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1. 发明申请

WO2012004399A1 DRY COMPOSITIONS AND DEVICES CONTAINING SUCH DRY COMPOSITIONS FOR USE IN PHOTODYNAMIC THERAPY OR PHOTODYNAMIC DIAGNOSIS 审中-公开
标题翻译：含有这种干燥组合物的干燥组合物和装置用于光化学治疗或光化学诊断
公开(公告)号：WO2012004399A1
公开(公告)日：2012-01-12
申请号：PCT/EP2011/061688
申请日：2011-07-08
申请人： PHOTOCURE ASA , KLEM, Bjørn , LANGE, Norbert
发明人： KLEM, Bjørn , LANGE, Norbert
IPC分类号： A61N5/06 , A61K9/70 , A61K41/00 , A61K47/36
CPC分类号： A61K31/197 , A61K9/19 , A61K9/7007 , A61K41/0061 , A61K49/0017 , A61K49/0036 , A61N5/0601 , A61N5/062
摘要： This invention relates to dry pharmaceutical compositions comprising an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA, or a pharmaceutically acceptable salt thereof. The compositions may be used in the photodynamic treatment (PDT) or photodynamic diagnosis (PDD) of cancer, pre-cancerous conditions and non-cancerous conditions. The invention relates further to irradiation devices comprising dry compositions and the use of such devices in the photodynamic treatment (PDT) or photodynamic diagnosis (PDD) of cancer, pre-cancerous conditions and non-cancerous conditions.
摘要翻译：本发明涉及包含5-氨基乙酰丙酸（5-ALA）或5-ALA的前体或衍生物的活性成分或其药学上可接受的盐的干燥药物组合物。组合物可用于癌症，癌前病症和非癌症病症的光动力学治疗（PDT）或光动力学诊断（PDD）。本发明进一步涉及包含干组合物的照射装置以及在光动力学治疗（PDT）或癌症，癌前病症和非癌症病症的光动力学诊断（PDD）中使用这些装置。

2. 发明申请

WO2009074811A2 USE 审中-公开
标题翻译：使用
公开(公告)号：WO2009074811A2
公开(公告)日：2009-06-18
申请号：PCT/GB2008/004113
申请日：2008-12-12
申请人： PHOTOCURE ASA , GOLDING, Louise , KLAVENESS, Jo , STENSRUD, Gry , GODAL, Aslak , BRAENDEN, Jon, Erik , KLEM, Bjørn
发明人： KLAVENESS, Jo , STENSRUD, Gry , GODAL, Aslak , BRAENDEN, Jon, Erik , KLEM, Bjørn
IPC分类号： A61K41/00 , A61P35/00 , A61K49/00 , A61K9/02 , A61K9/28 , A61K9/48 , A61K31/197
CPC分类号： A61K9/02 , A61K9/0031 , A61K9/0034 , A61K9/0075 , A61K9/14 , A61K9/1635 , A61K9/1652 , A61K9/20 , A61K9/2013 , A61K9/205 , A61K9/2054 , A61K9/2077 , A61K9/28 , A61K9/284 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K9/48 , A61K9/4858 , A61K9/4891 , A61K9/5042 , A61K9/5073 , A61K31/197 , A61K31/221 , A61K41/0057 , A61K41/0061 , A61K49/00 , A61K49/0021
摘要： The present invention relates to the use of a photosensitiser which is 5-ALA or a precursor or derivative thereof (e.g. an ALA ester), in the manufacture of a pharmaceutical product for use in the photodynamic treatment or diagnosis of cancer, an infection associated with cancer, or in the treatment or diagnosis of a non-cancerous condition, wherein said pharmaceutical product is in the form of a solid. The invention also relates to solid pharmaceutical products for use in such methods, e.g. suppositories, pessaries, tablets, pellets and capsules which comprise 5-ALA or a precursor or derivative thereof (e.g. an ALA ester) and at least one pharmaceutically acceptable carrier or excipient. Such products are particularly suitable for use in the photodynamic treatment or diagnosis of cancerous or non¬ cancerous conditions in the lower part of the gastrointestinal system or in the female reproductive system, e.g. in the treatment or diagnosis of colorectal cancer or cervical cancer.
摘要翻译：本发明涉及使用5-ALA或其前体或衍生物（例如ALA酯）的光敏剂在制造用于癌症的光动力学治疗或诊断的药物产品中，与癌症或治疗或诊断非癌症状况，其中所述药物产品为固体形式。本发明还涉及用于这些方法的固体药物产品，例如。栓剂，阴道栓剂，片剂，丸剂和胶囊，其包含5-ALA或其前体或衍生物（例如ALA酯）和至少一种药学上可接受的载体或赋形剂。这些产品特别适用于光动力学治疗或诊断胃肠系统下部或女性生殖系统中的癌性或非癌性病症，例如，在结直肠癌或宫颈癌的治疗或诊断中。

3. 发明申请

WO2009001103A1 OPTICAL FILM 审中-公开
标题翻译：光学胶片
公开(公告)号：WO2009001103A1
公开(公告)日：2008-12-31
申请号：PCT/GB2008/002228
申请日：2008-06-27
申请人： MICROSHARP CORPORATION LIMITED , WALKER, Nicholas, Simon
发明人： WALKER, Nicholas, Simon
IPC分类号： G02B5/18 , G02B1/11
CPC分类号： G02B1/118 , B82Y20/00 , G02B5/1809 , G02B2207/101 , Y10T428/24479 , Y10T428/2457 , Y10T428/24612
摘要： The present invention provides a nanostructure comprising a plurality of nanoridges wherein the height of each nanoridge is modulated whereby to form one or more peaks (e.g. a series of peaks) along the length of each nanoridge.
摘要翻译：本发明提供一种包含多个纳米级的纳米结构，其中每个纳米晶片的高度被调制，从而沿着每个纳米晶的长度形成一个或多个峰（例如一系列的峰）。

4. 发明申请

WO2010112865A1 5-HT RECEPTOR MODULATING COMPOUNDS 审中-公开
标题翻译： 5-HT受体调节化合物
公开(公告)号：WO2010112865A1
公开(公告)日：2010-10-07
申请号：PCT/GB2010/000656
申请日：2010-04-01
申请人： SERODUS AS , KLAVENESS, Jo , BRUDELI, Bjame , LEVY, Finn, Olav , MOLTZAU, Lise Román , GULBRANDSEN, Trygve , GOLDING, Louise
发明人： KLAVENESS, Jo , BRUDELI, Bjame , LEVY, Finn, Olav , MOLTZAU, Lise Román , GULBRANDSEN, Trygve
IPC分类号： C07D211/34 , C07D498/04 , A61K31/5365 , A61K31/445 , A61P1/00 , A61P9/00
CPC分类号： C07D498/04 , C07D211/34
摘要： The present invention relates to compounds having 5-hydroxytryptamine receptor modulating activity, in particular compounds having an acidic moiety held distant from the 5-HT pharmacophore by a rigid linker group, to compositions containing such compounds and methods of treatment using them. Such compounds have an increased affinity for the 5-HT receptor and a reduced hERG effect. Certain compounds of the invention further exhibit an angiotensin II receptor modulating activity. Claimed are compounds of formula (I): HT - L - A. HT is a 5-HT receptor modulating moiety containing a basic nitrogen atom; A is an acid moiety; L is a linker moiety. Examples of particular preterred HT groups are: (a) (b). Examples of particular preferred L groups comprise formula ( Vl ) and (VII) moieties: Examples of acid moieties are: -C(O)OR I. -OP(O)(OR2)2, -P(O)(OR2)2, -SO2OR2, -S03H, -0S03H, -P(O)(OH )2.
摘要翻译：本发明涉及具有5-羟色胺受体调节活性的化合物，特别是具有通过刚性连接基保持远离5-HT药效团的酸性部分的化合物，含有这些化合物的组合物和使用它们的治疗方法。这样的化合物对5-HT受体的亲和力增加并且hERG效应降低。本发明的某些化合物还表现出血管紧张素II受体调节活性。要求的是式（I）的化合物：HT-L-A。HT是含有碱性氮原子的5-HT受体调节部分; A是酸性部分; L是连接体部分。特定的早产HT组的实例是：（a）（b）。特别优选的L基团的实例包括式（VI）和（VII）部分：酸部分的实例是：-C（O）OR I -OP（O）（OR 2）2，-P（O）（OR 2）2 ，-SO 2 OR 2，-SO 3 H，-OSO 3 H，-P（O）（OH）2。

5. 发明申请

WO2013053927A1 PHOTODYNAMIC DIAGNOSIS OF ABNORMALITIES OF THE EPITHELIAL LINING OF THE OESOPHAGUS WITH THE MEANS OF A 5-ALA ESTER 审中-公开
标题翻译：用5-ALA ESTER的手段对ESOPHAGUS上皮层的异常进行光度诊断
公开(公告)号：WO2013053927A1
公开(公告)日：2013-04-18
申请号：PCT/EP2012/070346
申请日：2012-10-12
申请人： PHOTOCURE ASA
发明人： WIDERERG, Ketil
IPC分类号： A61K49/00 , A61K41/00
CPC分类号： A61K49/0052 , A61B5/0071 , A61K41/00 , A61K49/0036
摘要： This invention relates to the diagnosis of abnormalities of the epithelial-lined surface of the esophagus and, in particular, to the use of esters of 5-aminolevulinic acid (5-ALA) in methods of photodynamic diagnosis (PDD) of Barrett's esophagus and in diagnostic methods which monitor the progression of the disease with high specificity.
摘要翻译：本发明涉及食管上皮内表面异常的诊断，尤其涉及在Barrett食管的光动力学诊断（PDD）方法中使用5-氨基乙酰丙酸（5-ALA）的酯类和以高特异性监测疾病进展的诊断方法。

6. 发明申请

WO2011161220A1 HYPEROSMOTIC PREPARATIONS COMPRISING 5 -AMINO LEVULINIC ACID OR DERIVATIVE AS PHOTOSENSITIZING AGENT 审中-公开
标题翻译：包含5亚氨基酸或衍生物作为光敏剂的高效制剂
公开(公告)号：WO2011161220A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060574
申请日：2011-06-23
申请人： PHOTOCURE ASA , HEGLUND, Inger Ferner , GODAL, Aslak , KLAVENESS, Jo
发明人： HEGLUND, Inger Ferner , GODAL, Aslak , KLAVENESS, Jo
IPC分类号： A61K41/00 , A61K9/00 , A61P35/00
CPC分类号： A61K41/0061 , A61B5/0071 , A61B5/0084 , A61K9/0031 , A61K47/10 , A61K47/26
摘要： Provided herein are improved methods of photodynamic treatment and diagnosis of cancer and non-cancerous conditions in the gastrointestinal tract, e.g. in the colon, and in particular hyperosmotic enema preparations for use in such methods. The enema preparations comprise a photosensitizer which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative thereof, e.g. a 5-ALA ester, in combination with at least one hyperosmotic agent. The methods and preparations herein described are particularly suitable for use in photodynamic methods of treating and/or diagnosing colorectal cancer.
摘要翻译：本文提供了光动力学治疗和诊断胃肠道中的癌症和非癌性病症的改进方法，例如。在结肠中，特别是用于这些方法的高渗灌肠剂。灌肠制剂包含5-氨基乙酰丙酸（5-ALA）或其前体或衍生物的光敏剂，例如5-氨基乙酰丙酸。 5-ALA酯，与至少一种高渗剂组合。本文描述的方法和制剂特别适用于治疗和/或诊断结肠直肠癌的光动力学方法。

7. 发明申请

WO2009080342A1 PURIFICATION OF CUMENE 审中-公开
标题翻译：蒸发器的净化
公开(公告)号：WO2009080342A1
公开(公告)日：2009-07-02
申请号：PCT/EP2008/011009
申请日：2008-12-22
申请人： BOREALIS TECHNOLOGY OY , PUROLA, Veli-Matti
发明人： PUROLA, Veli-Matti
IPC分类号： C07C7/10 , C07C15/085
CPC分类号： C07C7/10 , C07C15/085
摘要： The present invention concerns a process for removing impurities from cumene to be used in phenol production, which process comprises providing a cumene feed containing cumene as well as phenol and other acidic components, mixing the cumene feed with an aqueous alkaline solution containing alkaline compounds to form a first aqueous cumene mixture, separating the aqueous solution from the first aqueous cumene mixture to provide a first purified cumene stream, mixing the first purified cumene stream with water to form a second aqueous cumene mixture, separating water from the second aqueous cumene mixture to provide a second purified cumene stream, and recovering the second purified cumene stream. The resulting cumene stream is particularly suitable for use in a dry oxidation process.
摘要翻译：本发明涉及从用于苯酚生产的枯烯中除去杂质的方法，该方法包括提供含异丙基苯以及苯酚和其它酸性组分的枯烯原料，将异丙基苯进料与含碱性化合物的碱性水溶液混合形成将第一含水枯烯混合物分离出第一含水枯烯混合物以提供第一纯化枯烯物流，将第一纯化枯烯物流与水混合以形成第二含水枯烯混合物，从第二含水异丙苯混合物中分离出水以提供第二纯化枯烯物流，并回收第二纯化枯烯物流。所得异丙苯流特别适用于干氧化过程。

8. 发明申请

WO2009080341A1 TREATMENT OF AIR 审中-公开
标题翻译：空气处理
公开(公告)号：WO2009080341A1
公开(公告)日：2009-07-02
申请号：PCT/EP2008/011008
申请日：2008-12-22
申请人： BOREALIS TECHNOLOGY OY , PENTTI, Ismo , SAUKONOJA, Jouni , PAKALA, Timo , MANNERLA, Anja
发明人： PENTTI, Ismo , SAUKONOJA, Jouni , PAKALA, Timo , MANNERLA, Anja
IPC分类号： C07C37/08 , B01D53/50
CPC分类号： C07C37/08 , B01D53/1406 , B01D53/40 , B01D53/501 , B01D53/78 , B01D2251/304 , C07C39/04
摘要： The present invention concerns a process for removing impurities from air to be used in the oxidation of cumene, which process comprises providing an air feed containing air and at least one acidic component, contacting the air with an aqueous caustic solution, which contains at least one alkaline compound whereby to neutralize the acidic components in the air feed, e.g. to form inorganic salts, separating a first purified air stream from the caustic solution, contacting the first purified air stream with fresh water to dissolve residual caustic solution and/or salts in the water, and separating a second purified air stream from the water containing residual caustic solution and salts. Further, the present invention concerns a purification column for use in purifying air.
摘要翻译：本发明涉及从用于异丙苯氧化的空气中除去杂质的方法，该方法包括提供含有空气和至少一种酸性组分的空气进料，使空气与苛性碱水溶液接触，该含水溶液含有至少一种碱性化合物，从而中和空气进料中的酸性组分，例如形成无机盐，从苛性碱溶液中分离出第一纯化空气流，使第一纯化空气流与淡水接触以将残留的苛性碱溶液和/或盐溶解在水中，并将第二纯化空气流从含水残留物中分离出来苛性碱溶液和盐。此外，本发明涉及一种用于净化空气的纯化塔。

9. 发明申请

WO2014020164A1 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2014020164A1
公开(公告)日：2014-02-06
申请号：PCT/EP2013/066317
申请日：2013-08-02
申请人： PHOTOCURE ASA
发明人： BRÆNDEN, Jon Erik , CHARNOCK, Colin Barry , GODAL, Aslak , KLAVENESS, Jo , NILSEN, Nils Olav
IPC分类号： C07C229/22
CPC分类号： C07C229/24 , A61K41/0061 , C07C229/22
摘要： The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis: wherein R 1 represents a hydrogen atom or an optionally substituted alkyl or cycloalkyl group; R 2 , each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group; and X is a linking group.
摘要翻译：本发明涉及5-氨基乙酰丙酸（5-ALA）的新衍生物及其作为光敏剂的用途。特别地，本发明涉及通式I化合物及其药学上可接受的盐，制备这些化合物的方法及其医疗和化妆品用途，例如光动力学治疗和诊断方法：其中R1代表氢原子或任选取代的烷基或环烷基; R2各自可以相同或不同，表示氢原子或任选取代的烷基; X是连接基团。

10. 发明申请

WO2010142457A1 SEMI-SOLID COMPOSITIONS AND PHARMACEUTICAL PRODUCTS 审中-公开
标题翻译：半固体组合物和药物产品
公开(公告)号：WO2010142457A1
公开(公告)日：2010-12-16
申请号：PCT/EP2010/003532
申请日：2010-06-11
申请人： PHOTOCURE ASA , STENSRUD, Gry
发明人： STENSRUD, Gry
IPC分类号： A61K31/195 , A61K9/06 , A61K47/10 , A61K47/14 , A61K47/44
CPC分类号： A61K31/221 , A61K9/0031 , A61K9/0034 , A61K9/06 , A61K31/195 , A61K41/0061 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/24 , A61K47/26
摘要： This invention relates to semi-solid compositions and semi-solid pharmaceutical products for use in the photodynamic treatment (PDT) of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, preferably for use in PDT of endometrial, cervical, vulvar, vaginal, anal and penile dysplasia and HPV infections of the uterus, cervix, the vulva, the vagina, the anus and the penis. The semi-solid compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of PDT of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, wherein said semi-solid compositions and pharmaceutical products are used.
摘要翻译：本发明涉及用于癌症的光动力学治疗（PDT），女性生殖系统，肛门和阴茎中的癌前病症和非癌症状态的半固体组合物和半固体药物产品，优选使用在子宫内膜，子宫颈，外阴，阴道，肛门和阴茎发育异常和子宫，子宫颈，外阴，阴道，肛门和阴茎的HPV感染的PDT中。半固体组合物和药物产品包含5-氨基乙酰丙酸（5-ALA）或5-ALA的前体或衍生物的活性成分或其药学上可接受的盐。本发明还涉及在雌性生殖系统，肛门和阴茎中的癌症的PDT，癌前病症和非癌症病症的方法，其中使用所述半固体组合物和药物产品。

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