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1. 发明申请

WO2022169974A1 INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF 审中-公开
公开(公告)号：WO2022169974A1
公开(公告)日：2022-08-11
申请号：PCT/US2022/015115
申请日：2022-02-03
申请人： NEXYS THERAPEUTICS, INC.
发明人： WU, Tom Yao-Hsiang , JIN, Qihui
IPC分类号： C07D471/04 , C07D487/04 , A61K31/437 , A61K31/4985 , A61K31/519 , A61P19/06
摘要： The present invention relates to pharmaceutical compounds, compositions, combinations, and methods, especially as they are related to compositions and methods for the treatment and/or prevention of conditions such as gout that are associated with excessive levels of uric acid. The invention provides compounds of Formula (I) as further described herein, which inhibit activity of urate reabsorption transporter 1 (URAT1, also known as SLC22A12). The compounds are useful to treat conditions associated with excessive levels of uric acid, such as gout.

2. 发明申请

WO2018058093A1 NEEDLE HANDLE WITH SPRING RETRACTION 审中-公开
标题翻译：带弹簧回缩的针柄
公开(公告)号：WO2018058093A1
公开(公告)日：2018-03-29
申请号：PCT/US2017/053400
申请日：2017-09-26
申请人： SPIRATION INC., D/B/A OLYMPUS RESPIRATORY AMERICA
发明人： GRAHAM, Madeline
IPC分类号： A61B10/04 , A61B10/02 , A61B17/34
CPC分类号： A61B10/04 , A61B10/0233 , A61B17/3496 , A61B2010/045
摘要： A medical instrument having an aspiration needle and handle retraction mechanism. The handle device controls the force required for a user to activate the needle and provides a higher force to activate and a counter force to auto-retract the needle.
摘要翻译：具有抽吸针和手柄回缩机构的医疗器械。手柄装置控制使用者启动针所需的力，并提供较高的力以激活并且施加反作用力以自动缩回针。

3. 发明申请

WO2019108709A1 REMOTELY AND DYNAMICALLY INJECTING ROUTES INTO AN IP NETWORK 审中-公开
公开(公告)号：WO2019108709A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/062927
申请日：2018-11-28
申请人： T-MOBILE USA, INC.
发明人： TAPPIN, John , AMIN, Rahul , SHAHIN, Samih , MRNDIC, Senad
IPC分类号： H04L12/751 , H04L12/715 , H04L12/733 , H04L12/741
摘要： Systems and methods are described herein for remotely and dynamically injecting routes into an Internet Protocol (IP) network. In some embodiments, the systems and methods provide a route injection server as a peer or neighbor node with an IP network. The systems and methods then utilize the route injection server (e.g., remote and dynamic route injection server, or RDRIS) to advertise IP routes to other nodes within the IP network. For example, the RDRIS may send UPDATE messages to other nodes within an IP network, such as via the Border Gateway Protocol (BGP) in order to advertise the IP routes to the other nodes of the IP network.

4. 发明申请

WO2016022475A2 SYSTEMS AND METHODS OF REMOTELY CONTROLLING MOBILE DEVICE SETTINGS AND FUNCTIONALITY 审中-公开
标题翻译：远程控制移动设备设置和功能的系统和方法
公开(公告)号：WO2016022475A2
公开(公告)日：2016-02-11
申请号：PCT/US2015/043427
申请日：2015-08-03
申请人： T-MOBILE USA, INC.
发明人： SOINI, Jonathan
IPC分类号： H04W4/00 , H04W8/24 , H04W12/06
CPC分类号： H04W8/22 , H04W24/02 , H04W24/04 , H04W88/02
摘要： Systems and methods for a customer care system. An example diagnostics back-end system may be associated with a telecommunications provider. The diagnostics back-end system may perform diagnostic analyses of information and settings associated with a mobile device, identify resolvable issues based on the diagnostic analyses, determine execution eligibility of each of one or more solution actions associated with each resolvable issue and upon determination that execution of the one or more solution actions are eligible, cause display of a single graphical user interface button at a user interface device of a customer care agent terminal, wherein activation of the single graphical user interface button causes execution of associated solution actions performed on the mobile device.
摘要翻译：客户关怀系统的系统和方法。示例性诊断后端系统可以与电信提供商相关联。诊断后端系统可以执行与移动设备相关联的信息和设置的诊断分析，基于诊断分析识别可解决的问题，确定与每个可解决问题相关联的一个或多个解决方案行动中的每一个的执行资格，以及在确定执行所述一个或多个解决方案动作是合格的，导致在客户关怀代理终端的用户界面设备处显示单个图形用户界面按钮，其中所述单个图形用户界面按钮的激活导致执行在所述移动设备。

5. 发明申请

WO2015200025A1 TOUCH SCREEN TESTING PLATFORM HAVING COMPONENTS FOR PROVIDING CONDUCTIVITY TO A TIP 审中-公开
标题翻译：触摸屏测试平台，具有提供电导率的组件
公开(公告)号：WO2015200025A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/035844
申请日：2015-06-15
申请人： T-MOBILE USA, INC.
发明人： JENKINSON, David, Ross
IPC分类号： G06F3/041
CPC分类号： G06F3/044 , G06F3/0488 , G06F11/2221 , G06F2203/04808
摘要： A touch screen testing platform may be used to perform repeatable testing of a touch screen enabled device using a robotic device tester and a controller. The platform may use various types of conductive tips that engage the touch screen, thereby simulating human behavior. The platform may perform multi-touch operations by employing multiple tips that can engage the touch screen simultaneously. The tips activate a touch screen from at least a trace of conductive coating located on nonconductive components of the robotic device tester.
摘要翻译：可以使用触摸屏测试平台来执行使用机器人设备测试器和控制器的启用触摸屏的设备的可重复测试。平台可以使用接触触摸屏的各种类型的导电尖端，从而模拟人的行为。该平台可以通过使用可以同时接触触摸屏的多个提示来执行多点触摸操作。尖端从位于机器人装置测试仪的非导电部件上的至少一层导电涂层激活触摸屏。

6. 发明申请

WO2020139636A1 (PYRIDIN-2-YL)AMINE DERIVATIVES AS TGF-BETA R1 (ALK5) INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2020139636A1
公开(公告)日：2020-07-02
申请号：PCT/US2019/066993
申请日：2019-12-17
申请人： NEXYS THERAPEUTICS, INC.
发明人： WU, Tom Yao-hsiang , JIN, Qihui
IPC分类号： C07D401/14 , C07D401/12 , C07D405/14 , C07D213/74 , A61K31/444 , A61K31/4439 , A61K31/4155 , A61K31/41 , A61P35/00
摘要： The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder associated with ΤGFβR1 activity, such as a cancer or fibrosis. The invention provides compounds of Formula (I) and Formula (II) as further described herein having an acidic moiety that enhances tissue specificity for targeted tissues and organs. The invention includes pharmaceutical compositions, pharmaceutical combinations, and methods of use of these compounds for treating conditions including cancer or fibrosis.

7. 发明申请

WO2018064575A1 PROTECTING MOBILE DEVICES FROM UNAUTHORIZED DEVICE RESETS 审中-公开
标题翻译：保护移动设备免遭未授权的设备重置
公开(公告)号：WO2018064575A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/054499
申请日：2017-09-29
申请人： T-MOBILE USA, INC.
发明人： FINGER, Joshua , BYLUND, Kimberly , KARIMLI, Yasmin
IPC分类号： H04L29/06 , H04W12/06 , H04W8/20
CPC分类号： G06F21/88 , G06F21/31 , G06F21/44 , G06F21/629 , H04L67/34 , H04W4/50
摘要： Systems and methods are described herein for authorizing master resets (e.g., factory resets) of mobile devices, such as smart phones, tablets, and so on. In some embodiments, the systems and methods employ a server-based authorization schema or mechanism, where at least one step or operation is performed, or caused to be performed, by a server or other system that is remote from the mobile device being reset.
摘要翻译：这里描述了用于授权诸如智能电话，平板电脑等的移动设备的主重置（例如，工厂重置）的系统和方法。在一些实施例中，所述系统和方法采用基于服务器的授权方案或机制，其中至少一个步骤或操作由远离所述移动设备的服务器或其他系统执行或被执行。

8. 发明申请

WO2017210093A1 EMERGENCY CALL HANDLING WITHIN IP MULTIMEDIA SYSTEM (IMS) NETWORKS 审中-公开
标题翻译： IP多媒体系统（IMS）网络中的紧急呼叫处理
公开(公告)号：WO2017210093A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/034578
申请日：2017-05-25
申请人： T-MOBILE USA, INC.
发明人： KAUL, Mayank , MUFTI, Shujaur, Rehman
IPC分类号： H04W76/00 , H04W4/22 , H04L29/06
摘要： Systems and methods are described herein for handling E911 communications within IMS networks, such as Voice over LTE (VoLTE) networks. In some embodiments, the systems and methods, via various communication nodes, handle or otherwise govern emergency calls within the VoLTE network, by sending an INVITE message from a sender node of the VoLTE network to a recipient node of the VoLTE network, and starting a retry timer at the sender node that is specific to handling E911 calls by the VoLTE network.
摘要翻译：这里描述了用于处理诸如LTE上的语音（VoLTE）网络等IMS网络内的E911通信的系统和方法。在一些实施例中，系统和方法经由各种通信节点处理或以其他方式管理VoLTE网络内的紧急呼叫，通过从VoLTE网络的发送方节点向VoLTE网络的接收方节点发送INVITE消息，重发定时器在发件人节点，专门用于处理VoLTE网络的E911呼叫。

9. 发明申请

WO2018084857A1 ELECTROSURGICAL INSTRUMENT 审中-公开
标题翻译：电外科仪器
公开(公告)号：WO2018084857A1
公开(公告)日：2018-05-11
申请号：PCT/US2016/060633
申请日：2016-11-04
申请人： SPIRATION, INC., D.B.A. OLYMPUS RESPIRATORY AMERICA , SHUMAN, Brandon, J. , LAMBE, Peter, A. , SALEIRA, Christopher, A. , ENGMAN, Zoie, R.
发明人： SHUMAN, Brandon, J. , LAMBE, Peter, A. , SALEIRA, Christopher, A. , ENGMAN, Zoie, R.
IPC分类号： A61B18/14
摘要： An electrosurgical instrument includes a needle configured as a first electrode and a coil extending through the needle and configured as a second electrode. The coil movable relative to the needle, and as the needle and the coil are inserted into tissue and energized with an electrical energy source, the needle and the coil apply current to the tissue to coagulate the tissue. The coil includes a fluid transmission feature that allows a fluid to flow distally for cooling the coil.
摘要翻译：电外科器械包括构造为第一电极的针和延伸穿过针并构造为第二电极的线圈。线圈可相对于针移动，并且随着针和线圈被插入组织中并且由电能源供能，针和线圈向组织施加电流以凝结组织。线圈包括流体传输特征，允许流体向远侧流动以冷却线圈。

10. 发明申请

WO2017091682A1 SHEATHS FOR NEEDLE DELIVERY 审中-公开
标题翻译：针状物递送
公开(公告)号：WO2017091682A1
公开(公告)日：2017-06-01
申请号：PCT/US2016/063516
申请日：2016-11-23
申请人： SPIRATION, INC.
发明人： BAILLARGEON, Jean-Martin , RALPH, Christopher R.
IPC分类号： A61B17/34 , A61B10/04
CPC分类号： A61B17/3478 , A61B2010/045 , A61B2090/0801 , A61B2090/3925
摘要： A needle apparatus having a sheath (34) with a protective hypotube insert (50) and a method of making the needle sheath. An example needle apparatus includes a handle, a needle (40) having a proximal end connected to the handle and a sheath. The sheath is configured to receive of the needle. The sheath includes a proximal end connected to the handle, a distal end, a lumen and the protective insert. The lumen passes from the proximal end to the distal end of the sheath. The protective insert is received within the lumen at the distal end of the sheath when force and/or heat are applied.
摘要翻译：具有带有保护性海波管插入件（50）的护套（34）的针设备以及制造针护套的方法。示例性针装置包括手柄，具有连接到手柄的近端和护套的针（40）。护套构造成接收针。护套包括连接到手柄的近端，远端，内腔和防护插件。内腔从护套的近端通到远端。当施加力和/或加热时，保护插入物被接收在护套远端的管腔内。

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