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1. 发明申请

WO2021019095A1 BINDING MEMBERS 审中-公开
公开(公告)号：WO2021019095A1
公开(公告)日：2021-02-04
申请号：PCT/EP2020/071725
申请日：2020-07-31
申请人： SCANCELL LIMITED
发明人： DURRANT, Linda Gillian , VANKEMMELBEKE, Mireille , PARSONS, Tina Rose
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , A61K39/00
摘要： The present invention relates to specific binding members, such as antibodies and fragments thereof, that are capable of specifically binding a Lewis Y (Le y ) carbohydrate. It also relates to the use of such binding members in medicine and to nucleic acids encoding such binding members.

2. 发明申请

WO2020254670A1 MONOCLONAL ANTIBODY TARGETING A UNIQUE CANCER-ASSOCIATED EPITOPE OF CD43 审中-公开
公开(公告)号：WO2020254670A1
公开(公告)日：2020-12-24
申请号：PCT/EP2020/067258
申请日：2020-06-19
申请人： UNIVERSITÀ DEGLI STUDI MAGNA GRAECIA CATANZARO
发明人： TASSONE, Pierfrancesco
IPC分类号： C07K16/28 , A61P35/00 , A61K39/00 , C07K14/725 , G01N33/574
摘要： The present invention relates to a monoclonal mouse antibody produced by the hybridoma cell deposited under ICLC accession number ICLC PD n° 16001. Furthermore, the invention relates to an antibody comprising a heavy chain variable region comprising complementarity determining regions CDRH1, CDRH2 and CDRH3, and a light chain variable region comprising complementarity determining regions CDRL1, CDRL2 and CDRL3, wherein CDRH1, CDRH2, CDRH3, CDRL1, CDRL2, and CDRL3 comprise the amino acid sequences GFTFSSFGMH (SEQ ID NO: 1), YISSGSGNFYYVDTVKG (SEQ ID NO: 43), STYYHGSRGAMDY (SEQ ID NO: 3), SASSSVSSMYWY (SEQ ID NO: 4), DTSKMAS (SEQ ID NO: 5), and QQWSSYPPIT (SEQ ID NO: 6), respectively. In addition, the invention relates to antibodies recognizing the same epitope.

3. 发明申请

WO2018234319A1 T CELL RECEPTORS 审中-公开
公开(公告)号：WO2018234319A1
公开(公告)日：2018-12-27
申请号：PCT/EP2018/066287
申请日：2018-06-19
申请人： IMMUNOCORE LIMITED
发明人： ADDIS, Philip William , BEDKE, Nicole Joy , BOUARD, Lucie , HARPER, Stephen , LIDDY, Nathaniel , MAHON, Tara , O’DWYER, Ronan Pádraic
IPC分类号： C07K14/725 , C07K14/47 , A61K39/00
摘要： The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide SLLQHLIGL (SEQ ID NO: 1) derived from the germline cancer antigen PRAME. Said TCRs may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native PRAME TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.

4. 发明申请

WO2010038010A1 SOMATOSTATIN ANALOGUES 审中-公开
公开(公告)号：WO2010038010A1
公开(公告)日：2010-04-08
申请号：PCT/GB2009/002316
申请日：2009-09-30
申请人： IMPERIAL INNOVATIONS LIMITED , SHAUNAK, Sunil , TEO, Ian
发明人： SHAUNAK, Sunil , TEO, Ian
IPC分类号： A61K47/48 , C12N15/63 , C07K14/655
CPC分类号： C07K14/6555 , A61K47/60 , Y02P20/582
摘要： The invention relates generally to an isolated peptide consisting of the amino acid sequence X 1 CX 2 WKX 3 CT, wherein X 1 is F or A, X 2 is F or Y and X 3 is T or V in any combination or permutation, and wherein each of the amino acids is in the L- configuration and the peptide contains a disulphide bond between the two cysteine residues. Alternatively, the two sulphur atoms of the two cysteine residues may be linked via three carbon atoms. The invention also relates generally to fusion proteins comprising the peptide, to polynucleotides encoding the peptide or fusion proteins, to methods of producing the peptide or fusion proteins, to pharmaceuticals containing the peptide or fusion proteins, and to uses of the same.
摘要翻译：本发明一般涉及由氨基酸序列X1CX2WKX3CT组成的分离肽，其中X1为F或A，X2为F或Y，X3为任意组合或置换的T或V，其中每个氨基酸均位于 L-构型，并且肽在两个半胱氨酸残基之间含有二硫键。或者，两个半胱氨酸残基的两个硫原子可以通过三个碳原子连接。本发明一般还涉及包含肽的融合蛋白，编码肽或融合蛋白的多核苷酸，产生肽或融合蛋白的方法，含有肽或融合蛋白的药物及其用途。

5. 发明申请

WO2009004339A3 MODULATION OF REACTIVE OXYGEN SPECIES IN THE TREATMENT OF RESPIRATORY INFECTION 审中-公开
公开(公告)号：WO2009004339A3
公开(公告)日：2009-01-08
申请号：PCT/GB2008/002280
申请日：2008-07-03
申请人： IMPERIAL INNOVATIONS LIMITED , HUSSELL, Tracy , SNELLGROVE, Robert
发明人： HUSSELL, Tracy , SNELLGROVE, Robert
IPC分类号： A61K31/409 , A61P11/00 , A61P31/00 , A61K38/17
摘要： The invention relates to therapeutic compositions for use in treating, ameliorating or preventing an infection such as a microbial infection in a subject, comprising a compound modulative of reactive oxygen species level, or CD200 level, or CD200R level, or a combination of two or more of said levels in said subject. The invention also relates to methods of treatment using such compositions. In addition, the invention relates to therapeutic compositions for use in treating, ameliorating or preventing an inflammatory pulmonary infection in a mammalian host having a CD200-CD200R axis comprising a compound modulative of said axis, and to methods of treatment using such compositions. Furthermore, the invention relates to therapeutic compositions for use in treating, ameliorating or preventing a microbial infection and/or pulmonary inflammation in a subject comprising a compound mimetic of superoxide dismutase, and to methods of treatment using such compositions.

6. 发明申请

WO2007049010A1 DEVICE FOR DETECTING ANALYTES IN FLUID SAMPLES 审中-公开
标题翻译：用于检测流体样品中分析物的装置
公开(公告)号：WO2007049010A1
公开(公告)日：2007-05-03
申请号：PCT/GB2006/003910
申请日：2006-10-20
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , LEE, Nicholas, John , WU, Yuzhang , HU, Haipeng , DAI, Jielin , GOU, Lijian
发明人： WU, Yuzhang , HU, Haipeng , DAI, Jielin , GOU, Lijian
IPC分类号： G01N33/543 , A61B10/00 , B01L3/00
CPC分类号： G01N33/54366 , A61B10/007 , B01L3/502 , B01L2300/0663 , B01L2300/087 , B01L2400/0478 , Y10T436/2575
摘要： The present invention provides a device (100) for detecting the presence of an analyte in a liquid sample. The device (100) has an opening (115) for introducing the liquid sample into a first chamber (301) for collecting the liquid sample, and a second chamber (601) connected to the first chamber (301) by a passageway (205) and containing a test element. The device also has a third chamber (701) connected to the second chamber (601) by a channel and containing a movable member (311) having first and second positions. The third chamber (701) is divided by the movable member (311) into first (901) and second (902) zones, and the first zone (901) has a vent hole (165). The movable member (311) is in contact with at least one wall of the third chamber (701) to prevent gas communication between the first and second zones (901, 902).
摘要翻译：本发明提供一种用于检测液体样品中分析物的存在的装置（100）。装置（100）具有用于将液体样品引入用于收集液体样品的第一室（301）的开口（115）和通过通道（205）连接到第一室（301）的第二室（601）并包含测试元素。该装置还具有通过通道连接到第二室（601）的第三室（701）并且容纳具有第一和第二位置的可动构件（311）。第三室（701）由可移动部件（311）分成第一（901）和第二（902）区域，第一区域（901）具有通气孔（165）。可移动构件（311）与第三腔室（701）的至少一个壁接触，以防止第一和第二区域（901,902）之间的气体连通。

7. 发明申请

WO2005121792A1 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO2005121792A1
公开(公告)日：2005-12-22
申请号：PCT/GB2005/002248
申请日：2005-06-07
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , BIRCH, Brian, Jeffrey , FORSSTEN, Camilla, Sofia , KABIL, Alena , PORTER, Robert, Andrew
发明人： BIRCH, Brian, Jeffrey , FORSSTEN, Camilla, Sofia , KABIL, Alena , PORTER, Robert, Andrew
IPC分类号： G01N33/543
CPC分类号： G01N33/5438 , G01N33/54313
摘要： The present invention provides a method for determining the presence or amount of a metal-labelled species in a sample. In the method, the metal of the metal-labelled species in the sample is caused to form a soluble electrochemically-active complex which is then electrochemically measuring to provide an indication of the presence or amount of the metal-labelled species. The soluble electrochemically-active complex is stable relative to moieties present or potentially present in the sample which will form an insoluble and/or electrochemically-inactive complex with the metal. The metal-labelled species may be formed by the binding of an analyte to be detected with a metal-labelled binding partner, such as an antibody or antigen binding fragment thereof.
摘要翻译：本发明提供了一种用于确定样品中金属标记物质的存在或量的方法。在该方法中，使样品中的金属标记物质的金属形成可溶的电化学活性复合物，然后电化学测量以提供金属标记物质的存在或量的指示。可溶性电化学活性复合物相对于样品中存在或潜在存在的部分是稳定的，其将与金属形成不溶性和/或电化学惰性复合物。金属标记的物质可以通过将被检测分析物与金属标记的结合配偶体（例如抗体或其抗原结合片段）的结合形成。

8. 发明申请

WO2004071208A1 SKIN COMPOSITION 审中-公开
标题翻译：皮肤组成
公开(公告)号：WO2004071208A1
公开(公告)日：2004-08-26
申请号：PCT/GB2004/000539
申请日：2004-02-12
申请人： MARS UK LIMITED , FRAY, Timothy, Richard , MARKWELL, Peter, John , WATSON, Adrian, Leslie
发明人： FRAY, Timothy, Richard , MARKWELL, Peter, John , WATSON, Adrian, Leslie
IPC分类号： A23K1/00
CPC分类号： A23K50/40 , A23K20/105 , A23K20/132 , A23K20/142 , A23K20/158 , A23K20/163 , A23K20/174
摘要： The present invention provides a composition preferably a pet foodstuff comprising pantothenic acid, nicotinamide, histidine, inositol and choline wherein pantothenic acid is provided at a level of 10mg to 500mg per 400 kcal per day, its use in the treatment of a skin disorder and methods of controlling a skin disorder. The invention further provides a method of manufacturing a composition of the invention.
摘要翻译：本发明提供一种组合物，优选包含泛酸，烟酰胺，组氨酸，肌醇和胆碱的宠物食品，其中提供泛酸的水平为每天400千卡每天10mg至500mg，其用于治疗皮肤病症和方法控制皮肤病。本发明还提供一种制备本发明组合物的方法。

9. 发明申请

WO2003026693A3 INHIBITORS OF COSTIMULATION BY 0X40 AND THEIR USE AGAINST INFECTIOUS DISEASES 审中-公开
公开(公告)号：WO2003026693A3
公开(公告)日：2003-04-03
申请号：PCT/GB2002/004386
申请日：2002-09-27
申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED , HUSSELL, Tracey , HUMPHREYS, Ian
发明人： HUSSELL, Tracey , HUMPHREYS, Ian
IPC分类号： A61K38/17
摘要： The present invention relates to the use of one or more compounds that can inhibit immune system costimulation by OX40 in the preparation of pharmaceutical compositions to treat, ameliorate or prevent diseases associated with virus, bacteria or other infective agent.

10. 发明申请

WO2003006993A2 GEL COMPOSITIONS 审中-公开
标题翻译：凝胶组合物
公开(公告)号：WO2003006993A2
公开(公告)日：2003-01-23
申请号：PCT/GB2002/003183
申请日：2002-07-10
申请人： DE MONTFORT UNIVERSITY , TAYLOR, Margaret, Joan
发明人： TAYLOR, Margaret, Joan
IPC分类号： G01N33/543
CPC分类号： G01N33/559 , A61K9/0014 , A61K47/32 , A61K47/36 , A61K47/42 , G01N33/54313 , G01N33/548
摘要： The present invention relates to a gel composition, comprising first and second gel-forming moieties which bind reversibly to one another to form a gel. The binding of the moieties is sensitive to the level of an analyte, and either or both of the gel-forming moieties are attached to cross-linked particulate entities such that the interstices between the entities allow gel-sol and sol-gel transformation, and yet are not so small that the analyte cannot diffuse therethrough. The invention also provides drug delivery systems and sensors for detecting an analyte utilising such a gel.
摘要翻译：本发明涉及一种凝胶组合物，其包含第一和第二凝胶形成部分，其彼此可逆地结合以形成凝胶。部分的结合对分析物的水平敏感，并且凝胶形成部分中的任一个或两者连接到交联的颗粒实体，使得实体之间的间隙允许凝胶溶胶和溶胶 - 凝胶转化，以及但没有那么小，使得分析物不能通过其扩散。本发明还提供用于使用这种凝胶检测分析物的药物递送系统和传感器。

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