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1. 发明公开

EP0948612A2 BETA-AMYLOID TOXICITY 失效
标题翻译： β-淀粉样蛋白毒性
公开(公告)号：EP0948612A2
公开(公告)日：1999-10-13
申请号：EP97952623.0
申请日：1997-12-31
申请人： University Technology Corporation
发明人： LINK, Christopher
IPC分类号： A01K67 , C07K14 , C12N15
CPC分类号： A01K67/0336 , A01K2217/05 , A01K2217/20 , A01K2227/703 , A01K2267/0312 , A01K2267/0337 , A01K2267/0393 , C07K14/43595 , C07K14/4711 , C12N15/8509 , C12N2830/008
摘要： The present invention relates to methods and compositions for visualization of the toxic effects of transgenes in vivo. In particular, the present invention provides methods and compositions for the production and use of transgenic, including dually transgenic, Caenorhabditis elegans for visualization of the toxic effects of β-amyloid accumulation in vivo.

2. 发明公开

EP0939627A1 PENTAFLUOROBENZENESULFONAMIDES AND ANALOGS 失效
标题翻译：五氟苯基磺酰胺类化合物
公开(公告)号：EP0939627A1
公开(公告)日：1999-09-08
申请号：EP97936133.0
申请日：1997-07-18
申请人： TULARIK, INC.
发明人： FLYGARE, John , MEDINA, Julio , SHAN, Bei , CLARK, David , ROSEN, Terry
IPC分类号： C07D295 , A61K31 , A61P35 , C07C309 , C07C311 , C07C313 , C07C323 , C07D209 , C07D213 , C07D231 , C07D317 , C07D319 , C07K14
CPC分类号： C07K14/47 , A61K31/18 , A61K31/255 , A61K31/357 , A61K31/36 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/47 , A61K31/5375 , C07C309/73 , C07C311/21 , C07C313/06 , C07C323/49 , C07D209/08 , C07D213/76 , C07D231/56 , C07D295/135 , C07D317/66 , C07D319/18 , Y02A50/411
摘要： The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, vascular restenosis, microbial infections, and psoriasis, or as lead compounds for the development of such agents. The compositions include compounds of the general formula I:
摘要翻译：本发明提供涉及新型五氟苯基磺酰胺衍生物和类似物的方法和组合物及其作为药理活性剂的用途。该组合物特别用作治疗疾病，特别是癌症，血管再狭窄，微生物感染和牛皮癣的药理学试剂，或作为开发这些试剂的先导化合物。该组合物包括通式（I）的化合物。

3. 发明公开

EP0935662A2 MULTIPLE EPITOPE FUSION PROTEIN 失效
标题翻译：融合蛋白mit Dopen Epitopen
公开(公告)号：EP0935662A2
公开(公告)日：1999-08-18
申请号：EP97927767.0
申请日：1997-05-23
申请人： CHIRON CORPORATION
发明人： VALENZUELA, Pablo, D., T. , CHIEN, David, Ying
IPC分类号： G01N33 , C07K14 , C12N15 , C12Q1
CPC分类号： C07K14/005 , C07K2319/00 , C12N2770/24222
摘要： Multiple copy epitope immunoassays are produced by: (1) identifying nucleotide sequences that encode a plurality of different epitopes; (2) placing the nucleotide sequences into an expression cassette wherein at least two copies of a sequence coding for the same epitope, preferably from different strains of a pathogen, are placed in the cassette; (3) transforming a suitable host with the cassette in order to express the sequences encoding the epitopes; (4) purifying the expressed epitopes; and (5) coating the epitopes on a surface of a substrate. The purified epitopes are encompassed by the general structural formula (A)x-(B)y-(C)z which represents a linear amino acid sequence, B is an amino acid sequence of an epitope or cluster of epitopes and each B contains at least five and not more than 1,000 amino acids, y is an integer of 2 or more, A and C are each independently an amino acid sequence of an epitope or cluster of epitopes not adjacent to B in nature and x and z are each independently an integer of 0 or more wherein at least one of x and z is 1 or more. The epitopes of the invention are more soluble than and are therefore more easily purified than conventional epitopes. Further, the presence of repeating epitope sequences (repeating at least B in the same linear amino acid sequence from different strains of a pathogen) increases the sensitivity and specificity of the assay. Repeated epitope sequences in a single linear antigen also decreases masking problems and makes it possible to include a greater number of epitopes on a unit area of substrate thereby improving sensitivity in the detection of antibodies.
摘要翻译：多拷贝表位免疫测定通过以下方式产生：（1）鉴定编码多个不同表位的核苷酸序列; （2）将核苷酸序列置于表达盒中，其中编码相同表位，优选来自病原体的不同菌株的序列的至少两个拷贝被放置在盒中; （3）用盒子转化合适的宿主以表达编码表位的序列; （4）纯化表达的表位; 和（5）在基底表面上涂覆表位。纯化的表位被代表线性氨基酸序列的一般结构式（A）x-（B）y-（C）z所涵盖，B是表位或表位簇的氨基酸序列，每个B含有至少5个且不超过1,000个氨基酸，y是2或更大的整数，A和C各自独立地是本质上不与B相邻的表位的表位或簇的氨基酸序列，x和z各自独立地为 0或更大的整数，其中x和z中的至少一个为1或更大。本发明的表位比常规表位更可溶，因此更容易纯化。此外，重复表位序列的存在（在来自不同病原体的菌株的同一线性氨基酸序列中至少重复B）增加了测定的灵敏度和特异性。单一线性抗原中的重复表位序列也减少掩蔽问题，并且可以在底物的单位面积上包含更多数目的表位，从而提高抗体检测的灵敏度。

4. 发明公开

EP0923733A1 METHOD FOR ANALYSING ABSORPTION, DISTRIBUTION, METABOLISM, EXCRETION (ADME) AND PHARMACOKINETICS PROPERTIES OF COMPOUND MIXTURES 失效
标题翻译：法分析的吸收，分布，代谢，排泄的药代动力学特性和多个连接的混合物
公开(公告)号：EP0923733A1
公开(公告)日：1999-06-23
申请号：EP97941390.0
申请日：1997-08-28
申请人： CHIRON CORPORATION
发明人： DIETZ, Corine, M. , GIBBONS, Jacqueline, A. , TAYLOR, Eric, W.
IPC分类号： G01N33 , A61K9
CPC分类号： A61K9/0026 , G01N33/5088 , G01N33/557 , Y10S514/832 , Y10T436/19
摘要： A method for analyzing the ADME/PK properties of a mixture of compounds is (1) perfusing an animal or organ with a perfluorocarbon emulsion blood substitute, (2) administering the mixture of test compounds, (3) withdrawing an aliquot of the perfusate, (4) disrupting the emulsion, and (5) analyzing the aqueous phase of the perfusate for the concentration of test compounds.

5. 发明公开

EP0923591A1 NOVEL BORONIC ACID-CONTAINING NUCLEIC ACIDS AND THEIR USE AS DIAGNOSTIC AGENTS 失效
标题翻译：新BORSA您含有核酸和它们作为诊断试剂
公开(公告)号：EP0923591A1
公开(公告)日：1999-06-23
申请号：EP97935061.0
申请日：1997-07-31
申请人： PROLINX, INC.
发明人： STOLOWITZ, Mark, L. , KAISER, Robert, J.
IPC分类号： C12N15 , C07H19 , C07H21 , C07H23 , C12P19 , C12Q1
CPC分类号： C07H23/00 , C07H21/00 , C12P19/34
摘要： Modified nucleotides and polynucleotides which are useful in hybridization assays for the detection of target genes are provided. The modified polynucleotides contain at least one boronic acid moiety which is attached to a nucleotide base in a position which does not interfere with the hydrogen bonding capabilities of that base during duplex formation. The modified polynucleotides are typically formed from naturally occurring nucleotides and one or more modified nucleotides.

6. 发明公开

EP0910794A1 MULTILAYER ENZYME ELECTRODE MEMBRANES AND METHODS OF MAKING SAME 失效
标题翻译：多层膜对酶电极及其制备方法
公开(公告)号：EP0910794A1
公开(公告)日：1999-04-28
申请号：EP97928393.0
申请日：1997-07-11
申请人： Chiron Diagnostics Corporation
发明人： MCCAFFREY, Robert , DALZELL, Bonnie , TKACIK, Katarina , HOLBERT, Susan , BODEN, Mark , FLAHERTY, James , FLANAGAN, Michael , BROWN, Josef , TAKESHITA, Kimiya , EDELMAN, Peter
IPC分类号： G01N27 , C12Q1
CPC分类号： C12Q1/002 , Y10S435/817
摘要： A sensor for use in detecting a concentration of an analyte in a sample solution. The sensor to have a longer useful lifetime, improved stability and improved response time for single or multiple use applications. In one aspect, some of these goals are achieved by providing the multilayer enzyme electrode membrane having both nonporous and microporous layers. The microporous layer is formed from a polymer binder, a polymer powder, a surfactant and a mineral powder. In another aspect, certain of these goals are achieved by the use of a layer comprised of an enzyme disposed within a polymer matrix. In certain embodiments, the multilayer enzyme electrode membrane includes an outermost layer which is capable of dissolving in the sample solution such that the interface between the multilayer enzyme electrode membrane and the sample solution is continually renewed.

7. 发明公开

EP0910670A1 COVALENT ATTACHMENT OF NUCLEIC ACID MOLECULES ONTO SOLID-PHASES VIA DISULFIDE BONDS 失效
标题翻译： COVALENT固氮菌核酸分子固相二硫
公开(公告)号：EP0910670A1
公开(公告)日：1999-04-28
申请号：EP98911457.0
申请日：1998-03-04
申请人： MOLECULAR TOOL, INC.
发明人： ANDERSON, Stephen , ROGERS, Yu-Hui
IPC分类号： C12N15 , C07H21 , C12Q1 , G01N33 , G01N37 , C40B40
CPC分类号： C07H21/00 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , C12Q1/6834 , C12Q1/6837 , C12Q1/6858 , C40B40/06
摘要： Methods for the covalent, specific and reversible immobilization of nucleic acid molecules onto solid-phases by means of a reversible disulfide bond for nucleic acid molecule array preparation are described. These methods can be used to prepare reusable nucleic acid molecule arrays with high specificity and high efficiency.

8. 发明公开

EP0889894A1 PHOSPHORAMIDATES AND PHOSPHINIC AMIDES, THEIR USE TO MODULATE THE ACTIVITY OF ENDOTHELIN 失效
标题翻译：磷酸酯基和phosphinamides，它们用于调制内皮素的效果
公开(公告)号：EP0889894A1
公开(公告)日：1999-01-13
申请号：EP97915161.0
申请日：1997-03-18
申请人： TEXAS BIOTECHNOLOGY CORPORATION
发明人： CHAN, Ming, F. , VERNER, Erik, J.
IPC分类号： A61K31 , A61P1 , A61P9 , A61P11 , A61P13 , A61P15 , A61P17 , A61P27 , A61P29 , A61P37 , A61P43 , C07F9
CPC分类号： C07F9/650941 , C07F9/247 , C07F9/65127 , C07F9/653
摘要： Phosphoramidates and phosphinic amides and related compounds are provided. Also provided are methods that use the compounds for modulating the activity of the endothelin family of peptides are provided. In particular, compounds having formula (IIa) or (II), in which A, B, R?1 and R2¿ are as described are provided. Also provided are methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these compounds or prodrugs thereof. Methods for elucidating the physiological and pathophysiological roles of endothelin, as well as isolating endothelin receptors are also provided.

9. 发明公开

EP0877639A1 HYDROUS PYROLYSIS/OXIDATION PROCESS FOR IN SITU DESTRUCTION OF HYDROCARBON CONTAMINANTS 失效
标题翻译：水热解/氧化过程的原位碳氢化合物污染破坏
公开(公告)号：EP0877639A1
公开(公告)日：1998-11-18
申请号：EP96932996.0
申请日：1996-09-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： KNAUSS, Kevin, G. , COPENHAVER, Sally, C. , AINES, Roger, D.
IPC分类号： B09C1 , C02F1
CPC分类号： B09C1/002 , B09C1/06 , B09C1/08 , B09C2101/00 , C02F1/025 , C02F1/302 , C02F2101/32 , C02F2101/36 , C02F2103/06
摘要： In situ hydrous pyrolysis/oxidation process is useful for in situ degradation of hydrocarbon water (20) and soil contaminants. Fuel hydrocarbons, chlorinated hydrocarbons, polycyclic aromatic hydrocarbons, petroleum distillates and other organic contaminants present in the soil and water (20) are degraded by the process involving hydrous pyrolysis/oxidation into non-toxic products of the degradation. The process uses heat which is distributed through soils and water (20), optionally combined with oxygen and/or hydrocarbon degradation catalysts, and is particularly useful for remediation of solvent, fuel or other industrially contaminated sites (30).

10. 发明公开

EP0870035A2 A NOVEL PROTEIN KINASE REQUIRED FOR RAS SIGNAL TRANSDUCTION 失效
标题翻译：新的蛋白质激酶需的RAS信号转
公开(公告)号：EP0870035A2
公开(公告)日：1998-10-14
申请号：EP96943751.0
申请日：1996-12-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： RUBIN, Gerry , THERRIEN, Marc , CHANG, Henry , KARIM, Felix , WASSARMAN, David
IPC分类号： C12N15 , A61K31 , A61K45 , A61P43 , C12N1 , C12N5 , C12N9 , A61K38
CPC分类号： C12N9/1205 , A61K38/00
摘要： The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.

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