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1. 发明申请

WO2022124823A1 새우 급성간췌장괴사병 진단용 조성물 审中-公开
公开(公告)号：WO2022124823A1
公开(公告)日：2022-06-16
申请号：PCT/KR2021/018655
申请日：2021-12-09
申请人： 대한민국(해양수산부 국립수산물품질관리원장) NATIONAL FISHERY PRODUCTS QUALITY MANAGEMENT SERVICE. [KR]/[KR]
发明人： 황지연 HWANG, Jee Youn , 황성돈 HWANG, Seong Don , 권문경 KWON, Mun Gyeong , 정지민 JEONG, Ji Min
IPC分类号： C12Q1/689
摘要： 본 발명은 새우 급성간췌장괴사병 진단용 프라이머, 프로브 및 상기 프라이머 또는 프로브를 함유하는 새우 급성간췌장괴사병 진단용 조성물에 관한 것으로, 본 발명에 따르면, 종래 방법으로 2시간 이상이 소요되었던 새우 급성간췌장괴사병의 진단을 100 copy 유전자에 대해서 1 시간 ~ 30분 이내에 질병감염 유무를 확인할 수 있어, 새우 급성간췌장괴사병의 감염 및 확신을 조기에 차단할 수 있는 효과가 있다.

2. 发明申请

WO2019244086A1 CELL/TISSUE-SPECIFIC CELL-PENETRATING ANTIBODIES 审中-公开
公开(公告)号：WO2019244086A1
公开(公告)日：2019-12-26
申请号：PCT/IB2019/055193
申请日：2019-06-20
申请人： ORUM THERAPEUTICS INC.
发明人： KIM, Yong Sung , KIM, Ji Sun , PARK, Jae Yeong , PARK, Seong Wook , JUN, Sei Yong , CHOI, Dong-Ki
IPC分类号： C07K7/08 , C07K16/00 , C07K16/28 , C07K16/30 , A61K47/66 , A61P35/00 , A61K39/00
摘要： Presented herein are cyclic peptides that specifically bind to a cell surface molecule, thereby allowing cell/tissue-specific targeting. The cyclic peptides can be attached to an agent, for example, a polypeptide such as an antibody, e.g., a cell-penetrating antibody. Cyclic peptide-containing cell/tissue-specific cell-penetrating antibodies described herein are capable of targeted delivery in a cell type-specific or tissue-specific (i.e., cell/tissue-specific) manner. The cell/tissue-specific cell-penetrating antibodies described herein can be used as an effective anticancer agent for cancer that overexpresses a cell membrane protein that specifically binds to the fused cyclic peptides.

3. 发明申请

WO2018044060A1 PHARMACEUTICAL COMPOSITION FOR TREATING GROWTH HORMONE DEFICIENCY CONTAINING hGH FUSION PROTEIN 审中-公开
标题翻译：用于治疗含有hGH融合蛋白的生长激素缺乏的药物组合物
公开(公告)号：WO2018044060A1
公开(公告)日：2018-03-08
申请号：PCT/KR2017/009471
申请日：2017-08-30
申请人： GENEXINE,INC. , HANDOK INC.
发明人： KIM, Tae Kyung , WOO, Jung Won , LEE, Joan Yoon Ji , AHN, Young-Joo , CHA, Ji-Eun , RHIM, Hyou Young , JANG, Woo Ick
IPC分类号： A61K38/16 , A61K38/27
摘要： The present disclosure relates to a method for administering a human growth hormone fusion protein (GX-H9) for treating growth hormone deficiency. Specifically, the present disclosure relates to a pharmaceutical composition for treating growth hormone deficiency, which comprises an hGH fusion protein (GX-H9) and a pharmaceutically acceptable carrier, wherein the fusion protein (GX-H9) is administered once a week at a dose of 0.4 to 1.6 mg per body weight kg of a pediatric patient, or administered once every two weeks at a dose of 0.8 to 3.2 mg per body weight kg of a pediatric patient. In addition, the present disclosure relates to a method for treating growth hormone deficiency, which comprising a step of administering an hGH fusion protein (GX-H9) to a patient with growth hormone deficiency once a week at a dose of 0.4 to 1.6 mg per body weight kg of the patient, or once every two weeks at a dose of 0.8 to 3.2 mg per body weight kg of the patient.
摘要翻译：本公开涉及用于施用人生长激素融合蛋白（GX-H9）以治疗生长激素缺乏症的方法。具体而言，本公开涉及用于治疗生长激素缺乏的药物组合物，其包含hGH融合蛋白（GX-H9）和药学上可接受的载体，其中所述融合蛋白（GX-H9）每周一次以剂量体重每公斤体重0.4至1.6mg的儿科患者，或者每两周以0.8至3.2mg剂量每公斤体重的儿科患者施用一次。另外，本公开涉及用于治疗生长激素缺乏症的方法，其包括将hGH融合蛋白（GX-H9）以每周0.4-1.6mg的剂量给予患有生长激素缺乏的患者一周一次的步骤体重kg的患者，或者每两周一次，剂量为0.8-3.2mg / kg体重的患者。

4. 发明申请

WO2017074074A1 NOVEL ANTI-GLYPICAN 3 ANTIBODY AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：新型抗GLYPICAN 3抗体和含有该抗体的药物组合物
公开(公告)号：WO2017074074A1
公开(公告)日：2017-05-04
申请号：PCT/KR2016/012193
申请日：2016-10-27
申请人： MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
发明人： PARK, Jae Chan , KIM, Kisu , LEE, Mijung , LEE, Eun-Hee , KIM, Dong-Sik , SONG, Eun Jung , KIM, Sujeong , LIM, Hyung-Kwon , LEE, Kyuhyun , WON, Jongwha , CHOI, Soongyu , PARK, Young Seoub
IPC分类号： C07K16/30 , A61K39/395 , A61K47/48
CPC分类号： C07K16/303
摘要： The present invention relates to an antibody specifically binding to glypican 3 (GPC3), a nucleic acid encoding the antibody, a vector and a host cell containing the nucleic acid, a method of preparing the antibody, and a pharmaceutical composition for treating cancer or tumor, containing the antibody as an active ingredient. The antibody specifically binding to glypican 3 according to the present invention may be effectively used to treat cancer or tumor, particularly, hepatocellular carcinoma due to high affinity and specificity to glypican 3.
摘要翻译：本发明涉及与磷脂酰肌醇蛋白聚糖3（GPC3）特异性结合的抗体，编码该抗体的核酸，含有该核酸的载体和宿主细胞，制备该抗体的方法，以及含有抗体作为活性成分的用于治疗癌症或肿瘤的药物组合物。根据本发明特异性结合磷脂酰肌醇蛋白聚糖3的抗体由于对磷脂酰肌醇蛋白聚糖3具有高亲和力和特异性，可以有效地用于治疗癌症或肿瘤，特别是肝细胞癌。

5. 发明申请

WO2017052241A1 NOVEL ANTI-MESOTHELIN ANTIBODY AND COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：新型抗丝氨酸抗体及其组合物
公开(公告)号：WO2017052241A1
公开(公告)日：2017-03-30
申请号：PCT/KR2016/010604
申请日：2016-09-23
申请人： MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
发明人： KIM, Dong-Sik , SONG, Eun Jung , LEE, Mijung , LEE, Eun-Hee , OH, Miyoung , PARK, Jae Chan , KIM, Kisu , KIM, Sujeong , LIM, Hyung-Kwon , LEE, Kyuhyun , WON, Jongwha , CHOI, Soongyu , PARK, Young Seoub
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： C07K16/30 , C07K16/18 , C07K2317/21 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to an antibody specifically bound to mesothelin (MSLN), a nucleic acid encoding the antibody, a vector and a host cell including the nucleic acid, a method for producing the antibody, and a pharmaceutical composition for treating cancer or tumor including the antibody as an active ingredient. The antibody specifically bound to the mesothelin according to the present invention has high affinity and specificity to an antigen, such that it is possible to develop an antibody effectively usable for treatment or diagnosis of cancer or tumor diseases.
摘要翻译：本发明涉及特异性结合间皮素（MSLN）的抗体，编码抗体的核酸，载体和包含该核酸的宿主细胞，该抗体的制备方法和用于治疗癌症或肿瘤的药物组合物，包括该抗体作为活性成分。与本发明的间皮素特异性结合的抗体对抗原具有高亲和性和特异性，可以开发有效地用于治疗或诊断癌症或肿瘤疾病的抗体。

6. 发明申请

WO2016175567A1 MEDIUM COMPOSITION FOR PREPARING BOTULINUM TOXIN 审中-公开
标题翻译：用于制备BOTULINUM TOXIN的中间组合物
公开(公告)号：WO2016175567A1
公开(公告)日：2016-11-03
申请号：PCT/KR2016/004432
申请日：2016-04-28
申请人： DAEWOONG CO., LTD.
发明人： KIM, Kyoung-Yun , SUL, Hye-Young , MIN, Kyoung-Min
IPC分类号： C12N5/00 , C07K14/33
CPC分类号： C12N9/52 , C07K14/33 , C12N1/20 , C12Y304/24069
摘要： The present invention relates to a medium composition for production of botulinum toxin and, more particularly, to a medium composition for culture of Clostridium sp. capable of producing botulinum toxin. The medium composition of the present invention comprises a porcine peptone and at least one plant-derived peptone selected from the group consisting of a garden pea hydrolysate, a cotton seed hydrolysate and a wheat gluten hydrolysate. When the medium according to the present invention, which contains plant-derived peptones, porcine peptones and minerals, is used for culture of Clostridium botulinum , the growth rate of the bacterium in the medium is higher than that in each of the medium that is in current use and the medium comprising plant-derived peptones alone. In addition, when the medium of the present invention is used, a high concentration of botulinum toxin can be produced by culturing the bacterium in a safe manner.
摘要翻译：本发明涉及用于生产肉毒杆菌毒素的培养基组合物，更具体地说，涉及用于培养梭菌属的培养基组合物。能够产生肉毒杆菌毒素。本发明的培养基组合物包含猪蛋白胨和至少一种选自花生豌豆水解产物，棉花种子水解物和小麦麸质水解产物的植物来源的蛋白胨。当将含有植物来源的胨，猪胨和矿物质的本发明的培养基用于肉毒杆菌的培养时，培养基中细菌的生长速度高于培养基中培养的培养基目前的用途和包含单独植物来源的胨的培养基。此外，当使用本发明的培养基时，可以通过以安全的方式培养细菌来产生高浓度的肉毒杆菌毒素。

7. 发明申请

WO2016018036A1 NOVEL ISOPRENE SYNTHASE AND METHOD OF PREPARING ISOPRENE USING THEREOF 审中-公开
标题翻译：新型异丙苯合成酶及其制备方法
公开(公告)号：WO2016018036A1
公开(公告)日：2016-02-04
申请号：PCT/KR2015/007851
申请日：2015-07-28
申请人： SK INNOVATION CO., LTD. , TEKNOLOGIAN TUTKIMUSKESKUS VTT OY
发明人： OJA, Merja , HUUSKONEN, Anne , IIMEN, Marja , RUOHONEN, Laura , KOIVISTOINEN, Outi , JUNG, Simonmoongeun , JO, Jaehoon , LEE, Sangmin
IPC分类号： C12N9/88 , C12N15/60 , C12N15/63 , C12P5/02
CPC分类号： C12N9/88 , C12N15/74 , C12P5/007 , C12P5/026 , C12Y402/03027
摘要： Provided are a novel isoprene synthase derived from sweet potato and a method of preparing isoprene using the same, and more specifically, a novel isoprene synthase derived from sweet potato, a gene encoding the isoprene synthase, a host cell transformed with the gene, and a method of preparing isoprene using the same. The isoprene synthase of the present invention may have higher isoprene productivity as compared to isoprene synthases known in the related art to thereby be effectively used in isoprene biosynthesis and preparation of an isoprene polymer using the same.
摘要翻译：本发明提供一种来自甘薯的新型异戊二烯合成酶及使用其制备异戊二烯的方法，更具体地说，来自甘薯的新型异戊二烯合成酶，编码异戊二烯合酶的基因，用该基因转化的宿主细胞，以及使用其制备异戊二烯的方法。与现有技术中已知的异戊二烯合酶相比，本发明的异戊二烯合酶可以具有更高的异戊二烯生产能力，从而可有效地用于异戊二烯生物合成和使用该异戊二烯聚合物的制备。

8. 发明申请

WO2015152446A1 Melting curve analysis using PNA probe, Method and Kit for analyzing Nucleotide Polymorphism using melting curve analysis 审中-公开
标题翻译：使用PNA探针的熔解曲线分析，使用熔解曲线分析分析核苷酸多态性的方法和试剂盒
公开(公告)号：WO2015152446A1
公开(公告)日：2015-10-08
申请号：PCT/KR2014/002909
申请日：2014-04-04
申请人： PANAGENE INC.
发明人： JOE, Goon Ho , KIM, Sung-Kee , PARK, Heekyung , PARK, Chwang Siek , KIM, Se Ryun , KIM, Yongtae , KIM, Su Nam
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q2525/107 , C12Q2527/107 , C12Q2563/173
摘要： Provided are a PNA probe for detecting nucleotide polymorphism of a target gene, a melting curve analysis method for detecting the nucleotide polymorphism of the target gene using the same, a nucleotide polymorphism analysis method of a target gene including the melting curve analysis method, and a kit for detecting the nucleotide polymorphism of the target gene containing the PNA probe. It is characterized that the PNA probe according to the present invention contains negative charge molecules. The modified PNA probe according to the present invention contains the negative charge molecules to have a high recognition ability with respect to a target DNA and a high coupling ability to the target DNA and to be rapidly dissociated by heat, such that the nucleotide polymorphism analysis may be relatively easily performed even in a heterozygous sample showing two melting curve graphs, and two or more adjacent single nucleotide polymorphisms may be simultaneously analyzed.
摘要翻译：提供了用于检测靶基因的核苷酸多态性的PNA探针，使用该靶基因的靶基因的核苷酸多态性的检测的解链曲线分析方法，包含解链曲线分析法的靶基因的核苷酸多态性分析方法，以及用于检测含有PNA探针的靶基因的核苷酸多态性的试剂盒。其特征在于根据本发明的PNA探针含有负电荷分子。根据本发明的修饰的PNA探针含有相对于目标DNA具有高识别能力的负电荷分子和与目标DNA的高偶联能力并且通过热快速解离，使得核苷酸多态性分析可以即使在显示两个解链曲线图的杂合样品中也可以相对容易地进行，并且可以同时分析两个或更多个相邻的单核苷酸多态性。

9. 发明申请

WO2015005669A1 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME 审中-公开
标题翻译：肝癌相关基因特异性siRNA，包含siRNA的双链寡聚RNA分子，以及用于预防或治疗包含其的癌症的组合物
公开(公告)号：WO2015005669A1
公开(公告)日：2015-01-15
申请号：PCT/KR2014/006145
申请日：2014-07-09
申请人： BIONEER CORPORATION , SANOFI-AVENTIS KOREA CO., LTD.
发明人： CHAE, Jeiwook , PARK, Han Oh , YOON, Pyoung Oh , HAN, Boram , KIM, Han-Na , YUN, Sung-Il , PARK, Jun Hong , KO, Youngho , CHOI, Gi-Eun , JUNG, Junsoo , KIM, Jae Eun
IPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , A61P35/00
CPC分类号： C12N15/1135 , A61K9/0019 , A61K9/51 , A61K31/713 , A61K47/60 , C12N2310/14
摘要： There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly Gankyrin or BMI-1 specific siRNA. In addition, the present invention relates to a method of preparing the double-stranded oligo RNA molecules, and a pharmaceutical composition for preventing or treating cancer, particularly, liver cancer, containing the double-stranded oligo RNA molecules.
摘要翻译：提供了与相关肝癌相关的特异性siRNA和高效双链寡聚RNA分子。双链寡RNA分子具有通过简单的共价键或连接体介导的共价键将亲水和疏水化合物与双链寡RNA分子的两端缀合以便有效地递送到细胞中的结构，可以通过双链寡聚RNA分子的疏水相互作用在水溶液中转化成纳米颗粒。双链寡核苷酸分子中含有的siRNA可能是肝癌相关基因，特别是Gankyrin或BMI-1特异性siRNA。此外，本发明涉及制备双链寡聚RNA分子的方法和用于预防或治疗包含双链寡RNA分子的癌症，特别是肝癌的药物组合物。

10. 发明申请

WO2013191352A1 NEW USES OF MODIFIED HUMAN TUMOR NECROSIS FACTOR RECEPTOR-1 POLYPEPTIDE 审中-公开
标题翻译：改良人类肿瘤坏死因子受体-1多肽的新用途
公开(公告)号：WO2013191352A1
公开(公告)日：2013-12-27
申请号：PCT/KR2013/000983
申请日：2013-02-07
申请人： HANALL BIOPHARMA CO., LTD.
发明人： KIM, Sung Wuk , PARK, Seung Kook , SONG, Yeon Jung , KIM, Eun Sun , AHN, Hyea Kyung , JEONG, Jae Kap , LEE, Hung Keun
IPC分类号： A61K38/17 , A61K38/16 , A61K38/18 , A61P27/02
CPC分类号： C07K14/7151 , A61K38/1793 , C07K14/70575 , Y02A50/473
摘要： The present invention relates to new uses of modified human tumor necrosis factor receptor-1 (TNFRI) polypeptide, and more particularly, to uses thereof for prevention and treatment of dry eye syndrome. The modified TNFRI or modified TNFRI fragment of the present invention has excellent TNFα neutralizing activity, and inhibits TNFα activity on the ocular surface of the patient to suppress inflammation induction effects related to dry eye. Therefore, the modified TNFRI or modified TNFRI fragment of the present invention exhibits remarkable effects in the prevention and treatment of dry eye syndrome, and thus can be very useful in the prevention and treatment of dry eye syndrome.
摘要翻译：本发明涉及修饰的人肿瘤坏死因子受体-1（TNFRI）多肽的新用途，更具体地说，涉及其用于预防和治疗干眼综合征的用途。本发明的修饰的TNFRI或修饰的TNFRI片段具有优异的TNFα中和活性，并且抑制患者眼表面的TNFα活性以抑制与干眼有关的炎症诱导作用。因此，本发明的改良的TNFRI或修饰的TNFRI片段在预防和治疗干眼综合征中表现出显着的效果，因此在预防和治疗干眼综合征中非常有用。

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