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1. 发明公开

EP0958303A1 BIOREACTIVE ALLOSTERIC POLYNUCLEOTIDES 失效
标题翻译：生物反应变构多核苷酸
公开(公告)号：EP0958303A1
公开(公告)日：1999-11-24
申请号：EP97954296.0
申请日：1997-12-18
申请人： Yale University
发明人： BREAKER, Ronald, R.
IPC分类号： C12N15 , C12M1 , C12Q1
CPC分类号： C12N15/113 , C07K2319/00 , C12N15/101 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/322 , C12Q1/6811 , C12Q1/6825 , C12Q2521/337 , C12Q2525/205
摘要： Polynucleotides having allosteric properties that modify a function or configuration of the polynucleotide with a chemical effector and/or physical signal are employed primarily as biosensors and/or enzymes for diagnostic and catalytic purposes. In some preferred embodiments, the polynucleotides are DNA enzymes that are used in solution/suspension or attached to a solid support as biosensors to detect the presence or absence of a compound, its concentration, or physical change in a sample by observation of self-catalysis. Chemical effectors include organic compounds such as amino acids, amino acid derivatives, peptides, nucleosides, nucleotides, steroids, and mixtures of these with each other and with metal ions, cellular metabolites or blood components obtained from biological samples, steroids, pharmaceuticals, pesticides, herbicides, food toxins, and the like. Physical signals include radiation, temperature changes, and combinations thereof.

2. 发明公开

EP0909148A1 EXPANSIBLE BIOPROSTHETIC VALVE STENT 失效
标题翻译： EXTENDABLE生物圈心脏瓣膜支架
公开(公告)号：EP0909148A1
公开(公告)日：1999-04-21
申请号：EP97922793.0
申请日：1997-05-30
申请人： THE UNIVERSITY OF WESTERN ONTARIO
发明人： WAN, Wan-Kei-The University of Western Ontario , DUNCAN, Anthony-The University of Western Ontario , CAMPBELL, Gordon-The University of Western Ontario , BOUGHNER, Derek-The University of Western Ontario
IPC分类号： A61F2 , A61L27 , A61L31
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2415 , A61L27/52 , A61L31/145
摘要： A bioprosthetic valve stent fabricated from a hydrogel, wherein the hydrogel, when hydrated, has (a) a strain value at ultimate tensile stress (UTS) greater than the maximum strain occurring in a human aortic root under physiological conditions; (b) an elastic modulus similar to that of the aortic root; and (c) a relaxation rate similar to that of the aortic root.

3. 发明公开

EP0891313A1 METHOD AND APPARATUS FOR RECOVERING OIL FROM AN OIL-BEARING SOLID MATERIAL 失效
标题翻译：用于从含油固体材料中回收油的方法和设备
公开(公告)号：EP0891313A1
公开(公告)日：1999-01-20
申请号：EP97906911.0
申请日：1997-02-12
申请人： Hydrocarbon Minerals Technology L.L.C.
发明人： HAEFELE, Gary, R. , ALLEN, Peter, A. , DUNKEL, Gary, L. , WEGNER, Paul, C.
IPC分类号： B01D11 , C10G1
CPC分类号： C10G1/04 , B01D11/0242 , B01D11/028
摘要： A method and apparatus for continuously removing oil from oil-bearing solids such as tar sands, vegetables or other solid materials using a solvent is provided. By providing a pressure differential between the exterior and interior of an oil extraction chamber, substantially oil free solids may be removed from the oil extraction chamber through a solids extraction channel without removing any substantial volume of solvent through the solids extraction channel.
摘要翻译：一种利用溶剂萃取连续地从含油固体如焦油砂，蔬菜或其他固体材料中去除油的方法和设备。如图所示，在榨油室（10）的外部和内部之间产生压力差，其中通过固体抽取通道（24）从榨油室（10）除去基本上无油的固体，而不去除通过固体提取通道（24）的任何大量的溶剂。

4. 发明公开

EP0852628A1 PROCESS CHAMBER WITH INNER SUPPORT 失效
标题翻译：与内轴承结构工艺室
公开(公告)号：EP0852628A1
公开(公告)日：1998-07-15
申请号：EP96926233.0
申请日：1996-08-01
申请人： ADVANCED SEMICONDUCTOR MATERIALS AMERICA, INC.
发明人： WENGERT, John, F. , JACOBS, Loren, R. , HALPIN, Michael, W. , FOSTER, Derrick, W. , VAN DER JEUGD, Cornelius, A. , VYNE, Robert, M. , HAWKINS, Mark, R.
IPC分类号： B01J3 , C23C16 , H01L21
CPC分类号： B01J3/006 , C23C16/44 , C23C16/455 , C23C16/45502 , C23C16/46 , C23C16/481 , H01L21/67115 , H01L21/68735 , H01L21/68785
摘要： An improved chemical vapor deposition reaction chamber having an internal support plate (40) to enable reduced pressure processing. The chamber has a vertical-lateral lenticular cross section with a wide horizontal dimension and a shorter vertical dimension between bi-convex upper and lower walls (12, 14). A central horizontal support plate (40) is provided between two lateral side rails (16, 18) of the chamber. A large rounded rectangular aperture is formed in the support plate for positioning a rotatable susceptor on which a wafer is placed. The shaft of the susceptor extends downward through the aperture and through a lower tube depending from the chamber. The support plate segregates the reaction chamber into an upper region and a lower region (66, 68), with purge gas being introduced through the lower tube into the lower region to prevent unwanted deposition therein. A temperature compensation ring is provided surrounding the susceptor and supported by fingers connected to the support plate. The temperature compensation ring may be circular or may be built out to conform to the rounded rectangular shape of the support plate aperture. The ring may extend farther downstream from the susceptor than upstream. A separate sacrificial quartz plate may be provided between the circular temperature compensation ring and the rounded rectangular aperture. The quartz plate may have a horizontal portion and a vertical lip in close abutment with the aperture to prevent devitrification of the support plate. A gas injector abuts an inlet flange of the chamber and injects process gas into the upper region and purge gas into the lower region. The gas injector includes a plurality of independently controlled channels disposed laterally across the chamber, the channels merging at an outlet of the injector to allow mixing of the adjacent longitudinal edges of the separate flows well before reaching the wafer.

5. 发明公开

EP0746623A1 PROMOTER FROM A LIPID TRANSFER PROTEIN GENE 失效
标题翻译：启动子的脂质转移蛋白基因
公开(公告)号：EP0746623A1
公开(公告)日：1996-12-11
申请号：EP95910817.0
申请日：1995-02-23
申请人： Olsen, Odd-Arne , Kalla, Roger , Linnestad, Casper
发明人： Olsen, Odd-Arne , Kalla, Roger , Linnestad, Casper
IPC分类号： C07K14 , C12N15
CPC分类号： C07K14/415 , C12N15/8234
摘要： An expression system for at least the aleurone cells of a developing caryopsis or for at least the scutellar epithelial tissue or vascular tissue of a germinating seedling or developing grain or plant (e.g. in the root, leaves and stem) is described. The expression system comprises a gene promoter fused to a GOI (gene of interest). In a preferred embodiment the expression system comprises the GOI fused to a modified Ltp1 gene promoter.

6. 发明公开

EP0735894A1 COMPOSITION AND METHODS TO IMPROVE NEURAL OUTCOME 失效
标题翻译： GPE择期手术前，AS神经预防
公开(公告)号：EP0735894A1
公开(公告)日：1996-10-09
申请号：EP95904702.0
申请日：1994-12-20
申请人： AUCKLAND UNISERVICES LIMITED
发明人： GLUCKMAN, Peter, David , WILLIAMS, Chr. Ed., Auckland UniServices Ltd.
IPC分类号： A61K38 , A61P25 , C07K5
CPC分类号： A61K38/30 , A61K38/05 , A61K38/06
摘要： The tripeptide glycine-proline-glutamine (GPE) may be administered before or usually after injury, to reduce damage to the central nervous system. GPE appears useful for neuronal rescue particularly but not exclusively within the hippocampus. Advantages of GPE include: a) that it crosses the blood-brain barrier, so is effective by injected peripheral administration; b) it is unlikely to challenge the immune system; c) it is cheap; and d) its therapeutic ratio is high. GPE may be also be infused into the CSF. It may be administered prior to parturition or elective brain or cardiac surgery. Transdermal routes may be useful for chronic neural disorders. The CNS of mammals (including foetal mammals) after trauma including hypoxic/ischaemic experimental insults showed reduced damage under GPE protection as measured by histological assesment of cell damage or death and regional shrinkage.

7. 发明公开

EP0726779A1 METHODS OF STIMULATING PHAGOCYTOSIS 失效
标题翻译：方法，激发吞噬
公开(公告)号：EP0726779A1
公开(公告)日：1996-08-21
申请号：EP94929972.0
申请日：1994-09-30
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： SCHREIBER, Alan, D. , PARK, Jong-Gu
IPC分类号： C12N15 , A61K9 , A61K31 , A61K35 , A61K38 , A61K48 , A61P1 , A61P11 , A61P13 , A61P15 , A61P29 , A61P31 , A61P37 , C07H21 , C07K14 , C12N1 , C12N5 , C12P21
CPC分类号： C07K14/70535 , A61K9/12 , A61K38/00 , A61K38/193 , A61K48/00 , A61K2300/00
摘要： The present invention relates, in general, to methods of stimulating phagocytosis and thereby combating infection and/or modulating immune complex disease, in particular, to methods of modulating the number and type of Fc receptors present on cells that normally possess such receptors, including monocytes and macrophages, as well as on cells that normally do not possess Fc receptors, such as fibroblasts, and to compounds and compositions suitable for use in such methods.

8. 发明公开

EP0706387A1 NEW PROCEDURE TO BLOCK THE REPLICATION OF REVERSE TRANSCRIPTASE DEPENDENT VIRUSES BY THE USE OF INHIBITORS OF DEOXYNUCLEOTIDES SYNTHESIS 失效
标题翻译：用于抑制病毒的复制新步骤 - 通过使用Dideoxydenucleotide合成抑制剂取决于逆转录酶
公开(公告)号：EP0706387A1
公开(公告)日：1996-04-17
申请号：EP94918016.0
申请日：1994-05-17
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： LORI, Franco , CARA, Andrea , GAO, Wen-Yi , GALLO, Robert, C.
IPC分类号： C12N15 , A61K31 , A61K45 , A61P31 , A61P43 , B65F1 , C12N7
CPC分类号： A61K31/708 , A61K31/17 , A61K31/19 , A61K31/70 , A61K31/7072 , A61K31/7076 , A61K31/7088 , A61K45/06 , A61K2300/00
摘要： A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular pool of deoxyribonucleoside phosphate in an amount effective to inhibit replication of said virus. Hydroxyurea is one such suitable compound. Also disclosed is a method for producing incomplete reverse-transcriptase dependent viral DNA, by administering a deoxyribonucleoside phosphate-depleting drug to cells infected with such a virus.

9. 发明公开

EP0693883A1 FAT SUBSTITUTE 失效
标题翻译： FETTERSATZ
公开(公告)号：EP0693883A1
公开(公告)日：1996-01-31
申请号：EP94914172.0
申请日：1994-04-14
申请人： NURTURE, INC.
发明人： TARR, Bryan, D. , BIXBY, Steven, H.
IPC分类号： A23L1 , A23C11 , A23D7 , A23G1 , A23G3 , A23J1
CPC分类号： A23C11/06 , A23D7/015 , A23G3/346 , A23G2200/08 , A23J1/12 , A23J1/14 , A23L7/115 , A23L29/212 , A23L29/225 , A23L33/185 , Y10S426/804
摘要： The present invention provides a novel fat substitute composition, which is made from a defatted and mostly nondenatured proteinaceous particulate material, that, in a preferred embodiment, is derived from seed grains, and most preferably oats. In addition, a method of making and using the compositions to produce food products having a reduced caloric count, creamy texture and suitable mouth-feel, is disclosed. Further, a method to vary the viscosity of the resulting food products is disclosed, through changing the ratio of starch to protein in the fat substitute.

10. 发明公开

EP0693128A1 TRANSGENIC ORGANISM 失效
标题翻译：转基因生物
公开(公告)号：EP0693128A1
公开(公告)日：1996-01-24
申请号：EP94913121.0
申请日：1994-04-07
申请人： DANISCO A/S
发明人： VILLAND, Per , KLECZKOWSKI, Leszek , OLSEN, Odd-Arne , POULSEN, Peter , OKKELS, Finn , MARCUSSEN, Jan
IPC分类号： A01H5 , A23L1 , C12N5 , C12N9 , C12N15
CPC分类号： C12N9/1241 , C12N15/8245
摘要： A transgenic organism is described which has an increased starch yield. The preferred embodiment concerns a plant or plant cell containing a recombinant DNA construct containing, in operational relationship to a plant promoter sequence or sequences enabling the expression of the gene by the plant or plant cell thereby to enhance the rate of production and/or yield of starch by the plant or the plant cell, a DNA sequence encoding an exogenous ADP glucose pyrophosphorylase enzyme (AGP) or a sub-unit thereof which retains the enzymatic activity of the AGP enzyme, characterised in that the said DNA sequence is the gene sequence, including non-critical allelic variations thereof, encoding the barley (Hordeum vulgare) endosperm AGP or an active sub-unit thereof, or a variant thereof having non-critical amino acid substitution(s) or deletion(s) at one or more points in the amino acid sequences defining the barley endosperm AGP or either of its sub-units.

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