专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5618824A Treatment of obsessive-compulsive disorders with 5-HT.sub.2 antagonists 失效
标题翻译：用5-HT2拮抗剂治疗强迫症
公开(公告)号：US5618824A
公开(公告)日：1997-04-08
申请号：US209084
申请日：1994-03-09
申请人： Christopher J. Schmidt , John H. Kehne , Robert A. Padich
发明人： Christopher J. Schmidt , John H. Kehne , Robert A. Padich
IPC分类号： C07D211/22 , A61K31/445 , A61K31/451 , A61K45/00 , A61P43/00
CPC分类号： A61K31/445
摘要： The present invention is directed to 5-HT.sub.2 antagonists and their use as agents in the treatment of obsessive-compulsive disorders (OCD). The invention is particularly directed to the compound (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol which is a member of a class of 5-HT.sub.2 antagonists known as N-aralkyl piperidinemethanol derivatives which are potent and selective inhibitors of the binding of serotonin at the 5-HT.sub.2 receptor site.
摘要翻译：本发明涉及5-HT2拮抗剂及其作为治疗强迫症（OCD）的药物的用途。本发明特别涉及作为一类5-HT2拮抗剂的成员的化合物（+） - α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇称为N-芳烷基哌啶甲醇衍生物，其是5-羟色胺在5-HT2受体位点结合的有效和选择性抑制剂。

2. 发明授权

US5134149A (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[ 2-(4-fluorophenyl)ethyl]-4-piperidinemethanol 失效
标题翻译：（+） - （ALPHA） - （2,3-二甲氧基苯基）-1-（2-（4-氟代乙基）乙基）-4-哌啶子胺
公开(公告)号：US5134149A
公开(公告)日：1992-07-28
申请号：US736194
申请日：1991-07-26
申请人： Albert A. Carr , John M. Kane , David A. Hay , Christopher J. Schmidt
发明人： Albert A. Carr , John M. Kane , David A. Hay , Christopher J. Schmidt
IPC分类号： A61K31/445 , A61K31/451 , A61P1/14 , A61P7/02 , A61P9/06 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/20 , A61P43/00 , C07D211/22
CPC分类号： C07D211/22
摘要： The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol, and its use in the treatment of a number of disease states.
摘要翻译：本发明涉及一种新的5HT2拮抗剂（+） - α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇，其用于治疗疾病数量。

3. 发明授权

US07146837B2 Power crimping tool 失效
标题翻译：电动压接工具
公开(公告)号：US07146837B2
公开(公告)日：2006-12-12
申请号：US10941378
申请日：2004-09-15
申请人： Christopher J. Schmidt
发明人： Christopher J. Schmidt
IPC分类号： B23P11/00 , B21D39/00
CPC分类号： E04F13/06 , B27F7/025 , E04F19/022 , E04F2013/063 , Y10T29/53709
摘要： A tool for crimping work pieces to one another is disclosed. The tool is mounted on a power actuator having a reciprocating ram for effecting crimping. The tool includes a body engageable with the workpiece. A movable head is mounted on the body and receives the ram. A jaw is pivotably mounted on the body. A link connects the head to the jaw, which pivots in response to the ram engaging and moving the head. The jaw has a tooth that penetrates the work pieces upon pivoting of the jaw. Penetration of the work pieces by the tooth crimps the pieces to one another. A receiver is mounted on the body to permit its engagement with the actuator by means of an attachment device adapted to a particular actuator. The tool may be removably attachable to the actuator or permanently attached thereto.
摘要翻译：公开了一种用于将工件彼此压接的工具。该工具安装在具有用于实现卷曲的往复式压头的动力执行机构上。该工具包括可与工件接合的主体。可移动头安装在主体上并接收冲头。颚可枢转地安装在身上。一个连接头将头部连接到颚板上，该颚板响应于该凸块接合和移动头部而枢转。钳口具有在颚枢转时穿过工件的牙齿。通过牙齿将工件的穿透将件彼此压紧。接收器安装在主体上以允许其通过适于特定致动器的附接装置与致动器接合。工具可以可拆卸地附接到致动器或永久地附接到致动器。

4. 发明授权

US5500433A Method of treating drug abuse 失效
标题翻译：治疗药物滥用的方法
公开(公告)号：US5500433A
公开(公告)日：1996-03-19
申请号：US371063
申请日：1995-01-10
申请人： Albert A. Carr , Richard C. Dage , John E. Koerner , Tung Li , Francis P. Miller , Thaddeus R. Nieduzak , Mark W. Dudley , . Christopher J. Schmidt , Robert A. Frank
发明人： Albert A. Carr , Richard C. Dage , John E. Koerner , Tung Li , Francis P. Miller , Thaddeus R. Nieduzak , Mark W. Dudley , . Christopher J. Schmidt , Robert A. Frank
IPC分类号： C07D211/32 , A61K31/445
CPC分类号： C07D211/32 , Y10S514/81 , Y10S514/811 , Y10S514/812 , Y10S514/813 , Y10S514/821 , Y10S514/822
摘要： The present invention is directed to a new class of piperidinyl medicinal agents which are useful for treating drug abuse.
摘要翻译：本发明涉及可用于治疗药物滥用的新一类哌啶基药物。

5. 发明授权

US06677378B2 Monoamine reuptake inhibitors for treatment of CNS disorders 失效
标题翻译：用于治疗CNS疾病的单胺再摄取抑制剂
公开(公告)号：US06677378B2
公开(公告)日：2004-01-13
申请号：US09845992
申请日：2001-04-30
申请人： Harry R. Howard, Jr. , Christopher J. Schmidt , Thomas F. Seeger , Mark L. Elliott
发明人： Harry R. Howard, Jr. , Christopher J. Schmidt , Thomas F. Seeger , Mark L. Elliott
IPC分类号： A61K31137
CPC分类号： C07D207/08 , C07C217/58 , C07C217/90 , C07C233/18 , C07C235/34 , C07C255/37 , C07C255/59 , C07C311/29 , C07C317/32 , C07C323/20 , C07D211/22 , C07D265/30 , C07D279/12 , C07D295/096
摘要： The present invention relates to compounds of the formula wherein R1 through R4, X, Y, m and n are defined as in the specification. Such compounds are useful exhibit activity as serotonin, norepinephrine and dopamine reuptake inhibitors, and their pharmaceutically acceptable salts, and their use in the treatment of central nervous system and other disorders.
摘要翻译：本发明涉及式Ⅳa至Ⅳ的化合物，X，Y，m和n如说明书中所定义。这样的化合物可用作5-羟色胺，去甲肾上腺素和多巴胺再摄取抑制剂及其药学上可接受的盐及其在治疗中枢神经系统和其它疾病中的用途。

6. 发明授权

US5874445A (+) -.alpha.- (2,3-dimethoxyphenyl)-1-(2-(4-fluorephenyl) ethyl)-4-piepridinemethanol 失效
标题翻译：（+） - α-（2,3-二甲氧基苯基）-1-（2-（4-氟苯基）乙基）-β-（4-哌啶甲醇）Ü
公开(公告)号：US5874445A
公开(公告)日：1999-02-23
申请号：US942629
申请日：1997-10-02
申请人： Albert A. Carr , John M. Kane , David A. Hay , Christopher J. Schmidt
发明人： Albert A. Carr , John M. Kane , David A. Hay , Christopher J. Schmidt
IPC分类号： A61K31/445 , A61K31/451 , A61P1/14 , A61P7/02 , A61P9/06 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/20 , A61P43/00 , C07D211/22
CPC分类号： C07D211/22
摘要： The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-�2-(4-fluorophenyl)ethyl!-4-piperidinemethanol, and its use in the treatment of a number of disease states.
摘要翻译：本发明涉及一种新的5HT2拮抗剂（+） - α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇，其用于治疗疾病数量。

7. 发明授权

US5721249A (+)-.alpha.-(2,3-di methoxyphenyl)-1-�2-(4-flurophenyl)etyl!-4-piperidinemethanol 失效
标题翻译：（+） - α-（2,3-二甲氧基苯基）-1Ä2-（4-氟苯基）乙基-4-哌啶甲醇
公开(公告)号：US5721249A
公开(公告)日：1998-02-24
申请号：US476538
申请日：1995-06-07
申请人： Albert A. Carr , John M. Kane , David A. Hay , Christopher J. Schmidt
发明人： Albert A. Carr , John M. Kane , David A. Hay , Christopher J. Schmidt
IPC分类号： A61K31/445 , A61K31/451 , A61P1/14 , A61P7/02 , A61P9/06 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/20 , A61P43/00 , C07D211/22
CPC分类号： C07D211/22
摘要： The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-�2-(4-fluorophenyl)ethyl!-4-piperidinemethanol, and its use in the treatment of a number of disease states.
摘要翻译：本发明涉及一种新的5HT2拮抗剂（+） - α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇，其用于治疗疾病数量。

8. 发明授权

US5561144A (+)-.alpha.-(2,3-dime thoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol 失效
公开(公告)号：US5561144A
公开(公告)日：1996-10-01
申请号：US372694
申请日：1995-01-13
申请人： Albert A. Carr , John M. Kane , David A. Hay , Christopher J. Schmidt
发明人： Albert A. Carr , John M. Kane , David A. Hay , Christopher J. Schmidt
IPC分类号： A61K31/445 , A61K31/451 , A61P1/14 , A61P7/02 , A61P9/06 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/20 , A61P43/00 , C07D211/22
CPC分类号： C07D211/22
摘要： The present invention is directed to a new 5HT.sub.2 antagonist, (+)-.alpha.-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol, and its use in the treatment of a number of disease states.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式