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1. 发明专利

JP2016102722A 新規光安全性試験法审中-公开
标题翻译：新型光学安全测试方法
公开(公告)号：JP2016102722A
公开(公告)日：2016-06-02
申请号：JP2014241412
申请日：2014-11-28
申请人：一般財団法人化学物質評価研究機構
发明人：武吉正博 , 前田洋祐
IPC分类号： G01N33/50 , G01N33/15
摘要：【課題】体系的で信頼性のある光安全性試験を提供する。【解決手段】(1)被験物質のUV吸収スペクトル測定を行い、光毒性及び光アレルギー性試験の実施の要否を決定し、(2)皮膚感作性評価において、被験物質試験群が、対照物質試験群に対して3倍の皮膚感作性を示す前記被験物質の濃度の算出を行い、(3)光毒性評価において、(3−i)前記(2)で算出した前記被験物質濃度において、光ハプテン型試験及びプロハプテン型試験の2通りのUV照射方法で光毒性試験を行い、より感作性の高い試験方法を選択し、(3−ii)選択された前記UV照射方法において、前記被験物質について光毒性試験を行い、皮膚感作及び光毒性を生じない最高濃度を決定し、(4)光アレルギー性評価において、前記(3−i)において選択されたUV照射方法を用い、前記(3−ii)において決定された濃度で、前期被験物質の光アレルギー性を評価する光安全性試験方法。【選択図】図1
摘要翻译：要解决的问题：提供系统可靠的光学安全测试方法。解决方案：通过光学安全测试方法，（1）测量被测材料的紫外吸收光谱，以确定光学毒性和光学过敏测试诱导需要进行; （2）在皮肤敏感性评价中，计算出测试材料组中如试验材料对照组中表现为皮肤敏感性敏感度为3倍的测试材料的浓度; （3）在光学毒性评估（3-i）中，通过两种不同的紫外线照射方法（包括光学半抗原类型法和催眠型法）选择在上述（2）中计算的测试材料的浓度来测试光学毒性，以选择两种方法和（3-ii）通过选择的UV照射方法更敏感，评估测试材料的光学毒性以确定皮肤敏感性和光学毒性都不发生的最大浓度; 和（4）在光学过敏评价中，通过上述（3-i）所述的紫外线照射方法，用上述（3-ii）所述测定的浓度对被测物质的光学过敏诱导性能进行评价。图1

2. 发明专利

JP2013001675A Angiogenesis regulator and utilization thereof 审中-公开
标题翻译：血管生成调节因子及其利用
公开(公告)号：JP2013001675A
公开(公告)日：2013-01-07
申请号：JP2011133895
申请日：2011-06-16
申请人： Hiroshima Univ , 国立大学法人広島大学 , Chemicals Evaluation & Research Institute Japan , 一般財団法人化学物質評価研究機構
发明人： MATSUBARA CHIKANORI , TAKEYOSHI MASAHIRO , YOKOTA HIROFUMI
IPC分类号： A61K48/00 , A61K31/7088 , A61K31/7105 , A61K38/00 , A61K45/00 , A61P3/10 , A61P9/10 , A61P9/14 , A61P19/02 , A61P29/00 , A61P35/00 , C12N15/09 , C12N15/113 , C12Q1/02 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide an angiogenesis promoter, a method for promoting angiogenesis, an angiogenesis inhibitor, a method for inhibiting angiogenesis, and a method for screening an angiogenesis regulation composition in each of which novel genes involved in the mechanism of regulating angiogenesis are utilized.SOLUTION: The angiogenesis promoter comprises as an active ingredient a polynucleotide containing the base sequence shown in sequence No.1 (NCBI Accession No. AB044755) or a like polynucleotide, a polypeptide containing the amino acid sequence shown in sequence No.2 (NCBI Accession No. BAA96781) or a like polypeptide, an inhibitor of a polynucleotide containing the base sequence shown in sequence No.3 (NCBI Accession No. AB077880) or a like inhibitor, or an inhibitor of a polypeptide containing the amino acid sequence shown in sequence No.4 (NCBI Accession No. BAB83896) or a like inhibitor. The angiogenesis inhibitor comprises as an active ingredient an inhibitor of a polynucleotide containing the amino acid sequence shown in sequence No.1 (NCBI Accession No. AB044755) or a like inhibitor, an inhibitor of a polypeptide containing the amino acid sequence shown in sequence No.2 (NCBI Accession No. BAA96781) or a like inhibitor, a polynucleotide containing the base sequence shown in sequence No.3 (NCBI Accession No. AB077880) or a like polynucleotide, or a polypeptide containing the amino acid sequence shown in sequence No.4 (NCBI Accession No. BAB83896) or a like polypeptide.
摘要翻译：待解决的问题：提供血管生成促进剂，促进血管发生的方法，血管生成抑制剂，抑制血管发生的方法，以及筛选血管生成调节组合物的方法，其中每一种参与机制的新基因利用调节血管发生。解决方案：血管生成促进剂包含含有序列号1所示的碱基序列（NCBI登录号AB044755）等的多核苷酸作为活性成分，含有序列号2所示的氨基酸序列的多肽（NCBI登录号BAA96781）或类似多肽，含有序列号3所示碱基序列的多核苷酸的抑制剂（NCBI登录号AB077880）等抑制剂，或含有氨基酸序列的多肽的抑制剂如序列号4（NCBI登录号BAB83896）或类似的抑制剂。血管生成抑制剂含有含有序列号1所示氨基酸序列（NCBI登录号AB044755）等的抑制剂作为活性成分的抑制剂，含有序列号No所示的氨基酸序列的多肽的抑制剂（NCBI登录号BAA96781）等抑制剂，含有序列号3所示碱基序列的多核苷酸（NCBI登录号AB077880）等多核苷酸，或含有序列号No所示的氨基酸序列的多肽 .4（NCBI登录号BAB83896）或类似多肽。版权所有（C）2013，JPO＆INPIT

3. 发明专利

JP5032089B2 Water dispersion method of fullerenes 有权
公开(公告)号：JP5032089B2
公开(公告)日：2012-09-26
申请号：JP2006277832
申请日：2006-10-11
申请人：一般財団法人化学物質評価研究機構
发明人：恵子上村 , 義之井上 , 直明屋形
IPC分类号： C01B31/02 , C09C1/44
摘要： PROBLEM TO BE SOLVED: To provide a method of dispersing water into fullerenes, which is high in safety. SOLUTION: In the method of dispersing water into the fullerenes, water is added to a ground and crushed mixture obtained by grinding and crushing the crystal of a monosaccharide or oligosaccharide, fullerenes and a non-ionic or anionic surfactant, the fullerenes are hydroxylated fullerene. As the monosaccharide or oligosaccharide, sugar, glucose or the like can be used, and as the surfactant, polyoxyethylene hardened caster oil, a polyoxyethylene sorbitan fatty acid ester or the like can be used. It is possible to produce the aqueous dispersion of fullerenes by using a water-soluble saccharide and an inorganic salt such as KBr or NaCl in place of the crystal of the monosaccharide or oligosaccharide. COPYRIGHT: (C)2008,JPO&INPIT

4. 发明专利

JP4965300B2 Method of water-dispersed carbon nanotubes 有权
公开(公告)号：JP4965300B2
公开(公告)日：2012-07-04
申请号：JP2007075855
申请日：2007-03-23
申请人：一般財団法人化学物質評価研究機構
发明人：義之井上 , 直明屋形 , 峰夫高月
IPC分类号： C01B31/02 , B01F17/56 , B01J13/00 , B82B3/00
摘要： PROBLEM TO BE SOLVED: To provide a highly safe method for dispersing a carbon nanotube in water without making the operation complicated. SOLUTION: In the method for dispersing the carbon nanotube in water, a crystal of a monosaccharide or oligosaccharide, the carbon nanotube and a nonionic or anionic surfactant are ground to yield a ground mixture, and water is added to the ground mixture. Here, sucrose, glucose, etc. can be used as the monosaccharide or oligosaccharide, and polyoxyethylene-cured castor oil, polyoxyethylene sorbitan fatty acid ester etc., can be used as the surfactant. Alternatively, a carbon nanotube water dispersion can be produced by using a water-soluble saccharide and an inorganic salt such as KBr and NaCl instead of the crystal of the monosaccharide or oligosaccharide. COPYRIGHT: (C)2009,JPO&INPIT

5. 发明专利

JP2007298455A Device and method for filling column for high-performance liquid chromatography 有权
标题翻译：用于高性能液相色谱填充色谱柱的装置和方法
公开(公告)号：JP2007298455A
公开(公告)日：2007-11-15
申请号：JP2006127945
申请日：2006-05-01
申请人： Chemicals Evaluation & Research Institute , 財団法人化学物質評価研究機構
发明人： SAKAMAKI HIROSHI
IPC分类号： G01N30/56 , G01N30/88
摘要： PROBLEM TO BE SOLVED: To provide a device and method for filling a column for high-performance liquid chromatography (HPLC), capable of shortening remarkably a time for returning residual pressure in the filling device to atmospheric pressure after finishing filling, and capable of enhancing preparation efficiency of the column for the HPLC.
SOLUTION: The device 2 for filling the column 4 for the HPLC having a high-pressure liquid feed pump 8, and a liquid feed pipe 10 for connecting the pump 8 to a packer 6, includes a flow-dividing resistance tube 12 in the liquid feed pipe 10, a high-pressure liquid feed pump 8 delivery side or a packer 6 upper side. In this filling method using the device 2, a slurry dispersed with a bulking agent in a solvent is supplied to the packer 6, the liquid is fed thereafter to the packer 6 at 10-100 MPa of pressure by the high-pressure liquid feed pump 8, and the bulking agent is filled into the column 4 while discharging the liquid from the flow-dividing resistance tube 12.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于填充用于高效液相色谱（HPLC）的柱的装置和方法，其能够在完成填充之后显着缩短将填充装置中的残余压力恢复到大气压力的时间，以及能够提高HPLC柱的制备效率。解决方案：用于填充具有高压液体供给泵8的HPLC的柱4的装置2和用于将泵8连接到封隔器6的液体供给管10包括分流阻力管12 在液体供给管10中，高压液体供给泵8输送侧或封隔器6的上侧。在使用装置2的这种填充方法中，将在填充剂中分散的浆料溶解在封隔器6中，然后通过高压液体供给泵在10-100MPa的压力下将液体供给到封隔器6 8，在从分流阻力管12排出液体的同时将填充剂填充到塔4中。（C）2008，JPO＆INPIT

6. 发明专利

JP2007010495A Protein or polypeptide identifying method 审中-公开
标题翻译：蛋白质或多肽鉴定方法
公开(公告)号：JP2007010495A
公开(公告)日：2007-01-18
申请号：JP2005191906
申请日：2005-06-30
申请人： Chemicals Evaluation & Research Institute , 財団法人化学物質評価研究機構
发明人： SAKAMAKI HIROSHI , YAMANAKA HIDENORI , TAJIMA HARUHIKO
IPC分类号： G01N27/62 , B01J20/281 , B01J20/286 , G01N30/06 , G01N30/32 , G01N30/34 , G01N30/60 , G01N30/72 , G01N30/88
摘要： PROBLEM TO BE SOLVED: To provide an identification method of a very small amount of a protein or a polypeptide. SOLUTION: In the identification method of a protein or a polypeptide using a liquid chromatograph-mass analyzer/mass analyzer (LC-MS/MS), 50 fmol or below of the protein or the polypeptide is identified using a liquid chromatograph wherein a chemically modified silica gel reacted with an end cap agent at a reaction temperature of 250°C or above in a gaseous phase or a porous glass is charged in a column with an inner diameter of 50-300 μm and a length of 3-25 cm. The flow velocity of a mobile phase is preferably 0.1-5.0 μL/min. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供非常少量的蛋白质或多肽的鉴定方法。解决方案：在使用液相色谱 - 质谱分析仪（LC-MS / MS）的蛋白质或多肽的鉴定方法中，使用液相色谱鉴定50fmol或更低的蛋白质或多肽，其中，将在气相或多孔玻璃中在250℃或更高的反应温度下与封端剂反应的化学改性硅胶装入内径为50-300μm，长度为3-25的柱中厘米。流动相的流速优选为0.1-5.0μL/ min。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2006246767A Ecdysone receptor and method for evaluating bond strength of chemical substance to the receptor 审中-公开
标题翻译： ECDYSONE受体和评估化学物质对受体的结合强度的方法
公开(公告)号：JP2006246767A
公开(公告)日：2006-09-21
申请号：JP2005066608
申请日：2005-03-10
申请人： Chemicals Evaluation & Research Institute , 財団法人化学物質評価研究機構
发明人： YOKOTA HIROFUMI
IPC分类号： C12N15/09 , C07K14/435 , C07K14/72 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10
摘要： PROBLEM TO BE SOLVED: To provide a method for evaluating bond strength of a test chemical substance to an ecdysone receptor of a crustacea. SOLUTION: The method for evaluating the bond strength of a chemical substance comprises evaluating the bond strength of a chemical substance to an ecdysone receptor by making a protein containing a specific amino acid sequence, a protein containing another specific amino acid sequence, a ligand and a test chemical substance exist in a solution and assaying the amount of the ligand bonded to the protein containing the former amino acid sequence. Gene expression proteins produced in transformants to which genes having corresponding base sequences are transferred are used as the proteins containing the specific amino acid sequences. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种评价测试化学物质与甲壳类蜕皮激素受体的结合强度的方法。解决方案：用于评估化学物质的键强度的方法包括通过制备含有特定氨基酸序列的蛋白质，含有另外的特定氨基酸序列的蛋白质来评价化学物质与蜕皮激素受体的结合强度，配体和测试化学物质存在于溶液中并测定与含有前氨基酸序列的蛋白质结合的配体的量。使用转移到具有相应碱基序列的基因的转化体中产生的基因表达蛋白被用作含有特定氨基酸序列的蛋白质。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP3683208B2 Blood collection device 有权
公开(公告)号：JP3683208B2
公开(公告)日：2005-08-17
申请号：JP2001360263
申请日：2001-11-27
申请人：財団法人化学物質評価研究機構
发明人：信彦東原 , 啓二白石 , 栄司矢野
IPC分类号： A61B5/15
摘要： PROBLEM TO BE SOLVED: To provide a blood collector which allows a required quantity of blood to be collected in a short time, puts a collected blood sample into a good state without hemolysis or coagulation, enables a one-hand operation so as to be easily operated, and also enables frequent blood sampling. SOLUTION: This blood collector 8 is composed of a blood-collecting needle 2 and a coupler 4 for impacting a hematocrit tube 6, which is provided at a tail end of the needle 2. The blood collector 8 is also composed of the needle 2, the coupler 4 and the hematocrit tube 6 which is detachably fitted into the coupler 4. COPYRIGHT: (C)2003,JPO

9. 发明专利

JP2005095080A Method for rating sensitizing potential intensity of test chemical substance 审中-公开
标题翻译：评价测试化学物质的敏感性强度的方法
公开(公告)号：JP2005095080A
公开(公告)日：2005-04-14
申请号：JP2003333984
申请日：2003-09-25
申请人： Chemicals Evaluation & Research Institute , 財団法人化学物質評価研究機構
发明人： TAKEYOSHI MASAHIRO
IPC分类号： G01N33/15 , C12Q1/02 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for more accurately determining the sensitizing potential intensity of a test chemical substance in a short time. SOLUTION: The method for rating the sensitizing potential intensity of a test chemical substance comprises the step(1) of preparing a standard solution(A) made by dissolving a standard chemical substance with known sensitizing potential intensity to a specified concentration and a test solution(B) made by dissolving a test chemical substance to the same concentration as that for the standard solution(A), the step(2) of applying the solution(A) to a group of control test animals and the solution(B) to a group of test animals, the step(3) of sampling the auricular lymph nodes of each of the test animals and assaying an indicator representing the cell proliferation extent of each of the auricular lymph nodes, and the step(4) of making a relative comparison of an indicator representing the cell proliferation extent of the auricular lymph nodes for the control test animal group and that for the test animals. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于在短时间内更准确地确定测试化学物质的敏化势强度的方法。评价试验化学物质的敏化势强度的方法包括制备通过将具有已知敏化电位强度的标准化学物质溶解至规定浓度而制备的标准溶液（A）的步骤（1）通过将测试化学物质溶解成与标准溶液（A）相同的浓度制备的测试溶液（B），将溶液（A）施用于一组对照试验动物的步骤（2）和溶液（B ）给一组试验动物，对每个试验动物的耳淋巴结进行取样的步骤（3），并测定表示每个耳状淋巴结的细胞增殖程度的指标，以及制备步骤（4）表示对照试验动物组和试验动物组的耳淋巴结细胞增殖程度的指标的相对比较。版权所有（C）2005，JPO＆NCIPI

10. 发明专利

JP2013032436A Polymer composition 审中-公开
标题翻译：聚合物组合物
公开(公告)号：JP2013032436A
公开(公告)日：2013-02-14
申请号：JP2011168823
申请日：2011-08-01
申请人： Kyushu Univ , 国立大学法人九州大学 , Chemicals Evaluation & Research Institute Japan , 一般財団法人化学物質評価研究機構
发明人： TANAKA KEIJI , FUJII YOSHIHISA , TSURUTA HIROFUMI , OTAKE YOSHITO
IPC分类号： C08L83/02 , C08L9/00 , C08L25/06 , C08L101/00
摘要： PROBLEM TO BE SOLVED: To provide a new technique to modify a polymer so as to be applied to various applications.SOLUTION: The polymer composition is obtained by mixing a sol-gel reaction solution with a solution of rubber or a solution of an amorphous polymer, the sol-gel reaction solution containing alkoxysilane, an acid catalyst, an organic solvent, and water and being progressed in sol-gel reaction.

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