专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2021163163A1 NANOPORE DEVICE AND METHODS OF DETECTING AND CLASSIFYING CHARGED PARTICLES USING SAME 审中-公开
公开(公告)号：WO2021163163A1
公开(公告)日：2021-08-19
申请号：PCT/US2021/017418
申请日：2021-02-10
申请人： PALOGEN, INC.
发明人： KARIMIRED, Bita , HAN, Kyung Joon
IPC分类号： C12Q1/6816 , C12Q1/6869 , G01N27/414 , G01N33/487
摘要： A method of determining an oligonucleotide methylation percentage includes providing a 3D nanopore device having top and bottom chambers, and a 3D nanochannel array disposed therein. The method also includes purifying an oligonucleotide, and functionalizing the 3D nanochannel array by coupling an oligonucleotide probe. The method further includes forming an oligonucleotide solution having a known concentration, and adding the oligonucleotide solution to the top and bottom chambers. Moreover, the method includes placing top and bottom electrodes in the top and bottom chambers respectively, applying an electrophoretic bias between the top and bottom electrodes, applying a selection bias across first and second gating nanoelectrodes, applying a sensing bias through a sensing nanoelectrode in the 3D nanopore device. In addition, the method includes detecting an output current from the sensing nanoelectrode, and analyzing the output current from the sensing nanoelectrode to determine a methylation percentage of the oligonucleotide.

2. 发明申请

WO2020172633A1 SYSTEM AND METHOD FOR SAFETY SYRINGE 审中-公开
公开(公告)号：WO2020172633A1
公开(公告)日：2020-08-27
申请号：PCT/US2020/019365
申请日：2020-02-21
申请人： CREDENCE MEDSYSTEMS, INC.
发明人： TILLACK, Jeff , SHLUZAS, Alan E. , DIAZ, Stephen H. , STEESE-BRADLEY, Gary , MERHIGE, John , SHANLEY, Conor Edward , LEUNG, Mina M.
IPC分类号： A61M5/19 , A61M5/20 , A61M5/28 , A61J1/06 , A61M5/00 , A61M5/315 , A61M5/31 , B65B3/00 , B65B5/06 , A61M5/32
摘要： A method for preparing a pre-filled multi-chamber injection system includes providing an injection system body, the injection system body defining an open proximal end, a body interior, and an open distal end. The method includes introducing a first substance into a distal end of the body interior. The method includes disposing a distal stopper member in the body interior, the distal stopper member and the injection system body defining proximal and distal chambers in the body interior. The method includes introducing a second substance into the body interior. The method includes disposing a proximal stopper member in the body interior. The method includes inserting an elongate member at least partially into the body interior, the elongate member having a plurality of flow channels for fluidly coupling the proximal and distal chambers. The method includes coupling a plunger member to the proximal stopper member.

3. 发明申请

WO2020102446A2 SYSTEM AND METHOD FOR MULTIPLE SITE INJECTION 审中-公开
公开(公告)号：WO2020102446A2
公开(公告)日：2020-05-22
申请号：PCT/US2019/061313
申请日：2019-11-13
申请人： CREDENCE MEDSYSTEMS, INC.
发明人： SHANLEY, Conor Edward , SHLUZAS, Alan E. , LEUNG, Mina M. , DIAZ, Stephen H.
IPC分类号： A61M5/315
摘要： A system for injecting includes a syringe body having proximal and distal ends, a syringe interior, and a syringe flange at the proximal end thereof. The system also includes an injectable fluid disposed in the syringe interior. The system further includes a finger flange coupled to the syringe flange. Moreover, the system includes a stopper member disposed in the syringe interior. In addition, the system includes a plunger ratchet member coupled to the stopper member. The system also includes a plunger tube disposed coaxially around at least a portion of the plunger ratchet member and operatively coupled thereto.

4. 发明申请

WO2020023946A1 NANOPORE DEVICE AND METHODS OF DETECTING CHARGED PARTICLES USING SAME 审中-公开
公开(公告)号：WO2020023946A1
公开(公告)日：2020-01-30
申请号：PCT/US2019/043819
申请日：2019-07-27
申请人： PALOGEN, INC
发明人： KARIMIRAD, Bita , HAN, Kyung Joon , YAZDI, Reza Rahighi , YOO, Won Jong
IPC分类号： G01N33/487 , C12Q1/6869
摘要： A nanopore device for detecting charged biopolymer molecules and defining a nanochannel, includes a first gating nanoelectrode addressing a first end of the nanochannel. The device also includes a second gating nanoelectrode addressing a second end of the nanochannel opposite the first end. The device further includes a first sensing nanoelectrode addressing a first location in the nanochannel between the first and second ends.

5. 发明申请

WO2019133998A1 NANOPORE DEVICE AND METHODS OF ELECTRICAL ARRAY ADDRESSING AND SENSING 审中-公开
公开(公告)号：WO2019133998A1
公开(公告)日：2019-07-04
申请号：PCT/US2018/068224
申请日：2018-12-31
申请人： BIOTHLON, INC.
发明人： HAN, Kyung Joon , YOON, Jungkee
IPC分类号： C12Q1/6869 , G01N33/487
CPC分类号： G01N33/48721 , B82Y15/00 , B82Y40/00 , C12Q1/6869 , C12Q1/6874 , C12Q2565/631 , G01N27/4145 , G01N27/4146 , G01N27/44791 , C12Q2527/113 , C12Q2563/116
摘要： A method of manufacturing and using a nanofluidic NAND transistor sensor array scheme including a plurality of nanopore channel pillars, a plurality of respective fluidic channels, a plurality of gate electrodes, a top chamber, and a bottom chamber includes placing a sensor substrate in an electrolyte solution comprising biomolecules and DNA. The method also includes placing first and second electrodes in the electrolyte solution (Vpp and Vss of the nanofluidic NAND transistor); forming the nanopore channel pillars; placing the gate electrodes and gate insulators in respective walls of the nanopore channel pillars; applying an electrophoretic bias in the first and second electrodes; applying a bias in the gate electrodes; detecting a change in an electrode current in the electrolyte solution caused by a change in a gate voltage; and detecting a change in a surface charge in nanopore channel electrodes in the respective fluidic channels.

6. 发明申请

WO2018085467A3 SYSTEM AND METHOD FOR SAFETY SYRINGE 审中-公开
公开(公告)号：WO2018085467A3
公开(公告)日：2018-05-11
申请号：PCT/US2017/059617
申请日：2017-11-01
申请人： CREDENCE MEDSYSTEMS, INC.
发明人： SHLUZAS, Alan E. , DIAZ, Stephen H. , SHANLEY, John F. , SEGELKE, Scott , MERHIGE, John
IPC分类号： A61M5/178 , A61M5/28 , A61M5/32
摘要： A system for injecting includes a syringe body defining a proximal opening and a distal needle interface. The system also includes a plunger member defining a plunger interior and configured to be manually manipulated to insert a stopper member relative to the syringe body, the plunger member. The plunger member includes a needle retention feature (712) disposed in the plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The system further includes a needle hub assembly coupled to the distal needle interface of the syringe body. The needle assembly includes a needle having a needle proximal end feature (84), a hub, and a needle latching member configured to couple the needle to the hub. The needle is at least partially retractable into plunger interior. The needle proximal end feature includes an annular distally facing surface (104).

7. 发明申请

WO2018085462A1 CARTRIDGE SAFETY INJECTION SYSTEM AND METHODS 审中-公开
标题翻译：墨盒安全注射系统和方法
公开(公告)号：WO2018085462A1
公开(公告)日：2018-05-11
申请号：PCT/US2017/059612
申请日：2017-11-01
申请人： CREDENCE MEDSYSTEMS, INC.
发明人： SHLUZAS, Alan E. , LEUNG, Mina M. , DIAZ, Stephen H. , TILLACK, Jeff
IPC分类号： A61M5/178 , A61M5/28 , A61M5/32
摘要： A system for injecting includes a cartridge body (134) defining a proximal opening and a distal needle interface. The system also includes a plunger member defining a plunger interior and configured to be manually manipulated to insert a stopper member relative to the cartridge body. The plunger member includes a needle retention feature disposed in the plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The system further includes a needle hub assembly coupled to the distal needle interface of the cartridge body. The needle assembly includes a needle having a needle proximal end feature (50), a hub, and a needle latching member configured to couple the needle to the hub. The needle is retractable into plunger interior upon manipulation of the plunger member to actuate the energy-storage member latching member.
摘要翻译：用于注射的系统包括限定近侧开口和远侧针头界面的仓体（134）。该系统还包括柱塞构件，该柱塞构件限定了柱塞内部并且构造成被手动操纵以相对于仓体插入止动构件。柱塞构件包括设置在柱塞内部中的针保持特征件，设置在柱塞内部中的能量存储构件以及设置在柱塞内部中的能量存储构件闩锁构件。该系统还包括连接到仓体的远侧针接口的针座组件。针组件包括具有针近端特征（50）的针，毂和被配置为将针连接到毂的针闭锁构件。在操纵柱塞构件以致动能量存储构件闩锁构件时，针可缩回到柱塞内部。

8. 发明申请

WO2018085451A1 SAFETY SYRINGE 审中-公开
标题翻译：安全注射器
公开(公告)号：WO2018085451A1
公开(公告)日：2018-05-11
申请号：PCT/US2017/059596
申请日：2017-11-01
申请人： CREDENCE MEDSYSTEMS, INC.
发明人： SHLUZAS, Alan E. , DIAZ, Stephen H. , SHANLEY, John F. , TILLACK, Jeff , THAYER, Dan , STEESE-BRADLEY, Gary , LEUNG, Mina M.
IPC分类号： A61M5/178 , A61M5/28 , A61M5/32
摘要： A system for injecting includes a syringe body defining a proximal opening and a distal needle interface. The system also includes a plunger member defining a plunger interior and configured to be manually manipulated to insert a stopper member relative to the syringe body. The plunger member includes a needle retention feature disposed in the plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The system further includes a needle hub assembly coupled to the distal needle interface of the syringe body. The needle assembly includes a needle having a needle proximal end feature (84), a hub, and a needle latching member configured to couple the needle to the hub. The needle is retractable into plunger interior upon manipulation of the plunger member to actuate the energy-storage member latching member.
摘要翻译：用于注射的系统包括限定近侧开口和远侧针头界面的注射器主体。该系统还包括柱塞构件，该柱塞构件限定柱塞内部并且被配置为被手动操纵以相对于注射器本体插入止动构件。柱塞构件包括设置在柱塞内部中的针保持特征件，设置在柱塞内部中的能量存储构件以及设置在柱塞内部中的能量存储构件闩锁构件。该系统还包括连接到注射器本体的远侧针接口的针座组件。针头组件包括具有针头近端部件（84），针座和针头闩锁构件的针头，针头闩锁构件被构造成将针头连接到针头。在操纵柱塞构件以致动能量存储构件闩锁构件时，针可缩回到柱塞内部。

9. 发明申请

WO2018049066A1 VIRTUAL REALITY, AUGMENTED REALITY, AND MIXED REALITY SYSTEMS INCLUDING THICK MEDIA AND RELATED METHODS 审中-公开
标题翻译：虚拟现实，增强现实和混合现实系统，包括厚媒体和相关方法
公开(公告)号：WO2018049066A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050541
申请日：2017-09-07
申请人： MAGIC LEAP, INC.
发明人： ST. HILAIRE, Pierre
IPC分类号： F21V1/12 , F21V7/04 , G02B3/08 , G02B6/10 , G02B27/14
摘要： A head worn imaging system includes a light source configured to generate a light beam. The system also includes a light guiding optical element having a thickness between 0.1 and 1.5 mm and configured to propagate at least a portion of the light beam by total internal reflection. The system further includes an entry portion and an exit portion of the light guiding optical element configured to selectively allow light addressing the exit portion to exit the light guiding optical element based on the angle of incidence of the light, the radius of curvature of the light and/or the wavelength of the light.
摘要翻译：头戴式成像系统包括被配置为产生光束的光源。该系统还包括厚度在0.1和1.5mm之间并且被配置为通过全内反射来传播光束的至少一部分的光引导光学元件。该系统还包括光引导光学元件的入口部分和出口部分，该入口部分和出口部分被配置为基于光的入射角选择性地允许寻址出口部分的光离开光引导光学元件，光的曲率半径和/或光的波长。

10. 发明申请

WO2017136766A1 MANIPULATING VIRTUAL MEMORY PAGE TABLES TO FORM VIRTUALLY-CONTIGUOUS MEMORY CORRESPONDING TO NON-CONTIGUOUS REAL MEMORY ALLOCATIONS 审中-公开
标题翻译：操作虚拟内存页面以形成与非连续实际内存分配相对应的虚拟连续内存
公开(公告)号：WO2017136766A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/016569
申请日：2017-02-03
申请人： NUTANIX, INC.
发明人： SIVAPRAKASAM, Suresh
IPC分类号： G06F12/00
CPC分类号： G06F12/1009 , G06F12/023 , G06F12/0862 , G06F12/1027 , G06F2212/1044 , G06F2212/6026 , G06F2212/6028 , G06F2212/657 , G06F2212/68
摘要： Systems and methods for managing contiguous addressing via virtual paging registers in a page table used in a high-performance computing platform. One embodiment commences upon initializing a first paging register with a first virtual address of a first virtual address length to form a first virtual address space, then receiving a request from a process to allocate physical memory corresponding to a second virtual address request. A memory allocator allocates the requested physical memory from a physical memory location determined by the memory allocator. An operating system or other sufficiently privileged access identifies a second paging register that is contiguously adjacent to the first paging register. If the second paging register is already in use, then the method identifies an unused (third) paging register into which the contents of the second paging register can be relocated. The method stores the second virtual address into the now freed-up second paging register.
摘要翻译：通过高性能计算平台中使用的页表中的虚拟分页寄存器来管理连续寻址的系统和方法。一个实施例在利用第一虚拟地址长度的第一虚拟地址初始化第一页面寄存器以形成第一虚拟地址空间，然后从进程接收到分配对应于第二虚拟地址请求的物理存储器的请求时开始。存储器分配器从由存储器分配器确定的物理存储器位置分配所请求的物理存储器。操作系统或其他足够特权的访问标识与第一寻呼寄存器连续相邻的第二寻呼寄存器。如果第二个分页寄存器已经在使用中，那么该方法就会识别一个未使用的（第三个）分页寄存器，第二个分页寄存器的内容可以被重新分配到其中。该方法将第二个虚拟地址存储到现在释放的第二个分页寄存器中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式