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1. 发明申请

WO2019067660A1 HUMAN WASTE WATER AND HUMAN-DERIVED PATHOGEN SCOUTING TOOL 审中-公开
公开(公告)号：WO2019067660A1
公开(公告)日：2019-04-04
申请号：PCT/US2018/053014
申请日：2018-09-27
申请人： UNIVERSITY OF NORTH CAROLINA WILMINGTON
发明人： JASKOWIAK, Mary M. , CAHOON, Lawrence B.
IPC分类号： C12Q1/68 , G01N33/554 , G01N33/569
摘要： The present subject matter provides processes and kits for identifying the presence of waste water or human-derived pathogens, particularly those associated with the presence of human fecal matter, in surface or subsurface water sources.

2. 发明申请

WO2011106314A2 METHOD OF MAKING NUCLEIC ACID LIBRARIES 审中-公开
标题翻译：制备核酸图谱的方法
公开(公告)号：WO2011106314A2
公开(公告)日：2011-09-01
申请号：PCT/US2011/025711
申请日：2011-02-22
申请人： ADVANCED LIQUID LOGIC, INC. , POLLACK, Michael, G. , ECKHARDT, Allen, E. , SUDARSAN, Arjun , SRINIVASAN, Vijay , ROUSE, Jeremy , YI, Uichong , TROTTA, Nicholas , DHOPESHWARKAR, Rahul , THWAR, Prasanna , SMITH, Gregory, F. , NORTON, Scott , LINNARTZ, Peter
发明人： POLLACK, Michael, G. , ECKHARDT, Allen, E. , SUDARSAN, Arjun , SRINIVASAN, Vijay , ROUSE, Jeremy , YI, Uichong , TROTTA, Nicholas , DHOPESHWARKAR, Rahul , THWAR, Prasanna , SMITH, Gregory, F. , NORTON, Scott , LINNARTZ, Peter
IPC分类号： C12N15/10 , C40B50/08 , C40B40/06 , C07H21/00 , C12Q1/68
CPC分类号： C12N15/1075 , B01J19/0046 , C12N15/1006 , C40B40/08 , C40B50/06
摘要： A method of preparing a nucleic acid library in droplets in contact with oil, including: (a) blunt-ending nucleic acid fragments in a droplet in the oil to yield blunt-ended nucleic acid fragments; (b) phosphorylating the blunt-ended nucleic acid fragments in a droplet in the oil to yield phosphorylated nucleic acid fragments; coupling A-tails to the phosphorylated nucleic acid fragments in a droplet in the oil to yield A-tailed nucleic acid fragments; and (d) coupling nucleic acid adapters to the A-tailed nucleic acid fragments in a droplet in the oil to yield the nucleic acid library comprising adapter-ligated nucleic acid fragments.
摘要翻译：制备与油接触的液滴核酸文库的方法，包括：（a）在油中的液滴中的平端核酸片段以产生平端核酸片段; （b）使油中的液滴中的平端核酸片段磷酸化以产生磷酸化的核酸片段; 将A尾连接到油中的液滴中的磷酸化核酸片段以产生A尾核酸片段; 和（d）将核酸衔接子偶联到油中的液滴中的A尾核酸片段，以产生包含衔接子连接的核酸片段的核酸文库。

3. 发明申请

WO2010080941A2 CONSTRUCTION MODULUS TESTING APPARATUS AND METHOD 审中-公开
标题翻译：结构模量测试装置和方法
公开(公告)号：WO2010080941A2
公开(公告)日：2010-07-15
申请号：PCT/US2010/020412
申请日：2010-01-08
申请人： GEOPIER FOUNDATION COMPANY, INC. , WISSMANN, Kord J. , HILDRETH, John , SHERLOCK, Barry
发明人： WISSMANN, Kord J. , HILDRETH, John , SHERLOCK, Barry
IPC分类号： E02D7/18 , E02D7/00 , E02D13/00
CPC分类号： E02D1/022 , E02D3/046 , E02D3/054 , E02D3/08
摘要： A system and method of determining lift deflection during construction of aggregate columns allows for real time monitoring of construction to ensure meeting defined parameters. The amount of deflection of a tamper head during tamping is determined multiple times for each lift. When the amount of deflection matches a predetermined value, tamping is stopped.
摘要翻译：在建造集料柱期间确定升降机偏转的系统和方法允许实时监控建筑以确保满足所定义的参数。每次升降时，夯实头在捣固过程中的挠曲量将确定多次。当偏转量符合预定值时，停止捣固。

4. 发明申请

WO2008116221A1 BEAD SORTING ON A DROPLET ACTUATOR 审中-公开
标题翻译：珠子致动器上的珠子
公开(公告)号：WO2008116221A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/058047
申请日：2008-03-24
申请人： ADVANCED LIQUID LOGIC, INC. , SHENDEROV, Alexander , PAMULA, Vamsee , ECKHARDT, Allen
发明人： SHENDEROV, Alexander , PAMULA, Vamsee , ECKHARDT, Allen
IPC分类号： C40B50/08
CPC分类号： G01N33/54366 , G01N33/54326 , G01N35/0098
摘要： A method of sorting beads on a droplet actuator. The method may, for example, include the following steps: (a) providing a droplet actuator comprising a substrate comprising electrodes arranged for conducting droplet operations on a substrate surface; (b) providing an assay droplet on the substrate surface, the droplet comprising two or more target-capture bead populations comprising target-capture beads comprising: (i) a capture probe bound to a target substance; and (ii) a unique bar binding element which binds to a corresponding binder; (c) using droplet operations to combine the assay droplet with a bead-capture droplet comprising one or more bead-capture beads having affinity for the binding element; (d) immobilizing the one or more bead-capture beads while conducting droplet operations to separate the bead-capture beads from unbound target-capture beads; (e) resuspending the one or more bead-capture beads in a droplet, thereby providing a droplet comprising a substantially pure substance-capture bead population; and (f) using droplet operations to conduct one or more protocol steps for an assay protocol.
摘要翻译：一种在液滴致动器上分选珠粒的方法。该方法可以例如包括以下步骤：（a）提供液滴致动器，其包括基板，该基板包括布置成用于在基板表面上进行液滴操作的电极; （b）在基底表面上提供测定液滴，所述液滴包含两个或更多个目标捕获珠群，包含目标捕获珠，其包含：（i）与靶物质结合的捕获探针; 和（ii）结合相应的粘合剂的独特的棒结合元件; （c）使用液滴操作将测定液滴与包含对结合元件具有亲和性的一个或多个珠粒捕获珠粒的珠粒捕获液滴组合; （d）固定所述一个或多个珠粒捕获珠粒，同时进行液滴操作以将珠粒捕获珠粒与未结合的靶捕获珠粒分离; （e）将一个或多个珠粒捕获珠重新悬浮在液滴中，由此提供包含基本上纯的物质捕获珠粒的液滴; 和（f）使用液滴操作为测定方案进行一个或多个方案步骤。

5. 发明申请

WO2007120240A2 DROPLET-BASED PYROSEQUENCING 审中-公开
标题翻译：基于DROPLET的PYROSEQUENCING
公开(公告)号：WO2007120240A2
公开(公告)日：2007-10-25
申请号：PCT/US2006/047481
申请日：2006-12-11
申请人： ADVANCED LIQUID LOGIC, INC. , DUKE UNIVERSITY , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , POLLACK, Michael, G. , PAMULA, Vamsee, K. , ALLEN, Dwayne, J. , FAIR, Richard, B. , GRIFFIN, Peter
发明人： POLLACK, Michael, G. , PAMULA, Vamsee, K. , ALLEN, Dwayne, J. , FAIR, Richard, B. , GRIFFIN, Peter
IPC分类号： B01D57/00
CPC分类号： B01L3/502792 , B01F11/0071 , B01F13/0071 , B01F13/0076 , B01L3/502715 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2200/0668 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/089 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0436 , B01L2400/0442 , B01L2400/0448 , C12Q1/6869 , G01N33/49 , C12Q2565/629 , C12Q2565/301
摘要： The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using droplets. The invention includes a droplet microactuator or droplet microactuator system having one or more input reservoirs loaded with reagents for conducting sequencing protocols, such as the reagents for conducting a pyrosequencing protocol. The invention also includes a droplet microactuator or droplet microactuator system, having one or more input reservoirs loaded with a sample for conducting a pyrosequencing protocol.
摘要翻译：液滴微致动器技术领域本发明涉及液滴微致动器以及采用液滴微致动器来使用液滴执行各种协议的系统，装置和方法。本发明包括液滴微致动器或液滴微致动器系统，其具有一个或多个输入储存器，其中装载有用于进行测序方案的试剂，例如用于进行焦磷酸测序方案的试剂。本发明还包括液滴微致动器或液滴微致动器系统，其具有装载有用于进行焦磷酸测序方案的样品的一个或多个输入储存器。

6. 发明申请

WO2019139842A1 TANGENTIAL FLOW FILTRATION (TFF) SYSTEM AND DISPOSABLE TFF UNIT THAT INCLUDES AN INTEGRATED PUMP APPARATUS 审中-公开
公开(公告)号：WO2019139842A1
公开(公告)日：2019-07-18
申请号：PCT/US2019/012479
申请日：2019-01-07
申请人： FORMULATRIX, INC.
发明人： LOGAN, Baker , HEALEY, Steven , RODIONOV, Dmitry
IPC分类号： B01D61/14 , B01D61/18 , B01D61/20 , B01D61/22
摘要： A tangential flow filtration (TFF) system and disposable TFF unit that includes an integrated pump apparatus is disclosed. Namely, a TFF system is provided that includes a clamp assembly for integrating together a disposable TFF unit, two fluid reservoirs, and an air supply assembly. Further, the disposable TFF unit includes a diaphragm pump assembly and a concentration membrane. Further, methods of using the TFF system that includes the disposable TFF unit are provided.

7. 发明申请

WO2008118831A8 DROPLET ACTUATOR LOADING AND TARGET CONCENTRATION 审中-公开
标题翻译：滴落执行器负载和目标浓度
公开(公告)号：WO2008118831A8
公开(公告)日：2008-10-02
申请号：PCT/US2008/057963
申请日：2008-03-24
申请人： ADVANCED LIQUID LOGIC, INC. , PAMULA, Vamsee , POLLACK, Michael , SRINIVASAN, Vijay
发明人： PAMULA, Vamsee , POLLACK, Michael , SRINIVASAN, Vijay
IPC分类号： B01L3/00 , G01N33/543
摘要： A droplet actuator and method of providing a droplet comprising an target substance on the droplet actuator, and including discrete flow and continuous flow functionality. Discrete flow function is controlled by electrodes arranged for conducting droplet operations on a substrate surface. The continuous flow function includes a fluid path (101) arranged for flowing a fluid therethrough. The discrete flow and continuous flow functions may be separated by a barrier (103), including a second fluid path through the barrier. The continuous flow function may include a captux-e surface (501) comprising a component having an affinity for the target substance. Methods of the invention may include flowing a fluid comprising the target substance through the fluid path (101); capturing the target substance on the capture surface (501); and forming a droplet in the discrete flow region via the second fluid path and the electrodes comprising the captured target substance.
摘要翻译：液滴致动器和在液滴致动器上提供包含目标物质的液滴的方法，并且包括离散流动和连续流动功能。离散流动功能由布置为在基板表面上进行液滴操作的电极控制。连续流动功能包括布置用于使流体流过的流体路径（101）。离散流动和连续流动功能可以通过屏障（103）分开，屏障（103）包括穿过屏障的第二流体路径。连续流动功能可以包括包含对目标物质具有亲和力的组分的捕获表面（501）。本发明的方法可以包括使包含目标物质的流体流过流体路径（101）; 捕获捕获表面（501）上的目标物质; 并且经由第二流体路径和包括捕获的目标物质的电极在离散流动区域中形成液滴。

8. 发明申请

WO2007044579A2 TERMINAL APPLICATOR APPARATUS, SYSTEM, AND METHOD 审中-公开
标题翻译：终端应用装置，系统和方法
公开(公告)号：WO2007044579A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/039249
申请日：2006-10-05
申请人： SURETECH ASSEMBLY, INCORPORATED , GARNER, Wesley, Thomas, Jr.
发明人： GARNER, Wesley, Thomas, Jr.
IPC分类号： B23P19/00
CPC分类号： H01R43/055 , Y10T29/49174 , Y10T29/49181 , Y10T29/49185 , Y10T29/5149 , Y10T29/5193 , Y10T29/532 , Y10T29/53209 , Y10T29/53213 , Y10T29/53226 , Y10T29/53235 , Y10T29/53261 , Y10T29/5327
摘要： Apparatuses, systems, and methods are provided for automatically crimping terminals or connectors to wires wherein the terminals or connectors are provided in strip form and may be of varying sizes, shapes, and pitches. An apparatus according to the present invention includes an applicator body and a ram movably mounted in relation to the body and drivable in a first path through a working stroke towards, and a return stroke away from, a crimping anvil. The apparatus further includes a crimping die on the ram for cooperation with the anvil and adapted to crimp a terminal connector located therebetween onto a wire during each working stroke of the ram. The apparatus additionally includes a drive mechanism adapted to contact the strip through pressure engagement and to feed the strip along a second path to locate the leading connector on the strip between the anvil and the die.
摘要翻译：提供了用于将端子或连接器自动压接到电线的装置，系统和方法，其中端子或连接器以带状形式提供，并且可以具有不同尺寸，形状和间距。根据本发明的装置包括施加器主体和可相对于主体可移动地安装并且能够在通过工作冲程的第一路径中被驱动并且远离压接砧的返回行程的冲头。该装置还包括压头上的压接模具，用于与砧座配合，并且适用于在压头的每个工作冲程期间将位于其间的端子连接器压接在导线上。该装置还包括驱动机构，其适于通过压力接合接触条带并且沿着第二路径供给条带以将引导连接器定位在砧座和砧座之间的条带上。

9. 发明申请

WO2018232059A1 ELECTRIC-POWERED, CLOSED-LOOP, CONTINUOUS-FEED, ENDOTHERMIC ENERGY-CONVERSION SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2018232059A1
公开(公告)日：2018-12-20
申请号：PCT/US2018/037445
申请日：2018-06-14
申请人： NR-3, LLC
发明人： REDEKER, Martin , CARROLL, JR., Joseph P.
IPC分类号： C10B7/10 , C10B1/00 , C10B5/00 , C10J3/00 , C10J3/10
CPC分类号： C10B7/10 , C10B7/06 , C10B47/44 , C10B53/00 , C10G1/00 , C10G1/002 , C10G1/008 , C10G1/02 , C10G1/10 , C10G2300/1003 , C10G2300/1011 , C10G2300/1014 , C10G2300/1018 , C10J3/005 , C10J3/007 , C10J3/723 , C10J2200/158 , C10J2300/0909 , C10J2300/0946 , C10J2300/1246 , C10K1/024 , C10K1/04 , C10K1/18 , C10K1/34
摘要： Electric-powered, closed-loop, continuous-feed, endothermic energy-conversion systems and methods are disclosed. In one embodiment, the presently disclosed energy-conversion system includes a shaftless auger. In another embodiment, the presently disclosed energy-conversion system includes a drag conveyor. In yet another embodiment, the presently disclosed energy-conversion system includes a distillation and/or fractionating stage. The endothermic energy-conversion systems and methods feature mechanisms for natural resource recovery, refining, and recycling, such as secondary recovery of metals, minerals, nutrients, and/or carbon char.

10. 发明申请

WO2009011952A1 DEVICE AND METHOD FOR SAMPLE COLLECTION AND CONCENTRATION 审中-公开
标题翻译：样品收集和浓缩的装置和方法
公开(公告)号：WO2009011952A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/061223
申请日：2008-04-23
申请人： ADVANCED LIQUID LOGIC, INC. , SHENDEROV, Alexander
发明人： SHENDEROV, Alexander
IPC分类号： G01N1/22 , G01N27/26 , G01N1/10
CPC分类号： G01N1/4005 , G01N2001/4016
摘要： An apparatus and a method for concentrating a target substance in a liquid has been invented. The apparatus comprises a first reservoir with inlet openings for introducing a fluid comprising a target substance into the first reservoir and a second reservoir separated from the first reservoir by a partition permeable to permit the fluid to traverse the partition while retaining the target substance in the first reservoir.
摘要翻译：已经发明了用于将目标物质浓缩在液体中的装置和方法。该装置包括具有入口开口的第一储存器，用于将包含目标物质的流体引入到第一储存器中;以及第二储存器，其与第一储存器分隔开，所述第二储存器具有可渗透的隔板，以允许流体横过隔板，同时将目标物质保持在第一储存器中水库。

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