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1. 发明申请

WO2008141201A1 COMPOSITE MATERIALS 审中-公开
标题翻译：复合材料
公开(公告)号：WO2008141201A1
公开(公告)日：2008-11-20
申请号：PCT/US2008/063271
申请日：2008-05-09
申请人： FISH, Christopher, N. , GHIORSO, Frank
发明人： FISH, Christopher, N. , GHIORSO, Frank
IPC分类号： C08J5/04 , C08L101/00 , C08G77/62
CPC分类号： C08J5/04 , C08J5/24 , C08J2383/16
摘要： Fiber reinforced thermoset plastic composites with a glass transition temperature of greater than 500 0C are disclosed. Certain embodiments of the disclosed fiber reinforced thermoset plastic composites are produced using pre-ceramic resin and fibers that are stable under thermal stress. Also disclosed are methods of making these fiber reinforced thermoset plastic composites. These methods include infiltrating thermally stable fibrous material with a pre-ceramic resin and introducing crosslinking. The disclosed methods produce a non-ceramic highly crosslinked thermoset plastic composite that possesses both thermal stability and mechanical strength.
摘要翻译：公开了玻璃化转变温度大于500℃的纤维增强热固性塑料复合材料。所公开的纤维增强热固性塑料复合材料的某些实施方案使用在热应力下稳定的预陶瓷树脂和纤维来制备。还公开了制造这些纤维增强热固性塑料复合材料的方法。这些方法包括用预陶瓷树脂渗透热稳定的纤维材料并引入交联。所公开的方法产生具有热稳定性和机械强度的非陶瓷高度交联的热固性塑料复合材料。

2. 发明申请

WO2008097229A1 METHOD FOR SPECTROSCOPIC QUANTITATION OF HER-2 IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于生物样品中HER-2的光谱定量的方法
公开(公告)号：WO2008097229A1
公开(公告)日：2008-08-14
申请号：PCT/US2007/003478
申请日：2007-02-09
申请人： THE GOVERNMENT OF THE USA AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH AND HUMAN SERVICES , CONRADS, Thomas, P. , VEENSTRA, Timothy, D. , HOOD, Brian, L. , KRIZMAN, David, B. , DARFLER, Marlene, M.
发明人： CONRADS, Thomas, P. , VEENSTRA, Timothy, D. , HOOD, Brian, L. , KRIZMAN, David, B. , DARFLER, Marlene, M.
IPC分类号： G01N33/574 , G01N33/68 , G01N33/74
CPC分类号： G01N33/57484 , G01N33/6872
摘要： Disclosed are methods for the detection of HER-2 in a biological sample using mass spectrometry. Specifically, these methods detect a cysteine-free HER-2 fragment peptide in the biological sample. The presence of HER-2 in a biological sample can be used to determine if a subject has a HER-2 associated cancer. The presence of HER-2 associated cancer can be used to determine if a subject would benefit from a HER-2 targeted therapy, such as an anti-HER-2 antibody. In one aspect, these methods can be used to quantify HER-2 in a biological sample via mass spectrometry by using an optionally isotopically labeled peptide standard.
摘要翻译：公开了使用质谱法检测生物样品中的HER-2的方法。具体地，这些方法检测生物样品中的半胱氨酸的HER-2片段肽。可以使用生物样品中HER-2的存在来确定受试者是否具有HER-2相关癌症。可以使用HER-2相关癌症的存在来确定受试者是否将受益于HER-2靶向治疗，例如抗HER-2抗体。一方面，这些方法可用于通过使用任选的同位素标记的肽标准通过质谱法定量生物样品中的HER-2。

3. 发明申请

WO2007136776A2 PYRIMIDINE LOW MOLECULAR WEIGHT LIGANDS FOR MODULATING HORMONE RECEPTORS 审中-公开
标题翻译：用于调节激素受体的吡嗪低分子量配体
公开(公告)号：WO2007136776A2
公开(公告)日：2007-11-29
申请号：PCT/US2007/011951
申请日：2007-05-17
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , GERSHENGORN, Marvin, C. , NEUMANN, Susanne , THOMAS, Craig , JAESCHKE, Holger , MOORE, Susanna , KRAUSE, Gerd , RAAKA, Bruce , PASCHKE, Ralf
发明人： GERSHENGORN, Marvin, C. , NEUMANN, Susanne , THOMAS, Craig , JAESCHKE, Holger , MOORE, Susanna , KRAUSE, Gerd , RAAKA, Bruce , PASCHKE, Ralf
IPC分类号： C07D495/04 , A61K31/519 , A61P5/06 , A61P5/08
CPC分类号： A61K31/519 , C07D495/04
摘要： Disclosed herein are small molecule modulators hormone receptors, including agonists and antagonists of luteinizing hormone/choriogonadotropin, follicle stimulating hormone and thyroid stimulating hormone receptors. Exemplary disclosed compounds include those of the formula wherein X is -S(O) n R 5 ; n is 0, 1 or 2; Y is -OR 6 or -NR 7 R 8 R 1 and R 2 independently are selected from optionally substituted lower aliphatic, alkoxy, aralkyl, halogen, H and -OR5, wherein R5 is selected from lower alkyl, H, aralkyl, acyl, alkoxycarbonyl and aminocarbonyl; R 3 and R 4 independently are selected from acyl, alkoxycarbonyl, aminocarbonyl, aralkyl, H, lower alkyl and cycloalkyl; R 5 is selected from lower alkyl, aralkyl, cycloalkyl and haloalkyl; R 6 is selected from H, lower alkyl and aralkyl; R 7 and R8 independently are selected from H, lower alkyl, aralkyl and cycloalkyl.
摘要翻译：本文公开了小分子调节剂激素受体，包括促黄体激素/促性腺激素的激动剂和拮抗剂，促卵泡激素和促甲状腺激素受体。示例性的公开的化合物包括下式的那些化合物其中X是-S（O）n R 5; n为0,1或2; Y是-OR 6或-NR 7 R 8 R 12和R 2 O 2 独立地选自任选取代的低级脂族，烷氧基，芳烷基，卤素，H和-OR5，其中R5选自低级烷基，H，芳烷基，酰基，烷氧基羰基和氨基羰基; R 3和R 4独立地选自酰基，烷氧基羰基，氨基羰基，芳烷基，H，低级烷基和环烷基; R 5选自低级烷基，芳烷基，环烷基和卤代烷基; R 6选自H，低级烷基和芳烷基; R 7和R 8独立地选自H，低级烷基，芳烷基和环烷基。

4. 发明申请

WO2020243612A1 METHOD OF PREVENTING AND TREATING THROMBOSIS 审中-公开
公开(公告)号：WO2020243612A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/035383
申请日：2020-05-29
申请人： RIGEL PHARMACEUTICALS, INC. , MASUDA, Esteban
发明人： MASUDA, Esteban
IPC分类号： A61K31/506 , A61K31/727 , A61P7/02
摘要： A method of preventing or treating thrombosis in a patent is disclose, wherein the method comprises administering to the patient an amount of fostamatinib or a form or metabolite thereof effective to prevent or treat the thrombosis, respectively.

5. 发明申请

WO2008098138A1 SYNTHETIC MACROCYCLIC COMPOUNDS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的合成大环化合物
公开(公告)号：WO2008098138A1
公开(公告)日：2008-08-14
申请号：PCT/US2008/053334
申请日：2008-02-07
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , BEWLEY, Carole, A. , METAFERIA, Belhu, B.
发明人： BEWLEY, Carole, A. , METAFERIA, Belhu, B.
IPC分类号： C07D267/00 , A61K31/395 , A61P35/00
CPC分类号： C07D267/00
摘要： Disclosed herein are macrocyclic compounds that are effective to inhibit cell migration. In one embodiment, the compounds have the structure: or any pharmaceutically acceptable salt or solvate thereof, wherein: m is O or 1; R 1 , R 2 and R 3 independently are H, aralkyl, acyl, lower alkyl or silyl; X is -C(O)N(R 4 )- or -C(S)N(R 4 )-; -C(O)-; -C(S)-; Y is -OC(O)-; -OC(O)N(R 5 )-; -N(R 5 )C(0)-; or -OC(O)O-; G comprises a saturated or unsaturated aliphatic chain having from 2 to about 10 atoms in the chain, the chain optionally including 1, 2, or 3 heteroatoms; the chain optionally being substituted with 1, 2 or 3 substituents independently selected from lower alkyl, -OR 6 , epoxy, aziridinyl, cyclopropyl, -NR 7 R 8 and halo; R 4 , R 5 , R 6 , R 7 and R 8 independently are selected from H, lower alkyl and acyl. Also disclosed are methods for making and using compounds as well as pharmaceutical compositions including one or more of the disclosed macrocycles.
摘要翻译：本文公开了有效抑制细胞迁移的大环化合物。在一个实施方案中，所述化合物具有以下结构：或其任何药学上可接受的盐或溶剂合物，其中：m为O或1; R 1，R 2和R 3独立地是H，芳烷基，酰基，低级烷基或甲硅烷基; X是-C（O）N（R 4） - 或-C（S）N（R 4） - ; -C（O） - ; -C（S） - ; Y为-OC（O） - ; -OC（O）N（R ^{5 ） - ; -N（R ^{5 ）C（O） - ; 或-OC（O）O-; G包含在链中具有2至约10个原子的饱和或不饱和脂族链，该链任选地包括1,2或3个杂原子; 该链任选被1,2或3个独立地选自低级烷基，-OR 6，环氧基，氮丙啶基，环丙基，-NR 7 R 8的取代基取代和光环; R 4，R 5，R 6，R 7和R 8独立地是选自H，低级烷基和酰基。还公开了制备和使用化合物的方法以及包含一种或多种所公开的大环化合物的药物组合物。}}

6. 发明申请

WO2007025186A2 HYDRAZONE AGENTS TO TREAT CUTANEOUS LESIONS 审中-公开
标题翻译： HYDRAZONE代理治疗CUTANEOUS LESIONS
公开(公告)号：WO2007025186A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/033318
申请日：2006-08-25
申请人： DEKK-TEC, INC. , MORGAN, Lee, Roy
发明人： MORGAN, Lee, Roy
IPC分类号： A61K31/15 , A61P17/12 , A61P35/00 , A61P17/06
CPC分类号： A61K31/15
摘要： A method is disclosed for treating hyperproliferative body surface lesions, including cancerous or precancerous lesion, such as warts or anogenital cancers, by applying a polyaryl mononitro- or dinitrophenylhydrazone such as wherein R 1 is hydrogen, hydroxy, 2- or 4-hydroxyphenyl, acetate, nitroso, phosphate, azido, nitrile, amino, dimethylamino, sulfate, methylsulfonate, phosphate, succinate or another water soluble electrophilic group capable of hydrogen bonding; R2 is C 6 H 4 OH, C 6 H 4 N 3 , C 6 H 4 CN, 4-HO-C 6 H 4 -C 6 H 4 , C 6 H 4 OPO 2 OH, C 6 H 4 OSO 2 H, C 6 H 4 NH 2 , C 6 H 4 NHM e2 , C 6 H 4 OSO 2 Me, C 6 H 4 OCO(CH 2 ) x CO 2 H, or C 6 H 5 Cl; and X is C 6 H 3 -2,4(NO 2 ) 2 , C 6 H 4 -4(NO 2 ), C 6 H 4 -3 (NO 2 ), or C 6 H 3 -2,4(NO 2 ) 2 . In a particular example, R 1 is OH, R 2 is C 6 H 4 OH and X is C 6 H 3 -2,4(NO 2 ) 2 .
摘要翻译：公开了一种用于治疗过度增生的身体表面损伤的方法，包括癌或癌前病变，例如疣或肛门癌，通过应用多芳基单硝基或二硝基苯腙，其中R 1是氢，羟基，2 - 或4-羟基苯基，乙酸酯，亚硝基，磷酸酯，叠氮基，腈，氨基，二甲基氨基，硫酸酯，甲基磺酸酯，磷酸酯，琥珀酸酯或其他能够氢键合的水溶性亲电基团; R 2是C 6 H 4 OH，C 6 H 4 N 3 N， C 6 H 4 CN，4-HO-C 6 H 4 -C 6， C 4 H 4，C 6 H 4，OH 2，OH，C 6， H 4，OH 2，C 6 H 4，NH 2，C 6， C 6 H 4 NH 3 C 2 H 5，C 6 H 4，OH 2， C，C 6 H 2 O 2（CH 2）2 CO 2 CH 2， H或C 6 H 5 Cl; 和X为C 6 H 3 -2 4（NO 2）2，C 6 H 4 - 4（NO 2 2），C 6 H 4 - 3（NO 3）或者C 6 H 3 -2 4（NO 2 2）2 。在具体实例中，R 1是OH，R 2是C 6 H 4 OH，X是C _{6 ħ_{3 -2,4（NO _{2 ）_{2 。}}}}

7. 发明申请

WO2006119284A2 CONJUGATED AROMATIC COMPOUNDS FOR DIAGNOSIS AND THERAPY 审中-公开
标题翻译：联合用于诊断和治疗的芳香化合物
公开(公告)号：WO2006119284A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016824
申请日：2006-05-03
申请人： DEKK-TEC, INC. , MORGAN, Lee Roy
发明人： MORGAN, Lee Roy
IPC分类号： A61K31/15 , A61K41/00 , C07C251/80 , C07C251/82
CPC分类号： C07C251/80 , C07C251/82
摘要： Disclosed herein are compounds, compositions and methods for using such compounds and compositions in the treatment of hyperproliferative conditions, including precancerous and cancerous conditions. In one embodiment, the compounds include resonance modulating compounds that can be used in the method as a coupling agent that is capable of interacting with the immune system to monitor or stimulate immune function. Such resonance modulators have inherent electromagnetic properties that attract immune cells to a target area to which the resonance modulating agent has been applied. Electromagnetic properties (such as a voltage amplitude) of the target region are altered in the presence of the resonance modulator, and serve as an indicator of immune function. An external stimulus (such as an applied electromagnetic field) can also be applied to the resonance modulator to enhance its immune stimulating and attractant properties. Particular examples of resonance modulators are disclosed, and these substances generally possess resonating intramolecular dipole moments that are capable of electrostatic interaction with biological environments. In certain examples the compounds aggregate at sites of therapeutic action to enhance their therapeutic activity. In other examples the compounds stimulate platelet production.
摘要翻译：本文公开了使用这些化合物和组合物来治疗过度增殖病症（包括癌前病变和癌症病症）的化合物，组合物和方法。在一个实施方案中，所述化合物包括共振调节化合物，其可以在该方法中用作偶联剂，其能够与免疫系统相互作用以监测或刺激免疫功能。这种共振调制剂具有将免疫细胞吸引到已经施加共振调节剂的目标区域的固有电磁特性。在谐振调制器的存在下改变目标区域的电磁特性（如电压振幅），并且作为免疫功能的指标。外部刺激（例如施加的电磁场）也可以应用于共振调制器以增强其免疫刺激和引诱特性。公开了共振调制剂的具体实例，并且这些物质通常具有能够与生物环境静电相互作用的共振的分子内偶极矩。在某些实例中，化合物在治疗作用的部位聚集以增强其治疗活性。在其他实例中，化合物刺激血小板产生。

8. 发明申请

WO2006042146A3 MULTIFUNCTIONAL NANOPARTICLES CONJUGATES AND THEIR USE 审中-公开
公开(公告)号：WO2006042146A3
公开(公告)日：2006-04-20
申请号：PCT/US2005/036222
申请日：2005-10-07
申请人： EMORY UNIVERSITY , NIE, Shuming , LEE, Yong, Kyu , KIM, Gloria
发明人： NIE, Shuming , LEE, Yong, Kyu , KIM, Gloria
IPC分类号： A61K9/14 , A61K48/00 , G01N33/53
摘要： Disclosed herein are conjugates comprising a nanocarrier, a therapeutic agent or imaging agent and a targeting agent. Also disclosed herein are compositions comprising such conjugates and methods for using the conjugates to deliver therapeutic and/or imaging agents to cells. Also disclosed are methods for using the conjugates to treat particular disorders, such as proliferative disorders.

9. 发明申请

WO2004017042A2 METHODS AND REAGENTS FOR SURFACE FUNCTIONALIZATION 审中-公开
标题翻译：表面功能化的方法和试剂
公开(公告)号：WO2004017042A2
公开(公告)日：2004-02-26
申请号：PCT/US2003/025927
申请日：2003-08-18
申请人： ZYOMYX, INC. , CICERO, Ronald , FORMAN, Jonathan , KERNEN, Peter , LU, Hongbo , QUINCY, David , SCHWEISER, Stefan , WAGNER, Peter
发明人： CICERO, Ronald , FORMAN, Jonathan , KERNEN, Peter , LU, Hongbo , QUINCY, David , SCHWEISER, Stefan , WAGNER, Peter
IPC分类号： G01N
CPC分类号： G01N33/54353 , B82Y30/00
摘要： Reagents and method for making arrays of affinity agents are disclosed. Methods of using the arrays of affinity agents also are disclosed. The arrays are particularly useful for high throughput drug screening and clinical diagnostics applications.
摘要翻译：公开了用于制备亲和剂阵列的试剂和方法。还公开了使用亲和剂阵列的方法。阵列对于高通量药物筛选和临床诊断应用特别有用。

10. 发明申请

WO2021046437A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
公开(公告)号：WO2021046437A1
公开(公告)日：2021-03-11
申请号：PCT/US2020/049527
申请日：2020-09-04
申请人： RIGEL PHARMACEUTICALS, INC. , CHEN, Yan , YU, Jiaxin , SHAW, Simon , DARWISH, Ihab , TAYLOR, Vanessa , BHAMIDIPATI, Somasekhar , LUO, Zhushou , KOLLURI, Rao
发明人： CHEN, Yan , YU, Jiaxin , SHAW, Simon , DARWISH, Ihab , TAYLOR, Vanessa , BHAMIDIPATI, Somasekhar , LUO, Zhushou , KOLLURI, Rao
IPC分类号： C07D471/04 , C07D487/04 , A61K31/55 , A61P37/00
摘要： Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.

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