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1. 发明申请

WO2022241035A1 MULTI-PHASE HYBRID POWER CONVERTER ARCHITECTURE WITH LARGE CONVERSION RATIOS 审中-公开
公开(公告)号：WO2022241035A1
公开(公告)日：2022-11-17
申请号：PCT/US2022/028838
申请日：2022-05-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： PILAWA-PODGURSKI, Robert , YE, Zichao
IPC分类号： H02M3/07 , H02M3/145 , H02M3/06 , H02M3/155 , H02M3/156 , H02M1/0095 , H02M3/1586
摘要： A multi-phase hybrid power converter architecture which provides high efficiency, high power density and high conversion ratios for non-isolated DC to DC power conversion. Hybrid converters are described in which a switched-capacitor network is interoperably merged with a switched-inductor network having multiple inductors, resulting in a circuit with reduced component count and in which soft-charging of the capacitors is performed. Multi-phase switching is utilized and includes a freewheeling state for output voltage regulation in which inductor current ramps down. The SC converter can be configured to provide various conversion ratios, such as 4-to-1, 6-to-1 and 8-to-1, and optimized for the needs of specific application.

2. 发明申请

WO2022164858A1 METHOD FOR PRODUCING FOOD PRODUCTS USING CELLS GROWN IN CULTURE AS AN ALTERNATIVE TO ANIMAL HUSBANDRY 审中-公开
公开(公告)号：WO2022164858A1
公开(公告)日：2022-08-04
申请号：PCT/US2022/013843
申请日：2022-01-26
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： MAIORELLA, Brian
IPC分类号： A61L27/38 , A61L27/54
摘要： Systems and methods are provided for producing a product of cells organized into a desired macroscopic three-dimensional structure from one or more cell types with engineered donor and receptor pairs and optional scaffolds. Control over composition, timing and sequence in the organization of large numbers the types of cells that have been engineered and cultured in free suspension bioreactors is provided with the controlled binding of the donor/receptor pairs. The methods are suited to the production of food products. Because the final product is constructed with the same types of cells that are generally arranged in approximately the same three-dimensional structure as in animal muscle tissue, the final product can replicate the sensory and nutritional profile found in conventional, naturally produced meat.

3. 发明申请

WO2022125571A1 BIOELECTRIC NEUROMODULATION FOR HEMATOPOIESIS REGULATION DURING CHEMOTHERAPY 审中-公开
公开(公告)号：WO2022125571A1
公开(公告)日：2022-06-16
申请号：PCT/US2021/062243
申请日：2021-12-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US] , NATIONAL CHENG KUNG UNIVERSITY [CN]/[CN]
发明人： LIU, Wentai , SHEN, Meng-Ru , CHEN, Li-Hsien , HSU, Ya-Ting
IPC分类号： A61N1/36 , A61N1/00 , A61N1/32 , A61N2/00 , A61N1/40
摘要： A device and method are taught for stimulating sympathetic nerves toward mitigating negative impacts to hematopoiesis. An autonomic nerve actuator and stimulator system with a graphic user interface (GUI), controller circuit which converts treatment parameters into a series of Building Block Waveforms (BBW) which are output to Current/Voltage Driver Circuitry (CDC) whose electrical stimulus (ES) outputs are coupled to one or more electrodes and/or electrode arrays positioned proximal specific nerve situations. The use of this in combination with conventional chemotherapy treatments, such as use of carboplatin, was found to significantly enhance hematopoiesis, with improvements in white and red blood cell counts, platelet concentration and hemoglobin concentration, in addition to other measurable characteristics which increased survival rates in the experimental groups tested.

4. 发明申请

WO2011142760A1 HIGH CONTRAST GRATING INTEGRATED VCSEL USING ION IMPLANTATION 审中-公开
标题翻译：使用离子植入的高对比度光栅集成VCSEL
公开(公告)号：WO2011142760A1
公开(公告)日：2011-11-17
申请号：PCT/US2010/034731
申请日：2010-05-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CHANG-HASNAIN, Connie , CHASE, Christopher , RAO, Yi
发明人： CHANG-HASNAIN, Connie , CHASE, Christopher , RAO, Yi
IPC分类号： H01S3/0947 , H01S3/00
CPC分类号： H01S5/18386 , B82Y20/00 , H01S5/18308 , H01S5/18355 , H01S5/18366 , H01S5/18388 , H01S5/2063 , H01S5/3095 , H01S5/34306
摘要： A Vertical Cavity Surface Emitting Laser (VCSEL) and its fabrication are taught which incorporate a high contrast grating (HCG) to replace the top mirror of the device and which can operate at long-wavelengths, such as beyond 0.85 μm. The HCG beneficially provides a high degree of polarization differentiation and provides optical containment in response to lensing by the HCG. The device incorporates a quantum well active layer, a tunnel junction, and control of aperture width using ion implantation. A tunable VCSEL is taught which controls output wavelength in response to controlling a micro-mechanical actuator coupled to a HCG top mirror which can be moved to, or from, the body of the VCSEL. A fabrication process for the VCSEL includes patterning the HCG using a wet etching process, and highly anisotropic wet etching while precisely controlling temperature and PH.
摘要翻译：教导了垂直空腔表面发射激光器（VCSEL）及其制造方法，其结合了高对比度光栅（HCG）来代替器件的上反射镜，并可以在长波长（例如超过0.85μm）下工作。 HCG有利地提供高度的偏振微分，并且响应于HCG的透镜提供光学容纳。该器件采用量子阱有源层，隧道结，以及使用离子注入控制孔径宽度。教导了可调谐VCSEL，其响应于控制耦合到HCG上反射镜的微机械致动器来控制输出波长，HCG上反射镜可移动到VCSEL的主体或从VCSEL的主体移动。用于VCSEL的制造工艺包括使用湿蚀刻工艺对HCG进行图案化，并且在精确地控制温度和PH的同时进行高度各向异性的湿蚀刻。

5. 发明申请

WO2011050307A3 NANODEVICES FOR GENERATING POWER FROM MOLECULES AND BATTERYLESS SENSING 审中-公开
公开(公告)号：WO2011050307A3
公开(公告)日：2011-04-28
申请号：PCT/US2010/053827
申请日：2010-10-22
申请人： LAWRENCE LIVERMORE NATIONAL SECURITY, LLC , WANG, Yinmin , WANG, Xianying , HAMZA, Alex, V.
发明人： WANG, Yinmin , WANG, Xianying , HAMZA, Alex, V.
IPC分类号： H01M14/00 , H02N99/00 , B82B1/00
摘要： A nanoconverter or nanosensor is disclosed capable of directly generating electricity through physisorption interactions with molecules that are dipole containing organic species in a molecule interaction zone. High surface-to-volume ratio semiconductor nanowires or nanotubes (such as ZnO, silicon, carbon, etc.) are grown either aligned or randomly-aligned on a substrate. Epoxy or other nonconductive polymers are used to seal portions of the nanowires or nanotubes to create molecule noninteraction zones. By correlating certain molecule species to voltages generated, a nanosensor may quickly identify which species is detected. Nanoconverters in a series parallel arrangement may be constructed in planar, stacked, or rolled arrays to supply power to nano- and micro- devices without use of external batteries. In some cases breath, from human or other life forms, contain sufficient molecules to power a nanoconverter. A membrane permeable to certain molecules around the molecule interaction zone increases specific molecule nanosensor selectivity response.

6. 发明申请

WO2011017645A2 APPARATUS FOR PRODUCING X-RAYS FOR USE IN IMAGING 审中-公开
标题翻译：用于生产X射线以用于成像的装置
公开(公告)号：WO2011017645A2
公开(公告)日：2011-02-10
申请号：PCT/US2010/044762
申请日：2010-08-06
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TRAVISH, Gil , YODER, Rodney, B. , ROSENZWEIG, James
发明人： TRAVISH, Gil , YODER, Rodney, B. , ROSENZWEIG, James
IPC分类号： H05G1/52 , G01N23/20
CPC分类号： H01J35/065
摘要： An apparatus for producing x-rays for use in imaging applications is provided having a piezoelectric or pyroelecthc crystal with an upper surface and a conducting film coating the upper surface of the crystal. The crystal includes a plurality of field emitters formed as micrometer-scale exposed regions in the crystal having a one or more sharp peaks or ridges. In one embodiment, parallel trenches within the crystal form a wedge shaped emitter. The crystal is alternately heated and cooled over a period of several minutes with a heater/cooler adjacent the crystal so that spontaneous charge polarization occurs in the crystal. The spontaneous charge polarization causes a perpendicular electric field to arise on the crystal's top and bottom faces, in which case at the exposed surface of the crystal the electric field is enhanced by the sharp peaks or ridges, thereby causing field emission of surface electrons from that location. X-rays are produced when the emitted electrons strike a target material located adjacent to the emitting face, and may be filtered or collimated.
摘要翻译：提供了一种用于成像应用的用于生产x射线的装置，具有具有上表面的压电或热电晶体，并且涂覆了晶体的上表面的导电膜。晶体包括在晶体中形成有微米级暴露区域的多个场致发射体，其具有一个或多个尖峰或脊。在一个实施例中，晶体内的平行沟槽形成楔形发射体。将晶体交替地加热并用与晶体相邻的加热器/冷却器几分钟的时间冷却，使得在晶体中发生自发电荷极化。自发电荷极化导致在晶体的顶面和底面上产生垂直电场，在这种情况下，在晶体的暴露表面，电场被尖锐的峰或脊增强，从而引起表面电子的场发射位置。当发射的电子撞击位于发射面附近的目标材料时产生X射线，并且可以进行过滤或准直。

7. 发明申请

WO2010144497A3 DESIGN TREES FOR ADAPTIVE CODING OF IMAGES AND VIDEOS USING SET PARTITIONING IN GENERALIZED HIERARCHICAL TREES HAVING DIRECTIONALITY 审中-公开
公开(公告)号：WO2010144497A3
公开(公告)日：2010-12-16
申请号：PCT/US2010/037837
申请日：2010-06-08
申请人： SONY CORPORATION , LIU, Wei , GHARAVI-ALKHANSARI, Mohammad
发明人： LIU, Wei , GHARAVI-ALKHANSARI, Mohammad
IPC分类号： H04N7/26 , H04N7/30
摘要： Adaptive entropy encoding and decoding which utilizes Set Partitioning within Generalized Hierarchical Trees (SPRIGHT) and a method of designing trees utilizing directionality. After decorrelation and quantization a tree structure is selected from multiple candidates, based on geometric relationships within the image block, for coding the coefficients toward improving zero-clustering of coefficients. Trees for the SPRIGHT encoding are created in response to finding frequency position of each coefficient and scaling frequency position followed by use of octave-band partitioning of coefficient patterns into squares and L-shapes, and the L-shapes are iteratively partitioned into squares. The tree comprises leaf nodes containing coefficients associated with each non-leaf node. The number of zero clustered coefficients can be increased, thus decreasing the number of nodes coded into the encoded image output.

8. 发明申请

WO2010135186A8 DIPLEXER SYNTHESIS USING COMPOSITE RIGHT/LEFT-HANDED PHASE-ADVANCE/DELAY LINES 审中-公开
公开(公告)号：WO2010135186A8
公开(公告)日：2010-11-25
申请号：PCT/US2010/034903
申请日：2010-05-14
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ITOH, Tatsuo , CHI, Pei-Ling
发明人： ITOH, Tatsuo , CHI, Pei-Ling
IPC分类号： H01P1/213
摘要： A diplexing apparatus and method which utilizes composite right/left-handed (CRLH) phase-advance/delay lines combined with a coupler. By engineering CRLH- based transmission lines with desired phase responses at two arbitrary frequencies of interest, the connected CRLH delay line and/or CRLH coupler are excited in a manner such that signals at designated frequencies are separated to the corresponding output ports of the hybrid coupler. Benefits of the apparatus include elimination of design complexities such as optimization of the interconnection junctions and the harmonic spurious suppression involved in conventional filter-based diplexers. In addition, channel isolation is beneficially achieved from the isolation property of directional couplers. Measured insertion loss on the implementations was found to be less than 1 dB, with isolation greater than 20 dB in the dual bands. A high level of agreement was observed between simulated and measured results.

9. 发明申请

WO2010088553A3 INFRA-EXTENSIBLE LED ARRAY CONTROLLER FOR LIGHT EMISSION AND/OR LIGHT SENSING 审中-公开
公开(公告)号：WO2010088553A3
公开(公告)日：2010-08-05
申请号：PCT/US2010/022643
申请日：2010-01-29
申请人： NDSU RESEARCH FOUNDATION , PAVICIC, Mark, J.
发明人： PAVICIC, Mark, J.
IPC分类号： G09G3/36 , G09G3/32
摘要： An apparatus for controlling light emission and/or sensing in an array of optical elements. An infra-extensible array having a plurality of subarray display circuits interconnected with neighboring subarray display circuits. Each subarray display circuit is configured with a processor and a plurality of output and/or input elements. Messages and instructions can be propagated from one subarray display circuit to another to provide local processing relating to input and output elements, such as changing the pixels in the display from a subarray display circuit in response to locally sensed conditions or those communicated from neighboring subarray display circuits. Apparatus is infra-extensible as both the number of processors for executing display/sensor programming, and the number of communication channels available through which instructions can be received, increases automatically in response to increasing the number of subarray display circuits within the apparatus.

10. 发明申请

WO2010068705A2 ENCAPSULATED AGENT GUIDED IMAGING AND THERAPIES 审中-公开
标题翻译：包埋剂引导成像和治疗
公开(公告)号：WO2010068705A2
公开(公告)日：2010-06-17
申请号：PCT/US2009/067396
申请日：2009-12-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ANVARI, Bahman
发明人： ANVARI, Bahman
IPC分类号： A61K9/127 , A61K9/50 , A61K47/42 , A61K39/12 , A61K49/06
CPC分类号： C12N7/00 , A61K47/6901 , C12N2770/14023 , C12N2770/14042
摘要： A nano-capsule construct for imaging and therapeutic uses and method for production are provided. One nano-probe embodiment based on genome-depleted plant brome mosaic virus (BMV) whose interior is doped with indocyanine green (ICG), an FDA-approved near infrared fluorescent dye, is used to illustrate the invention. The material encapsulated in viral shell components may be coated with functionalized coatings such as branched, dendritic polymer coatings to improve longevity and distribution in the body as well as antibody conjugation for increased target specificity. The constructs can also be coated with ferromagnetic iron oxide nanoparticles, enabling the ICG-containing capsules to be used as nano-probes with the capability of being detected in both optical and magnetic resonance imaging. The capsules may be produced by purifying a plant or animal viruses and disassembling the viruses to provide virus shell components. The virus shell components are reassembled in the presence of a material for encapsulation thereby encapsulating said material within the core of the construct in one embodiment.
摘要翻译：提供了用于成像和治疗用途的纳米胶囊构建体和生产方法。使用FDA批准的近红外荧光染料，其内部掺杂有吲哚菁绿（ICG）的基于枯竭的植物杂色花叶病毒（BMV）的一个纳米探针实施例用于说明本发明。封装在病毒壳组分中的材料可以用官能化涂层涂覆，例如支化树枝状聚合物涂层，以改善身体的寿命和分布以及增加靶特异性的抗体缀合。构建体还可以用铁磁性氧化铁纳米颗粒涂覆，使得含ICG的胶囊能够用作具有在光学和磁共振成像中被检测的能力的纳米探针。胶囊可以通过纯化植物或动物病毒并分解病毒以提供病毒壳组分而产生。病毒壳组分在存在用于封装的材料的情况下重新组装，从而在一个实施方案中将所述材料封装在构建体的核心内。

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