patient's eyes. The images can be processed to obtain information regarding ocular perfusion and/or oxygen saturation. Changes in this regard can be used to identify a condition of interest.
摘要翻译：在诸如脊柱手术的医疗程序期间监视患者以识别指示可能发生的失明或对患者的眼睛或眼睛的损伤的状况。在这方面可以监测的参数包括眼部灌注，视网膜氧饱和度和眼压。在一个实施方式中，用于监视期望参数的装置包括其上安装有光纤通路的隐形眼镜。多个波长的光可以通过输入光路传输到患者的眼睛。输出光学路径与用于获得患者眼睛内的感兴趣区域的图像的照相机相关联。可以处理图像以获得关于眼部灌注和/或氧饱和度的信息。这方面的变化可以用来确定一个感兴趣的条件。

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