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1. 发明申请

WO2020023544A1 APPARATUS AND METHOD FOR EVERTING CATHETER FOR UTERINE ACCESS FOR BIOPSY AND CYTOLOGY 审中-公开
公开(公告)号：WO2020023544A1
公开(公告)日：2020-01-30
申请号：PCT/US2019/043098
申请日：2019-07-23
申请人： CROSSBAY MEDICAL, INC.
发明人： BACICH, Steven R. , YUREK, Matthew Thomas , VIDYARTHI, Piush
IPC分类号： A61B10/02 , A61B17/42
摘要： An everting balloon system is disclosed that can be used for biopsy within a body of a patient or animal. The everting balloon system can be used to access a bodily cavity or vessel for tissue specimen collection at specific bodily locations. The everting catheter system described simplifies the process of tissue biopsy.

2. 发明申请

WO2018217419A1 STABLE LIPID BILAYERS ON NANOPORE ARRAYS 审中-公开
公开(公告)号：WO2018217419A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/030708
申请日：2018-05-02
申请人： QUANTAPORE, INC.
发明人： ASSAD, Ossama
IPC分类号： G01N33/487 , B81B1/00 , B82Y15/00 , G01N27/416
摘要： The invention is directed to methods of making stable lipid bilayers supported by a solid state nanopore array. Exemplary methods include the steps of masking a first layer on a planar support to form dry etch zones; dry etching the dry etch zones to form an array of apertures extending into but not through the first layer; masking a second side of the planar support body to form an etch region aligned with the array of apertures; wet etching the etch region to expose a surface of the first layer; dry etching the exposed surface of the first layer to a depth overlapping the apertures so that apertures of the array provide fluid communication across the first layer; and disposing a lipid bilayer on a surface of the first layer on a side opposite the planar support which encompasses the array of apertures.

3. 发明申请

WO2018129169A1 MAGNETIC BIOSENSOR DESIGN FOR MANUFACTURING 审中-公开
公开(公告)号：WO2018129169A1
公开(公告)日：2018-07-12
申请号：PCT/US2018/012357
申请日：2018-01-04
申请人： SILICON BIODEVICES, INC.
发明人： IZYUMIN, Igor , FLORESCU, Octavian
IPC分类号： G01N27/74 , G01N27/72 , G01N33/53 , H01R12/72 , H01R12/70 , H05K1/02 , H05K1/14
摘要： A stand-alone assay system for POC IVD that is fast, easy to use, inexpensive and delivers laboratory quality results for one or more target analytes from a small volume of unprocessed aqueous sample is disclosed. The stand-alone assay system is a disposable digital device. The stand-alone assay system integrates a sampling system that relies on users swiping a lanced finger containing an unprocessed aqueous sample such as whole blood across a sample inlet to transfer or deposit the unprocessed aqueous sample on to a membrane filter or into a capillary. The system can have a planarized testing surface on which retained magnetic particles are sensed.

4. 发明申请

WO2018071273A1 CONTROLLING FLUORESCENT SIGNAL COMPOSITION IN OPTICALLY-BASED NANOPORE SEQUENCING 审中-公开
标题翻译：控制基于光学的纳米孔测序中的荧光信号组成
公开(公告)号：WO2018071273A1
公开(公告)日：2018-04-19
申请号：PCT/US2017/055435
申请日：2017-10-05
申请人： QUANTAPORE, INC.
发明人： HUBER, Martin
IPC分类号： C12Q1/68 , G01N21/64 , G01N33/487 , G01N21/76
摘要： The invention is directed to optically based methods for nanopore sequencing of polynucleotides which comprise steps of (i) translocating a polynucleotide through a bore of a nanopore at a translocation speed, wherein nucleotides of the polynucleotide are labeled with fluorescent labels such that in free solution fluorescent labels of nucleotides are substantially quenched and wherein fluorescent labels within the bore are constrained such that substantially no detectable fluorescent signal is generated therein; (ii) exciting the fluorescent label of each nucleotide upon exiting the nanopore and prior to quenching with a preceding mutually quenching fluorescent label or a quenching agent; (iii) measuring a fluorescent signal generated by fluorescent labels exiting the nanopore, wherein the translocation speed is selected so that the measured fluorescent signal comprises fluorescence from substantially a single fluorescent label; and (iv) determining a nucleotide sequence of the polynucleotide from a sequence of measured fluorescent signals.
摘要翻译：本发明涉及用于多核苷酸的纳米孔测序的基于光学的方法，其包括以下步骤：（i）以易位速度使多核苷酸易位穿过纳米孔的孔，其中多核苷酸的核苷酸用荧光标记，使得在游离溶液中核苷酸的荧光标记基本上被淬灭，并且其中孔内的荧光标记受到限制，使得其中基本上不产生可检测的荧光信号; （ii）激发离开纳米孔后每种核苷酸的荧光标记并在用先前的相互猝灭荧光标记或猝灭剂猝灭之前; （iii）测量由离开纳米孔的荧光标记产生的荧光信号，其中选择易位速度使得测量的荧光信号包括来自基本上单个荧光标记的荧光; 和（iv）从测量的荧光信号序列确定多核苷酸的核苷酸序列。

5. 发明申请

WO2018014031A1 WIRELESSLY SENSING PROPERTIES OF A CLOSED ENVIRONMENT AND DEVICES THEREOF 审中-公开
标题翻译：闭环境的无线感测性质及其装置
公开(公告)号：WO2018014031A1
公开(公告)日：2018-01-18
申请号：PCT/US2017/042435
申请日：2017-07-17
申请人： GATE SCIENTIFIC, INC.
发明人： SCABOO, Kristian Michael , JENSEN, Morten Juel
IPC分类号： H05B6/06 , H05B6/68 , H05B6/12
摘要： A wireless sensor measures properties of a substance and transmits the properties to a remote wireless receiver. The wireless sensor can be fully enclosed within a container containing the substance, allowing remote monitoring of the properties of the substance without compromising integrity of a closed system.
摘要翻译：无线传感器测量物质的属性并将属性传输到远程无线接收器。无线传感器可以完全封闭在含有该物质的容器内，允许远程监测物质的性质，而不会影响封闭系统的完整性。

6. 发明申请

WO2018009346A1 OPTICALLY BASED NANOPORE SEQUENCING 审中-公开
标题翻译：基于光学的纳米孔测序
公开(公告)号：WO2018009346A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/038813
申请日：2017-06-22
申请人： QUANTAPORE, INC.
发明人： ANDERSON, Brett N.
IPC分类号： G01N27/447 , C12Q1/68
摘要： In some aspects the invention is directed to methods of analyzing a polynucleotide which include steps of directing to a nanopore an excitation beam having a predetermined polarization state; translocating a polynucleotide through the nanopore, wherein nucleotides of the polynucleotide are labeled with fluorescent labels having absorption dipoles and wherein the nanopore spatially orients the fluorescent labels so that during translocation the adsorption dipoles are substantially unresponsive to the excitation beam; detecting changes in fluorescent signals generated by the fluorescent labels as nucleotides with fluorescent labels exit the nanopore and absorption dipoles thereof become responsive to excitation by the excitation beam with the predetermined polarization state; and identifying nucleotides exiting the nanopore from the changes in fluorescent signals.
摘要翻译：在一些方面，本发明涉及分析多核苷酸的方法，所述方法包括以下步骤：将具有预定偏振态的激发束引导至纳米孔; 使多核苷酸转位穿过纳米孔，其中多核苷酸的核苷酸用具有吸收偶极子的荧光标记标记，并且其中纳米孔在空间上定向荧光标记，使得在易位过程中吸附偶极对激发束基本上没有反应; 检测荧光标记产生的荧光信号的变化，如荧光标记的核苷酸离开纳米孔并且其吸收偶极子变得响应于具有预定偏振状态的激发束的激励; 并从荧光信号的变化中鉴定离开纳米孔的核苷酸。

7. 发明申请

WO2017180319A1 MIXED OPTICAL SIGNALS IN POLYMER ANALYSIS WITH NANOPORES 审中-公开
标题翻译：纳米粒子在聚合物分析中的混合光学信号
公开(公告)号：WO2017180319A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/024314
申请日：2017-03-27
申请人： QUANTAPORE, INC.
发明人： ANDERSON, Brett N. , HUBER, Martin , MACEVICZ, Stephen C.
IPC分类号： C12Q1/68 , C40B20/00
摘要： The invention is directed to nanopore-based methods for analyzing polymers, such as polynucleotides or proteins, containing optical labels specific for different kinds of monomers. In some embodiments, methods of the invention include steps of (a) translocating a polymer through a nanopore, wherein different kinds of monomers of the polymer are labeled with different optical labels that generate distinguishable optical signals and wherein the nanopore constrains the monomers to move single file through an excitation zone that encompasses a plurality of monomers; (b) detecting a time-ordered set of optical signals from the monomers as the polymer passes through the excitation zone; (c) separating optical signals from different kinds of monomers to form monomer-specific time-ordered sets of optical signals; and (d) determining a sequence of monomers from the monomer-specific time-ordered sets of optical signals from the polymer.
摘要翻译：本发明涉及用于分析聚合物（例如多核苷酸或蛋白质）的基于纳米孔的方法，所述聚合物含有对不同种类的单体特异的光学标记。在一些实施方案中，本发明的方法包括以下步骤：（a）使聚合物易位穿过纳米孔，其中聚合物的不同种类的单体用产生可区分的光信号的不同光学标记标记，并且其中纳米孔约束单体以移动单个通过包含多种单体的激发区进行培养; （b）当聚合物通过激发区时，检测来自单体的时间顺序的一组光信号; （c）从不同种类的单体分离光学信号以形成单体特定的时间有序的光学信号组; 和（d）从来自聚合物的单体特异性时间顺序的光学信号组中确定单体的顺序。

8. 发明申请

WO2017083088A1 ULTRASHIELD DEVICES AND METHODS FOR USE IN ULTRASONIC PROCEDURES 审中-公开
标题翻译：超声波装置和用于超声波程序的方法
公开(公告)号：WO2017083088A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/058522
申请日：2016-10-24
申请人： HEALTHCARE EVOLUTION, LLC
发明人： DESAI, Siddharth , JONES, Jerry
IPC分类号： A61B8/00 , A61B8/08 , A61B8/12 , A61B8/14 , A61B18/00 , A61H1/00 , A61N7/00
CPC分类号： A61B8/4281 , A61B8/4422 , A61B8/4444 , A61B8/4455
摘要： Devices and method are provided for ultrasound transmission without the need for external couplants, such as gels, which are typically used in conventional ultrasound procedures. In particular, ultrashields are provided for use with ultrasound probes, wherein the ultrashields have specialized layers to provide an uninterrupted pathway of acoustic conductance from the probe to the surface of the body throughout the procedure while introducing minimal to no attenuation of ultrasound wave transmission. In addition, combinations of ultrashields and probe covers are provided to provide additional features such as a microbial barrier.
摘要翻译：提供了用于超声波传输的设备和方法，而不需要通常用于常规超声程序中的外部耦合剂，例如凝胶。特别是，提供用于超声波探头的超高解析度屏，其中超高解析屏具有专用层，以在整个过程中提供从探针到身体表面的声传导的不间断路径，同时引入超声波传输的最小或不衰减。此外，还提供了超防护罩和探头盖的组合，以提供附加功能，例如微生物屏障。

9. 发明申请

WO2016205431A1 APPARATUS AND METHODS FOR ACCESSING AND TREATING BODILY VESSELS AND CAVITIES 审中-公开
标题翻译：装置和方法，用于进入和处理人体活动和空间
公开(公告)号：WO2016205431A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/037715
申请日：2016-06-15
申请人： CROSS BAY MEDICAL, INC.
发明人： BACICH, Steven, R.
IPC分类号： A61F7/12
CPC分类号： A61F7/123 , A61B18/04 , A61B2018/00023 , A61B2018/0022 , A61B2018/044 , A61F7/007 , A61F2007/0056 , A61F2007/0075 , A61F2007/0096 , A61F2007/126
摘要： Devices and methods for accessing and treating bodily vessels and cavities are disclosed. The devices can have everting balloon catheters that can deliver heating or cooling to biological vessels.
摘要翻译：公开了用于访问和处理身体血管和腔的装置和方法。该装置可以具有能够将生物容器加热或冷却的气道导管。

10. 发明申请

WO2014172589A1 METHOD AND APPARATUS FOR PASSING SUTURE 审中-公开
标题翻译：用于通行的方法和装置
公开(公告)号：WO2014172589A1
公开(公告)日：2014-10-23
申请号：PCT/US2014/034575
申请日：2014-04-17
申请人： SP SURGICAL INC.
发明人： FANTON, Gary S. , KRUMME, John F. , HENEVELD, Scott H. , NEWELL, Matthew B. , CLAUSON, Luke W.
IPC分类号： A61B17/068 , A61B17/28 , A61B17/295 , A61B17/32 , A61B17/115 , A61B17/125
CPC分类号： A61B17/0469 , A61B17/0482 , A61B17/06004 , A61B2017/06052 , A61B2017/2933
摘要： A device is disclosed that can pierce and hold tissue and then pass suture through tissue. The device can have a shuttle that can removably attach to a suture and jaws that can be rotatably opened and closed with respect to each other. A method for using the device to repeatedly pass the suture through the tissue without removing the suture or device from the target site is also disclosed.
摘要翻译：公开了一种可刺穿并保持组织然后使缝线穿过组织的装置。该装置可以具有可以可拆卸地附接到相对于彼此可旋转地打开和关闭的缝合线和钳口的梭子。还公开了一种使用该装置来重复地使缝线穿过组织而不从目标部位移除缝合线或装置的方法。

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